5b79777db683948253b885c370f2c03b 283228.pdf c94c8176f90ad46c1f4de678191b30ec64b4442e 283228.pdf 1f909b62e56ac1918da4d8040fe4abe5864acf199c7318602d3906801934fb22 283228.pdf Title: Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery Subject: Trials, 2022, doi:10.1186/s13063-021-05992-1 Keywords: Noncardiac surgery,Tranexamic acid,Perioperative bleeding,Perioperative hypotension,Cardiovascular complications,Randomized controlled trial Author: Maura Marcucci Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jan 26 09:05:56 2022 CET ModDate: Mon Jan 31 13:51:30 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1322785 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 22 0 ENCDEG+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 25 0 ENDMFN+AdvTTe45e47d2 Type 1C WinAnsi yes yes no 26 0 ENDMFO+AdvTTb5929f4c Type 1C WinAnsi yes yes no 27 0 ENDMNM+AdvTT99c4c969 Type 1C WinAnsi yes yes no 28 0 ENFCNG+AdvTT7329fd89.I Type 1C WinAnsi yes yes no 29 0 ENFDFI+AdvTT86d47313+22 Type 1C Custom yes yes yes 20 0 ENFDEG+AdvTTb5929f4c+22 Type 1C Custom yes yes yes 21 0 ENFDEH+AdvTT86d47313 Type 1C WinAnsi yes yes no 23 0 ENFDFH+AdvTT86d47313+20 Type 1C WinAnsi yes yes no 24 0 ENFDJI+AdvTTb5929f4c+03 Type 1C Custom yes yes yes 137 0 ENFDJJ+AdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 122 0 ENFDJK+AdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 129 0 ENFDNJ+AdvTT83913201.I Type 1C WinAnsi yes yes no 183 0 ENFLOJ+AdvTT4fa15320.B Type 1C WinAnsi yes yes no 206 0 ENFPAH+AdvTT8861b38f.I Type 1C WinAnsi yes yes no 351 0 ENFPEG+AdvTT99c4c969+20 Type 1C WinAnsi yes yes no 391 0 ENGAFB+AdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 366 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-09 02:33:38 CET RepresentationInformation: 283228.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-08 10:33:39 CET Size: 1322785 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM1' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM2' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM3' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM4' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM5' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM6' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig3' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM7' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM8' cannot be found Offset: 536524 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_MOESM10' cannot be found Offset: 536524 MIMEtype: application/pdf PDFMetadata: Objects: 596 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Trial registration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Trial design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Trial population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Patient recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Randomization and blinding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Trial interventions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: Tranexamic acid or placebo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Perioperative BP management strategies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Trial outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: TXA trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: BP management trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Follow-up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Data management Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Statistical considerations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Children: Item: Title: Sample size Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Children: Item: Title: Main analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Subgroup analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Interim analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Oversight and monitoring Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Children: Item: Title: Trial organization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Adverse event reporting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Dissemination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Trial progress Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Supplementary Information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: Declarations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22eeefeb Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17d0685f Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3891771e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78ac1102 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2de8284b Info: Title: Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery Author: Maura Marcucci Subject: Trials, 2022, doi:10.1186/s13063-021-05992-1 Keywords: Noncardiac surgery,Tranexamic acid,Perioperative bleeding,Perioperative hypotension,Cardiovascular complications,Randomized controlled trial Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jan 26 09:05:56 CET 2022 ModDate: Mon Jan 31 13:51:30 CET 2022 ID: 0xe9a35ebdcc09a48229b9eec3f1af973b, 0xfd165677105d24754f784dbffda802de Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 177 ImageHeight: 183 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 55 ImageHeight: 104 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1420 ImageHeight: 1590 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 574 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: ENFDJK+AdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: ENFDJK+AdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFPEG+AdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: ENFPEG+AdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFDJI+AdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: ENFDJI+AdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ENFLOJ+AdvTT4fa15320.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: ENFLOJ+AdvTT4fa15320.B Flags: Serif, Nonsymbolic FontBBox: -20, -239, 1052, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENGAFB+AdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: ENGAFB+AdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFDFI+AdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 139 FontDescriptor: FontName: ENFDFI+AdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ENFDEG+AdvTTb5929f4c+22 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: ENFDEG+AdvTTb5929f4c+22 Flags: Symbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ENFDEH+AdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: ENFDEH+AdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -20, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFDNJ+AdvTT83913201.I FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: ENFDNJ+AdvTT83913201.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFDFH+AdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: ENFDFH+AdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENCDEG+AdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: ENCDEG+AdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENDMFN+AdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: ENDMFN+AdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFDJJ+AdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: ENFDJJ+AdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENDMFO+AdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: ENDMFO+AdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENDMNM+AdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: ENDMNM+AdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFCNG+AdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ENFCNG+AdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ENFPAH+AdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 112 FontDescriptor: FontName: ENFPAH+AdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: Noncardiac surgery,Tranexamic acid,Perioperative bleeding,Perioperative hypotension,Cardiovascular complications,Randomized controlled trial Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13063-021-05992-1 Trials Trials, 2022, doi:10.1186/s13063-021-05992-1 Noncardiac surgery Tranexamic acid Perioperative bleeding Perioperative hypotension Cardiovascular complications Randomized controlled trial Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery Maura Marcucci Thomas W. Painter David Conen Kate Leslie Vladimir V. Lomivorotov Daniel Sessler Matthew T. V. Chan Flavia K. Borges Maria J. Martínez Zapata C. Y. Wang Denis Xavier Sandra N. Ofori Giovanni Landoni Sergey Efremov Ydo V. Kleinlugtenbelt Wojciech Szczeklik Denis Schmartz Amit X. Garg Timothy G. Short Maria Wittmann Christian S. Meyhoff Mohammed Amir David Torres Ameen Patel Emmanuelle Duceppe Kurtz Ruetzler Joel L. Parlow Vikas Tandon Michael K. Wang Edith Fleischmann Carisi A. Polanczyk Raja Jayaram Sergey V. Astrakov Mangala Rao Tomas VanHelder William K. K. Wu Chao Chia Cheong Sabry Ayad Marat Abubakirov Mikhail Kirov Keyur Bhatt Miriam Nadal Valery Likhvantsev Pilar Paniagua Iglesisas Hector J. Aguado Michael McGillion Andre Lamy Richard P. Whitlock Pavel Roshanov David Stillo Ingrid Copland Jessica Vincent Kumar Balasubramanian Shrikant I. Bangdiwala Bruce Biccard Andrea Kurz Sadeesh Srinathan Shirley Petit John Eikelboom Toby Richards Peter L. Gross Pascal Alfonsi Gordon Guyatt Emily Belley-Cote Jessica Spence William McIntyre Salim Yusuf P. J. Devereaux 2022-01-31T13:51:30+01:00 2022-01-31T13:51:30+01:00 2022-01-26T16:05:56+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:1ab36d6a-8d76-4159-ab2f-29a6fe54c7f8 uuid:009a9591-acc0-49da-89ca-55bb56bb1396 default 1 converted uuid:1ab36d6a-8d76-4159-ab2f-29a6fe54c7f8 converted to PDF/A-2b pdfToolbox 2022-01-27T22:45:18+08:00 2 B Maura Marcucci http://orcid.org/0000-0002-8468-7991 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 139, 521, 148, 530 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 183, 185, 190 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 140, 470, 205, 480 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 96, 326, 100, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 109, 326, 114, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 220, 302, 225, 312 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 266, 230, 276 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 266, 241, 276 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 218, 285, 228 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 103, 206, 108, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 207, 206, 217, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 134, 138, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 98, 269, 108 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 275, 98, 285, 108 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 74, 166, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 172, 74, 182, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 334, 350, 344, 360 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 342, 314, 352, 324 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 477, 266, 487, 276 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 230, 317, 240 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 323, 230, 333, 240 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 452, 182, 461, 192 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 467, 182, 476, 192 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 414, 134, 423, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 429, 134, 439, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 397, 110, 407, 120 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 412, 110, 422, 120 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 438, 98, 448, 108 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 453, 98, 463, 108 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 275, 681, 285, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 609, 69, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 76, 609, 86, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 92, 609, 102, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 150, 291, 216, 300 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 177, 255, 182, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 144, 165, 149, 174 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 249, 141, 254, 150 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 285, 141, 290, 150 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 247, 81, 252, 90 Flags: Print AppearanceDictionary: true Destination: 135 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 88, 549, 93, 558 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 243, 645, 248, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 405, 657, 409, 666 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 395, 406, 400, 415 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 95, 621, 100, 630 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 549, 106, 558 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 120, 513, 130, 522 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 345, 69, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 309, 143, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 297, 156, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 383, 561, 388, 570 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 171, 550, 176, 559 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 112, 406, 117, 415 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 123, 406, 133, 415 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 216, 346, 220, 355 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 113, 310, 118, 319 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 327, 681, 332, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 467, 333, 477, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 348, 100, 352, 107 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 522, 100, 526, 107 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 529, 100, 533, 107 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 374, 537, 383, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 537, 398, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 489, 327, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 516, 357, 521, 366 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 333, 538, 342 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 91, 345, 247, 354 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 353, 531, 360 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 344, 402, 351 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 187, 375, 191, 383 Flags: Print AppearanceDictionary: true Destination: 168 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 252, 574, 283, 581 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 565, 151, 572 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 213, 529, 284, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 520, 110, 527 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 492, 282, 500 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 483, 143, 491 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 160, 447, 280, 455 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 438, 118, 446 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 139, 411, 253, 418 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 225, 384, 283, 391 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 375, 165, 382 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 347, 281, 355 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 338, 131, 346 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 202, 302, 289, 310 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 293, 118, 301 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 257, 284, 264 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 248, 158, 255 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 220, 258, 228 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 175, 204, 183 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 129, 139, 258, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 146, 112, 276, 119 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 84, 284, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 75, 144, 83 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 405, 684, 525, 692 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 408, 657, 528, 664 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 366, 630, 462, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 454, 602, 521, 610 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 593, 367, 601 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 414, 557, 524, 564 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 548, 333, 555 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 376, 512, 499, 519 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 491, 484, 537, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 475, 419, 483 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 343, 439, 488, 447 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 403, 536, 410 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 347, 357, 482, 365 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 509, 312, 530, 320 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 303, 433, 311 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 383, 276, 497, 283 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 514, 249, 535, 256 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 240, 432, 247 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 203, 417, 211 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 462, 167, 533, 174 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 158, 383, 165 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 357, 113, 488, 120 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 420, 85, 500, 93 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 76, 374, 84 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 71, 675, 185, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 174, 639, 290, 647 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 630, 81, 638 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 603, 268, 611 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 576, 283, 584 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 567, 171, 575 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 549, 282, 557 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 540, 160, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 95, 495, 208, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 132, 468, 250, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 248, 441, 279, 449 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 432, 154, 440 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 99, 405, 192, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 211, 369, 278, 377 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 360, 106, 368 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 84803aa5 Type: CRC32 Checksum: 5b79777db683948253b885c370f2c03b Type: MD5 Checksum: c94c8176f90ad46c1f4de678191b30ec64b4442e Type: SHA-1