81f47982b786e12cf9e3d42738dacad4 284167.pdf db6639192fe126eb3d6b4061f4f0b29e98f18fbf 284167.pdf 4a555e2cedebcda3c2bc059cf0a5572f68ee0d76f94cfab49498553b354a37b7 284167.pdf Title: Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy Subject: Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation. Keywords: human milk; oxidative stress; oxygen therapy; premature infant; sepsis; newborn infant; ventilation support Author: Elisenda Moliner-Calderón, Sergio Verd, Alfonso Leiva, Jaume Ponce-Taylor, Gemma Ginovart, Pia Moll-McCarthy, Catian Gelabert and Josep Figueras-Aloy Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Sep 26 05:03:05 2022 CEST ModDate: Mon Sep 26 05:08:54 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 275035 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SOZKOC+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 FPPBTG+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VQRTYQ+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 XKHCKP+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 YJPPHJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 42 0 JDUPKS+CMSY10 Type 1 Builtin yes yes no 67 0 JLZORU+EURM10 Type 1 Builtin yes yes no 71 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 MOCBVF+VnURWPalladioL Type 1 Custom yes yes no 91 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-09 02:33:36 CET RepresentationInformation: 284167.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-08 10:46:53 CET Size: 275035 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 217 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Study Population, Design, Location, and Period Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Primary Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Secondary Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Analysis Plan Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Ethical Considerations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Info: Title: Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy Author: Elisenda Moliner-Calderón, Sergio Verd, Alfonso Leiva, Jaume Ponce-Taylor, Gemma Ginovart, Pia Moll-McCarthy, Catian Gelabert and Josep Figueras-Aloy Subject: Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation. 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