ab45b0ff759c1ed3955e151514050d60 organics-03-00018_10.pdf 55405ad7fdb58c55f49fb50c7bf783381a5d09b2 organics-03-00018_10.pdf b23c7ed4208f79590c4381784b770aece5e04660aae36c4122d26186a51d9126 organics-03-00018_10.pdf Title: Specific Bifunctionalization on the Surface of Phosphorus Dendrimers Syntheses and Properties Subject: Dendrimers are highly branched macromolecules possessing, in most cases, identical terminal functions. However, it is sometimes desirable to have two types of surface functions in order to fulfil specific properties. The stochastic functionalization is frequently used for such purposes, but the presence of an uncontrolled number of each type of terminal function, albeit acceptable for research purposes, has no practical use. Thus, it is highly desirable to find strategies suitable for the precise grafting of two different functional groups on the surface of dendrimers. The easiest way, and the most widely used, consists in using a bifunctional monomer to be grafted to all of the surface functions of the dendrimers. Two other strategies are known but are rarely used: the modification of an existing function, to generate two functions, and the sequential grafting of one function then of a second function. The three methods are illustrated in this review with polyphosphorhydrazone (PPH) dendrimers, together with their properties as catalysts, for materials, and as biological tools. Keywords: dendrimer; phosphorus; bifunctionalization; polyphosphorhydrazone; properties Author: Massimo Petriccone, Régis Laurent, Cédric-Olivier Turrin, Rosa Maria Sebastián and Anne-Marie Caminade Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Aug 3 09:44:27 2022 CEST ModDate: Wed Aug 3 09:50:26 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 9593687 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZNKOOR+VnURWPalladioL Type 1 Custom yes yes no 10 0 JAWJBI+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VCKXBJ+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 UKYHOW+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 GIFXFT+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 75 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 78 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 81 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 91 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 94 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 97 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 107 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 110 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 113 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 121 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 138 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 141 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 144 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 156 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 159 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 162 0 EBKEML+CMSY10 Type 1 Builtin yes yes no 171 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 182 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 185 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 188 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 201 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 204 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 207 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 219 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 222 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 225 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 233 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 244 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 247 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 253 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 256 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 267 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 270 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 273 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 285 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 288 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 294 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 297 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 308 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 311 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 314 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 322 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 325 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 331 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 334 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 344 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 347 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 353 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 356 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 364 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 367 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 373 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 376 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 390 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 393 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 396 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 407 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 410 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 413 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 424 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 427 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 430 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 442 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 445 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 448 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 459 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 462 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 468 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 471 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 479 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 482 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 485 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 493 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 496 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 502 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 505 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 516 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 519 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 522 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 530 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 533 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 536 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 547 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 550 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 556 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 559 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 568 0 IEJHCH+PalatinoLinotype CID TrueType Identity-H yes yes yes 571 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 577 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 580 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 592 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 595 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 598 0 IEJHCG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 607 0 IEJHCI+PalatinoLinotype TrueType WinAnsi yes yes no 610 0 IEJHDK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 613 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-14 02:31:19 CET RepresentationInformation: organics-03-00018_10.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-03 10:24:06 CET Size: 9593687 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 911 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Bifunctional Monomers Grafted to the Surface of PPH Dendrimers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Modification of a Function Already on the Surface of PPH Dendrimers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Sequential Grafting of a First, then a Second Function on the Surface of PPH Dendrimers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Info: Title: Specific Bifunctionalization on the Surface of Phosphorus Dendrimers Syntheses and Properties Author: Massimo Petriccone, Régis Laurent, Cédric-Olivier Turrin, Rosa Maria Sebastián and Anne-Marie Caminade Subject: Dendrimers are highly branched macromolecules possessing, in most cases, identical terminal functions. However, it is sometimes desirable to have two types of surface functions in order to fulfil specific properties. The stochastic functionalization is frequently used for such purposes, but the presence of an uncontrolled number of each type of terminal function, albeit acceptable for research purposes, has no practical use. Thus, it is highly desirable to find strategies suitable for the precise grafting of two different functional groups on the surface of dendrimers. The easiest way, and the most widely used, consists in using a bifunctional monomer to be grafted to all of the surface functions of the dendrimers. Two other strategies are known but are rarely used: the modification of an existing function, to generate two functions, and the sequential grafting of one function then of a second function. The three methods are illustrated in this review with polyphosphorhydrazone (PPH) dendrimers, together with their properties as catalysts, for materials, and as biological tools. Keywords: dendrimer; phosphorus; bifunctionalization; polyphosphorhydrazone; properties Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Aug 03 09:44:27 CEST 2022 ModDate: Wed Aug 03 09:50:26 CEST 2022 ID: 0xcc8f93df4aa67a136b75cad84dbf1021, 0xcc8f93df4aa67a136b75cad84dbf1021 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VCKXBJ+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 225 FontDescriptor: FontName: VCKXBJ+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UKYHOW+URWPalladioL-Ital FontSubset: true FirstChar: 44 LastChar: 150 FontDescriptor: FontName: UKYHOW+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QDCWHF+EURM10 FontSubset: true FirstChar: 11 LastChar: 12 FontDescriptor: FontName: QDCWHF+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: ZNKOOR+VnURWPalladioL FontSubset: true FirstChar: 177 LastChar: 226 FontDescriptor: FontName: ZNKOOR+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EBKEML+CMSY10 FontSubset: true FirstChar: 0 LastChar: 33 FontDescriptor: FontName: EBKEML+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: GIFXFT+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 178 FontDescriptor: FontName: GIFXFT+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JAWJBI+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: JAWJBI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 65, 335, 152, 344 Annotation: Subtype: Link Rect: 34, 323, 71, 332 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 139, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 178, 651, 190, 662 Annotation: Subtype: Link Rect: 244, 297, 250, 306 ActionDest: 619 Annotation: Subtype: Link Rect: 257, 259, 264, 268 ActionDest: 619 Annotation: Subtype: Link Rect: 411, 234, 418, 243 ActionDest: 619 Annotation: Subtype: Link Rect: 464, 234, 471, 243 ActionDest: 619 Annotation: Subtype: Link Rect: 333, 71, 340, 80 ActionDest: 619 Annotation: Subtype: Link Rect: 126, 17, 258, 28 Annotation: Subtype: Link Rect: 407, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 420, 87, 439 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 456, 735, 463, 744 ActionDest: 619 Annotation: Subtype: Link Rect: 233, 708, 240, 720 ActionDest: 69 Annotation: Subtype: Link Rect: 249, 446, 256, 458 ActionDest: 85 Annotation: Subtype: Link Rect: 490, 411, 497, 420 ActionDest: 619 Annotation: Subtype: Link Rect: 296, 373, 303, 382 ActionDest: 619 Annotation: Subtype: Link Rect: 425, 361, 432, 370 ActionDest: 619 Annotation: Subtype: Link Rect: 286, 336, 298, 345 ActionDest: 622 Annotation: Subtype: Link Rect: 350, 298, 362, 307 ActionDest: 622 Annotation: Subtype: Link Rect: 216, 260, 228, 269 ActionDest: 622 Annotation: Subtype: Link Rect: 289, 248, 301, 257 ActionDest: 622 Annotation: Subtype: Link Rect: 544, 223, 556, 232 ActionDest: 622 Annotation: Subtype: Link Rect: 294, 185, 306, 194 ActionDest: 622 Annotation: Subtype: Link Rect: 307, 185, 319, 194 ActionDest: 622 Annotation: Subtype: Link Rect: 527, 185, 539, 194 ActionDest: 622 Annotation: Subtype: Link Rect: 204, 172, 216, 181 ActionDest: 622 Annotation: Subtype: Link Rect: 298, 160, 310, 169 ActionDest: 622 Annotation: Subtype: Link Rect: 199, 122, 211, 131 ActionDest: 622 Annotation: Subtype: Link Rect: 284, 97, 296, 106 ActionDest: 622 Annotation: Subtype: Link Rect: 410, 60, 422, 69 ActionDest: 622 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 268, 468, 275, 480 ActionDest: 85 Annotation: Subtype: Link Rect: 529, 458, 541, 467 ActionDest: 622 Annotation: Subtype: Link Rect: 390, 430, 397, 442 ActionDest: 85 Annotation: Subtype: Link Rect: 544, 408, 556, 417 ActionDest: 622 Annotation: Subtype: Link Rect: 524, 383, 536, 392 ActionDest: 622 Annotation: Subtype: Link Rect: 266, 333, 278, 342 ActionDest: 622 Annotation: Subtype: Link Rect: 286, 320, 298, 329 ActionDest: 622 Annotation: Subtype: Link Rect: 474, 318, 481, 330 ActionDest: 101 Annotation: Subtype: Link Rect: 328, 242, 335, 254 ActionDest: 85 Annotation: Subtype: Link Rect: 314, 169, 326, 179 ActionDest: 622 Annotation: Subtype: Link Rect: 242, 144, 254, 153 ActionDest: 622 Annotation: Subtype: Link Rect: 219, 132, 231, 141 ActionDest: 622 Annotation: Subtype: Link Rect: 353, 119, 365, 128 ActionDest: 622 Annotation: Subtype: Link Rect: 412, 107, 424, 116 ActionDest: 625 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 549, 395, 556, 407 ActionDest: 85 Annotation: Subtype: Link Rect: 391, 358, 398, 370 ActionDest: 101 Annotation: Subtype: Link Rect: 405, 360, 417, 369 ActionDest: 625 Annotation: Subtype: Link Rect: 331, 101, 343, 110 ActionDest: 625 Annotation: Subtype: Link Rect: 457, 76, 469, 85 ActionDest: 625 Annotation: Subtype: Link Rect: 469, 64, 481, 73 ActionDest: 625 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 395, 735, 407, 744 ActionDest: 625 Annotation: Subtype: Link Rect: 356, 723, 368, 732 ActionDest: 625 Annotation: Subtype: Link Rect: 274, 710, 286, 719 ActionDest: 625 Annotation: Subtype: Link Rect: 220, 698, 232, 707 ActionDest: 625 Annotation: Subtype: Link Rect: 525, 632, 533, 644 ActionDest: 132 Annotation: Subtype: Link Rect: 199, 532, 206, 544 ActionDest: 132 Annotation: Subtype: Link Rect: 213, 535, 225, 544 ActionDest: 625 Annotation: Subtype: Link Rect: 544, 59, 550, 73 ActionDest: 132 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 512, 720, 519, 732 ActionDest: 168 Annotation: Subtype: Link Rect: 230, 695, 237, 707 ActionDest: 168 Annotation: Subtype: Link Rect: 399, 647, 411, 657 ActionDest: 625 Annotation: Subtype: Link Rect: 205, 620, 212, 632 ActionDest: 168 Annotation: Subtype: Link Rect: 200, 595, 207, 607 ActionDest: 168 Annotation: Subtype: Link Rect: 412, 572, 424, 581 ActionDest: 625 Annotation: Subtype: Link Rect: 455, 557, 462, 569 ActionDest: 168 Annotation: Subtype: Link Rect: 417, 535, 429, 544 ActionDest: 625 Annotation: Subtype: Link Rect: 545, 179, 552, 193 ActionDest: 168 Annotation: Subtype: Link Rect: 529, 165, 536, 177 ActionDest: 168 Annotation: Subtype: Link Rect: 258, 122, 270, 131 ActionDest: 625 Annotation: Subtype: Link Rect: 351, 122, 363, 131 ActionDest: 625 Annotation: Subtype: Link Rect: 418, 97, 430, 106 ActionDest: 625 Annotation: Subtype: Link Rect: 202, 69, 209, 81 ActionDest: 213 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 394, 695, 401, 707 ActionDest: 230 Annotation: Subtype: Link Rect: 399, 622, 411, 631 ActionDest: 625 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 552, 544, 559, 558 ActionDest: 213 Annotation: Subtype: Link Rect: 196, 499, 208, 508 ActionDest: 625 Annotation: Subtype: Link Rect: 371, 487, 383, 495 ActionDest: 625 Annotation: Subtype: Link Rect: 278, 436, 290, 445 ActionDest: 625 Annotation: Subtype: Link Rect: 458, 383, 465, 395 ActionDest: 261 Annotation: Subtype: Link Rect: 506, 358, 513, 370 ActionDest: 261 Annotation: Subtype: Link Rect: 248, 323, 260, 332 ActionDest: 625 Annotation: Subtype: Link Rect: 452, 270, 459, 282 ActionDest: 302 Annotation: Subtype: Link Rect: 264, 248, 276, 257 ActionDest: 625 Annotation: Subtype: Link Rect: 352, 210, 364, 219 ActionDest: 625 Annotation: Subtype: Link Rect: 286, 173, 298, 182 ActionDest: 625 Annotation: Subtype: Link Rect: 510, 160, 522, 169 ActionDest: 625 Annotation: Subtype: Link Rect: 360, 97, 372, 106 ActionDest: 625 Annotation: Subtype: Link Rect: 287, 70, 294, 82 ActionDest: 302 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 195, 723, 207, 732 ActionDest: 625 Annotation: Subtype: Link Rect: 544, 710, 556, 719 ActionDest: 628 Annotation: Subtype: Link Rect: 436, 685, 448, 694 ActionDest: 628 Annotation: Subtype: Link Rect: 405, 660, 417, 669 ActionDest: 628 Annotation: Subtype: Link Rect: 309, 119, 315, 131 ActionDest: 261 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 225, 207, 232, 219 ActionDest: 338 Annotation: Subtype: Link Rect: 211, 185, 223, 194 ActionDest: 622 Annotation: Subtype: Link Rect: 223, 185, 235, 194 ActionDest: 628 Annotation: Subtype: Link Rect: 289, 172, 300, 181 ActionDest: 628 Annotation: Subtype: Link Rect: 331, 160, 343, 169 ActionDest: 628 Annotation: Subtype: Link Rect: 444, 160, 456, 169 ActionDest: 628 Annotation: Subtype: Link Rect: 511, 160, 523, 169 ActionDest: 628 Annotation: Subtype: Link Rect: 210, 147, 222, 156 ActionDest: 628 Annotation: Subtype: Link Rect: 393, 135, 405, 144 ActionDest: 628 Annotation: Subtype: Link Rect: 521, 69, 528, 81 ActionDest: 338 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 313, 735, 325, 744 ActionDest: 622 Annotation: Subtype: Link Rect: 325, 735, 337, 744 ActionDest: 628 Annotation: Subtype: Link Rect: 510, 735, 522, 744 ActionDest: 628 Annotation: Subtype: Link Rect: 506, 390, 513, 402 ActionDest: 85 Annotation: Subtype: Link Rect: 436, 353, 448, 365 ActionDest: 338 Annotation: Subtype: Link Rect: 257, 305, 269, 314 ActionDest: 628 Annotation: Subtype: Link Rect: 424, 98, 437, 110 ActionDest: 382 Annotation: Subtype: Link Rect: 248, 85, 261, 97 ActionDest: 338 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 319, 723, 331, 732 ActionDest: 628 Annotation: Subtype: Link Rect: 347, 429, 359, 441 ActionDest: 382 Annotation: Subtype: Link Rect: 477, 417, 484, 429 ActionDest: 382 Annotation: Subtype: Link Rect: 300, 382, 312, 391 ActionDest: 625 Annotation: Subtype: Link Rect: 198, 119, 209, 131 ActionDest: 382 Annotation: Subtype: Link Rect: 553, 72, 560, 84 ActionDest: 338 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 384, 695, 396, 707 ActionDest: 436 Annotation: Subtype: Link Rect: 430, 683, 436, 695 ActionDest: 338 Annotation: Subtype: Link Rect: 443, 685, 455, 694 ActionDest: 628 Annotation: Subtype: Link Rect: 247, 632, 259, 644 ActionDest: 436 Annotation: Subtype: Link Rect: 266, 635, 278, 644 ActionDest: 628 Annotation: Subtype: Link Rect: 515, 305, 527, 317 ActionDest: 453 Annotation: Subtype: Link Rect: 544, 283, 556, 292 ActionDest: 628 Annotation: Subtype: Link Rect: 524, 255, 531, 267 ActionDest: 453 Annotation: Subtype: Link Rect: 398, 245, 410, 254 ActionDest: 628 Annotation: Subtype: Link Rect: 357, 192, 369, 204 ActionDest: 453 Annotation: Subtype: Link Rect: 189, 157, 201, 166 ActionDest: 628 Annotation: Subtype: Link Rect: 482, 107, 494, 116 ActionDest: 628 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 244, 135, 250, 147 ActionDest: 85 Annotation: Subtype: Link Rect: 221, 125, 233, 134 ActionDest: 622 Annotation: Subtype: Link Rect: 234, 125, 246, 134 ActionDest: 622 Annotation: Subtype: Link Rect: 428, 60, 440, 72 ActionDest: 510 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 483, 710, 495, 719 ActionDest: 628 Annotation: Subtype: Link Rect: 518, 526, 530, 538 ActionDest: 510 Annotation: Subtype: Link Rect: 537, 528, 549, 538 ActionDest: 628 Annotation: Subtype: Link Rect: 468, 303, 481, 315 ActionDest: 541 Annotation: Subtype: Link Rect: 384, 265, 396, 277 ActionDest: 541 Annotation: Subtype: Link Rect: 403, 268, 415, 277 ActionDest: 628 Annotation: Subtype: Link Rect: 498, 205, 510, 214 ActionDest: 628 Annotation: Subtype: Link Rect: 281, 127, 293, 139 ActionDest: 541 Annotation: Subtype: Link Rect: 301, 130, 313, 139 ActionDest: 628 Annotation: Subtype: Link Rect: 349, 117, 361, 126 ActionDest: 628 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 420, 158, 433, 170 ActionDest: 541 Annotation: Subtype: Link Rect: 292, 109, 304, 120 ActionDest: 586 Annotation: Subtype: Link Rect: 311, 111, 323, 120 ActionDest: 628 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 252, 352, 264, 364 ActionDest: 586 Annotation: Subtype: Link Rect: 246, 330, 258, 339 ActionDest: 632 Annotation: Subtype: Link Rect: 532, 330, 544, 339 ActionDest: 632 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 316, 297, 354, 308 Annotation: Subtype: Link Rect: 293, 274, 330, 285 Annotation: Subtype: Link Rect: 461, 251, 499, 262 Annotation: Subtype: Link Rect: 519, 240, 557, 251 Annotation: Subtype: Link Rect: 59, 229, 95, 239 Annotation: Subtype: Link Rect: 519, 205, 557, 216 Annotation: Subtype: Link Rect: 59, 195, 95, 205 Annotation: Subtype: Link Rect: 479, 171, 516, 182 Annotation: Subtype: Link Rect: 521, 171, 557, 182 Annotation: Subtype: Link Rect: 327, 148, 364, 159 Annotation: Subtype: Link Rect: 370, 148, 406, 159 Annotation: Subtype: Link Rect: 59, 114, 96, 124 Annotation: Subtype: Link Rect: 344, 91, 381, 101 Annotation: Subtype: Link Rect: 387, 91, 423, 101 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 104, 711, 142, 721 Annotation: Subtype: Link Rect: 439, 687, 477, 698 Annotation: Subtype: Link Rect: 59, 653, 96, 664 Annotation: Subtype: Link Rect: 253, 630, 291, 640 Annotation: Subtype: Link Rect: 468, 606, 505, 617 Annotation: Subtype: Link Rect: 511, 606, 547, 617 Annotation: Subtype: Link Rect: 59, 561, 96, 571 Annotation: Subtype: Link Rect: 102, 561, 138, 571 Annotation: Subtype: Link Rect: 279, 526, 316, 537 Annotation: Subtype: Link Rect: 322, 526, 358, 537 Annotation: Subtype: Link Rect: 104, 492, 142, 502 Annotation: Subtype: Link Rect: 148, 492, 184, 502 Annotation: Subtype: Link Rect: 344, 468, 382, 479 Annotation: Subtype: Link Rect: 191, 435, 228, 445 Annotation: Subtype: Link Rect: 104, 400, 142, 410 Annotation: Subtype: Link Rect: 148, 400, 184, 410 Annotation: Subtype: Link Rect: 328, 376, 366, 387 Annotation: Subtype: Link Rect: 477, 353, 515, 364 Annotation: Subtype: Link Rect: 521, 353, 557, 364 Annotation: Subtype: Link Rect: 162, 331, 199, 341 Annotation: Subtype: Link Rect: 206, 331, 242, 341 Annotation: Subtype: Link Rect: 520, 307, 557, 318 Annotation: Subtype: Link Rect: 140, 274, 177, 284 Annotation: Subtype: Link Rect: 308, 250, 345, 261 Annotation: Subtype: Link Rect: 152, 228, 190, 238 Annotation: Subtype: Link Rect: 104, 193, 142, 203 Annotation: Subtype: Link Rect: 104, 159, 142, 169 Annotation: Subtype: Link Rect: 148, 159, 184, 169 Annotation: Subtype: Link Rect: 351, 123, 388, 134 Annotation: Subtype: Link Rect: 395, 123, 431, 134 Annotation: Subtype: Link Rect: 437, 89, 475, 100 Annotation: Subtype: Link Rect: 481, 89, 517, 100 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 135, 711, 173, 721 Annotation: Subtype: Link Rect: 126, 676, 164, 687 Annotation: Subtype: Link Rect: 86, 653, 124, 664 Annotation: Subtype: Link Rect: 130, 653, 166, 664 Annotation: Subtype: Link Rect: 389, 629, 427, 640 Annotation: Subtype: Link Rect: 140, 596, 177, 606 Annotation: Subtype: Link Rect: 515, 572, 553, 583 Annotation: Subtype: Link Rect: 104, 538, 142, 548 Annotation: Subtype: Link Rect: 118, 504, 155, 514 Annotation: Subtype: Link Rect: 161, 504, 197, 514 Annotation: Subtype: Link Rect: 218, 480, 256, 491 Annotation: Subtype: Link Rect: 262, 480, 298, 491 Annotation: Subtype: Link Rect: 374, 457, 412, 468 Annotation: Subtype: Link Rect: 319, 434, 356, 445 Annotation: Subtype: Link Rect: 386, 411, 423, 422 Annotation: Subtype: Link Rect: 293, 388, 330, 399 Annotation: Subtype: Link Rect: 520, 365, 557, 376 Annotation: Subtype: Link Rect: 245, 330, 283, 341 Annotation: Subtype: Link Rect: 59, 308, 96, 318 Annotation: Subtype: Link Rect: 325, 284, 363, 295 Annotation: Subtype: Link Rect: 468, 261, 505, 272 Annotation: Subtype: Link Rect: 244, 227, 282, 238 Annotation: Subtype: Link Rect: 476, 204, 514, 215 Annotation: Subtype: Link Rect: 520, 204, 556, 215 Annotation: Subtype: Link Rect: 82, 170, 119, 180 Annotation: Subtype: Link Rect: 519, 146, 557, 157 Annotation: Subtype: Link Rect: 59, 136, 95, 146 Annotation: Subtype: Link Rect: 428, 112, 465, 123 Annotation: Subtype: Link Rect: 472, 112, 508, 123 Annotation: Subtype: Link Rect: 161, 78, 199, 88 Annotation: Subtype: Link Rect: 205, 78, 241, 88 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 59, 711, 96, 721 Annotation: Subtype: Link Rect: 59, 676, 96, 687 Annotation: Subtype: Link Rect: 102, 676, 138, 687 Annotation: Subtype: Link Rect: 476, 652, 514, 664 Annotation: Subtype: Link Rect: 518, 629, 556, 640 Annotation: Subtype: Link Rect: 117, 596, 155, 606 Annotation: Subtype: Link Rect: 161, 596, 197, 606 Annotation: Subtype: Link Rect: 126, 561, 163, 571 Annotation: Subtype: Link Rect: 169, 561, 205, 571 Annotation: Subtype: Link Rect: 508, 537, 545, 548 Annotation: Subtype: Link Rect: 520, 514, 557, 525 Annotation: Subtype: Link Rect: 59, 504, 95, 514 Annotation: Subtype: Link Rect: 113, 469, 151, 479 Annotation: Subtype: Link Rect: 478, 445, 515, 456 Annotation: Subtype: Link Rect: 521, 445, 557, 456 Annotation: Subtype: Link Rect: 117, 412, 155, 422 Annotation: Subtype: Link Rect: 161, 412, 197, 422 Annotation: Subtype: Link Rect: 104, 389, 142, 399 Annotation: Subtype: Link Rect: 180, 365, 218, 376 Annotation: Subtype: Link Rect: 455, 330, 492, 341 Annotation: Subtype: Link Rect: 113, 297, 150, 307 Annotation: Subtype: Link Rect: 325, 261, 362, 272 Annotation: Subtype: Link Rect: 369, 261, 405, 272 Annotation: Subtype: Link Rect: 175, 228, 212, 238 Annotation: Subtype: Link Rect: 218, 228, 254, 238 Annotation: Subtype: Link Rect: 360, 204, 398, 215 Annotation: Subtype: Link Rect: 59, 170, 96, 180 Annotation: Subtype: Link Rect: 445, 146, 482, 157 Annotation: Subtype: Link Rect: 271, 123, 309, 134 Annotation: Subtype: Link Rect: 204, 101, 242, 111 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 458, 710, 496, 721 Annotation: Subtype: Link Rect: 502, 710, 538, 721 Annotation: Subtype: Link Rect: 104, 676, 141, 687 Checksum: 7fd018cb Type: CRC32 Checksum: ab45b0ff759c1ed3955e151514050d60 Type: MD5 Checksum: 55405ad7fdb58c55f49fb50c7bf783381a5d09b2 Type: SHA-1