f0142bdce434e574271268f344ebceb4 284446.pdf 3d7d4d361714c3c9ceee9c86e79dd4729b380f7f 284446.pdf 9a14e257819d4018c4d1af3ac03d75a34f622a80a86f8634ad2028e3293c134e 284446.pdf Title: Diabetes Does Not Increase the Risk of Hospitalization Due to COVID-19 in Patients Aged 50 Years or Older in Primary Care—APHOSDIAB—COVID-19 Multicenter Study Subject: The purpose of this study was to identify clinical, analytical, and sociodemographic variables associated with the need for hospital admission in people over 50 years infected with SARS-CoV-2 and to assess whether diabetes mellitus conditions the risk of hospitalization. A multicenter case-control study analyzing electronic medical records in patients with COVID-19 from 1 March 2020 to 30 April 2021 was conducted. We included 790 patients: 295 cases admitted to the hospital and 495 controls. Under half (n = 386, 48.8%) were women, and 8.5% were active smokers. The main comorbidities were hypertension (50.5%), dyslipidemia, obesity, and diabetes (37.5%). Multivariable logistic regression showed that hospital admission was associated with age above 65 years (OR from 2.45 to 3.89, ascending with age group); male sex (OR 2.15, 95% CI 1.47–3.15), fever (OR 4.31, 95% CI 2.87–6.47), cough (OR 1.89, 95% CI 1.28–2.80), asthenia/malaise (OR 2.04, 95% CI 1.38–3.03), dyspnea (4.69, 95% CI 3.00–7.33), confusion (OR 8.87, 95% CI 1.68–46.78), and a history of hypertension (OR 1.61, 95% CI 1.08–2.41) or immunosuppression (OR 4.97, 95% CI 1.45–17.09). Diabetes was not associated with increased risk of hospital admission (OR 1.18, 95% CI 0.80–1.72; p = 0.38). Diabetes did not increase the risk of hospital admission in people over 50 years old, but advanced age, male sex, fever, cough, asthenia, dyspnea/confusion, and hypertension or immunosuppression did. Keywords: COVID-19; obesity and diabetes mellitus type 2; research; hospitalization; primary care Author: Domingo Orozco-Beltrán, Juan Francisco Merino-Torres, Antonio Pérez, Ana M. Cebrián-Cuenca, Ignacio Párraga-Martínez, Luis Ávila-Lachica, Gemma Rojo-Martínez, Francisco J. Pomares-Gómez, Fernando Álvarez-Guisasola, Manuel Sánchez-Molla, Felix Gutiérrez, Francisco J. Ortega, Manel Mata-Cases, Enrique Carretero-Anibarro, Josep Maria Vilaseca and Jose A. Quesada Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Apr 8 12:01:04 2022 CEST ModDate: Fri Apr 8 12:10:02 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 632385 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BWUVNI+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 SORBVI+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 QVNRYI+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 OPNYWB+VnURWPalladioL Type 1 Custom yes yes no 23 0 FFAYKL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 59 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 87 0 OGDLFD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 98 0 OGDLFF+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 OGDLFH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 OGEBDF+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 107 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 115 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2023-12-05 02:34:33 CET RepresentationInformation: 284446.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-12-04 15:30:08 CET Size: 632385 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 266 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Selection Criteria Destination: subsection.2.1 Item: Title: Follow-Up Period Destination: subsection.2.2 Item: Title: Sample Size Destination: subsection.2.3 Item: Title: Data Collection and Analysis Destination: subsection.2.4 Item: Title: Ethical Aspects Destination: subsection.2.5 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Diabetes Does Not Increase the Risk of Hospitalization Due to COVID-19 in Patients Aged 50 Years or Older in Primary Care APHOSDIAB COVID-19 Multicenter Study Author: Domingo Orozco-Beltrán, Juan Francisco Merino-Torres, Antonio Pérez, Ana M. Cebrián-Cuenca, Ignacio Párraga-Martínez, Luis Ávila-Lachica, Gemma Rojo-Martínez, Francisco J. Pomares-Gómez, Fernando Álvarez-Guisasola, Manuel Sánchez-Molla, Felix Gutiérrez, Francisco J. Ortega, Manel Mata-Cases, Enrique Carretero-Anibarro, Josep Maria Vilaseca and Jose A. Quesada Subject: The purpose of this study was to identify clinical, analytical, and sociodemographic variables associated with the need for hospital admission in people over 50 years infected with SARS-CoV-2 and to assess whether diabetes mellitus conditions the risk of hospitalization. A multicenter case-control study analyzing electronic medical records in patients with COVID-19 from 1 March 2020 to 30 April 2021 was conducted. We included 790 patients: 295 cases admitted to the hospital and 495 controls. Under half (n = 386, 48.8%) were women, and 8.5% were active smokers. The main comorbidities were hypertension (50.5%), dyslipidemia, obesity, and diabetes (37.5%). Multivariable logistic regression showed that hospital admission was associated with age above 65 years (OR from 2.45 to 3.89, ascending with age group); male sex (OR 2.15, 95% CI 1.47 3.15), fever (OR 4.31, 95% CI 2.87 6.47), cough (OR 1.89, 95% CI 1.28 2.80), asthenia/malaise (OR 2.04, 95% CI 1.38 3.03), dyspnea (4.69, 95% CI 3.00 7.33), confusion (OR 8.87, 95% CI 1.68 46.78), and a history of hypertension (OR 1.61, 95% CI 1.08 2.41) or immunosuppression (OR 4.97, 95% CI 1.45 17.09). Diabetes was not associated with increased risk of hospital admission (OR 1.18, 95% CI 0.80 1.72; p = 0.38). Diabetes did not increase the risk of hospital admission in people over 50 years old, but advanced age, male sex, fever, cough, asthenia, dyspnea/confusion, and hypertension or immunosuppression did. 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