59340b0305b491a552db833d5b518f94 284462.pdf ab8e18f0a4de6f37130d3c85d450de916078f5c1 284462.pdf 90250b061a7d24848f9e781f1caebef8882f753d03b7c2bca33baff7796933c1 284462.pdf Title: Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study Subject: Alz & Dem Diag Ass & Dis Mo 2022.14:e12288 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Tue Mar 29 17:00:39 2022 CEST ModDate: Wed Feb 21 12:45:26 2024 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 649646 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EOMLBD+Lato-Regular Type 1C WinAnsi yes yes no 41 0 EOMLHB+Lato-Bold Type 1C WinAnsi yes yes no 42 0 EOMLOP+Lato-Italic Type 1C WinAnsi yes yes no 43 0 EOMMFO+STIXTwoText-Italic Type 1C Custom yes yes yes 44 0 EOMMHO+Lato-Black Type 1C WinAnsi yes yes no 45 0 EOMMHP+STIXTwoMath Type 1C Custom yes yes yes 46 0 Times-Roman Type 1 WinAnsi no no no 5 0 EOMMON+STIX-Regular Type 1C Custom yes yes yes 68 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-22 02:33:44 CET RepresentationInformation: 284462.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-21 12:53:00 CET Size: 649646 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'dad212288-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'dad212288-supitem-0002' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'dad212288-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 648443 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'dad212288-supitem-0002' cannot be found ID: PDF-HUL-122 Offset: 648443 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | INTRODUCTION Destination: section..1.1 Item: Title: 2 | MATERIALS AND METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study design and participants Destination: subsection..1.2.1 Item: Title: 2.2 | Neuroimaging data acquisition Destination: subsection..1.2.2 Children: Item: Title: 2.2.1 | Magnetic resonance imaging Destination: subsubsection..1.2.2.1 Item: Title: 2.2.2 | Positron emission tomography Destination: subsubsection..1.2.2.2 Item: Title: 2.3 | Neuroimaging data processing Destination: subsection..1.2.3 Item: Title: 3 | STATISTICAL ANALYSES Destination: section..1.3 Children: Item: Title: 3.1 | Comparisons between the TP1 and the TP2 Destination: subsection..1.3.1 Children: Item: Title: 3.1.1 | Change in PiB binding Destination: subsubsection..1.3.1.1 Item: Title: 3.1.2 | Change in cortical thickness Destination: subsubsection..1.3.1.2 Item: Title: 3.1.3 | PiB binding at TP1 and cortical thickness change at TP2 Destination: subsubsection..1.3.1.3 Item: Title: 3.1.4 | Multiple regression analyses Destination: subsubsection..1.3.1.4 Item: Title: 3.2 | Time point 3 Destination: subsection..1.3.2 Children: Item: Title: 3.2.1 | Comparison between tau deposition and cortical thickness Destination: subsubsection..1.3.2.1 Item: Title: 4 | RESULTS Destination: section..1.4 Children: Item: Title: 4.1 | Demographic features Destination: subsection..1.4.1 Item: Title: 4.2 | Comparisons between TP1 and TP2 Destination: subsection..1.4.2 Children: Item: Title: 4.2.1 | PiB binding differences between TP1 and TP2 Destination: subsubsection..1.4.2.1 Item: Title: 4.2.2 | Cortical thickness differences between TP1 and the TP2 Destination: subsubsection..1.4.2.2 Item: Title: 4.2.3 | PiB binding at TP1 and cortical thickness change between TP1 and TP2 Destination: subsubsection..1.4.2.3 Item: Title: 4.2.4 | Multiple regression analyses Destination: subsubsection..1.4.2.4 Item: Title: 4.3 | Time point 3 Destination: subsection..1.4.3 Children: Item: Title: 4.3.1 | Correlation between tau deposition and cortical thickness at time-point 3 Destination: subsubsection..1.4.3.1 Item: Title: 5 | DISCUSSION Destination: section..1.5 Item: Title: ACKNOWLEDGMENTS Destination: section*.16 Item: Title: CONFLICTS OF INTEREST Destination: section*.18 Item: Title: ORCID Destination: section*.20 Item: Title: REFERENCES Destination: section*.22 Item: Title: SUPPORTING INFORMATION Destination: 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