06155eeaf99579026af167aa1cb87ae0 284474.pdf c74aa6b31ff7f135b252c49eb31f479b227b8a01 284474.pdf 2825688055036d7b2305b2a49f13e0d35ec9fb3c40a4d2766c99ef6c2ce86062 284474.pdf Title: SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders Subject: Journal of Hematology & Oncology, https://doi.org/10.1186/s13045-022-01275-7 Keywords: SARS-CoV-2 vaccines;Breakthrough SARS-CoV-2 infection;Correlates of protection;Hematological malignancies;Allogeneic stem cell transplantation;Autologous stem cell transplantation;COVID-19;Vaccine;Immunocompromised patients;Moderna mRNA-1273;Pfizer-BioNTech BNT162b2 Author: José Luis Piñana Creator: Adobe InDesign 15.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Apr 30 14:26:48 2022 CEST ModDate: Sat May 7 12:40:12 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 915393 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 28 0 MyriadPro-Bold Type 1C Custom yes no yes 29 0 MyriadPro-It Type 1C Custom yes no yes 30 0 MyriadPro-Semibold Type 1C Custom yes no yes 31 0 MyriadPro-Light Type 1C Custom yes no yes 33 0 TDOSEV+MTSY Type 1C Custom yes yes yes 47 0 CXBOKC+MyriadPro-LightIt Type 1C WinAnsi yes yes yes 55 0 WarnockPro-Regular Type 1C Custom yes no yes 32 0 FDNXCD+WarnockPro-It Type 1C WinAnsi yes yes yes 46 0 MyriadPro-Regular2 Type 1C WinAnsi yes no yes 274 0 GBVFBA+MyriadPro-SemiboldIt Type 1C WinAnsi yes yes yes 54 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 249 0 ESXCPV+OpenSans-Light Type 1C Custom yes yes no 256 0 ESXCPV+OpenSans-Extrabold Type 1C WinAnsi yes yes no 252 0 DTIWBX+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 262 0 ESXCPV+OpenSans-Bold Type 1C WinAnsi yes yes no 259 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-24 02:31:16 CET RepresentationInformation: 284474.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-23 11:42:28 CET Size: 915393 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 408 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Patients and methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Introduction Item: Title: Patients and methods Children: Item: Title: Study population Item: Title: Inclusion criteria and cohort selection Item: Title: Technical considerations and definitions Item: Title: Endpoints and statistical analysis Item: Title: Results Children: Item: Title: Patient characteristics Item: Title: Breakthrough SARS-CoV-2 infection Item: Title: Risk factors (including antibody level titers) for breakthrough SARS-CoV-2 infection Item: Title: Discussion Item: Title: Conclusion Item: Title: Acknowledgements Item: Title: References Info: Title: SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders Author: José Luis Piñana Subject: Journal of Hematology & Oncology, https://doi.org/10.1186/s13045-022-01275-7 Keywords: SARS-CoV-2 vaccines;Breakthrough SARS-CoV-2 infection;Correlates of protection;Hematological malignancies;Allogeneic stem cell transplantation;Autologous stem cell transplantation;COVID-19;Vaccine;Immunocompromised patients;Moderna mRNA-1273;Pfizer-BioNTech BNT162b2 Creator: Adobe InDesign 15.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Apr 30 14:26:48 CEST 2022 ModDate: Sat May 07 12:40:12 CEST 2022 ID: 0x4127814c03fa8e6a826ce75baff64c37, 0x90da864af6c2a369dcf8eaeb4c78f346 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 589 ImageHeight: 154 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1595 ImageHeight: 924 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1595 ImageHeight: 935 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GBVFBA+MyriadPro-SemiboldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GBVFBA+MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CXBOKC+MyriadPro-LightIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: CXBOKC+MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FDNXCD+WarnockPro-It FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FDNXCD+WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TDOSEV+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: TDOSEV+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2022-04-30T12:26:48 Adobe InDesign 15.0 (Windows) 2022-05-07T12:40:12+02:00 2022-05-07T12:40:12+02:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) SARS-CoV-2 vaccines;Breakthrough SARS-CoV-2 infection;Correlates of protection;Hematological malignancies;Allogeneic stem cell transplantation;Autologous stem cell transplantation;COVID-19;Vaccine;Immunocompromised patients;Moderna mRNA-1273;Pfizer-BioNTech BNT162b2 False application/pdf https://doi.org/10.1186/s13045-022-01275-7 BioMed Central Journal of Hematology & Oncology, https://doi.org/10.1186/s13045-022-01275-7 SARS-CoV-2 vaccines Breakthrough SARS-CoV-2 infection Correlates of protection Hematological malignancies Allogeneic stem cell transplantation Autologous stem cell transplantation COVID-19 Vaccine Immunocompromised patients Moderna mRNA-1273 Pfizer-BioNTech BNT162b2 SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders José Luis Piñana Lucia López-Corral Rodrigo Martino Lourdes Vazquez Ariadna Pérez Gabriel Martin-Martin Beatriz Gago Gabriela Sanz-Linares Andrés Sanchez-Salinas Lucia Villalon Venancio Conesa-Garcia María T. Olave Magdalena Corona Sara Marcos-Corrales Mar Tormo José Ángel Hernández-Rivas Juan Montoro Alicia Rodriguez-Fernandez Irene Risco-Gálvez Pablo Rodríguez-Belenguer Juan Carlos Hernandez-Boluda Irene García-Cadenas Montserrat Ruiz-García Juan Luis Muñoz-Bellido Carlos Solano Ángel Cedillo Anna Sureda David Navarro 10.1186/s13045-022-01275-7 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s13045-022-01275-7 10.1186/s13045-022-01275-7 1756-8722 journal Journal of Hematology & Oncology The Author(s) 2010-04-23 true 10.1186/s13045-022-01275-7 noindex springer.com springerlink.com uuid:0d638eba-56a2-4bc4-8e44-c361421dcfbc uuid:9e75e04d-fe79-4a1e-9609-453ab3248e52 default 1 converted uuid:0d638eba-56a2-4bc4-8e44-c361421dcfbc converted to PDF/A-2b pdfToolbox 2022-04-30T13:35:17Z 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 530, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 276, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 212, 590, 217, 578 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 223, 590, 227, 578 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 264, 566, 269, 554 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 275, 566, 285, 554 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 219, 530, 229, 518 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 235, 530, 245, 518 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 158, 494, 168, 482 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 198, 254, 208, 242 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 216, 254, 225, 242 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 307, 291, 312, 279 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 455, 231, 460, 219 Flags: Print AppearanceDictionary: true Destination: 116 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 71, 668, 76, 656 Flags: Print AppearanceDictionary: true Destination: 116 Annotation: Subtype: Link Rect: 258, 308, 263, 296 Flags: Print AppearanceDictionary: true Destination: 49 Annotation: Subtype: Link Rect: 499, 596, 504, 584 Flags: Print AppearanceDictionary: true Destination: 56 Annotation: Subtype: Link Rect: 340, 488, 344, 476 Flags: Print AppearanceDictionary: true Destination: 76 Annotation: Subtype: Link Rect: 373, 140, 377, 128 Flags: Print AppearanceDictionary: true Destination: 112 Thumb: true Page: Sequence: 4 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 152, 405, 157, 386 Flags: Print AppearanceDictionary: true Destination: 116 Annotation: Subtype: Link Rect: 218, 201, 223, 182 Flags: Print AppearanceDictionary: true Destination: 116 Annotation: Subtype: Link Rect: 393, 260, 403, 248 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 410, 260, 420, 248 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 415, 224, 425, 212 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 429, 224, 439, 212 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 444, 224, 453, 212 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 458, 224, 468, 212 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 472, 224, 482, 212 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 478, 164, 488, 146 Flags: Print AppearanceDictionary: true Destination: 211 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 455, 244, 465, 232 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 456, 88, 461, 76 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 465, 88, 475, 76 Flags: Print AppearanceDictionary: true Destination: 211 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 136, 645, 146, 632 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 59, 585, 69, 572 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 232, 561, 242, 548 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 143, 549, 153, 536 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 84, 393, 94, 380 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 99, 393, 109, 380 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 184, 357, 194, 344 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 199, 357, 209, 344 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 74, 201, 84, 188 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 130, 189, 139, 176 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 504, 573, 509, 560 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 506, 525, 516, 512 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 522, 525, 533, 512 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 344, 405, 354, 392 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 531, 345, 536, 332 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 304, 333, 314, 320 Flags: Print AppearanceDictionary: true Destination: 128 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 248, 135, 281, 127 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 126, 156, 118 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 151, 129, 283, 121 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 213, 84, 285, 76 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 75, 132, 67 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 676, 534, 668 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 667, 406, 659 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 595, 452, 587 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 550, 504, 542 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 514, 532, 506 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 505, 373, 497 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 487, 528, 479 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 478, 446, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 451, 521, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 442, 521, 434 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 433, 363, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 424, 526, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 415, 524, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 406, 367, 398 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 361, 511, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 505, 334, 538, 326 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 325, 387, 317 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 391, 298, 533, 290 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 466, 271, 538, 263 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 262, 375, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 226, 440, 218 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 495, 199, 528, 191 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 190, 411, 182 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 511, 163, 533, 155 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 154, 398, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 469, 118, 523, 110 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 109, 367, 101 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 191, 676, 274, 668 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 667, 89, 659 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 631, 280, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 106, 442, 271, 434 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 433, 272, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 424, 112, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 415, 276, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 406, 257, 398 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 211, 370, 283, 362 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 361, 111, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 253, 204, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 157, 199, 281, 191 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 40da2968 Type: CRC32 Checksum: 06155eeaf99579026af167aa1cb87ae0 Type: MD5 Checksum: c74aa6b31ff7f135b252c49eb31f479b227b8a01 Type: SHA-1 Checksum: 2825688055036d7b2305b2a49f13e0d35ec9fb3c40a4d2766c99ef6c2ce86062 Type: SHA-256