3ab065fa62f73ddc921e07b9d0f837df 286309.pdf ab22be74277d6764b36d115b26b0cc985ec5562b 286309.pdf 53c93ecb7efe5b6a02515509ccdf34880bece951c1f2fc97b7c45d50772f76c1 286309.pdf Title: In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study Subject: Background: Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis Keywords: antifungal testing, antifungal resistance, Candida, ibrexafungerp, SCY-078, EUCAST, caspofungin, micafungin Author: Guillermo Quindó Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed May 11 13:42:14 2022 CEST ModDate: Wed May 11 12:50:58 2022 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 479430 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HJEIOC+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 1654 0 HJEIOD+AdvOT6601a1b9.BI+20 Type 1C WinAnsi yes yes no 1655 0 HJEIOE+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 1656 0 HJEIJJ+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 1631 0 HJEIJK+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 1632 0 HJEIJL+AdvOT01861455.I Type 1C WinAnsi yes yes no 1633 0 HJEIJM+AdvPSA18C Type 1C WinAnsi yes yes no 1634 0 HJEIJN+AdvOT01861455.I+20 Type 1C WinAnsi yes yes no 1635 0 HJEIKN+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 1636 0 HJEIKO+AdvOT1deab444.I Type 1C WinAnsi yes yes no 1637 0 HJEIKP+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 1638 0 HJEILA+AdvPSA323 Type 1C WinAnsi yes yes no 1639 0 HJEIMB+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 1646 0 HJEIMC+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 1647 0 HJEJHC+AdvOT6e5d2ec0+22 Type 1C Custom yes yes yes 314 0 HJEJHD+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 307 0 HJEJID+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 310 0 HJEJIE+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 295 0 HJEJIF+AdvTT58d178b9+03 Type 1C Custom yes yes yes 298 0 HJEJIG+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 303 0 HJEJIH+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 290 0 HJEJII+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 313 0 HJEJJJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 291 0 HJEJJK+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 284 0 HJEJLK+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 317 0 HJEJPK+AdvOT34fe1490.B+22 Type 1C Custom yes yes yes 326 0 HJEKLG+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 327 0 HJEKPG+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 335 0 HJEKPH+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 336 0 HJEKPI+AdvTT02dee1cd.I+03 Type 1C Custom yes yes yes 332 0 HJELAI+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 333 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-15 02:43:05 CET RepresentationInformation: 286309.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-14 14:03:40 CET Size: 479430 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1718 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study Destination: bmark_316938755 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and Methods Destination: s2 Children: Item: Title: Microorganisms Destination: s2_1 Item: Title: Antifungal Drugs and Susceptibility Testing Destination: s2_2 Item: Title: Data Analysis Destination: s2_3 Item: Title: Results Destination: s3 Item: Title: Discussion Destination: s4 Item: Title: Data Availability Statement Destination: s5 Item: Title: Author Contributions Destination: s6 Item: Title: Funding Destination: s7 Item: Title: Supplementary Material Destination: bmark_386646472 Item: Title: References Destination: bmark_2090415954 Info: Title: In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study Author: Guillermo Quindó Subject: Background: Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis Keywords: antifungal testing, antifungal resistance, Candida, ibrexafungerp, SCY-078, EUCAST, caspofungin, micafungin Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed May 11 13:42:14 CEST 2022 ModDate: Wed May 11 12:50:58 CEST 2022 ID: 0x772a6caed7b49cfb853a13ccca69b5b9, 0x125b8dbc1f5ccf40bb2cfc6abe018670 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: HJEJPK+AdvOT34fe1490.B+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJEJPK+AdvOT34fe1490.B+22 Flags: Symbolic FontBBox: -156, -166, 718, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEKLG+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJEKLG+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEKPI+AdvTT02dee1cd.I+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: HJEKPI+AdvTT02dee1cd.I+03 Flags: Symbolic FontBBox: -416, -354, 916, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJELAI+AdvOT7d6df7ab.I+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: HJELAI+AdvOT7d6df7ab.I+01 Flags: Serif, Nonsymbolic FontBBox: -156, -250, 1000, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: HJEKPG+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HJEKPG+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEKPH+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: HJEKPH+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJJK+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: HJEJJK+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: HJEIJJ+AdvOT6601a1b9.BI FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: HJEIJJ+AdvOT6601a1b9.BI Flags: Nonsymbolic FontBBox: -125, -208, 1020, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIJK+AdvOT34fe1490.B FontSubset: true FirstChar: 37 LastChar: 124 FontDescriptor: FontName: HJEIJK+AdvOT34fe1490.B Flags: Nonsymbolic FontBBox: -52, -208, 937, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIJL+AdvOT01861455.I FontSubset: true FirstChar: 42 LastChar: 167 FontDescriptor: FontName: HJEIJL+AdvOT01861455.I Flags: Nonsymbolic FontBBox: -125, -208, 1000, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIJM+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: HJEIJM+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJIH+AdvOT3f84ef53 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: HJEJIH+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIJN+AdvOT01861455.I+20 FontSubset: true FirstChar: 134 LastChar: 135 FontDescriptor: FontName: HJEIJN+AdvOT01861455.I+20 Flags: Nonsymbolic FontBBox: -156, -156, 1010, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJJJ+AdvOTb65e897d.B FontSubset: true FirstChar: 49 LastChar: 118 FontDescriptor: FontName: HJEJJJ+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIKN+AdvOT01861455.I+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: HJEIKN+AdvOT01861455.I+01 Flags: Nonsymbolic FontBBox: -41, -166, 1125, 927 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: HJEIKO+AdvOT1deab444.I FontSubset: true FirstChar: 38 LastChar: 241 FontDescriptor: FontName: HJEIKO+AdvOT1deab444.I Flags: Nonsymbolic FontBBox: -135, -208, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIKP+AdvOT1deab444.I+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: HJEIKP+AdvOT1deab444.I+01 Flags: Nonsymbolic FontBBox: -52, -166, 1093, 906 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: HJEILA+AdvPSA323 FontSubset: true FirstChar: 136 LastChar: 180 FontDescriptor: FontName: HJEILA+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJIE+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: HJEJIE+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJIF+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: HJEJIF+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEIMB+AdvOT6e5d2ec0 FontSubset: true FirstChar: 37 LastChar: 189 FontDescriptor: FontName: HJEIMB+AdvOT6e5d2ec0 Flags: Nonsymbolic FontBBox: -62, -208, 895, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIMC+AdvOT6e5d2ec0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJEIMC+AdvOT6e5d2ec0+fb Flags: Symbolic FontBBox: 0, 0, 500, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEJIG+AdvOT1ef757c0+20 FontSubset: true FirstChar: 147 LastChar: 150 FontDescriptor: FontName: HJEJIG+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJHD+AdvOT6e5d2ec0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: HJEJHD+AdvOT6e5d2ec0+20 Flags: Nonsymbolic FontBBox: -156, -145, 1041, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIOC+AdvOT1deab444.I+20 FontSubset: true FirstChar: 134 LastChar: 134 FontDescriptor: FontName: HJEIOC+AdvOT1deab444.I+20 Flags: Nonsymbolic FontBBox: -156, -145, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEJID+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 241 FontDescriptor: FontName: HJEJID+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIOD+AdvOT6601a1b9.BI+20 FontSubset: true FirstChar: 135 LastChar: 135 FontDescriptor: FontName: HJEIOD+AdvOT6601a1b9.BI+20 Flags: Nonsymbolic FontBBox: -156, -166, 1052, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HJEIOE+AdvOT1deab444.I+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJEIOE+AdvOT1deab444.I+fb Flags: Symbolic FontBBox: 9, 0, 572, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEJII+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJEJII+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEJHC+AdvOT6e5d2ec0+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: HJEJHC+AdvOT6e5d2ec0+22 Flags: Symbolic FontBBox: -156, -145, 718, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HJEJLK+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HJEJLK+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Acrobat Distiller 7.0 (Windows) antifungal testing, antifungal resistance, Candida, ibrexafungerp, SCY-078, EUCAST, caspofungin, micafungin 2022-05-11T19:42:14+08:00 2022-05-11T18:50:58+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-05-11T18:50:58+08:00 application/pdf In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study Guillermo Quind&oacute s Katherine Miranda-Cadena Rosario San-Millán Katyna Borroto-Esoda Emilia Cant&oacute n Mar&iacute a José Linares-Sicilia Axel Hamprecht Isabel Montesinos Anna Maria Tortorano Anna Prigitano Matxalen Vidal-Garc&iacute a Cristina Marcos-Arias Andrea Guridi Ferran Sanchez-Reus Jes&uacute s Machuca-Bárcena Manuel Antonio Rodr&iacute guez-Iglesias Estrella Mart&iacute n-Mazuelos Carmen Castro-Méndez Leyre L&oacute pez-Soria Alba Ruiz-Gaitán Marcelo Fernandez-Rivero Damaris Lorenzo Javier Capilla Antonio Rezusta Javier Pemán Josep Guarro Joana Pereira Célia Pais Orazio Romeo Guillermo Ezpeleta Nerea Jauregizar David Angulo Elena Eraso Background: Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis antifungal testing antifungal resistance Candida ibrexafungerp SCY-078 EUCAST caspofungin micafungin uuid:e504d0c9-2d74-40b9-8a95-238da11907de uuid:42d77958-d762-4da0-9109-bdd62a603394 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 603, 458, 624 Annotation: Subtype: Link Rect: 175, 580, 500, 601 Annotation: Subtype: Link Rect: 175, 557, 524, 578 Annotation: Subtype: Link Rect: 175, 534, 473, 555 Annotation: Subtype: Link Rect: 175, 511, 449, 532 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 472, 158, 480 Annotation: Subtype: Link Rect: 74, 323, 158, 330 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 477, 728, 549, 735 Annotation: Subtype: Link Rect: 450, 720, 549, 727 Annotation: Subtype: Link Rect: 45, 726, 323, 742 Annotation: Subtype: Link Rect: 521, 678, 549, 706 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 79, 226, 199, 236 Destination: 190 Annotation: Subtype: Link Rect: 206, 226, 287, 236 Destination: 231 Annotation: Subtype: Link Rect: 45, 215, 111, 224 Destination: 190 Annotation: Subtype: Link Rect: 116, 215, 185, 224 Destination: 231 Annotation: Subtype: Link Rect: 397, 398, 465, 408 Destination: 190 Annotation: Subtype: Link Rect: 428, 364, 547, 373 Destination: 190 Annotation: Subtype: Link Rect: 306, 352, 377, 362 Destination: 231 Annotation: Subtype: Link Rect: 309, 318, 421, 327 Destination: 190 Annotation: Subtype: Link Rect: 427, 318, 497, 327 Destination: 231 Annotation: Subtype: Link Rect: 503, 318, 549, 327 Destination: 231 Annotation: Subtype: Link Rect: 306, 306, 324, 316 Destination: 231 Annotation: Subtype: Link Rect: 329, 306, 398, 316 Destination: 190 Annotation: Subtype: Link Rect: 429, 272, 501, 281 Destination: 190 Annotation: Subtype: Link Rect: 512, 260, 549, 270 Destination: 231 Annotation: Subtype: Link Rect: 306, 249, 350, 258 Destination: 231 Annotation: Subtype: Link Rect: 356, 249, 424, 258 Destination: 231 Annotation: Subtype: Link Rect: 356, 226, 461, 235 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 70, 593, 159, 602 Destination: 231 Annotation: Subtype: Link Rect: 164, 593, 253, 602 Destination: 231 Annotation: Subtype: Link Rect: 227, 558, 289, 568 Destination: 231 Annotation: Subtype: Link Rect: 45, 547, 87, 556 Destination: 231 Annotation: Subtype: Link Rect: 159, 374, 246, 383 Destination: 190 Annotation: Subtype: Link Rect: 252, 374, 289, 383 Destination: 190 Annotation: Subtype: Link Rect: 45, 362, 94, 372 Destination: 190 Annotation: Subtype: Link Rect: 100, 362, 160, 372 Destination: 190 Annotation: Subtype: Link Rect: 166, 362, 226, 372 Destination: 190 Annotation: Subtype: Link Rect: 136, 201, 237, 211 Destination: 190 Annotation: Subtype: Link Rect: 309, 593, 339, 602 Destination: 45 Annotation: Subtype: Link Rect: 367, 558, 435, 568 Destination: 231 Annotation: Subtype: Link Rect: 345, 351, 376, 361 Destination: 55 Annotation: Subtype: Link Rect: 411, 259, 439, 269 Destination: 55 Annotation: Subtype: Link Rect: 442, 110, 471, 119 Destination: 55 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 82, 238, 111, 247 Destination: 111 Annotation: Subtype: Link Rect: 255, 203, 283, 213 Destination: 55 Annotation: Subtype: Link Rect: 159, 65, 189, 75 Destination: 150 Annotation: Subtype: Link Rect: 407, 169, 437, 178 Destination: 175 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Rotate: 90 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 516, 616, 549, 625 Destination: 231 Annotation: Subtype: Link Rect: 306, 604, 323, 614 Destination: 231 Annotation: Subtype: Link Rect: 330, 604, 447, 614 Destination: 190 Annotation: Subtype: Link Rect: 453, 604, 532, 614 Destination: 231 Annotation: Subtype: Link Rect: 508, 570, 549, 579 Destination: 190 Annotation: Subtype: Link Rect: 306, 558, 323, 568 Destination: 190 Annotation: Subtype: Link Rect: 329, 558, 397, 568 Destination: 231 Annotation: Subtype: Link Rect: 535, 535, 549, 545 Destination: 190 Annotation: Subtype: Link Rect: 306, 524, 376, 533 Destination: 190 Annotation: Subtype: Link Rect: 380, 524, 466, 533 Destination: 190 Annotation: Subtype: Link Rect: 488, 489, 549, 499 Destination: 190 Annotation: Subtype: Link Rect: 306, 478, 323, 487 Destination: 190 Annotation: Subtype: Link Rect: 328, 478, 395, 487 Destination: 231 Annotation: Subtype: Link Rect: 399, 478, 464, 487 Destination: 231 Annotation: Subtype: Link Rect: 468, 478, 547, 487 Destination: 190 Annotation: Subtype: Link Rect: 306, 466, 373, 476 Destination: 231 Annotation: Subtype: Link Rect: 378, 466, 452, 476 Destination: 190 Annotation: Subtype: Link Rect: 457, 466, 547, 476 Destination: 231 Annotation: Subtype: Link Rect: 306, 455, 386, 464 Destination: 231 Annotation: Subtype: Link Rect: 369, 432, 455, 441 Destination: 190 Annotation: Subtype: Link Rect: 462, 432, 547, 441 Destination: 190 Annotation: Subtype: Link Rect: 306, 420, 374, 430 Destination: 231 Annotation: Subtype: Link Rect: 379, 420, 453, 430 Destination: 231 Annotation: Subtype: Link Rect: 458, 420, 539, 430 Destination: 231 Annotation: Subtype: Link Rect: 367, 374, 476, 384 Destination: 190 Annotation: Subtype: Link Rect: 480, 374, 547, 384 Destination: 231 Annotation: Subtype: Link Rect: 306, 363, 371, 372 Destination: 231 Annotation: Subtype: Link Rect: 376, 363, 441, 372 Destination: 190 Annotation: Subtype: Link Rect: 477, 340, 547, 349 Destination: 231 Annotation: Subtype: Link Rect: 306, 328, 417, 338 Destination: 190 Annotation: Subtype: Link Rect: 422, 328, 496, 338 Destination: 190 Annotation: Subtype: Link Rect: 501, 328, 549, 338 Destination: 190 Annotation: Subtype: Link Rect: 306, 317, 324, 326 Destination: 190 Annotation: Subtype: Link Rect: 329, 317, 446, 326 Destination: 190 Annotation: Subtype: Link Rect: 452, 317, 522, 326 Destination: 231 Annotation: Subtype: Link Rect: 527, 317, 549, 326 Destination: 231 Annotation: Subtype: Link Rect: 306, 305, 347, 315 Destination: 231 Annotation: Subtype: Link Rect: 352, 305, 431, 315 Destination: 231 Annotation: Subtype: Link Rect: 436, 305, 505, 315 Destination: 190 Annotation: Subtype: Link Rect: 390, 213, 503, 223 Destination: 190 Annotation: Subtype: Link Rect: 507, 213, 549, 223 Destination: 231 Annotation: Subtype: Link Rect: 306, 202, 333, 211 Destination: 231 Annotation: Subtype: Link Rect: 361, 202, 461, 211 Destination: 190 Annotation: Subtype: Link Rect: 463, 144, 549, 154 Destination: 190 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 256, 460, 289, 469 Destination: 231 Annotation: Subtype: Link Rect: 45, 448, 87, 458 Destination: 231 Annotation: Subtype: Link Rect: 85, 425, 216, 435 Destination: 190 Annotation: Subtype: Link Rect: 227, 402, 289, 411 Destination: 190 Annotation: Subtype: Link Rect: 45, 391, 71, 400 Destination: 190 Annotation: Subtype: Link Rect: 211, 345, 289, 354 Destination: 190 Annotation: Subtype: Link Rect: 45, 333, 64, 342 Destination: 190 Annotation: Subtype: Link Rect: 71, 333, 153, 342 Destination: 190 Annotation: Subtype: Link Rect: 160, 333, 287, 342 Destination: 190 Annotation: Subtype: Link Rect: 45, 322, 128, 331 Destination: 190 Annotation: Subtype: Link Rect: 137, 322, 210, 331 Destination: 231 Annotation: Subtype: Link Rect: 202, 241, 256, 250 Destination: 231 Annotation: Subtype: Link Rect: 262, 241, 289, 250 Destination: 231 Annotation: Subtype: Link Rect: 45, 230, 88, 239 Destination: 231 Annotation: Subtype: Link Rect: 94, 230, 173, 239 Destination: 231 Annotation: Subtype: Link Rect: 45, 184, 164, 193 Destination: 190 Annotation: Subtype: Link Rect: 48, 149, 141, 159 Destination: 190 Annotation: Subtype: Link Rect: 148, 149, 223, 159 Destination: 231 Annotation: Subtype: Link Rect: 231, 149, 289, 159 Destination: 190 Annotation: Subtype: Link Rect: 45, 137, 101, 147 Destination: 190 Annotation: Subtype: Link Rect: 90, 115, 159, 124 Destination: 231 Annotation: Subtype: Link Rect: 309, 471, 375, 480 Destination: 231 Annotation: Subtype: Link Rect: 318, 367, 393, 377 Destination: 231 Annotation: Subtype: Link Rect: 369, 275, 464, 285 Destination: 231 Annotation: Subtype: Link Rect: 419, 206, 507, 216 Destination: 190 Annotation: Subtype: Link Rect: 436, 126, 544, 136 Destination: 190 Annotation: Subtype: Link Rect: 309, 80, 425, 90 Destination: 190 Annotation: Subtype: Link Rect: 430, 80, 499, 90 Destination: 231 Annotation: Subtype: Link Rect: 504, 80, 549, 90 Destination: 231 Annotation: Subtype: Link Rect: 306, 68, 324, 78 Destination: 231 Annotation: Subtype: Link Rect: 330, 68, 412, 78 Destination: 231 Annotation: Subtype: Link Rect: 417, 68, 501, 78 Destination: 190 Annotation: Subtype: Link Rect: 294, 510, 317, 517 Destination: 45 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 421, 685, 496, 694 Destination: 190 Annotation: Subtype: Link Rect: 503, 685, 549, 694 Destination: 231 Annotation: Subtype: Link Rect: 306, 673, 347, 683 Destination: 231 Annotation: Subtype: Link Rect: 364, 650, 436, 660 Destination: 190 Annotation: Subtype: Link Rect: 518, 616, 549, 625 Destination: 190 Annotation: Subtype: Link Rect: 306, 604, 390, 614 Destination: 190 Annotation: Subtype: Link Rect: 340, 570, 418, 579 Destination: 231 Annotation: Subtype: Link Rect: 306, 524, 374, 533 Destination: 231 Annotation: Subtype: Link Rect: 378, 524, 461, 533 Destination: 190 Annotation: Subtype: Link Rect: 442, 478, 514, 487 Destination: 231 Annotation: Subtype: Link Rect: 387, 374, 460, 384 Destination: 231 Annotation: Subtype: Link Rect: 347, 225, 421, 234 Destination: 190 Annotation: Subtype: Link Rect: 427, 225, 522, 234 Destination: 231 Annotation: Subtype: Link Rect: 529, 225, 549, 234 Destination: 231 Annotation: Subtype: Link Rect: 306, 213, 376, 223 Destination: 231 Annotation: Subtype: Link Rect: 382, 213, 473, 223 Destination: 231 Annotation: Subtype: Link Rect: 524, 213, 549, 223 Destination: 190 Annotation: Subtype: Link Rect: 306, 202, 352, 211 Destination: 190 Annotation: Subtype: Link Rect: 453, 121, 530, 131 Destination: 190 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 101, 485, 190, 494 Destination: 231 Annotation: Subtype: Link Rect: 104, 450, 205, 460 Destination: 190 Annotation: Subtype: Link Rect: 213, 392, 287, 402 Destination: 190 Annotation: Subtype: Link Rect: 45, 381, 111, 391 Destination: 231 Annotation: Subtype: Link Rect: 166, 381, 236, 391 Destination: 231 Annotation: Subtype: Link Rect: 216, 255, 289, 264 Destination: 231 Annotation: Subtype: Link Rect: 78, 186, 166, 195 Destination: 231 Annotation: Subtype: Link Rect: 48, 162, 110, 172 Destination: 231 Annotation: Subtype: Link Rect: 344, 461, 415, 471 Destination: 231 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 306, 596, 549, 605 Annotation: Subtype: Link Rect: 306, 584, 408, 594 Annotation: Subtype: Link Rect: 68, 483, 123, 491 Annotation: Subtype: Link Rect: 68, 436, 146, 443 Annotation: Subtype: Link Rect: 186, 398, 289, 405 Annotation: Subtype: Link Rect: 55, 388, 289, 396 Annotation: Subtype: Link Rect: 105, 350, 168, 358 Annotation: Subtype: Link Rect: 202, 322, 268, 330 Annotation: Subtype: Link Rect: 217, 303, 279, 310 Annotation: Subtype: Link Rect: 114, 255, 185, 263 Annotation: Subtype: Link Rect: 87, 208, 157, 216 Annotation: Subtype: Link Rect: 121, 180, 289, 187 Annotation: Subtype: Link Rect: 55, 170, 289, 177 Annotation: Subtype: Link Rect: 55, 161, 106, 168 Annotation: Subtype: Link Rect: 55, 141, 143, 149 Annotation: Subtype: Link Rect: 223, 103, 281, 111 Annotation: Subtype: Link Rect: 166, 65, 248, 73 Annotation: Subtype: Link Rect: 413, 502, 484, 510 Annotation: Subtype: Link Rect: 422, 464, 522, 472 Annotation: Subtype: Link Rect: 347, 417, 418, 424 Annotation: Subtype: Link Rect: 524, 379, 549, 386 Annotation: Subtype: Link Rect: 316, 369, 360, 377 Annotation: Subtype: Link Rect: 379, 322, 449, 330 Annotation: Subtype: Link Rect: 471, 274, 542, 282 Annotation: Subtype: Link Rect: 413, 236, 484, 244 Annotation: Subtype: Link Rect: 522, 198, 549, 206 Annotation: Subtype: Link Rect: 316, 189, 360, 197 Annotation: Subtype: Link Rect: 451, 151, 509, 158 Annotation: Subtype: Link Rect: 524, 113, 549, 120 Annotation: Subtype: Link Rect: 316, 103, 368, 111 Annotation: Subtype: Link Rect: 439, 65, 517, 73 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 68, 662, 126, 670 Annotation: Subtype: Link Rect: 151, 624, 221, 632 Annotation: Subtype: Link Rect: 153, 586, 210, 594 Annotation: Subtype: Link Rect: 202, 548, 278, 556 Annotation: Subtype: Link Rect: 68, 510, 128, 518 Annotation: Subtype: Link Rect: 189, 472, 247, 480 Annotation: Subtype: Link Rect: 211, 434, 281, 442 Annotation: Subtype: Link Rect: 153, 396, 223, 404 Annotation: Subtype: Link Rect: 259, 377, 289, 385 Annotation: Subtype: Link Rect: 55, 368, 110, 375 Annotation: Subtype: Link Rect: 174, 330, 257, 337 Annotation: Subtype: Link Rect: 98, 292, 197, 299 Annotation: Subtype: Link Rect: 102, 254, 182, 261 Annotation: Subtype: Link Rect: 212, 216, 270, 223 Annotation: Subtype: Link Rect: 173, 178, 243, 185 Annotation: Subtype: Link Rect: 201, 140, 261, 147 Annotation: Subtype: Link Rect: 261, 111, 289, 119 Annotation: Subtype: Link Rect: 55, 102, 100, 109 Annotation: Subtype: Link Rect: 523, 700, 549, 708 Annotation: Subtype: Link Rect: 316, 691, 360, 698 Annotation: Subtype: Link Rect: 329, 643, 406, 651 Annotation: Subtype: Link Rect: 524, 605, 549, 613 Annotation: Subtype: Link Rect: 316, 596, 348, 603 Annotation: Subtype: Link Rect: 475, 567, 540, 575 Annotation: Subtype: Link Rect: 329, 529, 412, 537 Annotation: Subtype: Link Rect: 473, 510, 536, 518 Annotation: Subtype: Link Rect: 358, 463, 417, 470 Annotation: Subtype: Link Rect: 471, 415, 542, 423 Annotation: Subtype: Link Rect: 524, 368, 549, 375 Annotation: Subtype: Link Rect: 316, 358, 345, 366 Annotation: Subtype: Link Rect: 420, 83, 512, 90 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 461, 710, 549, 717 Annotation: Subtype: Link Rect: 306, 700, 353, 708 Annotation: Subtype: Link Rect: 45, 29, 182, 36 Annotation: Subtype: Link Rect: 191, 29, 249, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Checksum: 5d22ccfa Type: CRC32 Checksum: 3ab065fa62f73ddc921e07b9d0f837df Type: MD5 Checksum: ab22be74277d6764b36d115b26b0cc985ec5562b Type: SHA-1 Checksum: 53c93ecb7efe5b6a02515509ccdf34880bece951c1f2fc97b7c45d50772f76c1 Type: SHA-256