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Klaska Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Mar 7 21:10:43 2022 CET ModDate: Mon Mar 7 21:56:21 2022 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 6350712 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GFDULI+CharisSIL CID TrueType Identity-H yes yes yes 553 0 TPOHKW+CharisSIL-Bold CID TrueType Identity-H yes yes yes 558 0 KRDZNN+CharisSIL-Italic CID TrueType Identity-H yes yes yes 563 0 GPNQOK+TimesNewRomanPS-ItalicMT CID TrueType Identity-H yes yes yes 568 0 AXGZCX+Univers Type 1C Builtin yes yes yes 573 0 KWQLIR+STIX-Italic Type 1C Custom yes yes yes 577 0 CBVRJZ+CharisSIL CID TrueType Identity-H yes yes yes 544 0 XPQUTY+STIX-Regular Type 1C Custom yes yes yes 215 0 WJVQYF+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 220 0 HBBSYX+CharisSIL-Italic CID TrueType Identity-H yes yes yes 207 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 225 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-01 02:36:22 CET RepresentationInformation: 289539.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-29 14:58:03 CET Size: 6350712 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 6315194 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 653 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Generation of recombinant opticin Destination: mk:H2_1 Item: Title: 2.2 Animal experiments Destination: mk:H2_2 Item: Title: 2.3 Mouse model of oxygen-induced retinopathy (OIR) Destination: mk:H2_3 Item: Title: 2.4 Immunofluorescence Destination: mk:H2_4 Item: Title: 2.5 Imaging and quantification Destination: mk:H2_5 Item: Title: 2.6 Safety studies Destination: mk:H2_6 Item: Title: 2.7 Electroretinography (ERG) Destination: mk:H2_7 Item: Title: 2.8 Statistical analysis Destination: mk:H2_8 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Opticin protects against the development of retinal neovascularization and reduces the avascular area in accelerated OIR Destination: mk:H2_9 Item: Title: 3.2 Opticin accelerates regression of established/pre-existing pathological neovascularization Destination: mk:H2_10 Item: Title: 3.3 Opticin appears to cause no perturbation of normal retinal vascularisation or function Destination: mk:H2_11 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusions Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: Declarations of interest Destination: mk:H1_7 Item: Title: Acknowledgements Destination: mk:HH1_2 Item: Title: Appendix A Supplementary data Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization Author: Izabela P. 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