5a78f64f953f3cf9eef43bfaeee90cda 290514.pdf 1f51ec4bbe6bf530a1d10cce6a68e42dc3550865 290514.pdf a3ed3a09c24f82ee071d0e50236f5ee140d1cb2f7d10d3cc0601618e06aafe83 290514.pdf Title: Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study Subject: Journal of Intensive Care, https://doi.org/10.1186/s40560-022-00648-x Keywords: Mechanical ventilation;Cardiogenic pulmonary edema;Ventilator-induced lung injury;Driving pressure Author: Laura Amado-Rodríguez Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Dec 25 11:43:14 2022 CET ModDate: Sun Dec 25 14:54:11 2022 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 987078 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 29 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 33 0 MyriadPro-It Type 1C Custom yes no yes 31 0 WarnockPro-Regular Type 1C Custom yes no yes 30 0 MyriadPro-Semibold Type 1C Custom yes no yes 32 0 MyriadPro-Light Type 1C Custom yes no yes 58 0 XMXMVP+MTSY Type 1C Custom yes yes yes 96 0 MyriadPro-LightIt Type 1C Custom yes no yes 164 0 BQLWBW+HelveticaNeue Type 1C WinAnsi yes yes no 56 0 BQLWBW+Helvetica-Bold Type 1C WinAnsi yes yes no 57 0 BQLWBW+Helvetica Type 1C WinAnsi yes yes no 59 0 FOBWKJ+WarnockPro-It Type 1C WinAnsi yes yes yes 60 0 MyriadPro-Regular2 Type 1C WinAnsi yes no yes 262 0 PTEDNN+MyriadPro-SemiboldIt Type 1C WinAnsi yes yes yes 268 0 BQLWBW+Helvetica-Bold2 Type 1C WinAnsi yes yes no 97 0 Helvetica2 Type 1C Custom yes no no 98 0 Helvetica3 Type 1C WinAnsi yes no no 116 0 BQLWBW+Helvetica-Bold3 Type 1C WinAnsi yes yes no 117 0 Helvetica4 Type 1C WinAnsi yes no no 169 0 BQLWBW+Helvetica-Bold4 Type 1C WinAnsi yes yes no 170 0 HelveticaNeue2 Type 1C WinAnsi yes no no 171 0 Helvetica6 Type 1C WinAnsi yes no no 172 0 Helvetica5 Type 1C WinAnsi yes no no 173 0 XWGXSE+Symbol Type 1C Custom yes yes no 174 0 Helvetica7 Type 1C WinAnsi yes no no 175 0 KMOKRE+OpenSans-Extrabold Type 1C WinAnsi yes yes no 245 0 VNWYPI+OpenSans-Bold Type 1C WinAnsi yes yes no 252 0 VNWYPI+OpenSans-Light Type 1C Custom yes yes no 249 0 VNWYPI+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 255 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-10 02:43:09 CEST RepresentationInformation: 290514.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-09 13:13:17 CEST Size: 987078 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 412 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Methods: Item: Title: Results: Item: Title: Conclusions: Item: Title: Background Item: Title: Methods Children: Item: Title: Study design Item: Title: Data collection Item: Title: Patient selection Item: Title: Follow-up and outcomes Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Non-invasive ventilation Item: Title: Clustering by ventilatory settings Item: Title: Prolonged ventilation Item: Title: Relationships between ventilatory settings and hemodynamics Item: Title: Role of driving pressure on survival Item: Title: Discussion Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study Author: Laura Amado-Rodríguez Subject: Journal of Intensive Care, https://doi.org/10.1186/s40560-022-00648-x Keywords: Mechanical ventilation;Cardiogenic pulmonary edema;Ventilator-induced lung injury;Driving pressure Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Dec 25 11:43:14 CET 2022 ModDate: Sun Dec 25 14:54:11 CET 2022 ID: 0x987b0934574ea0ab0dbb651f10ff6e3f, 0xc700550ca09636ce56e3d4aefbbb3960 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 597 ImageHeight: 98 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: XMXMVP+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XMXMVP+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BQLWBW+Helvetica-Bold2 FontSubset: true FirstChar: 32 LastChar: 68 FontDescriptor: FontName: BQLWBW+Helvetica-Bold2 Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica2 FirstChar: 31 LastChar: 122 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Helvetica4 FirstChar: 32 LastChar: 109 FontDescriptor: FontName: Helvetica4 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BQLWBW+Helvetica-Bold4 FontSubset: true FirstChar: 32 LastChar: 69 FontDescriptor: FontName: BQLWBW+Helvetica-Bold4 Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HelveticaNeue2 FirstChar: 32 LastChar: 112 FontDescriptor: FontName: HelveticaNeue2 Flags: Nonsymbolic FontBBox: -349, -213, 1076, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PTEDNN+MyriadPro-SemiboldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: PTEDNN+MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Helvetica6 FirstChar: 32 LastChar: 118 FontDescriptor: FontName: Helvetica6 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica5 FirstChar: 32 LastChar: 118 FontDescriptor: FontName: Helvetica5 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: XWGXSE+Symbol FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: XWGXSE+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: Helvetica7 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: Helvetica7 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Helvetica3 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: Helvetica3 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BQLWBW+Helvetica-Bold3 FontSubset: true FirstChar: 32 LastChar: 70 FontDescriptor: FontName: BQLWBW+Helvetica-Bold3 Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BQLWBW+HelveticaNeue FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BQLWBW+HelveticaNeue Flags: Nonsymbolic FontBBox: -349, -213, 1076, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BQLWBW+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: BQLWBW+Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BQLWBW+Helvetica FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: BQLWBW+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FOBWKJ+WarnockPro-It FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FOBWKJ+WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2022-12-25T10:43:14 Adobe InDesign 15.1 (Windows) 2022-12-25T14:54:11+01:00 2022-12-25T14:54:11+01:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Mechanical ventilation;Cardiogenic pulmonary edema;Ventilator-induced lung injury;Driving pressure False application/pdf https://doi.org/10.1186/s40560-022-00648-x BioMed Central Journal of Intensive Care, https://doi.org/10.1186/s40560-022-00648-x Mechanical ventilation Cardiogenic pulmonary edema Ventilator-induced lung injury Driving pressure Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study Laura Amado-Rodríguez Raquel Rodríguez-Garcia Giacomo Bellani Tài Pham Eddy Fan Fabiana Madotto John G. Laffey Guillermo M. Albaiceta Antonio Pesenti Laurent Brochard Andres Esteban Luciano Gattinoni Frank van Haren Anders Larsson DanielF McAuley Marco Ranieri Gordon Rubenfeld B. Taylor Thompson Hermann Wrigge Arthur S. Slutsky Fernando Rios Frank Van Haren Thierry Sottiaux Pieter Depuydt Fredy S. Lora Luciano Cesar Azevedo Guillermo Bugedo Haibo Qiu Marcos Gonzalez Juan Silesky Vladimir Cerny Jonas Nielsen Manuel Jibaja Hermann Wrigge Dimitrios Matamis Jorge Luis Ranero Pravin Amin S. M. Hashemian Kevin Clarkson Kiyoyasu Kurahashi Asisclo Villagomez Amine Ali Zeggwagh Leo M. Heunks Jon Henrik Laake Jose Emmanuel Palo Antero do Vale Fernandes Dorel Sandesc Yaasen Arabi Vesna Bumbasierevic Nicolas Nin Jose A. Lorente Anders Larsson Lise Piquilloud Fekri Abroug DanielF McAuley Lia McNamee Javier Hurtado Ed Bajwa Gabriel Démpaire Hektor Sula Lordian Nunci Alma Cani Alan Zazu Christian Dellera Carolina S. Insaurralde Sanatorio Las Lomas San Isidro Risso V. Alejandro Julio Daldin Mauricio Vinzio Ruben O. Fernandez Luis P. Cardonnet Lisandro R. Bettini Mariano Carboni Bisso Emilio M. Osman Mariano G. Setten Pablo Lovazzano Javier Alvarez Veronica Villar Norberto C. Pozo Nicolas Grubissich Gustavo A. Plotnikow Daniela N. Vasquez Santiago Ilutovich Norberto Tiribelli Ariel Chena Carlos A. Pellegrini María G. Saenz Elisa Estenssoro Matias Brizuela Hernan Gianinetto Pablo E. Gomez Valeria I. Cerrato Marco G. Bezzi Silvina A. Borello Flavia A. Loiacono Adriana M. Fernandez Serena Knowles Claire Reynolds Deborah M. Inskip Jennene J. Miller Jing Kong Christina Whitehead Shailesh Bihari Aylin Seven Amanda Krstevski Helen J. Rodgers Rebecca T. Millar Toni E. McKenna Irene M. Bailey Gabrielle C. Hanlon Anders Aneman Joan M. Lynch Raman Azad John Neal Paul W. Woods Brigit L. Roberts Mark R. Kol Helen S. Wong Katharina C. Riss Thomas Staudinger Xavier Wittebole Caroline Berghe Pierre A. Bulpa Alain M. Dive Rik Verstraete Herve Lebbinck Pieter Depuydt Joris Vermassen Philippe Meersseman Helga Ceunen JonasI Rosa Daniel O. Beraldo Claudio Piras Adenilton M. Rampinelli Antonio P. Nassar Jr Sergio Mataloun Marcelo Moock MarlusM Thompson Claudio H. Gonçalves Ana Carolina P. Antônio Aline Ascoli Rodrigo S. Biondi Danielle C. Fontenele Danielle Nobrega Vanessa M. Sales Ahmad Yazid BinHJAbul Wahab Maizatul Ismail Suresh Shindhe John Laffey Francois Beloncle Kyle G. Davies Rob Cirone Venika Manoharan Mehvish Ismail Ewan C. Goligher Mandeep Jassal Erin Nishikawa Areej Javeed Gerard Curley Nuttapol Rittayamai Matteo Parotto Niall D. Ferguson Sangeeta Mehta Jenny Knoll Antoine Pronovost Sergio Canestrini Alejandro R. Bruhn Patricio H. Garcia Felipe A. Aliaga Pamela A. Farías Jacob S. Yumha Claudia A. Ortiz Javier E. Salas Alejandro A. Saez Luis D. Vega Eduardo F. Labarca Felipe T. Martinez Nicolás G. Carreño Pilar Lora Haitao Liu Haibo Qiu Ling Liu Rui Tang Xiaoming Luo Youzhong An Huiying Zhao Yan Gao Zhe Zhai Zheng L. Ye Wei Wang Wenwen Li Qingdong Li Ruiqiang Zheng Wenkui Yu Juanhong Shen Xinyu Li Tao Yu Weihua Lu Ya Q. Wu Xiao B. Huang Zhenyang He Yuanhua Lu Hui Han Fan Zhang Renhua Sun Hua X. Wang Shu H. Qin Bao H. Zhu Jun Zhao Jian Liu Bin Li Jing L. Liu Fa C. Zhou Qiong J. Li Xing Y Zhang Zhou Li-Xin Qiang Xin-Hua Liangyan Jiang Yuan N. Gao Xian Y. Zhao Yuan Y. Li Xiao L. Li Chunting Wang Qingchun Yao Rongguo Yu Kai Chen Huanzhang Shao Bingyu Qin Qing Q. Huang Wei H. Zhu Ai Y. Hang Ma X. Hua Yimin Li Yonghao Xu Yu D. Di Long L. Ling Tie H. Qin ShouH Wang Junping Qin Yi Han Suming Zhou Monica P. Vargas Juan I. Silesky Jimenez Manuel A. González Rojas Jaime E. SolisQuesada ChristianM Ramirez-Alfaro Jan Máca Peter Sklienka Jakob Gjedsted Aage Christiansen Jonas Nielsen BorisG Villamagua Iguel Llano Philippe Burtin Gautier Buzancais Pascal Beuret Nicolas Pelletier Satar Mortaza Alain Mercat Jonathan Chelly Sébastien Jochmans Nicolas Terzi Cédric Daubin Guillaume Carteaux Nicolas de Prost Jean-Daniel Chiche Fabrice Daviaud Muriel Fartoukh Guillaume Barberet Jerome Biehler Jean Dellamonica Denis Doyen Jean-Michel Arnal Anais Briquet Sami Hraiech Laurent Papazian Arnaud Follin Damien Roux Jonathan Messika Evangelos Kalaitzis Laurence Dangers Alain Combes Gaetan Béduneau Dorothée Carpentier Elie H. Zogheib Herve Dupont Sylvie Ricome FrancescoL Santoli Sebastien L. Besset Philippe Michel Bruno Gelée Pierre-Eric Danin Bernard Goubaux Philippe J. Crova Nga T. Phan Frantz Berkelmans Julio C. Badie Romain Tapponnier Josette Gally Samy Khebbeb Jean-Etienne Herbrecht Francis Schneider PierreLouis M. Declercq Jean-Philippe Rigaud Jacques Duranteau Anatole Harrois Russell Chabanne Julien Marin Charlene Bigot Sandrine Thibault Mohammed Ghazi Messabi Boukhazna Salem Ould Zein Jack R. Richecoeur DanieleM Combaux Fabien Grelon Charlene Le Moal EliseP Sauvadet Adrien Robine Virginie Lemiale Danielle Reuter Martin Dres Alexandre Demoule Dany Goldgran-Toledano Loredana Baboi Claude Guérin Ralph Lohner Jens Kraßler Susanne Schäfer Kai D. Zacharowski Patrick Meybohm Andreas W. Reske Philipp Simon HansBernd F. Hopf Michael Schuetz Thomas Baltus Metaxia N. Papanikolaou Theonymfi G. Papavasilopoulou Giannis A. Zacharas Vasilis Ourailogloy Eleni K. Mouloudi Eleni V. Massa Eva O. Nagy Electra E. Stamou Ellada V. Kiourtzieva Marina A. Oikonomou Luis E. Avila Cesar A. Cortez Johanna E. Citalán Sameer A. Jog Safal D. Sable Bhagyesh Shah Mohan Gurjar Arvind K. Baronia Mohammedfaruk Memon Radhakrishnan Muthuchellappan Venkatapura J. Ramesh Anitha Shenoy Ramesh Unnikrishnan Subhal B. Dixit RachanaV Rhayakar Nagarajan Ramakrishnan VallishK Bhardwaj HeeraL Mahto Sudha V. Sagar Vijayanand Palaniswamy Deeban Ganesan Seyed Mohammadreza Hashemian Hamidreza Jamaati Farshad Heidari Edel A. Meaney Alistair Nichol Karl M. Knapman Donall O’Croinin EimhinS Dunne Dorothy M. Breen Kevin P. Clarkson Rola F. Jaafar Rory Dwyer Fahd Amir Olaitan O. Ajetunmobi Aogan C. O’Muircheartaigh ColinS Black Nuala Treanor Daniel V. Collins Wahid Altaf Gianluca Zani Maurizio Fusari Savino Spadaro Carlo A. Volta Romano Graziani Barbara Brunettini Salvatore Palmese Paolo Formenti Michele Umbrello Andrea Lombardo Elisabetta Pecci Marco Botteri Monica Savioli Alessandro Protti Alessia Mattei Lorenzo Schiavoni Andrea Tinnirello Manuel Todeschini Antonino Giarratano Andrea Cortegiani Sara Sher Anna Rossi Massimo M. Antonelli Luca M. Montini Paolo Casalena Sergio Scafetti Giovanna Panarello Giovanna Occhipinti Nicolò Patroniti Matteo Pozzi RobertoR Biscione Michela M. Poli Ferdinando Raimondi Daniela Albiero Giulia Crapelli Eduardo Beck Vincenzo Pota Vincenzo Schiavone Alexandre Molin Fabio Tarantino Giacomo Monti Elena Frati Lucia Mirabella Gilda Cinnella Tommaso Fossali Riccardo Colombo Pierpaolo Terragni Ilaria Pattarino Francesco Mojoli Antonio Braschi Erika E. Borotto Andrea N. Cracchiolo Daniela M. Palma Francesco Raponi Giuseppe Foti EttoreR Vascotto Andrea Coppadoro Luca Brazzi Leda Floris Giorgio A. Iotti Aaron Venti Osamu Yamaguchi Shunsuke Takagi Hiroki N. Maeyama Eizo Watanabe Yoshihiro Yamaji Kazuyoshi Shimizu Kyoko Shiozaki Satoru Futami Sekine Ryosuke Koji Saito Yoshinobu Kameyama Keiko Ueno Masayo Izawa Nao Okuda Hiroyuki Suzuki Tomofumi Harasawa Michitaka Nasu Tadaaki Takada Fumihito Ito Shin Nunomiya Kansuke Koyama Toshikazu Abe Kohkichi Andoh Kohei Kusumoto Akira Hirata Akihiro Takaba Hiroyasu Kimura Shuhei Matsumoto Ushio Higashijima Hiroyuki Honda Nobumasa Aoki Hiroshi Imai Yasuaki Ogino Ichiko Mizuguchi Kazuya Ichikado Kenichi Nitta Katsunori Mochizuki Tomoaki Hashida Hiroyuki Tanaka Tomoyuki Nakamura Daisuke Niimi Takeshi Ueda Yozo Kashiwa Akinori Uchiyama Olegs Sabelnikovs Peteris Oss Youssef Haddad Kong Y. Liew Silvio A. Ñamendys-Silva YvesD Jarquin-Badiola Luis A. Sanchez-Hurtado Saira S. Gomez-Flores Maria C. Marin AsiscloJ Villagomez Jordana S. Lemus Jonathan M. Fierro Mavy Ramirez Cervantes Francisco Javier Flores Mejia Dulce Dector Alejandro Rojas Daniel R. Gonzalez Claudia R. Estrella Jorge R. Sanchez-Medina Alvaro Ramirez-Gutierrez Fernando G. George Janet S. Aguirre Juan A. Buensuseso Manuel Poblano Tarek Dendane Amine Ali Zeggwagh Hicham Balkhi Mina Elkhayari Nacer Samkaoui Hanane Ezzouine Abdellatif Benslama Mourad Amor Wajdi Maazouzi Nedim Cimic Oliver Beck Monique M. Bruns Jeroen A. Schouten Myra Rinia Monique Raaijmakers Leo M. Heunks Hellen M. Van Wezel SergeJ Heines Ulrich Strauch Marc P. Buise Fabienne D. Simonis Marcus J. Schultz Jennifer C. Goodson Troy S. Browne Leanlove Navarra Anna Hunt Robyn A. Hutchison Mathew B. Bailey Lynette Newby Colin McArthur Michael Kalkoff Alex Mcleod Jonathan Casement DanielleJ Hacking Finn H. Andersen Merete S. Dolva Jon H. Laake Andreas Barratt-Due Kim Andre L. Noremark Eldar Søreide BritÅ Sjøbø AnneB Guttormsen Hector H. LeonYoshido Ronald Zumaran Aguilar Fredy A. Montes Oscanoa Alain U. Alisasis Joanne B. Robles Rossini Abbie B. Pasanting-Lim Beatriz C. Tan Pawel Andruszkiewicz Karina Jakubowska Cristina M. Coxo António M. Alvarez Bruno S. Oliveira Gustavo M. Montanha Nelson C. Barros Carlos S. Pereira António M. Messias Jorge M. Monteiro AnaM Araujo NunoT Catorze Susan M. Marum Maria J. Bouw Rui M. Gomes Vania A. Brito Silvia Castro Joana M. Estilita Filipa M. Barros IsabelM Serra Aurelia M. Martinho Dana R. Tomescu Alexandra Marcu Ovidiu H. Bedreag Marius Papurica Dan E. Corneci Silvius Ioan Negoita Evgeny Grigoriev Alexey I. Gritsan Andrey A. Gazenkampf Ghaleb Almekhlafi Mohamad M. Albarrak Ghanem M. Mustafa Khalid A. Maghrabi Nawal Salahuddin Tharwat M. Aisa AhmedS AlJabbary Edgardo Tabhan YaseenM Arabi Yaseen M. Arabi Olivia A. Trinidad Hasan M. Al Dorzi Edgardo E. Tabhan Vesna Bumbasirevic Bojan Jovanovic Stefan Bolon Oliver Smith Jordi Mancebo Hernan Aguirre-Bermeo JuanC Lopez-Delgado Francisco Esteve Gemma Rialp Catalina Forteza Candelaria De Haro Antonio Artigas GuillermoM Albaiceta Sara De Cima-Iglesias Leticia Seoane-Quiroga Alexandra Ceniceros-Barros AntonioL RuizAguilar LuisM Claraco-Vega Juan Alfonso Soler Maria del CarmenLorente Cecilia Hermosa Federico Gordo Miryam PrietoGonzález JuanB López-Messa ManuelP Perez CesarP Perez Raquel Montoiro Allue Ferran RocheCampo Marcos Ibañez-Santacruz Susana Temprano Maria C. Pintado Raul De Pablo Pilar Ricart Aroa Gómez Silvia Rodriguez Ruiz Silvia Iglesias Moles M. Teresa Jurado Alfons Arizmendi Enrique A. Piacentini Nieves Franco Teresa Honrubia Meisy Perez Cheng Elena Perez Losada Javier Blanco Luis J. Yuste Cecilia Carbayo-Gorriz Francisca G. Cazorla-Barranquero Javier G. Alonso Rosa S. Alda Ángela Algaba Gonzalo Navarro Enrique Cereijo Esther Diaz-Rodriguez Diego Pastor Marcos Laura Alvarez Montero Luis Herrera Para Roberto Jimenez Sanchez Miguel Angel Blasco Navalpotro Ricardo Diaz Abad Raquel Montiel González Dácil Parrilla Toribio Alejandro G. Castro Maria Jose D. Artiga Oscar Penuelas Tomas P. Roser Moreno F. Olga Elena Gallego Curto Rocío Manzano Sánchez Vallverdu P. Imma Garcia M. Elisabet Laura Claverias Monica Magret Ana M. Pellicer Lucia L. Rodriguez Jesús Sánchez-Ballesteros Ángela González-Salamanca AntonioG Jimenez FranciscoP Huerta Juan Carlos J. Sotillo Diaz Esther Bermejo Lopez David D. Llinares Moya Alec A. Tallet Alfonso Palazon Sanchez Eugenio Luis Palazon Sanchez Cesar Sánchez I. Rafael CorcolesG Virgilio NoeliaN Recio Richard O. Adamsson Christian C. Rylander Bernhard Holzgraefe Lars M Broman Joanna Wessbergh Linnea Persson Fredrik Schiöler Hans Kedelv Anna Oscarsson Tibblin Henrik Appelberg Lars Hedlund Johan Helleberg KarinE Eriksson Rita Glietsch Niklas Larsson Ingela Nygren SilviaL Nunes Anna-Karin Morin Thomas Kander Anne Adolfsson HervéO Zender Corinne Leemann-Refondini Souheil Elatrous Slaheddine Bouchoucha Imed Chouchene Islem Ouanes Asma Ben Souissi Salma Kamoun Oktay Demirkiran Mustafa Aker Emre Erbabacan Ilkay Ceylan Nermin Kelebek Girgin Menekse Ozcelik Necmettin Ünal Basak Ceyda Meco OnatO Akyol SuleymanS Derman Barry Kennedy Ken Parhar Latha Srinivasa Lia McNamee Danny McAuley Phil Hopkins Clare Mellis Vivek Kakar Dan Hadfield Andre Vercueil Kaushik Bhowmick Sally K. Humphreys Andrew Ferguson Raymond Mckee Ashok S. Raj Danielle A. Fawkes Philip Watt Linda Twohey Rajeev R. Jha Matthew Thomas Alex Morton Varsha Kadaba Mark J. Smith Anil P. Hormis Santhana G. Kannan Miriam Namih Henrik Reschreiter Julie Camsooksai Alek Kumar Szabolcs Rugonfalvi Christopher Nutt Orla Oneill Colette Seasman Ged Dempsey ChristopherJ Scott HelenE Ellis Stuart Mckechnie PaulaJ Hutton Nora N. Di Tomasso Michela N. Vitale Ruth O. Griffin MichaelN Dean JuliusH Cranshaw EmmaL Willett Nicholas Ioannou Sarah Gillis Peter Csabi Rosaleen Macfadyen Heidi Dawson PieterD Preez Alexandra J Williams Owen Boyd Laura Ortiz-Ruiz de Gordoa Jon Bramall Sophie Symmonds SimonK Chau Tim Wenham Tamas Szakmany Piroska Toth-Tarsoly KatieH McCalman Peter Alexander Lorraine Stephenson Thomas Collyer Rhiannon Chapman Raphael Cooper Russell M Allan Malcolm Sim David W Wrathall DonaldA Irvine Charing Kim S. Zantua John C. Adams Andrew J. Burtenshaw Gareth P. Sellors Ingeborg D. Welters Karen E. Williams Robert J. Hessell Matthew G. Oldroyd Ceri E. Battle Suresh Pillai Istvan Kajtor Mageswaran Sivashanmugavel Sinead C. Okane Adrian Donnelly Aniko D. Frigyik Jon P. Careless Martin M May Richard Stewart T. John Trinder SamanthaJ Hagan JadeM Cole Caroline C. MacFie AnnaT Dowling Javier Hurtado Nicolás Nin Javier Hurtado Edgardo Nuñez Gustavo Pittini Ruben Rodriguez María C. Imperio Cristina Santos Ana G França Alejandro Ebeid Alberto Deicas Carolina Serra Aditya Uppalapati Ghassan Kamel Valerie M. BannerGoodspeed Jeremy R. Beitler Satyanarayana Reddy Mukkera Shreedhar Kulkarni John O. Shinn III Dina Gomaa Christopher Tainter Jarone Lee Tomaz Mesar DaleJ Yeatts Jessica Warren MichaelJ Lanspa Russel R. Miller ColinK Grissom SamuelM Brown Philippe R. Bauer Ryan J. Gosselin Barrett T. Kitch Jason E. Cohen Scott H. Beegle Shazia Choudry Renaud M. Gueret Aiman Tulaimat William Stigler Hitesh Batra Nidhi G. Huff Keith D. Lamb Trevor W. Oetting Nicholas M. Mohr Claine Judy Shigeki Saito Fayez M. Kheir Fayez Kheir Adam B. Schlichting Angela Delsing Daniel R. Crouch Mary Elmasri Daniel R. Crouch Dina Ismail Kyle R. Dreyer Thomas C. Blakeman Dina Gomaa Rebecca M. Baro Peter C. Hou Raghu Seethala Imo Aisiku Galen Henderson Gyorgy Frendl Sen-Kuang Hou RobertL Owens Ashley Schomer 10.1186/s40560-022-00648-x 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s40560-022-00648-x 10.1186/s40560-022-00648-x 2052-0492 journal Journal of Intensive Care The Author(s) 2010-04-23 true 10.1186/s40560-022-00648-x noindex springer.com springerlink.com uuid:8510e159-a867-4bd8-87b8-d8e8e90d0cf2 uuid:cbc894cf-0c8b-415e-8790-9fea92fcae1f default 1 converted uuid:8510e159-a867-4bd8-87b8-d8e8e90d0cf2 converted to PDF/A-2b pdfToolbox 2022-12-25T13:27:26Z 2 B Guillermo M. Albaiceta http://orcid.org/0000-0002-9276-3253 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 530, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 276, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 572, 356, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 336, 219, 341, 207 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 431, 183, 436, 171 Flags: Print AppearanceDictionary: true Destination: 219 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 192, 680, 197, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 203, 680, 208, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 83, 644, 88, 632 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 93, 644, 97, 632 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 73, 620, 78, 608 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 84, 620, 89, 608 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 104, 596, 114, 584 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 118, 596, 128, 584 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 173, 536, 182, 524 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 125, 500, 135, 488 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 206, 476, 216, 464 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 221, 476, 231, 464 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 207, 428, 217, 416 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 161, 320, 171, 308 Flags: Print AppearanceDictionary: true Destination: 219 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 116, 680, 125, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 155, 680, 165, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 221, 680, 231, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 277, 680, 287, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 114, 668, 124, 656 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 273, 560, 278, 548 Flags: Print AppearanceDictionary: true Destination: 35 Annotation: Subtype: Link Rect: 279, 476, 284, 464 Flags: Print AppearanceDictionary: true Destination: 35 Annotation: Subtype: Link Rect: 443, 668, 448, 656 Flags: Print AppearanceDictionary: true Destination: 73 Annotation: Subtype: Link Rect: 371, 571, 376, 559 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 484, 535, 489, 523 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 408, 487, 413, 475 Flags: Print AppearanceDictionary: true Destination: 192 Thumb: true Page: Sequence: 4 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 246, 657, 251, 638 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 245, 609, 250, 597 Flags: Print AppearanceDictionary: true Destination: 106 Annotation: Subtype: Link Rect: 111, 573, 116, 561 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 150, 561, 155, 549 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 394, 681, 398, 668 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 408, 669, 413, 656 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 521, 657, 526, 644 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 408, 633, 413, 620 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 524, 633, 529, 620 Flags: Print AppearanceDictionary: true Destination: 110 Annotation: Subtype: Link Rect: 383, 621, 388, 608 Flags: Print AppearanceDictionary: true Destination: 110 Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 216, 143, 221, 131 Flags: Print AppearanceDictionary: true Destination: 192 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 113, 693, 117, 680 Flags: Print AppearanceDictionary: true Destination: 124 Annotation: Subtype: Link Rect: 220, 693, 225, 680 Flags: Print AppearanceDictionary: true Destination: 124 Annotation: Subtype: Link Rect: 98, 681, 103, 668 Flags: Print AppearanceDictionary: true Destination: 124 Annotation: Subtype: Link Rect: 182, 681, 187, 668 Flags: Print AppearanceDictionary: true Destination: 124 Annotation: Subtype: Link Rect: 183, 645, 187, 632 Flags: Print AppearanceDictionary: true Destination: 124 Annotation: Subtype: Link Rect: 234, 561, 239, 548 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 100, 549, 105, 536 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 283, 525, 288, 512 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 120, 501, 125, 488 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 242, 489, 247, 476 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 190, 465, 194, 452 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 71, 441, 75, 428 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 118, 429, 123, 416 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 165, 345, 170, 332 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 174, 345, 184, 332 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 188, 345, 198, 332 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 59, 225, 64, 212 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 338, 705, 348, 692 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 383, 681, 393, 668 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 443, 585, 452, 572 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 458, 585, 468, 572 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 449, 513, 459, 500 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 492, 381, 502, 368 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 307, 297, 317, 284 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 505, 165, 515, 152 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 452, 141, 462, 128 Flags: Print AppearanceDictionary: true Destination: 219 Thumb: true Page: Sequence: 9 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 194, 585, 204, 572 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 138, 501, 148, 488 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 153, 501, 163, 488 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 116, 477, 125, 464 Flags: Print AppearanceDictionary: true Destination: 219 Annotation: Subtype: Link Rect: 96, 393, 106, 380 Flags: Print AppearanceDictionary: true Destination: 238 Annotation: Subtype: Link Rect: 113, 393, 122, 380 Flags: Print AppearanceDictionary: true Destination: 238 Annotation: Subtype: Link Rect: 210, 345, 220, 332 Flags: Print AppearanceDictionary: true Destination: 238 Annotation: Subtype: Link Rect: 496, 689, 529, 681 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 680, 403, 672 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 360, 435, 363, 427 Flags: Print AppearanceDictionary: true Destination: 192 Annotation: Subtype: Link Rect: 508, 264, 530, 256 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 255, 426, 247 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 71, 450, 227, 442 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 106, 126, 241, 118 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 490, 586, 513, 578 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 577, 437, 564 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Thumb: true Checksum: 76fa72e8 Type: CRC32 Checksum: 5a78f64f953f3cf9eef43bfaeee90cda Type: MD5 Checksum: 1f51ec4bbe6bf530a1d10cce6a68e42dc3550865 Type: SHA-1 Checksum: a3ed3a09c24f82ee071d0e50236f5ee140d1cb2f7d10d3cc0601618e06aafe83 Type: SHA-256