69a87c93060e58f2bddf788605ffd32c  290532.pdf
770579de71f47c8315e7ae0cca2e55e5dde04bcd  290532.pdf
120bc30d699fd888886063cb66d6d87e28a6e8770010d7a274af57fd53b32d1c  290532.pdf

Title:           Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort
Subject:         BLOOD, 139 (2022) 3278-3289. doi:10.1182/blood.2021014488
Keywords:        
Author:          Constantine S. Tam
Creator:         Elsevier
Producer:        Acrobat Distiller 6.0 for Windows
CreationDate:    Tue May 24 09:20:21 2022 CEST
ModDate:         Wed Jun  1 11:17:46 2022 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       593.972 x 782.986 pts
Page rot:        0
File size:       1183681 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OJPLCL+AdvOT5e4d79fc                 Type 1C           WinAnsi          yes yes no     460  0
OJPLDM+AdvOTfe809cc4+fb              Type 1C           Custom           yes yes yes    459  0
OJPLFM+MinionPro-Regular             Type 1C           WinAnsi          yes yes no     471  0
OJPLFN+AdvOT0906c96e                 Type 1C           WinAnsi          yes yes no     470  0
OJPLBC+AdvOTa851a675.B               Type 1C           WinAnsi          yes yes no     438  0
OJPLBD+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no     435  0
OJPLBE+AdvOTfe809cc4                 Type 1C           WinAnsi          yes yes no     440  0
OJPLCE+AdvOTfe809cc4+20              Type 1C           WinAnsi          yes yes no     441  0
OJPLCF+AdvP4C4E59                    Type 1C           Custom           yes yes yes    442  0
OJPLCG+AdvOT3b9b4d35                 Type 1C           WinAnsi          yes yes no     443  0
OJPLCH+AdvP4C4E74                    Type 1C           Custom           yes yes yes    439  0
OJPLCI+AdvOTa851a675.B+fb            Type 1C           Custom           yes yes yes    445  0
OJPLCJ+AdvPS_SSYB                    Type 1C           WinAnsi          yes yes no     446  0
OJPLCK+AdvOTa9e6a8c4.BI              Type 1C           WinAnsi          yes yes no     461  0
OJPLIN+AdvOT8817665d                 Type 1C           WinAnsi          yes yes no     204  0
OJPLJO+AdvOT8f428072.I               Type 1C           WinAnsi          yes yes no     207  0
OJPLMN+AdvOT9d186844                 Type 1C           WinAnsi          yes yes no     209  0
OJPLMO+AdvOTa851a675.B+20            Type 1C           WinAnsi          yes yes no     212  0
OJPMBB+AdvOT0906c96e+fb              Type 1C           Custom           yes yes yes    222  0
OJPMBC+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     223  0
OJPMAO+AvenirLTStd-Heavy             Type 1C           WinAnsi          yes yes no     224  0
OJPMAP+AvenirLTStd-Roman             Type 1C           MacRoman         yes yes no     218  0
OJPMBA+AdvOT0906c96e+20              Type 1C           WinAnsi          yes yes no     216  0
OJPMFB+AvenirLTStd-Black             Type 1C           WinAnsi          yes yes no     236  0
OJPMFC+AvenirLTStd-Roman             Type 1C           Custom           yes yes yes    229  0
OJPMFD+AvenirNextLTPro-Cn            Type 1C           WinAnsi          yes yes no     228  0
OJPMFE+AvenirLTStd-Oblique           Type 1C           WinAnsi          yes yes no     241  0
OJPMFF+AvenirLTStd-Heavy             Type 1C           Custom           yes yes yes    234  0
OJPMFG+AvenirLTStd-HeavyOblique      Type 1C           WinAnsi          yes yes no     249  0
OJPMGH+AdvOTf1c06d06.I               Type 1C           WinAnsi          yes yes no     237  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-04-04 02:50:19 CEST
 RepresentationInformation: 290532.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-04-03 13:48:23 CEST
  Size: 1183681
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 536
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Fixed-duration ibrutinib plus venetoclax for first-line
treatment of CLL: primary analysis of the CAPTIVATE
FD cohort
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design and participants
         Item: 
          Title: Treatment
         Item: 
          Title: Outcomes and assessments
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Patients
         Item: 
          Title: Efficacy
         Item: 
          Title: Tumor debulking
         Item: 
          Title: Safety
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Authorship
       Item: 
        Title: Footnotes
       Item: 
        Title: REFERENCES
   Info: 
    Title: Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort
    Author: Constantine S. Tam
    Subject: BLOOD, 139 (2022) 3278-3289. doi:10.1182/blood.2021014488
    Keywords: 
    Creator: Elsevier
    Producer: Acrobat Distiller 6.0 for Windows
    CreationDate: Tue May 24 09:50:21 CEST 2022
    ModDate: Wed Jun 01 11:47:46 CEST 2022
   ID: 0x6a9cdd7f1aedc27e645209c4f580b424, 0xc971c97eca4b2e4d90d3c8472e0946d1
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 128
      ImageHeight: 209
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OJPLDM+AdvOTfe809cc4+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OJPLDM+AdvOTfe809cc4+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 768
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPLCL+AdvOT5e4d79fc
      FontSubset: true
      FirstChar: 65
      LastChar: 119
      FontDescriptor: 
       FontName: OJPLCL+AdvOT5e4d79fc
       Flags: Nonsymbolic
       FontBBox: -23, -250, 964, 860
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLIN+AdvOT8817665d
      FontSubset: true
      FirstChar: 35
      LastChar: 97
      FontDescriptor: 
       FontName: OJPLIN+AdvOT8817665d
       Flags: Nonsymbolic
       FontBBox: -30, -210, 1000, 779
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLCK+AdvOTa9e6a8c4.BI
      FontSubset: true
      FirstChar: 51
      LastChar: 84
      FontDescriptor: 
       FontName: OJPLCK+AdvOTa9e6a8c4.BI
       Flags: Nonsymbolic
       FontBBox: -78, -275, 1102, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLJO+AdvOT8f428072.I
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: OJPLJO+AdvOT8f428072.I
       Flags: Nonsymbolic
       FontBBox: -63, -288, 1044, 920
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLMN+AdvOT9d186844
      FontSubset: true
      FirstChar: 53
      LastChar: 53
      FontDescriptor: 
       FontName: OJPLMN+AdvOT9d186844
       Flags: Nonsymbolic
       FontBBox: -26, -240, 928, 773
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLMO+AdvOTa851a675.B+20
      FontSubset: true
      FirstChar: 134
      LastChar: 134
      FontDescriptor: 
       FontName: OJPLMO+AdvOTa851a675.B+20
       Flags: Nonsymbolic
       FontBBox: -161, -133, 1135, 740
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLFN+AdvOT0906c96e
      FontSubset: true
      FirstChar: 37
      LastChar: 124
      FontDescriptor: 
       FontName: OJPLFN+AdvOT0906c96e
       Flags: Nonsymbolic
       FontBBox: -30, -250, 939, 932
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLFM+MinionPro-Regular
      FontSubset: true
      FirstChar: 98
      LastChar: 174
      FontDescriptor: 
       FontName: OJPLFM+MinionPro-Regular
       Flags: Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMBA+AdvOT0906c96e+20
      FontSubset: true
      FirstChar: 134
      LastChar: 135
      FontDescriptor: 
       FontName: OJPMBA+AdvOT0906c96e+20
       Flags: Nonsymbolic
       FontBBox: -167, -138, 1000, 742
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMAP+AvenirLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 224
      FontDescriptor: 
       FontName: OJPMAP+AvenirLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1000, 928
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OJPMBB+AdvOT0906c96e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OJPMBB+AdvOT0906c96e+fb
       Flags: Symbolic
       FontBBox: 0, 0, 500, 768
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPMBC+AdvOT46dcae81
      FontSubset: true
      FirstChar: 167
      LastChar: 167
      FontDescriptor: 
       FontName: OJPMBC+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -46, -250, 838, 879
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMAO+AvenirLTStd-Heavy
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: OJPMAO+AvenirLTStd-Heavy
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -250, 1160, 939
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMFD+AvenirNextLTPro-Cn
      FontSubset: true
      FirstChar: 32
      LastChar: 135
      FontDescriptor: 
       FontName: OJPMFD+AvenirNextLTPro-Cn
       Flags: Nonsymbolic
       FontBBox: -105, -244, 846, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMFC+AvenirLTStd-Roman
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: OJPMFC+AvenirLTStd-Roman
       Flags: Symbolic
       FontBBox: -166, -250, 1000, 928
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPMFF+AvenirLTStd-Heavy
      FontSubset: true
      FirstChar: 2
      LastChar: 129
      FontDescriptor: 
       FontName: OJPMFF+AvenirLTStd-Heavy
       Flags: Symbolic, ForceBold
       FontBBox: -166, -250, 1160, 939
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPMFB+AvenirLTStd-Black
      FontSubset: true
      FirstChar: 65
      LastChar: 66
      FontDescriptor: 
       FontName: OJPMFB+AvenirLTStd-Black
       Flags: Nonsymbolic, ForceBold
       FontBBox: -161, -250, 1135, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMGH+AdvOTf1c06d06.I
      FontSubset: true
      FirstChar: 51
      LastChar: 84
      FontDescriptor: 
       FontName: OJPMGH+AdvOTf1c06d06.I
       Flags: Nonsymbolic
       FontBBox: -62, -277, 1039, 932
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMFE+AvenirLTStd-Oblique
      FontSubset: true
      FirstChar: 51
      LastChar: 84
      FontDescriptor: 
       FontName: OJPMFE+AvenirLTStd-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -277, 1057, 928
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLBD+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: OJPLBD+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -25, -257, 956, 855
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLBC+AdvOTa851a675.B
      FontSubset: true
      FirstChar: 37
      LastChar: 121
      FontDescriptor: 
       FontName: OJPLBC+AdvOTa851a675.B
       Flags: Nonsymbolic
       FontBBox: -73, -250, 1002, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLCH+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 106
      FontDescriptor: 
       FontName: OJPLCH+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPLBE+AdvOTfe809cc4
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: OJPLBE+AdvOTfe809cc4
       Flags: Nonsymbolic
       FontBBox: -31, -288, 944, 920
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLCE+AdvOTfe809cc4+20
      FontSubset: true
      FirstChar: 134
      LastChar: 148
      FontDescriptor: 
       FontName: OJPLCE+AdvOTfe809cc4+20
       Flags: Nonsymbolic
       FontBBox: -167, -140, 1000, 740
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPMFG+AvenirLTStd-HeavyOblique
      FontSubset: true
      FirstChar: 51
      LastChar: 84
      FontDescriptor: 
       FontName: OJPMFG+AvenirLTStd-HeavyOblique
       Flags: Nonsymbolic, Italic, ForceBold
       FontBBox: -165, -276, 1185, 939
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLCF+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 160
      FontDescriptor: 
       FontName: OJPLCF+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPLCG+AdvOT3b9b4d35
      FontSubset: true
      FirstChar: 69
      LastChar: 89
      FontDescriptor: 
       FontName: OJPLCG+AdvOT3b9b4d35
       Flags: Nonsymbolic
       FontBBox: -46, -282, 961, 924
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OJPLCI+AdvOTa851a675.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OJPLCI+AdvOTa851a675.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 587, 768
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OJPLCJ+AdvPS_SSYB
      FontSubset: true
      FirstChar: 60
      LastChar: 163
      FontDescriptor: 
       FontName: OJPLCJ+AdvPS_SSYB
       Flags: Nonsymbolic
       FontBBox: -197, -270, 1135, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1182/blood.2021014488</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Constantine S. Tam</rdf:li>
               <rdf:li>John N. Allan</rdf:li>
               <rdf:li>Tanya Siddiqi</rdf:li>
               <rdf:li>Thomas J. Kipps</rdf:li>
               <rdf:li>Ryan Jacobs</rdf:li>
               <rdf:li>Stephen Opat</rdf:li>
               <rdf:li>Paul M. Barr</rdf:li>
               <rdf:li>Alessandra Tedeschi</rdf:li>
               <rdf:li>Livio Trentin</rdf:li>
               <rdf:li>Rajat Bannerji</rdf:li>
               <rdf:li>Sharon Jackson</rdf:li>
               <rdf:li>Bryone J. Kuss</rdf:li>
               <rdf:li>Carol Moreno</rdf:li>
               <rdf:li>Edith Szafer-Glusman</rdf:li>
               <rdf:li>Kristin Russell</rdf:li>
               <rdf:li>Cathy Zhou</rdf:li>
               <rdf:li>Joi Ninomoto</rdf:li>
               <rdf:li>James P. Dean</rdf:li>
               <rdf:li>William G. Wierda</rdf:li>
               <rdf:li>Paolo Ghia</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BLOOD, 139 (2022) 3278-3289. doi:10.1182/blood.2021014488</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>American Society of Hematology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BLOOD</prism:publicationName>
         <prism:copyright>Copyright © 2022 American Society of Hematology. All rights reserved.</prism:copyright>
         <prism:issn>0006-4971</prism:issn>
         <prism:volume>139</prism:volume>
         <prism:number>22</prism:number>
         <prism:coverDisplayDate>2 June 2022</prism:coverDisplayDate>
         <prism:coverDate>2022-06-02</prism:coverDate>
         <prism:pageRange>3278-3289</prism:pageRange>
         <prism:startingPage>3278</prism:startingPage>
         <prism:endingPage>3289</prism:endingPage>
         <prism:doi>10.1182/blood.2021014488</prism:doi>
         <prism:url>http://dx.doi.org/10.1182/blood.2021014488</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1182/blood.2021014488</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <X9O3Cod79zgr_yM2GntyQzsNNy9z8lt6LmM-GntyKywuPm.yPzgf8o9eQmtiKndqJoteTma/>
         <pdfx:doi>10.1182/blood.2021014488</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomainsↂ005B2ↂ005D>elsevier.com</pdfx:CrossMarkDomainsↂ005B2ↂ005D>
         <pdfx:CrossMarkDomainsↂ005B1ↂ005D>sciencedirect.com</pdfx:CrossMarkDomainsↂ005B1ↂ005D>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2022-05-24T12:50:21+05:30</xap:CreateDate>
         <xap:ModifyDate>2022-06-01T14:47:46+05:30</xap:ModifyDate>
         <xap:MetadataDate>2022-06-01T14:47:46+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords/>
         <pdf:Producer>Acrobat Distiller 6.0 for Windows</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:821efb0f-454f-48e5-b092-fdf80a663275</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:5cf74f87-4a81-4a0d-9a46-ca01fd872ef8</xapMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 3278
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 126, 65, 135
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 65, 130, 67, 139
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 67, 126, 70, 135
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 277, 126, 280, 135
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 282, 126, 285, 135
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 118, 59, 121, 67
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 420, 155, 424, 163
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 424, 159, 426, 167
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 426, 155, 429, 163
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 339, 59, 342, 67
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 344, 59, 351, 67
       Destination: 159
    Page: 
     Label: 3279
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 705, 68, 713
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 69, 705, 76, 713
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 76, 708, 78, 717
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 78, 705, 85, 713
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 195, 682, 199, 690
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 200, 682, 207, 690
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 209, 682, 216, 690
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 221, 647, 224, 656
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 226, 647, 233, 656
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 234, 647, 241, 656
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 78, 613, 85, 621
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 85, 617, 87, 625
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 87, 613, 94, 621
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 78, 499, 84, 508
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 196, 349, 202, 357
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 132, 128, 135, 136
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 380, 682, 387, 690
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 388, 682, 395, 690
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 435, 437, 442, 446
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 506, 359, 509, 368
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 318, 293, 325, 301
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 354, 270, 361, 279
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 509, 270, 516, 279
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 388, 59, 395, 67
       Destination: 193
    Page: 
     Label: 3280
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 507, 393, 535, 402
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 460, 338, 486, 346
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 481, 293, 512, 302
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 305, 215, 342, 223
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 348, 193, 354, 201
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 428, 170, 466, 179
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 305, 103, 342, 112
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 131, 337, 135, 344
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 378, 622, 382, 630
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 303, 538, 306, 544
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 303, 528, 307, 534
       Destination: 31
    Page: 
     Label: 3281
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 705, 255, 714
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 236, 595, 274, 603
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 181, 528, 217, 536
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 359, 628, 396, 636
       Destination: 117
      Annotation: 
       Subtype: Link
       Rect: 502, 484, 539, 492
       Destination: 117
    Page: 
     Label: 3282
     Sequence: 5
    Page: 
     Label: 3283
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 186, 449, 222, 457
       Destination: 129
      Annotation: 
       Subtype: Link
       Rect: 115, 382, 150, 391
       Destination: 129
      Annotation: 
       Subtype: Link
       Rect: 238, 315, 267, 323
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 117, 215, 146, 223
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 310, 706, 338, 714
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 369, 333, 376, 341
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 436, 300, 443, 309
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 445, 300, 451, 309
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 453, 300, 460, 309
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 489, 212, 495, 221
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 495, 216, 497, 225
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 497, 212, 504, 221
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 508, 180, 515, 188
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 537, 158, 543, 166
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 514, 125, 518, 133
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 520, 125, 526, 133
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 528, 125, 535, 133
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 537, 125, 543, 133
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 511, 103, 518, 111
       Destination: 193
    Page: 
     Label: 3284
     Sequence: 7
    Page: 
     Label: 3285
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 511, 126, 518, 135
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 381, 70, 388, 79
       Destination: 159
    Page: 
     Label: 3286
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 92, 224, 101
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 452, 183, 459, 192
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 515, 82, 522, 90
       Destination: 159
    Page: 
     Label: 3287
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 220, 274, 227, 283
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 69, 183, 76, 192
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 108, 103, 115, 112
       Destination: 193
      Annotation: 
       Subtype: Link
       Rect: 417, 606, 425, 614
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 427, 606, 434, 614
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 125, 659, 128, 666
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 128, 535, 132, 542
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 53, 377, 56, 383
       Destination: 142
      Annotation: 
       Subtype: Link
       Rect: 53, 360, 57, 366
       Destination: 142
    Page: 
     Label: 3288
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 392, 729, 466, 737
      Annotation: 
       Subtype: Link
       Rect: 501, 729, 540, 737
      Annotation: 
       Subtype: Link
       Rect: 303, 720, 339, 727
      Annotation: 
       Subtype: Link
       Rect: 369, 720, 443, 727
      Annotation: 
       Subtype: Link
       Rect: 482, 720, 540, 727
      Annotation: 
       Subtype: Link
       Rect: 303, 710, 321, 718
      Annotation: 
       Subtype: Link
       Rect: 345, 710, 419, 718
      Annotation: 
       Subtype: Link
       Rect: 443, 710, 517, 718
      Annotation: 
       Subtype: Link
       Rect: 303, 701, 377, 708
      Annotation: 
       Subtype: Link
       Rect: 500, 666, 540, 674
      Annotation: 
       Subtype: Link
       Rect: 303, 657, 366, 665
      Annotation: 
       Subtype: Link
       Rect: 518, 526, 540, 534
      Annotation: 
       Subtype: Link
       Rect: 303, 517, 350, 524
      Annotation: 
       Subtype: Link
       Rect: 337, 470, 402, 477
    Page: 
     Label: 3289
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 408, 425, 533, 431
      Annotation: 
       Subtype: Link
       Rect: 391, 416, 523, 422
  Checksum: 50fed6fa
   Type: CRC32
  Checksum: 69a87c93060e58f2bddf788605ffd32c
   Type: MD5
  Checksum: 770579de71f47c8315e7ae0cca2e55e5dde04bcd
   Type: SHA-1
  Checksum: 120bc30d699fd888886063cb66d6d87e28a6e8770010d7a274af57fd53b32d1c
   Type: SHA-256