5e548863528fa2b43eedcd7c195526a4 290535.pdf ef03fa185666bde6b02aac4ce06bfa327e6db77f 290535.pdf fd2c7a23efe70dbae2c0419635d3c2b9f3fad63214d47b5521fa63f7292188bc 290535.pdf Title: Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography Subject: Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50–69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies. Keywords: breast neoplasms; mass screening; longitudinal studies; benign breast disease Author: Marta Román, Javier Louro, Margarita Posso, Carmen Vidal, Xavier Bargalló, Ivonne Vázquez, María Jesús Quintana, Rodrigo Alcántara, Francina Saladié, Javier del Riego, Lupe Peñalva, Maria Sala, Xavier Castells and on behalf of the BELE and IRIS Study Groups Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 24 13:02:05 2022 CET ModDate: Thu Feb 24 13:14:23 2022 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1353388 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OWJUNQ+VnURWPalladioL Type 1 Custom yes yes no 10 0 ROFBGR+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 BEUWJP+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 XUCOQO+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 DGBDNV+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 59 0 WOWCNF+CMSY10 Type 1 Builtin yes yes no 84 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 91 0 JEPCOO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 105 0 JEPCPA+PalatinoLinotype TrueType WinAnsi yes yes no 108 0 JEPCPC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 111 0 JEPCOO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 125 0 JEPCPA+PalatinoLinotype TrueType WinAnsi yes yes no 128 0 JEPCPC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 131 0 JEPCOO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 146 0 JEPCPA+PalatinoLinotype TrueType WinAnsi yes yes no 149 0 JEPCPC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 152 0 JEPGIP+SimSun CID TrueType Identity-H yes yes yes 155 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-10 02:43:02 CEST RepresentationInformation: 290535.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-08 19:26:26 CEST Size: 1353388 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 302 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Setting and Study Population Destination: subsection.2.1 Item: Title: Analyses Destination: subsection.2.2 Item: Title: Results Destination: section.3 Children: Item: Title: Study Population Characteristics Destination: subsection.3.1 Item: Title: Rates of Breast Cancer among Women with and witthout a Benign Breast Disease Destination: subsection.3.2 Item: Title: Cumulative Incidence of Breast Cancer by Year and Age at Index Mammogram Destination: subsection.3.3 Item: Title: Risk of Breast Cancer among Women with and without a Benign Breast Disease Destination: subsection.3.4 Item: Title: Supplementary Analyses Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography Author: Marta Román, Javier Louro, Margarita Posso, Carmen Vidal, Xavier Bargalló, Ivonne Vázquez, María Jesús Quintana, Rodrigo Alcántara, Francina Saladié, Javier del Riego, Lupe Peñalva, Maria Sala, Xavier Castells and on behalf of the BELE and IRIS Study Groups Subject: Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50 69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies. 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