66ec4ea7fd6131634ca4dafa7c443531 290555.pdf 8729fa9ea4b84c178620959b089a3203cd24da8d 290555.pdf 02e18ff704afbfd41f68897d01ac1d558c5f111379dd7e09643ea9605222d183 290555.pdf Title: Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study Subject: A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m2, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population. Keywords: advanced glycation end-products; glycosylated hemoglobin; prediabetes; skin autofluorescence Author: Enric Sánchez, Mohsen Kerkeni, Marta Hernández, Ricard Gavaldà, Ferran Rius, Ariadna Sauret, Gerard Torres, Marcelino Bermúdez-López, Elvira Fernández, Eva Castro-Boqué, Francisco Purroy, Dídac Mauricio, Cristina Farràs-Sallés, Miquel Buti, Pere Godoy, Reinald Pamplona and Albert Lecube Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Mar 5 14:04:27 2022 CET ModDate: Sat Mar 5 14:09:45 2022 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1068261 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DLFLAB+VnURWPalladioL Type 1 Custom yes yes no 10 0 PJODBK+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 IMCDTM+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 VNGNTP+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 UQZHSH+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 81 0 AAOFOO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 92 0 AAOFOP+PalatinoLinotype CID TrueType Identity-H yes yes yes 95 0 AAOFPA+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 AAOGAB+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 112 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 120 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 124 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 128 0 BCDHEE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 132 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 136 0 AHKBIA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 154 0 AHKBIB+PalatinoLinotype CID TrueType Identity-H yes yes yes 157 0 AHKBIC+PalatinoLinotype TrueType WinAnsi yes yes no 163 0 AHKBIE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 166 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-13 02:43:57 CEST RepresentationInformation: 290555.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-12 12:26:51 CEST Size: 1068261 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 291 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Ethical Statement Destination: subsection.2.1 Item: Title: Design of the Study and Data of the Study Participants Destination: subsection.2.2 Item: Title: Measurement of Skin Autofluorescence Destination: subsection.2.3 Item: Title: Diagnosis of Prediabetes and Type 2 Diabetes Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study Author: Enric Sánchez, Mohsen Kerkeni, Marta Hernández, Ricard Gavaldà, Ferran Rius, Ariadna Sauret, Gerard Torres, Marcelino Bermúdez-López, Elvira Fernández, Eva Castro-Boqué, Francisco Purroy, Dídac Mauricio, Cristina Farràs-Sallés, Miquel Buti, Pere Godoy, Reinald Pamplona and Albert Lecube Subject: A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m2, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population. 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