0fa91c7861b98a69042dab313bcb21b1 290566.pdf cb60aa62c80e02d20d49f6c69d3accdf0539232d 290566.pdf 9481bf10f8eed609fe2c1fc0d397192d68881c9fe3e9cfe53dfd095cc3706849 290566.pdf Title: Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study Subject: Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 36.48 vs. 34.3 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 37.37) compared to those who did not develop MF (+6.2 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score ( = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up. Keywords: burden; follow-up; non-motor symptoms; motor fluctuations; Parkinson’s disease Author: Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Ester Suárez Castro, Héctor Canfield, Cristina Martínez Miró, Silvia Jesús, Miquel Aguilar, Pau Pastor, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández-Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fábregues, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M. López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir and COPPADIS Study Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue May 10 12:03:57 2022 CEST ModDate: Tue May 10 12:05:55 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1102451 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SHXXIN+VnURWPalladioL Type 1 Custom yes yes no 10 0 CAFEDV+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 KDDGHD+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 QPIDYW+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 WIRPUU+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 BXZUUH+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 68 0 CZMDWU+CMSY10 Type 1 Builtin yes yes no 72 0 AUNAJP+VnURWPalladioL-Italic Type 1 Custom yes yes no 82 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 89 0 VMVBOC+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 100 0 GIJFMG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 108 0 GXMPMG+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 112 0 ZFWUSU+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 116 0 VMVBOC+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 129 0 GIJFMG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 137 0 GXMPMG+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 141 0 ZFWUSU+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 145 0 VMVBOC+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 161 0 GIJFMG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 169 0 GXMPMG+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 173 0 ZFWUSU+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 177 0 BOLMEN+SFRM0900 Type 1 Custom yes yes no 208 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-17 02:47:35 CEST RepresentationInformation: 290566.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-16 10:55:32 CEST Size: 1102451 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 367 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Item: Title: Data Analysis Destination: section.3 Item: Title: Standard Protocol Approvals, Registrations, and Patient Consents Destination: section.4 Item: Title: Data Availability Destination: section.5 Item: Title: Results Destination: section.6 Item: Title: Discussion Destination: section.7 Item: Title: Appendix A Destination: section.A. Item: Title: References Destination: section.A. Info: Title: Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study Author: Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Ester Suárez Castro, Héctor Canfield, Cristina Martínez Miró, Silvia Jesús, Miquel Aguilar, Pau Pastor, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández-Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fábregues, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M. López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir and COPPADIS Study Group Subject: Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 36.48 vs. 34.3 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 37.37) compared to those who did not develop MF (+6.2 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score ( = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up. 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