04a0da917a1139cdcdf07e470cead414 290604.pdf 2fc20482cd1c4b4fbb1e9698e23a5657ee62a422 290604.pdf 7e843addc78ca97f49adf7df04e80b8fb64f537889a1f0b5a3fa98395b3f10c1 290604.pdf Title: European guideline (EuroGuiDerm) on atopic eczema: part I – systemic therapy Subject: Acad Dermatol Venereol 2022.36:1409-1431 Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 15.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Wed Aug 17 15:12:13 2022 CEST ModDate: Fri Apr 12 20:32:50 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 908313 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OHIBDN+AdvOT340fc0d1 Type 1C WinAnsi yes yes no 80 0 OHIBCK+AdvTTec369687+20 Type 1C WinAnsi yes yes no 112 0 OHIBDO+AdvOT7fe89a09+fb Type 1C Custom yes yes yes 113 0 OHIBCL+AdvOTe8225e7f+20 Type 1C WinAnsi yes yes no 81 0 OHIBCM+AdvOTe8225e7f+fb Type 1C Custom yes yes yes 1070 0 OHIBEB+AdvMINION-I Type 1C MacRoman yes yes no 87 0 OHIBFB+AdvMINION-BI Type 1C WinAnsi yes yes no 1071 0 OHIBDP+AdvPSSym Type 1C Custom yes yes no 88 0 OHIBEA+AdvOT928142ec.I Type 1C WinAnsi yes yes no 89 0 OHHPEP+AdvOT7fe89a09 Type 1C WinAnsi yes yes no 90 0 OHHPFA+AdvOTd1f5cc91.B Type 1C WinAnsi yes yes no 91 0 OHHPFB+AdvTT689d5d16.B+20 Type 1C WinAnsi yes yes no 1072 0 OHHPFC+AdvTTec369687 Type 1C WinAnsi yes yes no 118 0 OHHPPP+AdvP4C4E59 Type 1C Custom yes yes yes 437 0 OHIBBJ+AdvOTe8225e7f Type 1C WinAnsi yes yes no 92 0 OHICHA+AdvOTc4f305bd.I Type 1C WinAnsi yes yes no 82 0 OHIBJD+AdvTT3713a231+20 Type 1C WinAnsi yes yes no 83 0 OHIBPC+AdvOTd1f5cc91.B+fb Type 1C Custom yes yes yes 84 0 OHIBIB+AdvOT340fc0d1+fb Type 1C Custom yes yes yes 85 0 OHIBJC+AdvMINION-R Type 1C Custom yes yes no 86 0 Times-Roman Type 1 WinAnsi no no no 5 0 OHICNO+AdvTT7b6c0d50.B Type 1C WinAnsi yes yes no 111 0 OHICNP+AdvTT7b6c0d50.B+fb Type 1C Custom yes yes yes 114 0 OHICPC+AdvTT82c4f4c4+20 Type 1C WinAnsi yes yes no 115 0 OHICOA+AdvTT82c4f4c4 Type 1C WinAnsi yes yes no 116 0 OHICPB+AdvTT82c4f4c4+fb Type 1C Custom yes yes yes 117 0 OHIFPD+Calibri-Bold Type 1C Custom yes yes yes 151 0 OHIFAH+Helvetica-Bold Type 1C WinAnsi yes yes no 152 0 OHIFFG+Helvetica Type 1C WinAnsi yes yes no 153 0 OHIEJI+AdvOT7fe89a09+20 Type 1C WinAnsi yes yes no 154 0 OHIJCD+AdvTTdf37bfe4+25 Type 1C Custom yes yes yes 169 0 OHIJKB+Helvetica-Oblique Type 1C WinAnsi yes yes no 170 0 OHIGLP+AdvOTc4f305bd.I+fb Type 1C Custom yes yes yes 171 0 OHIINE+AdvPSMPi6 Type 1C WinAnsi yes yes no 172 0 OHILGL+Wingdings3 Type 1C Custom yes yes no 193 0 OHILGJ+Helvetica Type 1C WinAnsi yes yes no 194 0 OHILGK+Helvetica-Bold Type 1C WinAnsi yes yes no 195 0 OHILAJ+Calibri Type 1C Custom yes yes yes 196 0 OHILFI+ArialMT Type 1C WinAnsi yes yes no 197 0 OHINJA+MyriadPro-Regular Type 1C Custom yes yes yes 217 0 OHINEB+Helvetica Type 1C WinAnsi yes yes no 218 0 OHJANO+Helvetica Type 1C WinAnsi yes yes no 233 0 OHJAOP+Helvetica-Bold Type 1C WinAnsi yes yes no 234 0 OHIPDH+AdvTTec369687+22 Type 1C Custom yes yes yes 235 0 OHJAGA+Helvetica Type 1C WinAnsi yes yes no 236 0 OHJBBP+Helvetica Type 1C Custom yes yes yes 237 0 OHJEOK+Helvetica-Oblique Type 1C WinAnsi yes yes no 274 0 OHJEFM+Helvetica-Bold Type 1C WinAnsi yes yes no 275 0 OHJFOF+AdvP4C4E74 Type 1C Custom yes yes yes 297 0 OHJGPP+AdvPSMP13 Type 1C WinAnsi yes yes no 308 0 OHJKAN+AdvTir_symb Type 1C WinAnsi yes yes no 336 0 OHJNPH+Arial-ItalicMT Type 1C WinAnsi yes yes no 384 0 OHJNOH+Wingdings2 Type 1C Custom yes yes no 385 0 OHKBBF+Helvetica-Bold Type 1C WinAnsi yes yes no 404 0 OHKCIN+AdvMINION-B Type 1C WinAnsi yes yes no 420 0 OHKCNM+Helvetica-Bold Type 1C WinAnsi yes yes no 421 0 OHKFCP+AdvSPSASORT Type 1C Custom yes yes no 442 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-16 02:41:41 CEST RepresentationInformation: 290604.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-04-12 20:34:57 CEST Size: 908313 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Outlines: Item: Title: Abstract Destination: head2_2135445 Item: Title: Scop„ing and defin„ing the pur„pose of the guide„line Destination: head3_1282662 Item: Title: Pop„u„la„tion and health ques„tions cov„ered by the guide„line Destination: head4_1874519 Item: Title: Tar„geted users of this guide„line Destination: head5_1367012 Item: Title: Meth„ods sec„tion Destination: head6_1704412 Children: Item: Title: Nom„i„na„tion of experts, man„age„ment of con„flict of inter„est Destination: head7_2126162 Item: Title: Devel„op„ment of the guide„line and the con„sen„sus pro„cess Destination: head8_535852 Item: Title: Evi„dence Destination: head9_786402 Item: Title: Overview of rec„om„men„da„tions Destination: head10_1545552 Item: Title: Intro„duc„tion to sys„temic treat„ment Destination: head11_1798602 Item: Title: Con„ven„tional sys„temic drugs Destination: head12_325100 Children: Item: Title: Aza„thio„prine (AZA) Destination: head13_355752 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head14 Item: Title: Dosage: acute flare, short term, long term Destination: head15 Item: Title: Safety Destination: head16 Item: Title: Mon„i„tor„ing Destination: head17 Item: Title: Com„bi„na„tion with other treat„ments Destination: head18 Item: Title: Spe„cial con„sid„er„a„tions Destination: head19 Item: Title: jdv18345-fig-0001 Destination: ljdv18345-fig-0001 Item: Title: jdv18345-fig-0002 Destination: ljdv18345-fig-0002 Item: Title: Ciclosporin Destination: head20_325100 Item: Title: Ciclosporin Destination: head20_325100 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head21 Item: Title: Dosage: acute flare, short term, long term Destination: head22 Item: Title: Safety Destination: head23 Item: Title: Mon„i„tor„ing Destination: head24 Item: Title: Com„bi„na„tion with other treat„ments Destination: head25 Item: Title: Spe„cial con„sid„er„a„tions Destination: head26 Item: Title: Sys„temic glu„co„cor„ti„cos„teroids Destination: head27_1076517 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head28 Item: Title: Dosage: acute flare, short term, long term Destination: head29 Item: Title: Safety Destination: head30 Item: Title: Mon„i„tor„ing Destination: head31 Item: Title: Com„bi„na„tion with other treat„ments Destination: head32 Item: Title: Spe„cial con„sid„er„a„tions Destination: head33 Item: Title: Methotrex„ate Destination: head34_325100 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head35 Item: Title: Dosage: acute flare, short term, long term Destination: head36 Item: Title: Safety Destination: head37 Item: Title: Mon„i„tor„ing Destination: head38 Item: Title: Com„bi„na„tion with other treat„ments Destination: head39 Item: Title: Spe„cial con„sid„er„a„tions Destination: head40 Item: Title: Mycophe„no„late mofetil Destination: head41_1158477 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head42 Item: Title: Dosage: acute flare, short term, long term Destination: head43 Item: Title: Safety Destination: head44 Item: Title: Mon„i„tor„ing Destination: head45 Item: Title: Com„bi„na„tion with other treat„ments Destination: head46 Item: Title: Spe„cial con„sid„er„a„tions Destination: head47 Item: Title: Bio„log„ics Destination: head48_325100 Children: Item: Title: Dupilumab Destination: head49_359752 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head50 Item: Title: Dosage: acute flare, short term, long term Destination: head51 Item: Title: Safety Destination: head52 Item: Title: Mon„i„tor„ing Destination: head53 Item: Title: Com„bi„na„tion with other treat„ments Destination: head54 Item: Title: Spe„cial con„sid„er„a„tions Destination: head55 Item: Title: Lebrik„izumab Destination: head56_492482 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head57 Item: Title: Dosage: Acute flare, short term, long term Destination: head58 Item: Title: Safety Destination: head59 Item: Title: Mon„i„tor„ing Destination: head60 Item: Title: Com„bi„na„tion with other treat„ments Destination: head61 Item: Title: Nemolizumab Destination: head62_399327 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head63 Item: Title: Dosage: acute flare, short term, long term Destination: head64 Item: Title: Safety Destination: head65 Item: Title: Mon„i„tor„ing Destination: head66 Item: Title: Com„bi„na„tion with other treat„ments Destination: head67 Item: Title: Omal„izumab Destination: head68_1369352 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head69 Item: Title: Dosage: acute flare, short term, long term Destination: head70 Children: Item: Title: Adult Destination: head71_937059 Item: Title: Chil„dren Destination: head72_2114227 Item: Title: Safety Destination: head73 Item: Title: Mon„i„tor„ing Destination: head74 Item: Title: Tralok„inumab Destination: head75_1580227 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head76 Item: Title: Dosage: acute flare, short term, long term Destination: head77 Item: Title: Safety Destination: head78 Item: Title: Mon„i„tor„ing Destination: head79 Item: Title: Com„bi„na„tion with other treat„ments Destination: head80 Item: Title: JAK-Inhibitors Destination: head81_777707 Children: Item: Title: Abroc„i„tinib Destination: head82_1494682 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head83 Item: Title: Dosage: acute flare, short term, long term Destination: head84 Item: Title: Safety Destination: head85 Item: Title: Mon„i„tor„ing Destination: head86 Item: Title: Com„bi„na„tion with other treat„ments Destination: head87 Item: Title: Spe„cial con„sid„er„a„tions Destination: head88 Item: Title: Baric„i„tinib Destination: head89_941602 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head90 Item: Title: Dosage: acute flare, short term, long term Destination: head91 Item: Title: Safety Destination: head92 Item: Title: Mon„i„tor„ing Destination: head93 Item: Title: Com„bi„na„tion with other treat„ments Destination: head94 Item: Title: Spe„cial con„sid„er„a„tions Destination: head95 Item: Title: Upadac„i„tinib Destination: head96_755532 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head97 Item: Title: Dosage: acute flare, short term, long term Destination: head98 Item: Title: Safety Destination: head99 Item: Title: Mon„i„tor„ing Destination: head100 Item: Title: Com„bi„na„tion with other treat„ments Destination: head101 Item: Title: Spe„cial con„sid„er„a„tions Destination: head102 Item: Title: Other sys„temic treat„ment Destination: head103_777707 Children: Item: Title: Alitretinoin Destination: head104_862057 Children: Item: Title: Mech„a„nisms of action and effi„cacy Destination: head105 Item: Title: Dosage: acute flare, short term, long term Destination: head106 Item: Title: Safety Destination: head107 Item: Title: Mon„i„tor„ing Destination: head108 Item: Title: Com„bi„na„tion with other treat„ments Destination: head109 Item: Title: Spe„cial con„sid„er„a„tions Destination: head110 Item: Title: Acknowl„edge„ment Destination: head111_1571732 Item: Title: Data avail„abil„ity state„ment Destination: head112_1698257 Item: Title: Ref„er„ences Destination: head113_1856957 Children: Item: Title: jdv18345-bib-0001 Destination: ljdv18345-bib-0001 Item: Title: jdv18345-bib-0002 Destination: ljdv18345-bib-0002 Item: Title: jdv18345-bib-0003 Destination: ljdv18345-bib-0003 Item: Title: jdv18345-bib-0004 Destination: ljdv18345-bib-0004 Item: Title: jdv18345-bib-0005 Destination: ljdv18345-bib-0005 Item: Title: jdv18345-bib-0006 Destination: ljdv18345-bib-0006 Item: Title: jdv18345-bib-0007 Destination: ljdv18345-bib-0007 Item: Title: jdv18345-bib-0008 Destination: ljdv18345-bib-0008 Item: Title: jdv18345-bib-0009 Destination: ljdv18345-bib-0009 Item: Title: jdv18345-bib-0010 Destination: ljdv18345-bib-0010 Item: Title: jdv18345-bib-0011 Destination: ljdv18345-bib-0011 Item: Title: jdv18345-bib-0012 Destination: ljdv18345-bib-0012 Item: Title: jdv18345-bib-0013 Destination: ljdv18345-bib-0013 Item: Title: jdv18345-bib-0014 Destination: ljdv18345-bib-0014 Item: Title: jdv18345-bib-0015 Destination: ljdv18345-bib-0015 Item: Title: jdv18345-bib-0016 Destination: ljdv18345-bib-0016 Item: Title: jdv18345-bib-0017 Destination: ljdv18345-bib-0017 Item: Title: jdv18345-bib-0018 Destination: ljdv18345-bib-0018 Item: Title: jdv18345-bib-0019 Destination: ljdv18345-bib-0019 Item: Title: jdv18345-bib-0020 Destination: ljdv18345-bib-0020 Item: Title: jdv18345-bib-0021 Destination: ljdv18345-bib-0021 Item: Title: jdv18345-bib-0022 Destination: ljdv18345-bib-0022 Item: Title: jdv18345-bib-0023 Destination: ljdv18345-bib-0023 Item: Title: jdv18345-bib-0024 Destination: ljdv18345-bib-0024 Item: Title: jdv18345-bib-0025 Destination: ljdv18345-bib-0025 Item: Title: jdv18345-bib-0026 Destination: ljdv18345-bib-0026 Item: Title: jdv18345-bib-0027 Destination: ljdv18345-bib-0027 Item: Title: jdv18345-bib-0028 Destination: ljdv18345-bib-0028 Item: Title: jdv18345-bib-0029 Destination: ljdv18345-bib-0029 Item: Title: jdv18345-bib-0030 Destination: ljdv18345-bib-0030 Item: Title: jdv18345-bib-0031 Destination: ljdv18345-bib-0031 Item: Title: jdv18345-bib-0032 Destination: ljdv18345-bib-0032 Item: Title: jdv18345-bib-0033 Destination: ljdv18345-bib-0033 Item: Title: jdv18345-bib-0034 Destination: ljdv18345-bib-0034 Item: Title: jdv18345-bib-0035 Destination: ljdv18345-bib-0035 Item: Title: jdv18345-bib-0036 Destination: ljdv18345-bib-0036 Item: Title: jdv18345-bib-0037 Destination: ljdv18345-bib-0037 Item: Title: jdv18345-bib-0038 Destination: ljdv18345-bib-0038 Item: Title: jdv18345-bib-0039 Destination: ljdv18345-bib-0039 Item: Title: jdv18345-bib-0040 Destination: ljdv18345-bib-0040 Item: Title: jdv18345-bib-0041 Destination: ljdv18345-bib-0041 Item: Title: jdv18345-bib-0042 Destination: ljdv18345-bib-0042 Item: Title: jdv18345-bib-0043 Destination: ljdv18345-bib-0043 Item: Title: jdv18345-bib-0044 Destination: ljdv18345-bib-0044 Item: Title: jdv18345-bib-0045 Destination: ljdv18345-bib-0045 Item: Title: jdv18345-bib-0046 Destination: ljdv18345-bib-0046 Item: Title: jdv18345-bib-0047 Destination: ljdv18345-bib-0047 Item: Title: jdv18345-bib-0048 Destination: ljdv18345-bib-0048 Item: Title: jdv18345-bib-0049 Destination: ljdv18345-bib-0049 Item: Title: jdv18345-bib-0050 Destination: ljdv18345-bib-0050 Item: Title: jdv18345-bib-0051 Destination: ljdv18345-bib-0051 Item: Title: jdv18345-bib-0052 Destination: ljdv18345-bib-0052 Item: Title: jdv18345-bib-0053 Destination: ljdv18345-bib-0053 Item: Title: jdv18345-bib-0054 Destination: ljdv18345-bib-0054 Item: Title: jdv18345-bib-0055 Destination: ljdv18345-bib-0055 Item: Title: jdv18345-bib-0056 Destination: ljdv18345-bib-0056 Item: Title: jdv18345-bib-0057 Destination: ljdv18345-bib-0057 Item: Title: jdv18345-bib-0058 Destination: ljdv18345-bib-0058 Item: Title: jdv18345-bib-0059 Destination: ljdv18345-bib-0059 Item: Title: jdv18345-bib-0060 Destination: ljdv18345-bib-0060 Item: Title: jdv18345-bib-0061 Destination: ljdv18345-bib-0061 Item: Title: jdv18345-bib-0062 Destination: ljdv18345-bib-0062 Item: Title: jdv18345-bib-0063 Destination: ljdv18345-bib-0063 Item: Title: jdv18345-bib-0064 Destination: ljdv18345-bib-0064 Item: Title: jdv18345-bib-0065 Destination: ljdv18345-bib-0065 Item: Title: jdv18345-bib-0066 Destination: ljdv18345-bib-0066 Item: Title: jdv18345-bib-0067 Destination: ljdv18345-bib-0067 Item: Title: jdv18345-bib-0068 Destination: ljdv18345-bib-0068 Item: Title: jdv18345-bib-0069 Destination: ljdv18345-bib-0069 Item: Title: jdv18345-bib-0070 Destination: ljdv18345-bib-0070 Item: Title: jdv18345-bib-0071 Destination: ljdv18345-bib-0071 Item: Title: jdv18345-bib-0072 Destination: ljdv18345-bib-0072 Item: Title: jdv18345-bib-0073 Destination: ljdv18345-bib-0073 Item: Title: jdv18345-bib-0074 Destination: ljdv18345-bib-0074 Item: Title: jdv18345-bib-0075 Destination: ljdv18345-bib-0075 Item: Title: jdv18345-bib-0076 Destination: ljdv18345-bib-0076 Item: Title: jdv18345-bib-0077 Destination: ljdv18345-bib-0077 Item: Title: jdv18345-bib-0078 Destination: ljdv18345-bib-0078 Item: Title: jdv18345-bib-0079 Destination: ljdv18345-bib-0079 Item: Title: jdv18345-bib-0080 Destination: ljdv18345-bib-0080 Item: Title: jdv18345-bib-0081 Destination: ljdv18345-bib-0081 Item: Title: jdv18345-bib-0082 Destination: ljdv18345-bib-0082 Item: Title: jdv18345-bib-0083 Destination: ljdv18345-bib-0083 Item: Title: jdv18345-bib-0084 Destination: ljdv18345-bib-0084 Item: Title: jdv18345-bib-0085 Destination: ljdv18345-bib-0085 Item: Title: jdv18345-bib-0086 Destination: ljdv18345-bib-0086 Item: Title: jdv18345-bib-0087 Destination: ljdv18345-bib-0087 Item: Title: jdv18345-bib-0088 Destination: ljdv18345-bib-0088 Item: Title: jdv18345-bib-0089 Destination: ljdv18345-bib-0089 Item: Title: jdv18345-bib-0090 Destination: ljdv18345-bib-0090 Item: Title: jdv18345-bib-0091 Destination: ljdv18345-bib-0091 Item: Title: jdv18345-bib-0092 Destination: ljdv18345-bib-0092 Item: Title: jdv18345-bib-0093 Destination: ljdv18345-bib-0093 Item: Title: jdv18345-bib-0094 Destination: ljdv18345-bib-0094 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: OHJNPH+Arial-ItalicMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: OHJNPH+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJNOH+Wingdings2 FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: OHJNOH+Wingdings2 Flags: Symbolic FontBBox: 0, -211, 1111, 843 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OHJEOK+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: OHJEOK+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJEFM+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: OHJEFM+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHKBBF+Helvetica-Bold FontSubset: true FirstChar: 69 LastChar: 114 FontDescriptor: FontName: OHKBBF+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIFPD+Calibri-Bold FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: OHIFPD+Calibri-Bold Flags: Symbolic FontBBox: -519, -306, 1263, 1039 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIFAH+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: OHIFAH+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIFFG+Helvetica FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OHIFFG+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIEJI+AdvOT7fe89a09+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: OHIEJI+AdvOT7fe89a09+20 Flags: Nonsymbolic FontBBox: -156, -145, 1072, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHKCIN+AdvMINION-B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: OHKCIN+AdvMINION-B Flags: Nonsymbolic FontBBox: -145, -239, 1145, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHKCNM+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: OHKCNM+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIJCD+AdvTTdf37bfe4+25 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIJCD+AdvTTdf37bfe4+25 Flags: Symbolic FontBBox: 0, -291, 1010, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHJFOF+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 48 FontDescriptor: FontName: OHJFOF+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIJKB+Helvetica-Oblique FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OHIJKB+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIGLP+AdvOTc4f305bd.I+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OHIGLP+AdvOTc4f305bd.I+fb Flags: Symbolic FontBBox: 19, 0, 520, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIINE+AdvPSMPi6 FontSubset: true FirstChar: 115 LastChar: 115 FontDescriptor: FontName: OHIINE+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBCM+AdvOTe8225e7f+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIBCM+AdvOTe8225e7f+fb Flags: Symbolic FontBBox: 0, 0, 375, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIBFB+AdvMINION-BI FontSubset: true FirstChar: 65 LastChar: 86 FontDescriptor: FontName: OHIBFB+AdvMINION-BI Flags: Nonsymbolic FontBBox: -187, -239, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHHPFB+AdvTT689d5d16.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: OHHPFB+AdvTT689d5d16.B+20 Flags: Nonsymbolic FontBBox: -208, -208, 1177, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJGPP+AdvPSMP13 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: OHJGPP+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHHPPP+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 128 FontDescriptor: FontName: OHHPPP+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHKFCP+AdvSPSASORT FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHKFCP+AdvSPSASORT Flags: Symbolic FontBBox: -281, -437, 1343, 989 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OHILGL+Wingdings3 FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: OHILGL+Wingdings3 Flags: Symbolic FontBBox: 0, -211, 1027, 928 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OHILGJ+Helvetica FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: OHILGJ+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHILGK+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OHILGK+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHILAJ+Calibri FontSubset: true FirstChar: 2 LastChar: 147 FontDescriptor: FontName: OHILAJ+Calibri Flags: Serif, Symbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHILFI+ArialMT FontSubset: true FirstChar: 129 LastChar: 149 FontDescriptor: FontName: OHILFI+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBDN+AdvOT340fc0d1 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: OHIBDN+AdvOT340fc0d1 Flags: Nonsymbolic FontBBox: -31, -229, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJKAN+AdvTir_symb FontSubset: true FirstChar: 57 LastChar: 57 FontDescriptor: FontName: OHJKAN+AdvTir_symb Flags: Nonsymbolic FontBBox: -166, -208, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBCL+AdvOTe8225e7f+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OHIBCL+AdvOTe8225e7f+20 Flags: Nonsymbolic FontBBox: -156, -145, 1041, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHICHA+AdvOTc4f305bd.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: OHICHA+AdvOTc4f305bd.I Flags: Nonsymbolic FontBBox: -125, -208, 979, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBJD+AdvTT3713a231+20 FontSubset: true FirstChar: 129 LastChar: 129 FontDescriptor: FontName: OHIBJD+AdvTT3713a231+20 Flags: Nonsymbolic FontBBox: -468, -208, 1708, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBPC+AdvOTd1f5cc91.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIBPC+AdvOTd1f5cc91.B+fb Flags: Symbolic FontBBox: 0, 0, 552, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIBIB+AdvOT340fc0d1+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OHIBIB+AdvOT340fc0d1+fb Flags: Symbolic FontBBox: 9, 0, 583, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHIBJC+AdvMINION-R FontSubset: true FirstChar: 25 LastChar: 146 FontDescriptor: FontName: OHIBJC+AdvMINION-R Flags: Serif, Nonsymbolic FontBBox: -135, -239, 1104, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OHIBEB+AdvMINION-I FontSubset: true FirstChar: 45 LastChar: 222 FontDescriptor: FontName: OHIBEB+AdvMINION-I Flags: Nonsymbolic FontBBox: -135, -239, 1104, 750 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: OHIBDP+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIBDP+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: OHIBEA+AdvOT928142ec.I FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: OHIBEA+AdvOT928142ec.I Flags: Nonsymbolic FontBBox: -135, -197, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHINJA+MyriadPro-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHINJA+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHHPEP+AdvOT7fe89a09 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: OHHPEP+AdvOT7fe89a09 Flags: Nonsymbolic FontBBox: -52, -208, 906, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHINEB+Helvetica FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OHINEB+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHHPFA+AdvOTd1f5cc91.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: OHHPFA+AdvOTd1f5cc91.B Flags: Nonsymbolic FontBBox: -52, -208, 937, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBBJ+AdvOTe8225e7f FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: OHIBBJ+AdvOTe8225e7f Flags: Nonsymbolic FontBBox: -62, -208, 895, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJANO+Helvetica FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OHJANO+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJAOP+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: OHJAOP+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIPDH+AdvTTec369687+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIPDH+AdvTTec369687+22 Flags: Symbolic FontBBox: -156, -208, 802, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHJAGA+Helvetica FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OHJAGA+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJBBP+Helvetica FontSubset: true FirstChar: 1 LastChar: 144 FontDescriptor: FontName: OHJBBP+Helvetica Flags: Symbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHICNO+AdvTT7b6c0d50.B FontSubset: true FirstChar: 68 LastChar: 121 FontDescriptor: FontName: OHICNO+AdvTT7b6c0d50.B Flags: Nonsymbolic FontBBox: -41, -250, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBCK+AdvTTec369687+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: OHIBCK+AdvTTec369687+20 Flags: Nonsymbolic FontBBox: -208, -208, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHIBDO+AdvOT7fe89a09+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHIBDO+AdvOT7fe89a09+fb Flags: Symbolic FontBBox: 9, 0, 447, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHICNP+AdvTT7b6c0d50.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OHICNP+AdvTT7b6c0d50.B+fb Flags: Symbolic FontBBox: 0, 0, 541, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHICPC+AdvTT82c4f4c4+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: OHICPC+AdvTT82c4f4c4+20 Flags: Nonsymbolic FontBBox: -156, -156, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHICOA+AdvTT82c4f4c4 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OHICOA+AdvTT82c4f4c4 Flags: Nonsymbolic FontBBox: -10, -250, 947, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHICPB+AdvTT82c4f4c4+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OHICPB+AdvTT82c4f4c4+fb Flags: Symbolic FontBBox: 0, 0, 427, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OHHPFC+AdvTTec369687 FontSubset: true FirstChar: 42 LastChar: 126 FontDescriptor: FontName: OHHPFC+AdvTTec369687 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1111/jdv.18345 10.1111/jdv.18345https://doi.org/10.1111/jdv.18345 2022-08-18trueonlinelibrary.wiley.com10.1111/jdv.18345 onlinelibrary.wiley.comtrue10.1111/jdv.183452022-08-18 VoR Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 126, 625, 128, 634 Annotation: Subtype: Link Rect: 126, 625, 128, 634 Annotation: Subtype: Link Rect: 128, 625, 135, 636 Annotation: Subtype: Link Rect: 405, 625, 407, 634 Annotation: Subtype: Link Rect: 405, 625, 407, 634 Annotation: Subtype: Link Rect: 407, 625, 414, 636 Annotation: Subtype: Link Rect: 278, 614, 280, 623 Annotation: Subtype: Link Rect: 278, 614, 280, 623 Annotation: Subtype: Link Rect: 280, 614, 287, 625 Annotation: Subtype: Link Rect: 103, 603, 105, 612 Annotation: Subtype: Link Rect: 103, 603, 105, 612 Annotation: Subtype: Link Rect: 105, 603, 111, 614 Annotation: Subtype: Link Rect: 117, 592, 119, 601 Annotation: Subtype: Link Rect: 117, 592, 119, 601 Annotation: Subtype: Link Rect: 119, 592, 126, 603 Annotation: Subtype: Link Rect: 194, 592, 196, 601 Annotation: Subtype: Link Rect: 194, 592, 196, 601 Annotation: Subtype: Link Rect: 196, 592, 203, 603 Annotation: Subtype: Link Rect: 302, 592, 304, 601 Annotation: Subtype: Link Rect: 302, 592, 304, 601 Annotation: Subtype: Link Rect: 304, 592, 311, 603 Annotation: Subtype: Link Rect: 287, 571, 289, 580 Annotation: Subtype: Link Rect: 287, 570, 289, 579 Annotation: Subtype: Link Rect: 289, 570, 296, 581 Annotation: Subtype: Link Rect: 194, 184, 299, 191 Annotation: Subtype: Link Rect: 367, 184, 440, 191 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 395, 575, 479, 583 Annotation: Subtype: Link Rect: 62, 563, 97, 571 Annotation: Subtype: Link Rect: 406, 563, 480, 571 Annotation: Subtype: Link Rect: 62, 551, 179, 559 Annotation: Subtype: Link Rect: 389, 192, 541, 201 Annotation: Subtype: Link Rect: 308, 180, 399, 189 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 204, 455, 207, 464 Destination: 418 Annotation: Subtype: Link Rect: 126, 392, 131, 401 Destination: 109 Annotation: Subtype: Link Rect: 151, 392, 155, 401 Destination: 109 Annotation: Subtype: Link Rect: 75, 368, 80, 377 Destination: 148 Annotation: Subtype: Link Rect: 460, 584, 464, 593 Destination: 148 Annotation: Subtype: Link Rect: 366, 564, 370, 573 Destination: 418 Annotation: Subtype: Link Rect: 468, 528, 471, 537 Destination: 418 Annotation: Subtype: Link Rect: 312, 444, 315, 453 Destination: 418 Annotation: Subtype: Link Rect: 529, 420, 532, 429 Destination: 435 Annotation: Subtype: Link Rect: 512, 372, 515, 381 Destination: 418 Annotation: Subtype: Link Rect: 410, 349, 413, 357 Destination: 435 Annotation: Subtype: Link Rect: 508, 309, 513, 318 Destination: 190 Annotation: Subtype: Link Rect: 419, 297, 423, 306 Destination: 204 Annotation: Subtype: Link Rect: 528, 297, 532, 306 Destination: 215 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 99, 311, 103, 320 Destination: 435 Annotation: Subtype: Link Rect: 92, 174, 95, 183 Destination: 435 Annotation: Subtype: Link Rect: 371, 387, 375, 396 Destination: 215 Annotation: Subtype: Link Rect: 490, 236, 501, 245 Destination: 435 Annotation: Subtype: Link Rect: 328, 176, 331, 185 Destination: 418 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 252, 398, 259, 407 Destination: 435 Annotation: Subtype: Link Rect: 75, 362, 78, 371 Destination: 418 Annotation: Subtype: Link Rect: 242, 314, 248, 323 Destination: 435 Annotation: Subtype: Link Rect: 255, 278, 265, 287 Destination: 435 Annotation: Subtype: Link Rect: 255, 278, 271, 287 Destination: 435 Annotation: Subtype: Link Rect: 110, 218, 117, 227 Destination: 435 Annotation: Subtype: Link Rect: 146, 171, 160, 180 Destination: 435 Annotation: Subtype: Link Rect: 197, 147, 212, 156 Destination: 435 Annotation: Subtype: Link Rect: 323, 254, 329, 263 Destination: 435 Annotation: Subtype: Link Rect: 320, 123, 327, 132 Destination: 435 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 142, 224, 148, 233 Destination: 435 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 245, 205, 251, 214 Destination: 435 Annotation: Subtype: Link Rect: 450, 205, 457, 214 Destination: 435 Annotation: Subtype: Link Rect: 318, 169, 325, 178 Destination: 435 Annotation: Subtype: Link Rect: 462, 121, 468, 130 Destination: 435 Page: Label: 8 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 72, 213, 86, 222 Destination: 435 Annotation: Subtype: Link Rect: 94, 177, 106, 186 Destination: 418 Annotation: Subtype: Link Rect: 117, 153, 132, 162 Destination: 435 Annotation: Subtype: Link Rect: 120, 117, 126, 126 Destination: 435 Annotation: Subtype: Link Rect: 86, 81, 93, 90 Destination: 435 Annotation: Subtype: Link Rect: 385, 140, 400, 149 Destination: 435 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 262, 553, 277, 562 Destination: 435 Annotation: Subtype: Link Rect: 77, 493, 83, 502 Destination: 435 Annotation: Subtype: Link Rect: 226, 481, 233, 490 Destination: 435 Annotation: Subtype: Link Rect: 148, 223, 154, 232 Destination: 435 Annotation: Subtype: Link Rect: 246, 152, 261, 161 Destination: 435 Annotation: Subtype: Link Rect: 443, 535, 450, 544 Destination: 435 Annotation: Subtype: Link Rect: 338, 271, 345, 280 Destination: 435 Annotation: Subtype: Link Rect: 481, 139, 496, 148 Destination: 435 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 122, 426, 128, 435 Destination: 435 Annotation: Subtype: Link Rect: 213, 366, 223, 375 Destination: 435 Annotation: Subtype: Link Rect: 213, 366, 229, 375 Destination: 435 Annotation: Subtype: Link Rect: 211, 354, 217, 363 Destination: 435 Annotation: Subtype: Link Rect: 216, 342, 223, 351 Destination: 435 Annotation: Subtype: Link Rect: 154, 295, 164, 304 Destination: 435 Annotation: Subtype: Link Rect: 154, 295, 170, 304 Destination: 435 Annotation: Subtype: Link Rect: 98, 247, 101, 256 Destination: 418 Annotation: Subtype: Link Rect: 173, 223, 183, 232 Destination: 435 Annotation: Subtype: Link Rect: 173, 223, 190, 232 Destination: 435 Annotation: Subtype: Link Rect: 280, 151, 287, 160 Destination: 435 Annotation: Subtype: Link Rect: 459, 306, 466, 314 Destination: 435 Annotation: Subtype: Link Rect: 380, 180, 394, 189 Destination: 435 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 249, 219, 256, 228 Destination: 435 Annotation: Subtype: Link Rect: 240, 207, 247, 216 Destination: 435 Annotation: Subtype: Link Rect: 453, 152, 459, 161 Destination: 435 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 66, 288, 72, 297 Destination: 440 Annotation: Subtype: Link Rect: 170, 228, 177, 237 Destination: 440 Annotation: Subtype: Link Rect: 456, 371, 463, 380 Destination: 440 Annotation: Subtype: Link Rect: 517, 311, 532, 320 Destination: 440 Annotation: Subtype: Link Rect: 467, 287, 473, 296 Destination: 440 Annotation: Subtype: Link Rect: 370, 192, 377, 201 Destination: 440 Annotation: Subtype: Link Rect: 441, 108, 448, 117 Destination: 440 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 109, 444, 116, 453 Destination: 440 Annotation: Subtype: Link Rect: 196, 408, 202, 417 Destination: 440 Annotation: Subtype: Link Rect: 188, 172, 195, 181 Destination: 440 Annotation: Subtype: Link Rect: 377, 518, 383, 527 Destination: 440 Annotation: Subtype: Link Rect: 514, 470, 529, 479 Destination: 440 Annotation: Subtype: Link Rect: 529, 466, 529, 475 Destination: 440 Annotation: Subtype: Link Rect: 518, 422, 524, 431 Destination: 440 Annotation: Subtype: Link Rect: 480, 207, 487, 216 Destination: 440 Annotation: Subtype: Link Rect: 326, 183, 332, 192 Destination: 440 Annotation: Subtype: Link Rect: 477, 88, 484, 97 Destination: 440 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 280, 649, 287, 658 Destination: 440 Annotation: Subtype: Link Rect: 92, 542, 98, 551 Destination: 440 Annotation: Subtype: Link Rect: 133, 506, 139, 515 Destination: 440 Annotation: Subtype: Link Rect: 193, 128, 199, 137 Destination: 440 Annotation: Subtype: Link Rect: 394, 661, 408, 670 Destination: 440 Annotation: Subtype: Link Rect: 474, 638, 481, 646 Destination: 440 Annotation: Subtype: Link Rect: 506, 626, 520, 635 Destination: 440 Annotation: Subtype: Link Rect: 517, 602, 532, 611 Destination: 440 Annotation: Subtype: Link Rect: 400, 566, 407, 575 Destination: 440 Annotation: Subtype: Link Rect: 423, 446, 429, 455 Destination: 440 Annotation: Subtype: Link Rect: 395, 187, 401, 196 Destination: 440 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 266, 649, 273, 658 Destination: 440 Annotation: Subtype: Link Rect: 273, 646, 273, 654 Destination: 440 Annotation: Subtype: Link Rect: 80, 518, 86, 527 Destination: 440 Annotation: Subtype: Link Rect: 218, 410, 224, 419 Destination: 440 Annotation: Subtype: Link Rect: 228, 108, 235, 117 Destination: 440 Annotation: Subtype: Link Rect: 481, 685, 487, 694 Destination: 440 Annotation: Subtype: Link Rect: 421, 119, 428, 128 Destination: 440 Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 123, 566, 130, 575 Destination: 440 Annotation: Subtype: Link Rect: 280, 518, 287, 527 Destination: 440 Annotation: Subtype: Link Rect: 157, 363, 172, 372 Destination: 440 Annotation: Subtype: Link Rect: 193, 100, 196, 109 Destination: 418 Annotation: Subtype: Link Rect: 196, 96, 196, 105 Destination: 418 Annotation: Subtype: Link Rect: 332, 685, 338, 694 Destination: 440 Annotation: Subtype: Link Rect: 338, 681, 338, 690 Destination: 440 Annotation: Subtype: Link Rect: 382, 602, 388, 611 Destination: 440 Annotation: Subtype: Link Rect: 388, 598, 388, 607 Destination: 440 Annotation: Subtype: Link Rect: 355, 398, 361, 407 Destination: 440 Annotation: Subtype: Link Rect: 342, 209, 348, 218 Destination: 440 Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 105, 190, 108, 199 Destination: 418 Annotation: Subtype: Link Rect: 108, 186, 108, 195 Destination: 418 Annotation: Subtype: Link Rect: 202, 166, 209, 175 Destination: 440 Annotation: Subtype: Link Rect: 209, 162, 209, 171 Destination: 440 Annotation: Subtype: Link Rect: 258, 130, 264, 139 Destination: 440 Annotation: Subtype: Link Rect: 98, 94, 104, 103 Destination: 440 Annotation: Subtype: Link Rect: 341, 566, 347, 575 Destination: 440 Annotation: Subtype: Link Rect: 416, 273, 422, 282 Destination: 440 Page: Label: 19 Annotations: Annotation: Subtype: Link Rect: 138, 638, 145, 647 Destination: 440 Annotation: Subtype: Link Rect: 72, 274, 78, 283 Destination: 440 Annotation: Subtype: Link Rect: 82, 190, 91, 199 Destination: 447 Annotation: Subtype: Link Rect: 82, 190, 98, 199 Destination: 447 Annotation: Subtype: Link Rect: 502, 575, 508, 584 Destination: 447 Annotation: Subtype: Link Rect: 396, 322, 403, 331 Destination: 440 Page: Label: 20 Annotations: Annotation: Subtype: Link Rect: 289, 638, 295, 647 Destination: 447 Annotation: Subtype: Link Rect: 295, 634, 295, 643 Destination: 447 Annotation: Subtype: Link Rect: 101, 566, 108, 575 Destination: 447 Annotation: Subtype: Link Rect: 146, 290, 152, 299 Destination: 447 Annotation: Subtype: Link Rect: 158, 218, 164, 227 Destination: 447 Annotation: Subtype: Link Rect: 402, 341, 408, 350 Destination: 447 Page: Label: 21 Page: Label: 22 Page: Label: 23 Checksum: 278f8560 Type: CRC32 Checksum: 04a0da917a1139cdcdf07e470cead414 Type: MD5 Checksum: 2fc20482cd1c4b4fbb1e9698e23a5657ee62a422 Type: SHA-1 Checksum: 7e843addc78ca97f49adf7df04e80b8fb64f537889a1f0b5a3fa98395b3f10c1 Type: SHA-256