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Keywords: Alzheimer’s disease, plasma proteomics, amyloid β, tau, neurodegeneration, machine learning, artificial neural networks Author: Yuting Zhang Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Nov 25 06:32:01 2022 CET ModDate: Tue Nov 29 02:52:48 2022 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 880164 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MKUFNP+MuseoSans-500 Type 1C Custom yes yes yes 1340 0 JDGNXV+MuseoSans-300 Type 1C Custom yes yes yes 1343 0 HAHBVZ+MuseoSans-700 Type 1C Custom yes yes yes 1346 0 FXDPTD+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 1348 0 DUEDRH+STIXGeneral-Regular Type 1C Custom yes yes yes 172 0 BRFRPL+STIXGeneral-Bold Type 1C 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PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Participants Item: Title: Statistical analysis Item: Title: Building NNs Item: Title: Discrimination of AT(N) Item: Title: Enrichment analysis Item: Title: Results Children: Item: Title: Demographic and clinical variables Item: Title: Discrimination of AT(N) markers using NNs Item: Title: Discrimination of A + T + N+ from A – T – N − using NNs Item: Title: Enriched terms Item: Title: Discussion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Conflict of interest Item: Title: Publisher’s note Item: Title: Supplementary material Item: Title: References Filters: FilterPipeline: 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Buckley Sebastiaan Engelborghs Kristel Sleegers Giovanni B. Frisoni Anders Wallin Alberto Lleó Julius Popp Pablo Martinez-Lage Cristina Legido-Quigley Frederik Barkhof Henrik Zetterberg Pieter Jelle Visser Lars Bertram Simon Lovestone Alejo J. Nevado-Holgado Liu Shi Background and objective: Blood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Alzheimer’s disease plasma proteomics amyloid β tau neurodegeneration machine learning artificial neural networks Alzheimer’s disease, plasma proteomics, amyloid β, tau, neurodegeneration, machine learning, artificial neural networks Adobe PDF Library 15.0 False 4281058394 PalatinoLTStd-Bold Adobe Systems 2.040 0 Palatino LT Std 4281058394 OpenType - PS 0 603650848 PalatinoLTStd-Italic Adobe Systems 2.040 0 Palatino LT Std 603650848 OpenType - PS 0 1660192022 PalatinoLTStd-Roman Adobe Systems 2.040 0 Palatino LT Std 1660192022 OpenType - PS 0 58239931 GothamNarrow-BoldItalic -- 2.201 0 Gotham Narrow 58239931 OpenType - PS 0 3415421137 GothamNarrow-Bold -- 2.201 0 Gotham Narrow 3415421137 OpenType - PS 0 449541274 GothamNarrow-Black -- 2.201 0 Gotham Narrow 449541274 OpenType - PS 0 3887558863 GothamNarrow-Book -- 2.201 0 Gotham Narrow 3887558863 OpenType - PS 0 13438472 GothamNarrow-Light -- 2.201 0 Gotham Narrow 13438472 OpenType - PS 0 Pages: Page: Sequence: 1 Annotations: 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