0c8dc6912ca1a799fc43fed6ad11d15a 292096.pdf d29a4683febc4b52a4821b2d15acea13c852ed36 292096.pdf 40e02a46d47bc4187b6de4b1df039df8d7678f51746945bdf9f78d234e45998f 292096.pdf Title: Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona Subject: Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d’Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7.3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life. Keywords: Zika virus; Zika virus infection; arboviruses; microcephaly; congenital infection; adverse outcome; travel-associated; children; neonate; mother-to-child transmission Author: Natàlia Romaní, Maria Pieras, Marie Antoinette Frick, Elena Sulleiro, Carlota Rodó, Aroa Silgado, Anna Suy, Maria Espiau, Claire Thorne, Carlo Giaquinto, Ana Felipe-Rucián, Pere Soler-Palacín and Antoni Soriano-Arandes Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Oct 25 10:27:32 2022 CEST ModDate: Wed Oct 26 07:10:51 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1038697 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OSZXWL+VnURWPalladioL Type 1 Custom yes yes no 10 0 BFVUYQ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VUPZYL+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 ZILVLP+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 HSNKGA+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 YJPPHJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 68 0 JLZORU+EURM10 Type 1 Builtin yes yes no 75 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 90 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 94 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 98 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 102 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 114 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 118 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 122 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 126 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 149 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-18 02:35:51 CEST RepresentationInformation: 292096.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-17 16:31:29 CEST Size: 1038697 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 282 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Population Destination: subsection.2.1 Children: Item: Title: Mother’s Cohort Destination: subsubsection.2.1.1 Item: Title: Children’s Cohort Destination: subsubsection.2.1.2 Item: Title: Cohort Follow-Up and Endpoints Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Characteristics of the Participants in the Cohort Destination: subsection.3.1 Item: Title: Adherence to Follow-Up Destination: subsection.3.2 Item: Title: Description of ZIKV Congenital Infection Destination: subsection.3.3 Children: Item: Title: ZIKV Congenital Infection Destination: subsubsection.3.3.1 Item: Title: Other Potential ZIKV-Related Outcomes (OPZROs) Destination: subsubsection.3.3.2 Item: Title: Neuroimaging Findings Not Attributed to ZIKV Exposure Destination: subsubsection.3.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona Author: Natàlia Romaní, Maria Pieras, Marie Antoinette Frick, Elena Sulleiro, Carlota Rodó, Aroa Silgado, Anna Suy, Maria Espiau, Claire Thorne, Carlo Giaquinto, Ana Felipe-Rucián, Pere Soler-Palacín and Antoni Soriano-Arandes Subject: Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d’Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7.3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life. 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