18fe0dadbb6f7a107ee126fc0e2354e3  292154.pdf
82c70169f0e7fe20e4a6421f3679572541538afb  292154.pdf
4e3598a6b9566ccbd6fe52e26ec1805db3bf1934dd6424d8029002f4f6d41aba  292154.pdf

Title:           Bone loss induced by cancer treatments in breast and prostate cancer patients
Subject:         Clinical and Translational Oncology, https://doi.org/10.1007/s12094-022-02872-1
Keywords:        Osteoporosis; Bone health; Cancer; Diagnosis; Bone turnover marker; Fragility fracture; Hormone therapy; Hormone deprivation therapy; Antiresorptive agents
Author:          Santos Castañeda 
Creator:         Springer
Producer:        Acrobat Distiller 10.1.8 (Windows)
CreationDate:    Fri Jul 29 04:27:05 2022 CEST
ModDate:         Thu Sep 22 21:36:54 2022 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           17
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1387183 bytes
Optimized:       yes
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    642  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    643  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    644  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes    645  0
VHNBLH+STIX-Regular                  Type 1C           Custom           yes yes yes    646  0
TDBGID+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    654  0
XSUVHC+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    677  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    683  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes    239  0
STIX-Italic                          Type 1C           Custom           yes no  yes    237  0
Springnew-Regular2                   Type 1C           WinAnsi          yes no  yes    255  0
HQQSPY+STIX-Bold                     Type 1C           WinAnsi          yes yes yes    523  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-23 02:43:01 CEST
 RepresentationInformation: 292154.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-05-22 15:36:33 CEST
  Size: 1387183
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 766
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Bone loss induced by cancer treatments in breast and prostate cancer patients
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Pathophysiology of osteoporosis in cancer patients
        Children: 
         Item: 
          Title: General risk factors for osteoporosis
         Item: 
          Title: Non-modifiable risk factors
         Item: 
          Title: Modifiable risk factors
       Item: 
        Title: Specific risk factors for osteoporosis
        Children: 
         Item: 
          Title: Breast cancer
         Item: 
          Title: Prostate cancer
         Item: 
          Title: Other tumors
       Item: 
        Title: Diagnosis and monitoring of osteoporosis in cancer patients
        Children: 
         Item: 
          Title: Role of bone biomarkers in treatment monitoring and evaluation
         Item: 
          Title: Diagnostic and monitoring tests: recommendations and frequency
         Item: 
          Title: Prevention and treatment of osteoporosis in cancer patients
         Item: 
          Title: Non-pharmacological measures
          Children: 
           Item: 
            Title: Dietary supplements: amino acids, calcium and vitamin D
         Item: 
          Title: Physical exercise
         Item: 
          Title: Fatty acids
         Item: 
          Title: Pharmacological measures
         Item: 
          Title: Bisphosphonates: breast cancer
         Item: 
          Title: Bisphosphonates: prostate cancer
         Item: 
          Title: Adverse events of bisphosphonates
         Item: 
          Title: Denosumab
         Item: 
          Title: Denosumab: breast cancer
         Item: 
          Title: Denosumab: prostate cancer
         Item: 
          Title: Other treatments
          Children: 
           Item: 
            Title: Bone-forming agents
         Item: 
          Title: Selective estrogen receptor modulators and calcitonin
         Item: 
          Title: Sequential treatment
         Item: 
          Title: Osteoporotic fractures in cancer patients: prevention and treatment
         Item: 
          Title: Surgical management
          Children: 
           Item: 
            Title: Implants and devices
         Item: 
          Title: Augmentation techniques
         Item: 
          Title: Rehabilitation
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Bone loss induced by cancer treatments in breast and prostate cancer patients
    Author: Santos Castañeda 
    Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-022-02872-1
    Keywords: Osteoporosis; Bone health; Cancer; Diagnosis; Bone turnover marker; Fragility fracture; Hormone therapy; Hormone deprivation therapy; Antiresorptive agents
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows)
    CreationDate: Fri Jul 29 04:57:05 CEST 2022
    ModDate: Thu Sep 22 22:06:54 CEST 2022
   ID: 0x186494f5cca2a84a86a74f1fc59c80d3, 0x1b049ee9646dac44bc5f024b061a4be2
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2032
      ImageHeight: 1731
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2032
      ImageHeight: 1380
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1772
      ImageHeight: 1189
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VHNBLH+STIX-Regular
      FontSubset: true
      FirstChar: 23
      LastChar: 252
      FontDescriptor: 
       FontName: VHNBLH+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HQQSPY+STIX-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HQQSPY+STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TDBGID+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: TDBGID+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <xmp:CreateDate>2022-07-29T07:57:05+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2022-09-23T01:06:54+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2022-09-23T01:06:54+05:30</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows)</pdf:Producer>
         <pdf:Keywords>Osteoporosis; Bone health; Cancer; Diagnosis; Bone turnover marker; Fragility fracture; Hormone therapy; Hormone deprivation therapy; Antiresorptive agents</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s12094-022-02872-1</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer International Publishing</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Clinical and Translational Oncology, https://doi.org/10.1007/s12094-022-02872-1</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Osteoporosis</rdf:li>
               <rdf:li>Bone health</rdf:li>
               <rdf:li>Cancer</rdf:li>
               <rdf:li>Diagnosis</rdf:li>
               <rdf:li>Bone turnover marker</rdf:li>
               <rdf:li>Fragility fracture</rdf:li>
               <rdf:li>Hormone therapy</rdf:li>
               <rdf:li>Hormone deprivation therapy</rdf:li>
               <rdf:li>Antiresorptive agents</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Bone loss induced by cancer treatments in breast and prostate cancer patients</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Santos Castañeda </rdf:li>
               <rdf:li>Ana Casas </rdf:li>
               <rdf:li>Aránzazu González-del-Alba </rdf:li>
               <rdf:li>Guillermo Martínez-Díaz-Guerra </rdf:li>
               <rdf:li>Xavier Nogués </rdf:li>
               <rdf:li>Cristina Ojeda Thies </rdf:li>
               <rdf:li>Óscar Torregrosa Suau </rdf:li>
               <rdf:li>Álvaro Rodríguez-Lescure </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s12094-022-02872-1</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s12094-022-02872-1</prism:url>
         <prism:doi>10.1007/s12094-022-02872-1</prism:doi>
         <prism:issn>1699-3055</prism:issn>
         <prism:volume>24</prism:volume>
         <prism:number>11</prism:number>
         <prism:startingPage>2090</prism:startingPage>
         <prism:endingPage>2106</prism:endingPage>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Clinical and Translational Oncology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s12094-022-02872-1</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>CVoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:43e0f558-e7ed-4b07-b789-6160933e926f</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:967e2873-f478-41cb-8666-9ad70ca8aa74</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:ce9b6219-c0b0-498c-bec4-a24453d6bd93</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-09-23T01:06:21+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:90ad5857-ac87-4e74-8c66-f5503053487d</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-09-23T01:06:54+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Álvaro Rodríguez-Lescure</author:name>
                  <author:orcid>http://orcid.org/0000-0002-6823-5290</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 2090
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 365, 622, 378, 609
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 304, 422, 289
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 449, 266, 454, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 459, 266, 464, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 309, 229, 314, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2091
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 83, 548, 88, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 430, 735, 435, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 441, 735, 446, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 335, 535, 340, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
     Thumb: true
    Page: 
     Label: 2092
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 281, 211, 286, 195
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 190, 173, 196, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 161, 161, 166, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 171, 161, 176, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 309, 236, 314, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 382, 174, 387, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 392, 174, 402, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 358, 86, 363, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
     Thumb: true
    Page: 
     Label: 2093
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 586, 146, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 151, 586, 156, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 161, 586, 171, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 176, 586, 186, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 196, 461, 206, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 211, 461, 221, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 73, 399, 83, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 259, 324, 269, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 275, 324, 285, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 72, 311, 77, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 227, 149, 238, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 243, 149, 253, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 258, 149, 268, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 181, 99, 192, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 439, 649, 444, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 453, 649, 463, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 468, 649, 478, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 512, 499, 522, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 528, 499, 538, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 309, 411, 319, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 459, 374, 469, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 475, 374, 485, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 490, 374, 500, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 390, 336, 400, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 406, 336, 416, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 368, 311, 378, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 383, 311, 393, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 468, 249, 478, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 483, 249, 493, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 415, 224, 425, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 430, 224, 440, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 473, 149, 484, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 497, 111, 507, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 359, 86, 364, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 373, 86, 384, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
     Thumb: true
    Page: 
     Label: 2094
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 246, 592, 256, 577
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 262, 592, 272, 577
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 206, 555, 216, 540
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 252, 323, 262, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 164, 248, 174, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 179, 248, 190, 233
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 309, 611, 319, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 528, 599, 538, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 395, 549, 405, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 455, 261, 460, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 387, 174, 392, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Label: 2095
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 178, 224, 189, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 194, 224, 204, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 177, 186, 187, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 245, 149, 255, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 259, 149, 269, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 389, 236, 399, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 404, 236, 414, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 309, 199, 319, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 369, 174, 379, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 322, 637, 442, 624
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 549, 521, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 254, 402, 267, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 521, 392, 530, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 223, 382, 227, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Label: 2096
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 216, 649, 226, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 184, 624, 194, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 199, 624, 209, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 194, 455, 204, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 204, 367, 214, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 219, 367, 230, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 131, 305, 141, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 128, 255, 139, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 144, 255, 154, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 159, 255, 169, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 128, 230, 138, 215
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 54, 192, 64, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 160, 98, 170, 83
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 331, 674, 337, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 498, 511, 508, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 494, 361, 505, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 528, 311, 538, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 442, 186, 452, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 531, 174, 541, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 306, 161, 316, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
     Thumb: true
    Page: 
     Label: 2097
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 636, 240, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 54, 574, 64, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 141, 524, 151, 509
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 207, 399, 217, 384
       Flags: Print
       AppearanceDictionary: true
       Destination: 212
      Annotation: 
       Subtype: Link
       Rect: 275, 299, 285, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 79, 286, 84, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 272, 224, 283, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 94, 174, 104, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 454, 661, 465, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 331, 515, 341, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 215
      Annotation: 
       Subtype: Link
       Rect: 346, 515, 356, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 411, 465, 421, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 357, 319, 367, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 466, 207, 476, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 510, 207, 515, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Label: 2098
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 661, 64, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 226, 624, 237, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 214, 411, 224, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 230, 411, 240, 396
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 272, 349, 283, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 231, 136, 241, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 246, 136, 256, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 95, 86, 105, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 457, 535, 467, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 374, 373, 384, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 493, 335, 503, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 508, 335, 518, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
     Thumb: true
    Page: 
     Label: 2099
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 449, 240, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 79, 336, 90, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 175, 199, 185, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 163, 161, 173, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 412, 699, 422, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 399, 561, 404, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 341, 424, 351, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 356, 424, 371, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 492, 386, 507, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 469, 361, 484, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 323, 336, 339, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 479, 249, 484, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 496, 236, 511, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 447, 211, 452, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 342, 149, 357, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
      Annotation: 
       Subtype: Link
       Rect: 481, 149, 496, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 226
     Thumb: true
    Page: 
     Label: 2100
     Sequence: 11
     Thumb: true
    Page: 
     Label: 2101
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 151, 311, 167, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 222, 299, 238, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 243, 299, 258, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 268, 261, 283, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 54, 199, 69, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 229
      Annotation: 
       Subtype: Link
       Rect: 158, 373, 162, 360
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 201, 373, 206, 360
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 122, 363, 126, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 238, 363, 243, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 282, 363, 286, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 534, 413, 539, 400
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 333, 403, 337, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 416, 403, 421, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 483, 393, 488, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
      Annotation: 
       Subtype: Link
       Rect: 425, 383, 430, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 204
     Thumb: true
    Page: 
     Label: 2102
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 627, 287, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 686, 542, 673
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2103
     Sequence: 14
     Thumb: true
    Page: 
     Label: 2104
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 228, 706, 289, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 696, 177, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 244, 676, 289, 663
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 666, 196, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 196, 193, 183
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2105
     Sequence: 16
     Thumb: true
    Page: 
     Label: 2106
     Sequence: 17
     Thumb: true
  Checksum: dd4da361
   Type: CRC32
  Checksum: 18fe0dadbb6f7a107ee126fc0e2354e3
   Type: MD5
  Checksum: 82c70169f0e7fe20e4a6421f3679572541538afb
   Type: SHA-1
  Checksum: 4e3598a6b9566ccbd6fe52e26ec1805db3bf1934dd6424d8029002f4f6d41aba
   Type: SHA-256