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modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Lynch Syndrome;Epidemiology;Prevention;Penetrance;Colorectal cancer;Segregation analysis;Prospective;Incidence;Over-diagnosis;Colonoscopy False application/pdf https://doi.org/10.1186/s13053-022-00241-1 BioMed Central Hereditary Cancer in Clinical Practice, https://doi.org/10.1186/s13053-022-00241-1 Lynch Syndrome Epidemiology Prevention Penetrance Colorectal cancer Segregation analysis Prospective Incidence Over-diagnosis Colonoscopy Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium Pål Møller Toni Seppälä James G. Dowty Saskia Haupt Mev Dominguez-Valentin Lone Sunde Inge Bernstein Christoph Engel Stefan Aretz Maartje Nielsen Gabriel Capella Dafydd Gareth Evans John Burn Elke Holinski-Feder Lucio Bertario Bernardo Bonanni Annika Lindblom Zohar Levi Finlay Macrae Ingrid Winship John-Paul Plazzer Rolf Sijmons Luigi Laghi Adriana Della Valle Karl Heinimann Elizabeth Half Francisco Lopez-Koestner Karin Alvarez-Valenzuela Rodney J. Scott Lior Katz Ido Laish Elez Vainer Carlos Alberto Vaccaro Dirce Maria Carraro Nathan Gluck Naim Abu-Freha Aine Stakelum Rory Kennelly Des Winter Benedito Mauro Rossi Marc Greenblatt Mabel Bohorquez Harsh Sheth Maria Grazia Tibiletti Leonardo S. Lino-Silva Karoline Horisberger Carmen Portenkirchner Ivana Nascimento Norma Teresa Rossi Leandro Apolinário da Silva Huw Thomas Attila Zaránd Jukka-Pekka Mecklin Kirsi Pylvänäinen Laura Renkonen-Sinisalo Anna Lepisto Päivi Peltomäki Christina Therkildsen Lars Joachim Lindberg Ole Thorlacius-Ussing Magnus von Knebel Doeberitz Markus Loeffler Nils Rahner Verena Steinke-Lange Wolff Schmiegel Deepak Vangala Claudia Perne Robert Hüneburg Aída Falcón de Vargas Andrew Latchford Anne-Marie Gerdes Ann-Sofie Backman Carmen Guillén-Ponce Carrie Snyder Charlotte K. Lautrup David Amor Edenir Palmero Elena Stoffel Floor Duijkers Michael J. Hall Heather Hampel Heinric Williams Henrik Okkels Jan Lubiński Jeanette Reece Joanne Ngeow Jose G. Guillem Julie Arnold Karin Wadt Kevin Monahan Leigha Senter Lene J. Rasmussen Liselotte P. van Hest Luigi Ricciardiello Maija R. J. Kohonen-Corish Marjolijn J. L. Ligtenberg Melissa Southey Melyssa Aronson Mohd N. Zahary N. Jewel Samadder Nicola Poplawski Nicoline Hoogerbrugge Patrick J. Morrison Paul James Grant Lee Rakefet Chen-Shtoyerman Ravindran Ankathil Rish Pai Robyn Ward Susan Parry Tadeusz Dębniak Thomas John Thomas van Overeem Hansen Trinidad Caldés Tatsuro Yamaguchi Verónica Barca-Tierno Pilar Garre Giulia Martina Cavestro Jürgen Weitz Silke Redler Reinhard Büttner Vincent Heuveline John L. Hopper Aung Ko Win Noralane Lindor Steven Gallinger Loïc Le Marchand Polly A. Newcomb Jane Figueiredo Daniel D. Buchanan Stephen N. Thibodeau Sanne W. ten Broeke Eivind Hovig Sigve Nakken Marta Pineda Nuria Dueñas Joan Brunet Kate Green Fiona Lalloo Katie Newton Emma J. Crosbie Miriam Mints Douglas Tjandra Florencia Neffa Patricia Esperon Revital Kariv Guy Rosner Walter Hernán Pavicic Pablo Kalfayan Giovana Tardin Torrezan Thiago Bassaneze Claudia Martin Gabriela Moslein Aysel Ahadova Matthias Kloor Julian R. Sampson Mark A. 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