ae3504bf45b2e9aa99a32915e279fff3 292233.pdf 26b07447ef85fe445f1a39d5ab4d052afaee6aa2 292233.pdf e3ee5950c41a4810b7dd444e2ac8b8bfb9b99215fd5a25745ac41bedf2b3d053 292233.pdf Title: Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery Subject: Surgery is the key treatment in retroperitoneal sarcoma (RPS), as completeness of resection is the most important prognostic factor related to treatment. Compartmental surgery/frontline extended approach is based on soft-tissue sarcoma surgical principles, and involves resecting adjacent viscera to achieve a wide negative margin. This extended approach is associated with improved local control and survival. This surgery must be tailored to tumor histology, tumor localization, and patient performance status. We herein present a review of compartmental surgery principles, covering the oncological and technical basis, and describing the tailored approach to each tumor subtype and localization in the retroperitoneum. Keywords: retroperitoneal sarcoma; liposarcoma; leiomyosarcoma; solitary fibrous tumor;compartmental surgery Author: Paula Munoz, Pedro Bretcha-Boix, Vicente Artigas and José Manuel Asencio Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Aug 24 11:11:56 2022 CEST ModDate: Wed Aug 24 11:17:48 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2171950 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KTITPW+VnURWPalladioL Type 1 Custom yes yes no 10 0 KDTVYD+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VSALJD+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 GBBFAP+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 LMIGKE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 81 0 LMIGKG+PalatinoLinotype TrueType WinAnsi yes yes no 84 0 LMIGKI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 87 0 LMIGKE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 97 0 LMIGKG+PalatinoLinotype TrueType WinAnsi yes yes no 100 0 LMIGKI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 103 0 PXTEMV+CMSY10 Type 1 Builtin yes yes no 111 0 LMIGKE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 118 0 LMIGKG+PalatinoLinotype TrueType WinAnsi yes yes no 121 0 LMIGKI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 124 0 LMILFP+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 134 0 LMIGKE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 137 0 LMIGKG+PalatinoLinotype TrueType WinAnsi yes yes no 140 0 LMIGKI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 143 0 TVGGGO+Dingbats Type 1 Builtin yes yes no 166 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-28 02:40:46 CEST RepresentationInformation: 292233.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-27 09:51:08 CEST Size: 2171950 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 428 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Frontline Extended Surgery: Background and Bases Destination: section.2 Item: Title: International Collaboration in RPS Care Destination: section.3 Item: Title: Standardized Surgical Technique of the Frontline Extended Approach Destination: section.4 Item: Title: Personalizing Surgery in Primary RPS Destination: section.5 Children: Item: Title: Histology Destination: subsection.5.1 Item: Title: Localization Destination: subsection.5.2 Item: Title: Patient Destination: subsection.5.3 Item: Title: Morbidity and Complications after Radical Resection of RPS Destination: section.6 Item: Title: Role of Systemic Treatment and Radiotherapy in RPS Destination: section.7 Children: Item: Title: Systemic Therapy Destination: subsection.7.1 Item: Title: Radiation Therapy Destination: subsection.7.2 Item: Title: Conclusions Destination: section.8 Item: Title: References Destination: section.8 Info: Title: Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery Author: Paula Munoz, Pedro Bretcha-Boix, Vicente Artigas and José Manuel Asencio Subject: Surgery is the key treatment in retroperitoneal sarcoma (RPS), as completeness of resection is the most important prognostic factor related to treatment. Compartmental surgery/frontline extended approach is based on soft-tissue sarcoma surgical principles, and involves resecting adjacent viscera to achieve a wide negative margin. This extended approach is associated with improved local control and survival. This surgery must be tailored to tumor histology, tumor localization, and patient performance status. We herein present a review of compartmental surgery principles, covering the oncological and technical basis, and describing the tailored approach to each tumor subtype and localization in the retroperitoneum. 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