7a186ba4b42c884cbc7f0846d56c14ea 292655.pdf 15119a6f31c70f74902539a2e785c2281c21013e 292655.pdf 62b2f4890abcd1e8b3e641185ed3fc84fad0c99210a96d3e7114f3e500456741 292655.pdf Title: Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID‐19 Requiring invasive ventilation Meta‐Trial (CHARTER‐MT): Protocol and statistical analysis plan for an investigator‐initiated international meta‐trial of prospective randomised clinical studies Subject: Keywords: 10.1111/bcp.15253 and ARDS; COVID‐19; meta‐trial; nebulised heparin; pandemic; randomised study; RCT; respiratory failure; SARS; SARS‐CoV‐2; unfractionated heparin Author: Frank M. P. Haren, John G. Laffey, Antonio Artigas, Clive Page, Marcus J. Schultz, David Cosgrave, Bairbre McNicholas, Thomas L. Smoot, Quentin Nunes, Alice Richardson, Hwan‐Jin Yoon, Lex M. Loon, Angajendra Ghosh, Simone Said, Rakshit Panwar, Roger Smith, John D. Santamaria, Barry Dixon, Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 22.0 (Windows) CreationDate: Mon Jun 6 18:30:05 2022 CEST ModDate: Thu Jun 9 05:44:15 2022 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 8969542 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNKHBN+AdvTT6071803a.B Type 1C WinAnsi yes yes no 611 0 NNKHLK+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 554 0 NNKHLL+AdvP4C4E59 Type 1C Custom yes yes no 556 0 NNLAPD+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 572 0 NNLAPE+AdvTTa9c1b374+20 Type 1C WinAnsi yes yes no 595 0 NNLBDE+AdvTT0459e7ca.B Type 1C WinAnsi yes yes no 6 0 NNLJMA+AdvOT8608a8d1+20 Type 1C WinAnsi yes yes no 232 0 NNMDAI+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 225 0 NNMDAJ+AdvP4C4E74 Type 1C Custom yes yes no 53 0 NNOIBH+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 87 0 NOCNOL+AdvTTa9c1b374+01 Type 1C WinAnsi yes yes no 180 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-29 02:40:39 CEST RepresentationInformation: 292655.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-28 16:40:56 CEST Size: 8969542 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 613 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID-19 Requiring invasive ventilation Meta... Destination: atl_BCP_15253_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingBCP_15253bcp15253-sec-5005 Item: Title: What is already known about this subject Destination: HeadingBCP_15253bcp15253-sec-0005 Item: Title: What this study adds Destination: HeadingBCP_15253bcp15253-sec-0004 Item: Title: 2 OBJECTIVES Destination: HeadingBCP_15253bcp15253-sec-0006 Item: Title: 3 STUDY CONCEPT AND DESIGN Destination: HeadingBCP_15253bcp15253-sec-0007 Item: Title: 4 PATIENT AND PUBLIC INVOLVEMENT Destination: HeadingBCP_15253bcp15253-sec-0008 Item: Title: 5 STUDY SETTING Destination: HeadingBCP_15253bcp15253-sec-0009 Item: Title: 6 STUDY ELIGIBILITY CRITERIA Destination: HeadingBCP_15253bcp15253-sec-0010 Item: Title: 7 RECRUITMENT Destination: HeadingBCP_15253bcp15253-sec-0011 Item: Title: 8 INTERVENTIONS Destination: HeadingBCP_15253bcp15253-sec-0012 Item: Title: 9 RELEVANT CONCOMITANT CARE PERMITTED OR PROHIBITED IN CONTRIBUTING STUDIES Destination: HeadingBCP_15253bcp15253-sec-0013 Item: Title: 10 PROVISIONS FOR POST-TRIAL CARE Destination: HeadingBCP_15253bcp15253-sec-0014 Item: Title: 11 OUTCOMES Destination: HeadingBCP_15253bcp15253-sec-0015 Children: Item: Title: 11.1 Primary outcome Destination: HeadingBCP_15253bcp15253-sec-0016 Item: Title: 11.2 Secondary outcomes Destination: HeadingBCP_15253bcp15253-sec-0017 Item: Title: 11.3 Safety outcomes Destination: HeadingBCP_15253bcp15253-sec-0018 Item: Title: 11.4 Process of care assessments Destination: HeadingBCP_15253bcp15253-sec-0019 Item: Title: 11.5 Other outcomes Destination: HeadingBCP_15253bcp15253-sec-0020 Item: Title: 12 DATA COLLECTION Destination: HeadingBCP_15253bcp15253-sec-0021 Item: Title: 13 DATA SAFETY MONITORING BOARD Destination: HeadingBCP_15253bcp15253-sec-0022 Item: Title: 14 DATA MANAGEMENT AND STATISTICAL ANALYSIS PLAN Destination: HeadingBCP_15253bcp15253-sec-0023 Children: Item: Title: 14.1 Randomisation and allocation concealment Destination: HeadingBCP_15253bcp15253-sec-0024 Item: Title: 14.2 Quality assurance monitoring Destination: HeadingBCP_15253bcp15253-sec-0025 Item: Title: 14.3 Sample size Destination: HeadingBCP_15253bcp15253-sec-0026 Item: Title: 14.4 Statistical analysis Destination: HeadingBCP_15253bcp15253-sec-0027 Children: Item: Title: 14.4.1 Principles Destination: HeadingBCP_15253bcp15253-sec-0028 Item: Title: 14.4.2 Monitoring and interim analyses Destination: HeadingBCP_15253bcp15253-sec-0029 Item: Title: 14.4.3 Trial profile Destination: HeadingBCP_15253bcp15253-sec-0030 Item: Title: 14.4.4 Participant characteristics and baseline comparisons Destination: HeadingBCP_15253bcp15253-sec-0031 Item: Title: 14.4.5 Analyses Destination: HeadingBCP_15253bcp15253-sec-0032 Children: Item: Title: Primary outcome Destination: HeadingBCP_15253bcp15253-sec-0033 Item: Title: Secondary outcomes Destination: HeadingBCP_15253bcp15253-sec-0034 Item: Title: 14.4.6 Subgroup analyses Destination: HeadingBCP_15253bcp15253-sec-0035 Item: Title: 14.4.7 Safety outcomes and adverse events Destination: HeadingBCP_15253bcp15253-sec-0036 Item: Title: 14.4.8 Future analyses Destination: HeadingBCP_15253bcp15253-sec-0037 Item: Title: 15 ETHICS AND DISSEMINATION Destination: HeadingBCP_15253bcp15253-sec-0038 Item: Title: 16 STUDY STATUS Destination: HeadingBCP_15253bcp15253-sec-0039 Item: Title: 17 CONCLUSION Destination: HeadingBCP_15253bcp15253-sec-0040 Children: Item: Title: 17.1 Nomenclature of targets and ligands Destination: HeadingBCP_15253bcp15253-sec-0041 Item: Title: ACKNOWLEDGEMENT Destination: HeadingBCP_15253bcp15253-sec-0045 Item: Title: COMPETING INTERESTS Destination: HeadingBCP_15253bcp15253-sec-0049 Item: Title: SPONSOR META-TRIAL Destination: HeadingBCP_15253bcp15253-sec-0043 Item: Title: ROLE SPONSOR Destination: HeadingBCP_15253bcp15253-sec-0044 Item: Title: ETHICS AND DISSEMINATION Destination: HeadingBCP_15253bcp15253-sec-0046 Item: Title: CONTRIBUTORS Destination: HeadingBCP_15253bcp15253-sec-0050 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: HeadingBCP_15253bcp15253-sec-0048 Item: Title: REFERENCES Destination: HeadingBCP_15253bcp15253-bibl-00011 Children: Item: Title: Reporting checklist for protocol of a clinical trial, based on the SPIRIT guidelines Destination: HeadingBCP_15253bcp15253-sec-0051 Item: Title: Instructions to authors Destination: HeadingBCP_15253bcp15253-sec-9051 Info: Title: Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID‐19 Requiring invasive ventilation Meta‐Trial (CHARTER‐MT): Protocol and statistical analysis plan for an investigator‐initiated international meta‐trial of prospective randomised clinical studies Author: Frank M. P. Haren, John G. Laffey, Antonio Artigas, Clive Page, Marcus J. Schultz, David Cosgrave, Bairbre McNicholas, Thomas L. Smoot, Quentin Nunes, Alice Richardson, Hwan‐Jin Yoon, Lex M. Loon, Angajendra Ghosh, Simone Said, Rakshit Panwar, Roger Smith, John D. Santamaria, Barry Dixon, Subject: Keywords: 10.1111/bcp.15253 and ARDS; COVID‐19; meta‐trial; nebulised heparin; pandemic; randomised study; RCT; respiratory failure; SARS; SARS‐CoV‐2; unfractionated heparin Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 22.0 (Windows) CreationDate: Mon Jun 06 18:30:05 CEST 2022 ModDate: Thu Jun 09 05:44:15 CEST 2022 ID: 0x5402e6fce83d25b25a68dc518ef9e89e, 0x5d2d9391843dfb002da34e8c2dae3778 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png 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integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 239 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1040 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1043 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 239 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1040 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1043 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 239 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1040 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1043 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 140 ImageHeight: 239 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1040 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 257 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 139 ImageHeight: 1043 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 913 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1447 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 999 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 187 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 147 ImageHeight: 869 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 283 ImageHeight: 134 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 247 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 900 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1169 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1014 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 862 ImageHeight: 436 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 725 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 1132 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 432 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 433 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 146 ImageHeight: 817 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 150 ImageHeight: 123 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 581 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 289 ImageHeight: 580 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 290 ImageHeight: 292 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 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