7ce9379239340221f009eccef91111c9 292665.pdf cccb88cca17af80a0eb2565b9cc582628f8e1498 292665.pdf 2db4d95111b22deafadb2a49050a35e72857d5c27781710222162341e3af0c3d 292665.pdf Title: Patisiran treatment in patients with hereditary transthyretin‐mediated amyloidosis with polyneuropathy after liver transplantation Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sun May 8 04:27:36 2022 CEST ModDate: Sun May 8 04:27:43 2022 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 901523 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ERAAVK+Lato-Bold CID TrueType Identity-H yes yes yes 341 0 VWLTZC+Lato-Regular CID TrueType Identity-H yes yes yes 342 0 LUNQPW+Lato-Bold TrueType WinAnsi yes yes yes 343 0 ESTLVK+Lato-Regular TrueType WinAnsi yes yes yes 344 0 TEEXXG+Lato-Italic TrueType WinAnsi yes yes yes 345 0 TQFTXG+AvantGarde-Book Type 1C WinAnsi yes yes no 318 0 TQFTXG+AvantGarde-Book Type 1C WinAnsi yes yes no 222 0 FMERJI+STIX-Regular Type 1C WinAnsi yes yes yes 220 0 EMOXVK+Lato-Regular-SC700 TrueType WinAnsi yes yes yes 216 0 CWSJEO+ArialMT Type 1C WinAnsi yes yes no 57 0 CWSJEO+ArialMT Type 1C WinAnsi yes yes no 58 0 BXDDQQ+Arial-BoldMT Type 1C WinAnsi yes yes no 56 0 EMOXVK+Lato-Regular-SC700 TrueType WinAnsi yes yes yes 230 0 XRFAMY+STIX-Bold Type 1C WinAnsi yes yes yes 236 0 BXDDQQ+Lato-BoldItalic TrueType WinAnsi yes yes yes 232 0 CWSJEO+ArialMT Type 1C WinAnsi yes yes no 139 0 BXDDQQ+Arial-BoldMT Type 1C WinAnsi yes yes no 137 0 WRGUTA+Arial-ItalicMT Type 1C WinAnsi yes yes no 138 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-01 02:36:16 CEST RepresentationInformation: 292665.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-31 15:49:36 CEST Size: 901523 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 373 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Language: en-US Outlines: Item: Title: Patisiran treatment in patients with hereditary transthyretin-­mediated amyloidosis with polyneuropathy after liver transplantation Children: Item: Title: 1|INTRODUCTION Item: Title: 2|METHODS Children: Item: Title: 2.1|Study oversight Item: Title: 2.2|Patients Item: Title: 2.3|Study design Item: Title: 2.4|Study endpoints and assessments Item: Title: 2.5|Statistical analysis Item: Title: 3|RESULTS Children: Item: Title: 3.1|Patient population and disposition Item: Title: 3.2|Serum TTR reduction (primary endpoint) Item: Title: 3.3|Secondary and exploratory efficacy endpoints Item: Title: 3.4|Safety Item: Title: 4|DISCUSSION Item: Title: ACKNOWLEDGMENTS Item: Title: DISCLOSURE Children: Item: Title: DATA AVAILABILITY STATEMENT Item: Title: REFERENCES Info: Title: Patisiran treatment in patients with hereditary transthyretin‐mediated amyloidosis with polyneuropathy after liver transplantation Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sun May 08 04:57:36 CEST 2022 ModDate: Sun May 08 04:57:43 CEST 2022 ID: 0x838620344f10b24cb2e7330ed8fd2e5e, 0xde37e2c1cc6a8b941a4ffe0b07c2b197 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2397 ImageHeight: 378 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2089 ImageHeight: 1997 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: ERAAVK+Lato-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: VWLTZC+Lato-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BXDDQQ+Arial-BoldMT FontSubset: true FirstChar: 78 LastChar: 118 FontDescriptor: FontName: BXDDQQ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CWSJEO+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: CWSJEO+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BXDDQQ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: BXDDQQ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CWSJEO+ArialMT FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: CWSJEO+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WRGUTA+Arial-ItalicMT FontSubset: true FirstChar: 32 LastChar: 110 FontDescriptor: FontName: WRGUTA+Arial-ItalicMT Flags: Nonsymbolic FontBBox: -517, -325, 1359, 998 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CWSJEO+ArialMT FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: CWSJEO+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FMERJI+STIX-Regular FontSubset: true FirstChar: 43 LastChar: 215 FontDescriptor: FontName: FMERJI+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XRFAMY+STIX-Bold FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: XRFAMY+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TQFTXG+AvantGarde-Book FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: TQFTXG+AvantGarde-Book Flags: Nonsymbolic FontBBox: -113, -222, 1148, 955 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: LUNQPW+Lato-Bold FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: LUNQPW+Lato-Bold Flags: Nonsymbolic FontBBox: -603, -285, 1344, 1100 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: ESTLVK+Lato-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: ESTLVK+Lato-Regular Flags: Nonsymbolic FontBBox: -546, -268, 1342, 1079 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BXDDQQ+Lato-BoldItalic FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: BXDDQQ+Lato-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -520, -283, 1293, 1098 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TEEXXG+Lato-Italic FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: TEEXXG+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -501, -268, 1290, 1077 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: ERAAVK+Lato-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ERAAVK+Lato-Bold Flags: Symbolic FontBBox: -603, -285, 1344, 1100 FontFile2: true Font: BaseFont: VWLTZC+Lato-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VWLTZC+Lato-Regular Flags: Symbolic FontBBox: -546, -268, 1342, 1079 FontFile2: true XMP: 2022-06-04T19:58:24+05:30 2022-06-04T19:58:24+05:30 2022-06-04T19:58:24+05:30 Acrobat Distiller 10.1.7 (Windows) 10.1111/ajt.17009 10.1111/(ISSN)1600-6143 3 VoR 10.1111/ajt.17009 application/pdf Patisiran treatment in patients with hereditary transthyretin‐mediated amyloidosis with polyneuropathy after liver transplantation uuid:18df532f-6a3d-4874-8ebc-5685c6a4cbb3 uuid:172df8a8-1432-4cb3-ac98-0728da6e55f7 Pages: Page: Label: 1646 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 76, 34, 133, 25 Annotation: Subtype: Link Rect: 152, 585, 152, 569 Annotation: Subtype: Link Rect: 152, 585, 157, 569 ActionDest: 292 Annotation: Subtype: Link Rect: 157, 583, 170, 570 Annotation: Subtype: Link Rect: 261, 585, 266, 569 ActionDest: 292 Annotation: Subtype: Link Rect: 436, 585, 448, 569 ActionDest: 292 Annotation: Subtype: Link Rect: 183, 567, 188, 551 ActionDest: 292 Annotation: Subtype: Link Rect: 271, 567, 283, 551 ActionDest: 292 Annotation: Subtype: Link Rect: 283, 565, 295, 552 Annotation: Subtype: Link Rect: 408, 567, 413, 551 ActionDest: 292 Annotation: Subtype: Link Rect: 506, 567, 510, 551 ActionDest: 292 Annotation: Subtype: Link Rect: 510, 565, 523, 552 Annotation: Subtype: Link Rect: 94, 549, 104, 533 ActionDest: 292 Annotation: Subtype: Link Rect: 181, 549, 191, 533 ActionDest: 292 Annotation: Subtype: Link Rect: 282, 549, 291, 533 ActionDest: 292 Annotation: Subtype: Link Rect: 382, 549, 403, 533 ActionDest: 292 Annotation: Subtype: Link Rect: 211, 84, 362, 75 Annotation: Subtype: Link Rect: 66, 255, 113, 246 Page: Label: 1647 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 261, 354, 271, 344 ActionDest: 166 Annotation: Subtype: Link Rect: 191, 315, 204, 305 ActionDest: 166 Annotation: Subtype: Link Rect: 153, 263, 169, 253 ActionDest: 166 Annotation: Subtype: Link Rect: 74, 211, 79, 201 ActionDest: 42 Annotation: Subtype: Link Rect: 83, 211, 97, 201 ActionDest: 189 Annotation: Subtype: Link Rect: 175, 198, 181, 188 ActionDest: 189 Annotation: Subtype: Link Rect: 86, 120, 110, 110 ActionDest: 189 Annotation: Subtype: Link Rect: 167, 94, 174, 84 ActionDest: 189 Annotation: Subtype: Link Rect: 148, 68, 163, 58 ActionDest: 189 Annotation: Subtype: Link Rect: 202, 55, 217, 45 ActionDest: 189 Annotation: Subtype: Link Rect: 386, 445, 393, 435 ActionDest: 189 Annotation: Subtype: Link Rect: 463, 406, 488, 396 ActionDest: 189 Annotation: Subtype: Link Rect: 431, 354, 438, 344 ActionDest: 189 Annotation: Subtype: Link Rect: 512, 263, 519, 253 ActionDest: 189 Annotation: Subtype: Link Rect: 518, 198, 522, 188 ActionDest: 42 Annotation: Subtype: Link Rect: 370, 120, 373, 108 ActionDest: 166 Annotation: Subtype: Link Rect: 502, 581, 542, 569 Annotation: Subtype: Link Rect: 203, 566, 250, 554 Page: Label: 1648 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 222, 328, 288, 318 Annotation: Subtype: Link Rect: 45, 315, 58, 305 Annotation: Subtype: Link Rect: 74, 107, 80, 97 ActionDest: 189 Page: Label: 1649 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 62, 614, 69, 604 ActionDest: 189 Annotation: Subtype: Link Rect: 232, 497, 238, 487 ActionDest: 189 Annotation: Subtype: Link Rect: 117, 432, 123, 422 ActionDest: 189 Annotation: Subtype: Link Rect: 281, 393, 288, 383 ActionDest: 189 Annotation: Subtype: Link Rect: 156, 328, 163, 318 ActionDest: 189 Annotation: Subtype: Link Rect: 376, 523, 382, 513 ActionDest: 189 Annotation: Subtype: Link Rect: 543, 107, 547, 97 ActionDest: 78 Page: Label: 1650 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 126, 627, 131, 617 ActionDest: 78 Annotation: Subtype: Link Rect: 215, 601, 219, 591 ActionDest: 78 Annotation: Subtype: Link Rect: 159, 562, 164, 552 ActionDest: 114 Annotation: Subtype: Link Rect: 279, 497, 284, 487 ActionDest: 78 Annotation: Subtype: Link Rect: 84, 406, 89, 396 ActionDest: 114 Annotation: Subtype: Link Rect: 279, 237, 284, 227 ActionDest: 140 Annotation: Subtype: Link Rect: 279, 185, 284, 173 ActionDest: 140 Annotation: Subtype: Link Rect: 367, 415, 369, 405 ActionDest: 101 Annotation: Subtype: Link Rect: 403, 401, 405, 391 ActionDest: 101 Page: Label: 1651 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 70, 172, 75, 162 ActionDest: 151 Annotation: Subtype: Link Rect: 178, 120, 183, 110 ActionDest: 151 Annotation: Subtype: Link Rect: 488, 94, 499, 84 ActionDest: 166 Annotation: Subtype: Link Rect: 407, 68, 422, 58 ActionDest: 189 Page: Label: 1652 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 138, 276, 167, 266 ActionDest: 166 Annotation: Subtype: Link Rect: 95, 172, 115, 162 ActionDest: 166 Annotation: Subtype: Link Rect: 334, 276, 346, 266 ActionDest: 166 Annotation: Subtype: Link Rect: 459, 237, 466, 227 ActionDest: 189 Annotation: Subtype: Link Rect: 439, 198, 442, 188 ActionDest: 166 Annotation: Subtype: Link Rect: 88, 714, 91, 703 ActionDest: 114 Annotation: Subtype: Link Rect: 243, 732, 246, 722 ActionDest: 114 Page: Label: 1653 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 75, 107, 105, 97 ActionDest: 189 Annotation: Subtype: Link Rect: 116, 81, 123, 71 ActionDest: 189 Page: Label: 1654 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 55, 406, 66, 396 ActionDest: 166 Annotation: Subtype: Link Rect: 87, 159, 93, 149 ActionDest: 189 Annotation: Subtype: Link Rect: 237, 120, 251, 110 ActionDest: 189 Annotation: Subtype: Link Rect: 247, 68, 254, 58 ActionDest: 189 Annotation: Subtype: Link Rect: 350, 718, 365, 708 ActionDest: 189 Page: Label: 1655 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 375, 447, 388, 435 Annotation: Subtype: Link Rect: 388, 445, 535, 435 Annotation: Subtype: Link Rect: 346, 434, 359, 422 Annotation: Subtype: Link Rect: 359, 432, 506, 422 Annotation: Subtype: Link Rect: 352, 421, 365, 409 Annotation: Subtype: Link Rect: 365, 419, 512, 409 Page: Label: 1656 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 63, 538, 150, 528 Annotation: Subtype: Link Rect: 324, 150, 489, 140 Annotation: Subtype: Link Rect: 324, 108, 549, 98 Annotation: Subtype: Link Rect: 324, 97, 462, 87 Page: Label: 1657 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 242, 727, 288, 717 Annotation: Subtype: Link Rect: 63, 717, 211, 707 Annotation: Subtype: Link Rect: 331, 661, 395, 650 Checksum: 19da61bd Type: CRC32 Checksum: 7ce9379239340221f009eccef91111c9 Type: MD5 Checksum: cccb88cca17af80a0eb2565b9cc582628f8e1498 Type: SHA-1 Checksum: 2db4d95111b22deafadb2a49050a35e72857d5c27781710222162341e3af0c3d Type: SHA-256