60193c3ad2b3834651deadf3e74ba95e fimmu_13_928039.pdf 3ea409b0d4fef88106543fe9aa55d8402cdd5666 fimmu_13_928039.pdf b5a11af6cd74c1669d72549612166b212f727f0d919d997189111646a344855f fimmu_13_928039.pdf Title: T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG Subject: T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear Keywords: HIV, humoral immune response, human immunodeficiency virus (HIV) control, T-follicular cytotoxic (Tfc) cells, viral control Author: Luis Romero-Martín; Ferran Tarrés-Freixas; Núria Pedreño-López; Maria L. Rodríguez de la Concepción; Francesc Cunyat; Dennis Hartigan-O'Connor; Jorge Carrillo; Beatriz Mothe; Julià Blanco; Marta Ruiz-Riol; Christian Brander; Alex Olvera Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Jun 14 11:28:50 2022 CEST ModDate: Tue Jun 14 11:29:03 2022 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 14203865 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GOGLDP+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 765 0 GOGLFA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 750 0 GOGLGA+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 751 0 GOGLGB+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 767 0 GOGLCF+AdvOT34fe1490.B Type 1C WinAnsi yes 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T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG Destination: bmark_-1523999585 Children: Item: Title: Introduction Destination: s1 Item: Title: Material and Methods Destination: s2 Children: Item: Title: Study Design Destination: s2_1 Item: Title: Boosted Flow Screening of HIV-Specific T-Cell Responses Destination: s2_2 Item: Title: Phenotypic Characterization of CD4+ Th2- and Tfh Cells and CD8+ Tc2- and Tfc- Cells Destination: s2_3 Item: Title: IL-4, IL-21, and IFN-γ ELISpot Destination: s2_4 Item: Title: Determination of Anti-Env IgM, IgA and IgG Humoral Response Destination: s2_5 Item: Title: IgG Avidity ELISA Destination: s2_6 Item: Title: Neutralization Assays Destination: s2_7 Item: Title: Antibody-Dependent Cellular Cytotoxicity (ADCC) Destination: s2_8 Item: Title: Statistical Analysis Destination: s2_9 Item: Title: Results Destination: s3 Children: Item: Title: HIV-Specific T-Cell Responses With CD4+ Tfh-Like and CD8+ Tc2-Like and Tfc-Like Cytokine Polarization Profile Are Associated With Viral Control Destination: s3_1 Item: Title: Circulating Type 2 and Follicular-Like T-Cells Show Different Memory Profiles in HIV+ Controllers and Non-Controllers Destination: s3_2 Item: Title: Expression of Cell Surface Specific Markers in Individuals Showing CD8+ Tc2- and Tfc-Like Responses Destination: s3_3 Item: Title: Higher Levels of CD8+ Tfc-Like Cells in HIV+ Controllers Are Associated With Maturation of the Humoral Immune Response and Antibody Effector Functions Destination: s3_4 Item: Title: HIV-Specific CD8+ Tfc-Like Responses Are Linked to Antibody Isotype Class Switching and Humoral Function Destination: s3_5 Item: Title: Discussion Destination: s4 Item: Title: Data Availability Statement Destination: s5 Item: Title: Ethics Statement Destination: s6 Item: Title: Author Contributions Destination: s7 Item: Title: Funding Destination: s8 Item: Title: Supplementary Material Destination: bmark_386646472 Item: Title: References Destination: bmark_2090415954 Info: Title: T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG Author: Luis Romero-Martín; Ferran Tarrés-Freixas; Núria Pedreño-López; Maria L. Rodríguez de la Concepción; Francesc Cunyat; Dennis Hartigan-O'Connor; Jorge Carrillo; Beatriz Mothe; Julià Blanco; Marta Ruiz-Riol; Christian Brander; Alex Olvera Subject: T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear Keywords: HIV, humoral immune response, human immunodeficiency virus (HIV) control, T-follicular cytotoxic (Tfc) cells, viral control Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Jun 14 11:28:50 CEST 2022 ModDate: Tue Jun 14 11:29:03 CEST 2022 ID: 0xbe7da7712f9d7d6a188e20f78e56822d, 0x3016d45e5f874a41a7904679ac32d317 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1185 ImageHeight: 651 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: 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T-follicular cytotoxic (Tfc) cells, viral control 2022-06-14T17:29:03+08:00 2022-06-14T17:28:50+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-06-14T17:29:03+08:00 application/pdf T-Follicular-Like CD8+ T Cell Responses in Chronic HIV Infection Are Associated With Virus Control and Antibody Isotype Switching to IgG Luis Romero-Martín; Ferran Tarrés-Freixas; Núria Pedreño-López; Maria L. Rodríguez de la Concepción; Francesc Cunyat; Dennis Hartigan-O'Connor; Jorge Carrillo; Beatriz Mothe; Julià Blanco; Marta Ruiz-Riol; Christian Brander; Alex Olvera T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear uuid:43977c13-9e9f-4874-866d-ffcb3f718669 uuid:02747c1e-82ff-4fc5-b714-1d68f5233294 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 609, 395, 630 Annotation: Subtype: Link Rect: 395, 600, 459, 621 Annotation: Subtype: Link Rect: 175, 577, 528, 598 Annotation: Subtype: Link Rect: 175, 554, 513, 575 Annotation: Subtype: Link Rect: 175, 531, 495, 552 Annotation: Subtype: Link Rect: 175, 508, 236, 529 Annotation: Subtype: Link Rect: 342, 87, 347, 96 Destination: 330 Annotation: Subtype: Link Rect: 352, 87, 356, 96 Destination: 330 Annotation: Subtype: Link Rect: 355, 64, 360, 73 Destination: 330 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: 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