3566e07d2c986c932bcceb17da9e256a pmc_35012606.pdf 147a4c4f88a9b45e95c840bb47ddf63404b976e3 pmc_35012606.pdf f975bbab50b69d8d89bcd4d32d0b14b2b6a26864dafd1fb3b3091afc0c4c2e0b pmc_35012606.pdf Title: Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)—protocol for a randomized clinical trial Subject: Trials, 2022, doi:10.1186/s13063-021-05991-2 Keywords: ICU,Acute respiratory failure,Hypoxemia,Prone position,Awake prone positioning,Invasive ventilation,Intubation,Invasive ventilation,Randomized controlled trial Author: L. Morales-Quinteros Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jan 5 17:36:06 2022 CET ModDate: Mon Jan 10 14:22:38 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1175024 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PKIMHD+AdvTT7329fd89.I Type 1C WinAnsi yes yes no 23 0 MyriadPro-Regular Type 1C Custom yes no yes 24 0 PKIDLD+AdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 26 0 PKIICI+AdvTTe45e47d2 Type 1C WinAnsi yes yes no 27 0 PKIICJ+AdvTTe45e47d2+20 Type 1C WinAnsi yes yes no 419 0 PKIICK+AdvTTb5929f4c Type 1C WinAnsi yes yes no 28 0 PKIIHJ+AdvTT99c4c969 Type 1C WinAnsi yes yes no 29 0 PKIMBE+AdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 30 0 PKIMME+AdvTT86d47313+20 Type 1C WinAnsi yes yes no 22 0 PKIMMD+AdvTT86d47313 Type 1C WinAnsi yes yes no 25 0 PKIMPE+AdvP4C4E74 Type 1C Custom yes yes no 215 0 PKIMPF+AdvTT43ccf47d Type 1C WinAnsi yes yes no 216 0 PKJFHC+AdvTT99c4c969+20 Type 1C WinAnsi yes yes no 363 0 PKJFIC+AdvTT86d47313+22 Type 1C Custom yes yes yes 393 0 PKJFJD+AdvTT8861b38f.I Type 1C WinAnsi yes yes no 394 0 PKJFLD+AdvTT8861b38f.I+03 Type 1C Custom yes yes yes 11 0 PKJJIO+AdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 96 0 PKJJIN+AdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 97 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-11 02:34:24 CET RepresentationInformation: pmc_35012606.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-17 03:35:02 CET Size: 1175024 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig3' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR22' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR23' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR38' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 404646 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR41' cannot be found Offset: 404646 MIMEtype: application/pdf PDFMetadata: Objects: 552 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Design and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Trial registration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Consort diagram Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Inclusion and exclusion criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Study endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Randomization and blinding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Prone positioning Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Standard of care Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Intubation criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Weaning from the noninvasive oxygen delivery system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Invasive ventilation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Fluid regimens Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Sedation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Weaning from invasive ventilation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Data collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Power calculation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Deferred informed consent Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Study organization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Trial status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Declarations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE) protocol for a randomized clinical trial Author: L. Morales-Quinteros Subject: Trials, 2022, doi:10.1186/s13063-021-05991-2 Keywords: ICU,Acute respiratory failure,Hypoxemia,Prone position,Awake prone positioning,Invasive ventilation,Intubation,Invasive ventilation,Randomized controlled trial Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jan 05 17:36:06 CET 2022 ModDate: Mon Jan 10 14:22:38 CET 2022 ID: 0xa24a3582cbba26a82d2ed1169edd2a2b, 0x896a96b0aa6784e9dee42dc85a3ba4f4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 177 ImageHeight: 183 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 55 ImageHeight: 104 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1428 ImageHeight: 1755 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1949 ImageHeight: 703 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1949 ImageHeight: 1904 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: PKJJIO+AdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: PKJJIO+AdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKJJIN+AdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: PKJJIN+AdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIICJ+AdvTTe45e47d2+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: PKIICJ+AdvTTe45e47d2+20 Flags: Nonsymbolic FontBBox: -447, -197, 1302, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKJFIC+AdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: PKJFIC+AdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PKJFJD+AdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: PKJFJD+AdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKJFHC+AdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: PKJFHC+AdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKJFLD+AdvTT8861b38f.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: PKJFLD+AdvTT8861b38f.I+03 Flags: Symbolic FontBBox: -291, -239, 937, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PKIMME+AdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: PKIMME+AdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIMHD+AdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: PKIMHD+AdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIMPE+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: PKIMPE+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PKIMPF+AdvTT43ccf47d FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PKIMPF+AdvTT43ccf47d Flags: Serif, Nonsymbolic FontBBox: -20, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIMMD+AdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: PKIMMD+AdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -20, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIDLD+AdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: PKIDLD+AdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIICI+AdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: PKIICI+AdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIICK+AdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 248 FontDescriptor: FontName: PKIICK+AdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIIHJ+AdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: PKIIHJ+AdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PKIMBE+AdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: PKIMBE+AdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: ICU,Acute respiratory failure,Hypoxemia,Prone position,Awake prone positioning,Invasive ventilation,Intubation,Invasive ventilation,Randomized controlled trial Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13063-021-05991-2 Trials Trials, 2022, doi:10.1186/s13063-021-05991-2 ICU Acute respiratory failure Hypoxemia Prone position Awake prone positioning Invasive ventilation Intubation Invasive ventilation Randomized controlled trial Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)—protocol for a randomized clinical trial L. Morales-Quinteros M. J. Schultz A. Serpa-Neto M. Antonelli D. L. Grieco O. Roca N. P. Juffermans C. Haro D. Mendoza Ll. Blanch M. Camprubí-Rimblas Gemma Gomà A. Artigas-Raventós 2022-01-10T14:22:38+01:00 2022-01-10T14:22:38+01:00 2022-01-06T00:36:06+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:5eb6f7e2-ee17-45cc-8512-220ec456c574 uuid:14296ef5-1920-4d8f-bbab-84d6bef46570 default 1 converted uuid:5eb6f7e2-ee17-45cc-8512-220ec456c574 converted to PDF/A-2b pdfToolbox 2022-01-06T03:40:26+08:00 2 B L. Morales-Quinteros http://orcid.org/0000-0002-8937-9824 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 521, 162, 530 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 192, 173, 199 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 171, 584, 189, 594 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 171, 584, 238, 594 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 73, 572, 135, 582 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 95, 476, 100, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 131, 212, 136, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 212, 147, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 200, 241, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 247, 200, 252, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 223, 188, 228, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 234, 188, 239, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 214, 152, 219, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 152, 230, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 152, 241, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 164, 92, 174, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 331, 296, 341, 306 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 260, 538, 270 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 365, 141, 375, 151 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 376, 129, 381, 139 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 69, 411, 79 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 85, 177, 90, 186 Flags: Print AppearanceDictionary: true Destination: 234 Annotation: Subtype: Link Rect: 169, 105, 174, 114 Flags: Print AppearanceDictionary: true Destination: 234 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 477, 273, 482, 282 Flags: Print AppearanceDictionary: true Destination: 234 Annotation: Subtype: Link Rect: 491, 249, 496, 258 Flags: Print AppearanceDictionary: true Destination: 234 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 102, 537, 106, 546 Flags: Print AppearanceDictionary: true Destination: 251 Annotation: Subtype: Link Rect: 490, 681, 500, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 681, 515, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 507, 429, 512, 438 Flags: Print AppearanceDictionary: true Destination: 251 Annotation: Subtype: Link Rect: 334, 249, 339, 258 Flags: Print AppearanceDictionary: true Destination: 251 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 59, 489, 69, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 75, 489, 85, 498 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 510, 537, 515, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 93, 317, 102 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 93, 333, 102 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 7 Thumb: true Page: Sequence: 8 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 240, 681, 249, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 681, 265, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 465, 64, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 127, 441, 132, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 441, 149, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 170, 369, 180, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 186, 369, 196, 378 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 216, 345, 226, 354 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 137, 321, 147, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 163, 273, 173, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 179, 273, 189, 282 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 153, 237, 163, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 125, 213, 135, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 91, 153, 101, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 107, 153, 117, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 416, 693, 426, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 693, 442, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 447, 693, 457, 702 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 505, 645, 515, 654 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 633, 416, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 323, 609, 328, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 333, 609, 343, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 597, 487, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 493, 597, 503, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 597, 518, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 597, 533, 606 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 398, 585, 408, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 449, 585, 459, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 585, 533, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 358, 201, 368, 210 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 516, 453, 537, 461 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 444, 392, 452 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 426, 417, 535, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 408, 335, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 431, 390, 532, 398 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 381, 338, 389 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 354, 530, 362 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 345, 409, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 456, 318, 532, 326 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 309, 379, 317 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 347, 264, 454, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 246, 529, 254 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 237, 429, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 496, 210, 526, 218 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 201, 425, 209 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 463, 165, 533, 173 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 156, 363, 164 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 432, 111, 536, 119 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 102, 340, 110 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 75, 517, 83 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 213, 693, 280, 701 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 684, 137, 692 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 198, 657, 265, 664 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 648, 118, 655 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 132, 621, 246, 628 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 159, 593, 273, 601 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 248, 566, 279, 573 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 557, 155, 564 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 267, 530, 288, 537 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 521, 157, 528 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 171, 493, 284, 501 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 448, 265, 456 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 412, 217, 419 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 164, 384, 261, 392 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 357, 284, 365 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 348, 135, 356 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 243, 321, 289, 328 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 312, 166, 319 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 255, 285, 286, 292 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 276, 151, 283 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 221, 200, 228 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 236, 194, 283, 201 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 185, 126, 192 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 187, 157, 280, 165 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 148, 104, 156 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 112, 239, 120 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 85, 285, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 71, 76, 126, 83 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 391, 684, 514, 692 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 430, 648, 532, 656 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 639, 342, 647 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 438, 612, 522, 620 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 603, 380, 611 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 470, 576, 537, 584 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 567, 358, 575 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 450, 540, 520, 548 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 531, 369, 539 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 383, 495, 494, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 463, 459, 530, 467 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 450, 385, 458 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 393, 414, 513, 422 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 370, 378, 494, 386 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 409, 351, 533, 359 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 383, 324, 497, 332 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 132e0abb Type: CRC32 Checksum: 3566e07d2c986c932bcceb17da9e256a Type: MD5 Checksum: 147a4c4f88a9b45e95c840bb47ddf63404b976e3 Type: SHA-1