54267ee45132f460333a8134b328af42 pmc_35049798.pdf 74fc4350f16be29308e3f0c59744c1e5c0db89cd pmc_35049798.pdf 553189b3e7989eed19a36ff00d82e8a97b0104814dcee6c31f9ea8de6f7b3f3f pmc_35049798.pdf Title: Alteration in Activity Patterns of Cows as a Result of Pain Due to Health Conditions Subject: The main conditions and diseases considered painful in dairy cows are mastitis, lameness, calving (including dystocia and caesarean section) and metritis. The cattle literature reports that deviation from normal daily activity patterns (both increased and/or reduced daily lying time) can be indicative of painful conditions and diseases in cows. This narrative review discusses on how pain due to several health conditions in dairy cows modifies its activity pattern and explores if non-steroidal anti-inflammatory drugs (NSAIDs) are capable of restoring it. Divergent outcomes may differ depending upon the painful cause, the severity and the moment, and consequently its interpretation should be properly explained. For instance, cows with clinical mastitis reduced their time lying and increased the number of lying bouts and stepping due to pain caused by the swollen udder when cows are lying. However, lame cows show longer lying times, with a lower number of lying bouts and longer and more variable lying bouts duration, as compared to non-lame cows. When the relationship between painful disorders and daily activity patterns is studied, factors such as parity, bedding type and severity of disease are important factors to take into consideration. The potential benefits of the NSAIDs treatment in painful health disorders depend upon the type of drug administered, its dosage and administration mode, and the time of administration relative to the painful health disorder. This narrative review can be used as a tool to properly interpret and grade pain in cows through behavioural activity patterns and proposes directions for future investigations. Keywords: cow; pain; activity; lying time; welfare Author: Eva Mainau, Pol Llonch, Déborah Temple, Laurent Goby and Xavier Manteca Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jan 12 11:35:53 2022 CET ModDate: Wed Jan 12 11:45:57 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 440452 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GGPNZA+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 YFAVSM+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 TTLECP+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 32 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 36 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 40 0 SZMRXJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 52 0 RZDHBS+CMSY10 Type 1 Builtin yes yes no 80 0 QIRGVG+VnURWPalladioL Type 1 Custom yes yes no 130 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 159 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-02-23 02:29:10 CET RepresentationInformation: pmc_35049798.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-22 11:10:33 CET Size: 440452 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 731 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: The Sensory and Emotional Experience of Pain Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Pain Identification and Assessment in Cows Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Pain Management in Dairy Cows Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Pain Associated with Mastitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Alteration in Activity Patterns as a Result of Pain Due to Mastitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: The Effect of NSAIDs on Activity Patterns in Cows with Mastitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Pain Associated with Lameness Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Alteration in Activity Patterns as a Result of Pain Due to Lameness Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: The Effect of NSAIDs on Activity Patterns in Cows with Lameness Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Pain Associated with Calving Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Alteration in Activity Patterns as a Result of Pain Due to Calving Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: The Effect of NSAIDs on Activity Patterns in Cows with Calving Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Pain Associated with Metritis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: Alteration in Activity Patterns as a Result of Pain Due to Metritis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: The Effect of NSAIDs on Activity Patterns in Cows with Metritis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Concluding Remarks and Potential Further Research Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Info: Title: Alteration in Activity Patterns of Cows as a Result of Pain Due to Health Conditions Author: Eva Mainau, Pol Llonch, Déborah Temple, Laurent Goby and Xavier Manteca Subject: The main conditions and diseases considered painful in dairy cows are mastitis, lameness, calving (including dystocia and caesarean section) and metritis. The cattle literature reports that deviation from normal daily activity patterns (both increased and/or reduced daily lying time) can be indicative of painful conditions and diseases in cows. This narrative review discusses on how pain due to several health conditions in dairy cows modifies its activity pattern and explores if non-steroidal anti-inflammatory drugs (NSAIDs) are capable of restoring it. Divergent outcomes may differ depending upon the painful cause, the severity and the moment, and consequently its interpretation should be properly explained. For instance, cows with clinical mastitis reduced their time lying and increased the number of lying bouts and stepping due to pain caused by the swollen udder when cows are lying. However, lame cows show longer lying times, with a lower number of lying bouts and longer and more variable lying bouts duration, as compared to non-lame cows. When the relationship between painful disorders and daily activity patterns is studied, factors such as parity, bedding type and severity of disease are important factors to take into consideration. The potential benefits of the NSAIDs treatment in painful health disorders depend upon the type of drug administered, its dosage and administration mode, and the time of administration relative to the painful health disorder. This narrative review can be used as a tool to properly interpret and grade pain in cows through behavioural activity patterns and proposes directions for future investigations. Keywords: cow; pain; activity; lying time; welfare Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jan 12 11:35:53 CET 2022 ModDate: Wed Jan 12 11:45:57 CET 2022 ID: 0xdc882e2bca8763b31f26febe2c8f5a54, 0xdc882e2bca8763b31f26febe2c8f5a54 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: RZDHBS+CMSY10 FontSubset: true FirstChar: 6 LastChar: 35 FontDescriptor: FontName: RZDHBS+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: QIRGVG+VnURWPalladioL FontSubset: true FirstChar: 161 LastChar: 243 FontDescriptor: FontName: QIRGVG+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TTLECP+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: TTLECP+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BTFGED+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 178 FontDescriptor: FontName: BTFGED+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GGPNZA+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: GGPNZA+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YFAVSM+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: YFAVSM+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CKBPVA+EURM10 FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: CKBPVA+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 50, 323, 152, 332 Annotation: Subtype: Link Rect: 34, 313, 74, 320 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 165, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 102, 663, 113, 676 Annotation: Subtype: Link Rect: 172, 663, 183, 676 Annotation: Subtype: Link Rect: 422, 155, 429, 164 ActionDest: 137 Annotation: Subtype: Link Rect: 432, 155, 439, 164 ActionDest: 137 Annotation: Subtype: Link Rect: 455, 143, 462, 152 ActionDest: 137 Annotation: Subtype: Link Rect: 515, 143, 522, 152 ActionDest: 137 Annotation: Subtype: Link Rect: 267, 130, 274, 139 ActionDest: 137 Annotation: Subtype: Link Rect: 356, 118, 363, 127 ActionDest: 137 Annotation: Subtype: Link Rect: 193, 105, 200, 114 ActionDest: 137 Annotation: Subtype: Link Rect: 213, 92, 220, 102 ActionDest: 137 Annotation: Subtype: Link Rect: 112, 17, 247, 28 Annotation: Subtype: Link Rect: 409, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 396, 86, 415 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 545, 572, 557, 581 ActionDest: 137 Annotation: Subtype: Link Rect: 514, 547, 526, 556 ActionDest: 137 Annotation: Subtype: Link Rect: 305, 484, 317, 493 ActionDest: 137 Annotation: Subtype: Link Rect: 318, 484, 330, 493 ActionDest: 137 Annotation: Subtype: Link Rect: 369, 434, 381, 443 ActionDest: 137 Annotation: Subtype: Link Rect: 476, 346, 488, 355 ActionDest: 137 Annotation: Subtype: Link Rect: 357, 308, 369, 317 ActionDest: 137 Annotation: Subtype: Link Rect: 314, 258, 326, 267 ActionDest: 137 Annotation: Subtype: Link Rect: 342, 183, 354, 192 ActionDest: 137 Annotation: Subtype: Link Rect: 354, 183, 366, 192 ActionDest: 137 Annotation: Subtype: Link Rect: 483, 145, 495, 154 ActionDest: 141 Annotation: Subtype: Link Rect: 498, 145, 510, 154 ActionDest: 141 Annotation: Subtype: Link Rect: 318, 95, 325, 104 ActionDest: 137 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 251, 736, 263, 744 ActionDest: 141 Annotation: Subtype: Link Rect: 264, 736, 276, 744 ActionDest: 141 Annotation: Subtype: Link Rect: 487, 723, 499, 732 ActionDest: 141 Annotation: Subtype: Link Rect: 480, 710, 492, 719 ActionDest: 141 Annotation: Subtype: Link Rect: 348, 610, 360, 619 ActionDest: 141 Annotation: Subtype: Link Rect: 361, 610, 373, 619 ActionDest: 141 Annotation: Subtype: Link Rect: 526, 534, 538, 543 ActionDest: 141 Annotation: Subtype: Link Rect: 412, 509, 424, 518 ActionDest: 141 Annotation: Subtype: Link Rect: 380, 471, 392, 481 ActionDest: 141 Annotation: Subtype: Link Rect: 392, 471, 404, 481 ActionDest: 141 Annotation: Subtype: Link Rect: 514, 459, 525, 468 ActionDest: 141 Annotation: Subtype: Link Rect: 467, 409, 479, 418 ActionDest: 141 Annotation: Subtype: Link Rect: 320, 384, 332, 393 ActionDest: 141 Annotation: Subtype: Link Rect: 480, 384, 492, 393 ActionDest: 141 Annotation: Subtype: Link Rect: 358, 359, 365, 368 ActionDest: 137 Annotation: Subtype: Link Rect: 229, 333, 241, 342 ActionDest: 141 Annotation: Subtype: Link Rect: 259, 321, 266, 330 ActionDest: 137 Annotation: Subtype: Link Rect: 266, 321, 278, 330 ActionDest: 141 Annotation: Subtype: Link Rect: 230, 283, 242, 292 ActionDest: 141 Annotation: Subtype: Link Rect: 486, 271, 498, 280 ActionDest: 141 Annotation: Subtype: Link Rect: 336, 233, 348, 242 ActionDest: 141 Annotation: Subtype: Link Rect: 508, 221, 515, 229 ActionDest: 137 Annotation: Subtype: Link Rect: 516, 220, 528, 229 ActionDest: 141 Annotation: Subtype: Link Rect: 451, 170, 463, 179 ActionDest: 141 Annotation: Subtype: Link Rect: 347, 158, 359, 167 ActionDest: 141 Annotation: Subtype: Link Rect: 223, 145, 235, 154 ActionDest: 141 Annotation: Subtype: Link Rect: 407, 107, 419, 117 ActionDest: 141 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 193, 685, 205, 694 ActionDest: 141 Annotation: Subtype: Link Rect: 206, 648, 218, 657 ActionDest: 141 Annotation: Subtype: Link Rect: 218, 647, 230, 657 ActionDest: 141 Annotation: Subtype: Link Rect: 340, 560, 352, 569 ActionDest: 141 Annotation: Subtype: Link Rect: 495, 484, 507, 493 ActionDest: 141 Annotation: Subtype: Link Rect: 427, 459, 434, 468 ActionDest: 137 Annotation: Subtype: Link Rect: 213, 422, 225, 431 ActionDest: 141 Annotation: Subtype: Link Rect: 368, 409, 380, 418 ActionDest: 141 Annotation: Subtype: Link Rect: 383, 409, 395, 418 ActionDest: 141 Annotation: Subtype: Link Rect: 376, 396, 388, 406 ActionDest: 141 Annotation: Subtype: Link Rect: 279, 384, 291, 393 ActionDest: 141 Annotation: Subtype: Link Rect: 343, 359, 350, 368 ActionDest: 137 Annotation: Subtype: Link Rect: 452, 334, 464, 343 ActionDest: 144 Annotation: Subtype: Link Rect: 544, 296, 556, 305 ActionDest: 144 Annotation: Subtype: Link Rect: 490, 258, 502, 267 ActionDest: 144 Annotation: Subtype: Link Rect: 300, 196, 312, 205 ActionDest: 144 Annotation: Subtype: Link Rect: 313, 196, 325, 205 ActionDest: 144 Annotation: Subtype: Link Rect: 438, 183, 450, 192 ActionDest: 144 Annotation: Subtype: Link Rect: 296, 70, 308, 79 ActionDest: 144 Annotation: Subtype: Link Rect: 386, 70, 398, 79 ActionDest: 144 Annotation: Subtype: Link Rect: 500, 70, 512, 79 ActionDest: 144 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 192, 735, 204, 744 ActionDest: 141 Annotation: Subtype: Link Rect: 486, 735, 498, 744 ActionDest: 144 Annotation: Subtype: Link Rect: 499, 735, 511, 744 ActionDest: 144 Annotation: Subtype: Link Rect: 216, 723, 228, 732 ActionDest: 144 Annotation: Subtype: Link Rect: 507, 723, 519, 732 ActionDest: 144 Annotation: Subtype: Link Rect: 522, 723, 534, 732 ActionDest: 144 Annotation: Subtype: Link Rect: 223, 710, 235, 719 ActionDest: 144 Annotation: Subtype: Link Rect: 307, 710, 319, 719 ActionDest: 144 Annotation: Subtype: Link Rect: 319, 710, 331, 719 ActionDest: 144 Annotation: Subtype: Link Rect: 399, 710, 411, 719 ActionDest: 144 Annotation: Subtype: Link Rect: 520, 710, 532, 719 ActionDest: 144 Annotation: Subtype: Link Rect: 420, 698, 432, 707 ActionDest: 144 Annotation: Subtype: Link Rect: 434, 698, 446, 707 ActionDest: 144 Annotation: Subtype: Link Rect: 543, 698, 555, 707 ActionDest: 144 Annotation: Subtype: Link Rect: 263, 685, 275, 694 ActionDest: 144 Annotation: Subtype: Link Rect: 485, 685, 497, 694 ActionDest: 144 Annotation: Subtype: Link Rect: 220, 560, 232, 568 ActionDest: 144 Annotation: Subtype: Link Rect: 233, 559, 245, 568 ActionDest: 144 Annotation: Subtype: Link Rect: 433, 522, 445, 531 ActionDest: 141 Annotation: Subtype: Link Rect: 415, 471, 427, 481 ActionDest: 141 Annotation: Subtype: Link Rect: 428, 471, 440, 481 ActionDest: 144 Annotation: Subtype: Link Rect: 204, 434, 216, 443 ActionDest: 144 Annotation: Subtype: Link Rect: 315, 421, 327, 430 ActionDest: 141 Annotation: Subtype: Link Rect: 229, 396, 241, 405 ActionDest: 144 Annotation: Subtype: Link Rect: 544, 371, 556, 380 ActionDest: 147 Annotation: Subtype: Link Rect: 314, 346, 321, 355 ActionDest: 137 Annotation: Subtype: Link Rect: 321, 346, 333, 355 ActionDest: 141 Annotation: Subtype: Link Rect: 333, 346, 345, 355 ActionDest: 147 Annotation: Subtype: Link Rect: 209, 333, 221, 342 ActionDest: 147 Annotation: Subtype: Link Rect: 324, 283, 336, 292 ActionDest: 147 Annotation: Subtype: Link Rect: 463, 271, 475, 280 ActionDest: 147 Annotation: Subtype: Link Rect: 431, 245, 443, 255 ActionDest: 147 Annotation: Subtype: Link Rect: 388, 170, 400, 179 ActionDest: 147 Annotation: Subtype: Link Rect: 218, 157, 230, 166 ActionDest: 147 Annotation: Subtype: Link Rect: 385, 145, 397, 154 ActionDest: 147 Annotation: Subtype: Link Rect: 198, 95, 210, 104 ActionDest: 141 Annotation: Subtype: Link Rect: 210, 95, 222, 104 ActionDest: 141 Annotation: Subtype: Link Rect: 223, 95, 235, 104 ActionDest: 147 Annotation: Subtype: Link Rect: 332, 69, 344, 79 ActionDest: 141 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 205, 710, 217, 719 ActionDest: 147 Annotation: Subtype: Link Rect: 477, 685, 489, 694 ActionDest: 147 Annotation: Subtype: Link Rect: 508, 647, 520, 657 ActionDest: 147 Annotation: Subtype: Link Rect: 367, 610, 379, 619 ActionDest: 147 Annotation: Subtype: Link Rect: 473, 597, 485, 606 ActionDest: 147 Annotation: Subtype: Link Rect: 283, 519, 290, 531 ActionDest: 90 Annotation: Subtype: Link Rect: 482, 509, 494, 518 ActionDest: 147 Annotation: Subtype: Link Rect: 495, 509, 507, 518 ActionDest: 147 Annotation: Subtype: Link Rect: 402, 484, 414, 493 ActionDest: 147 Annotation: Subtype: Link Rect: 500, 471, 512, 481 ActionDest: 147 Annotation: Subtype: Link Rect: 334, 446, 346, 455 ActionDest: 147 Annotation: Subtype: Link Rect: 305, 409, 317, 418 ActionDest: 147 Annotation: Subtype: Link Rect: 339, 384, 351, 393 ActionDest: 147 Annotation: Subtype: Link Rect: 314, 358, 326, 368 ActionDest: 147 Annotation: Subtype: Link Rect: 271, 346, 283, 355 ActionDest: 147 Annotation: Subtype: Link Rect: 486, 321, 498, 330 ActionDest: 147 Annotation: Subtype: Link Rect: 498, 321, 510, 330 ActionDest: 147 Annotation: Subtype: Link Rect: 241, 308, 253, 317 ActionDest: 147 Annotation: Subtype: Link Rect: 474, 258, 485, 267 ActionDest: 147 Annotation: Subtype: Link Rect: 487, 208, 499, 217 ActionDest: 147 Annotation: Subtype: Link Rect: 199, 195, 211, 204 ActionDest: 147 Annotation: Subtype: Link Rect: 440, 158, 452, 167 ActionDest: 147 Annotation: Subtype: Link Rect: 452, 158, 464, 167 ActionDest: 147 Annotation: Subtype: Link Rect: 467, 158, 484, 167 ActionDest: 147 Annotation: Subtype: Link Rect: 307, 133, 324, 142 ActionDest: 147 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 158, 371, 169, 379 ActionDest: 147 Annotation: Subtype: Link Rect: 158, 329, 169, 337 ActionDest: 147 Annotation: Subtype: Link Rect: 158, 290, 169, 299 ActionDest: 147 Annotation: Subtype: Link Rect: 158, 238, 169, 246 ActionDest: 147 Annotation: Subtype: Link Rect: 156, 200, 172, 208 ActionDest: 147 Annotation: Subtype: Link Rect: 158, 173, 169, 182 ActionDest: 147 Annotation: Subtype: Link Rect: 158, 136, 169, 144 ActionDest: 147 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 300, 690, 312, 699 ActionDest: 141 Annotation: Subtype: Link Rect: 515, 678, 527, 687 ActionDest: 147 Annotation: Subtype: Link Rect: 527, 678, 544, 687 ActionDest: 147 Annotation: Subtype: Link Rect: 533, 640, 545, 649 ActionDest: 147 Annotation: Subtype: Link Rect: 411, 627, 423, 636 ActionDest: 147 Annotation: Subtype: Link Rect: 424, 627, 441, 636 ActionDest: 147 Annotation: Subtype: Link Rect: 539, 514, 556, 523 ActionDest: 147 Annotation: Subtype: Link Rect: 450, 489, 467, 498 ActionDest: 147 Annotation: Subtype: Link Rect: 338, 476, 355, 486 ActionDest: 147 Annotation: Subtype: Link Rect: 379, 439, 396, 448 ActionDest: 147 Annotation: Subtype: Link Rect: 235, 426, 252, 435 ActionDest: 147 Annotation: Subtype: Link Rect: 539, 426, 556, 435 ActionDest: 147 Annotation: Subtype: Link Rect: 234, 414, 251, 423 ActionDest: 150 Annotation: Subtype: Link Rect: 254, 414, 271, 423 ActionDest: 150 Annotation: Subtype: Link Rect: 311, 401, 328, 410 ActionDest: 147 Annotation: Subtype: Link Rect: 457, 389, 474, 398 ActionDest: 150 Annotation: Subtype: Link Rect: 474, 389, 491, 398 ActionDest: 150 Annotation: Subtype: Link Rect: 244, 351, 261, 360 ActionDest: 147 Annotation: Subtype: Link Rect: 362, 326, 379, 335 ActionDest: 150 Annotation: Subtype: Link Rect: 319, 263, 331, 272 ActionDest: 141 Annotation: Subtype: Link Rect: 451, 250, 463, 260 ActionDest: 141 Annotation: Subtype: Link Rect: 285, 175, 292, 184 ActionDest: 137 Annotation: Subtype: Link Rect: 292, 175, 309, 184 ActionDest: 150 Annotation: Subtype: Link Rect: 191, 150, 198, 159 ActionDest: 137 Annotation: Subtype: Link Rect: 393, 137, 410, 147 ActionDest: 150 Annotation: Subtype: Link Rect: 290, 72, 297, 84 ActionDest: 102 Annotation: Subtype: Link Rect: 431, 74, 447, 84 ActionDest: 150 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 287, 700, 304, 709 ActionDest: 150 Annotation: Subtype: Link Rect: 419, 700, 436, 709 ActionDest: 150 Annotation: Subtype: Link Rect: 283, 649, 300, 659 ActionDest: 150 Annotation: Subtype: Link Rect: 303, 650, 320, 659 ActionDest: 150 Annotation: Subtype: Link Rect: 370, 599, 387, 608 ActionDest: 150 Annotation: Subtype: Link Rect: 539, 587, 556, 596 ActionDest: 150 Annotation: Subtype: Link Rect: 273, 562, 285, 571 ActionDest: 141 Annotation: Subtype: Link Rect: 286, 562, 303, 571 ActionDest: 150 Annotation: Subtype: Link Rect: 303, 562, 320, 571 ActionDest: 150 Annotation: Subtype: Link Rect: 398, 537, 410, 546 ActionDest: 141 Annotation: Subtype: Link Rect: 410, 537, 427, 546 ActionDest: 150 Annotation: Subtype: Link Rect: 370, 511, 387, 521 ActionDest: 150 Annotation: Subtype: Link Rect: 366, 486, 383, 495 ActionDest: 150 Annotation: Subtype: Link Rect: 409, 436, 426, 445 ActionDest: 150 Annotation: Subtype: Link Rect: 221, 411, 238, 420 ActionDest: 150 Annotation: Subtype: Link Rect: 544, 398, 556, 408 ActionDest: 144 Annotation: Subtype: Link Rect: 521, 373, 538, 382 ActionDest: 150 Annotation: Subtype: Link Rect: 539, 373, 556, 382 ActionDest: 150 Annotation: Subtype: Link Rect: 444, 348, 461, 357 ActionDest: 150 Annotation: Subtype: Link Rect: 364, 311, 376, 320 ActionDest: 144 Annotation: Subtype: Link Rect: 377, 311, 394, 320 ActionDest: 150 Annotation: Subtype: Link Rect: 293, 285, 310, 295 ActionDest: 150 Annotation: Subtype: Link Rect: 254, 260, 266, 269 ActionDest: 144 Annotation: Subtype: Link Rect: 343, 198, 360, 207 ActionDest: 150 Annotation: Subtype: Link Rect: 226, 185, 238, 194 ActionDest: 141 Annotation: Subtype: Link Rect: 409, 97, 421, 106 ActionDest: 144 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 59, 379, 75, 387 ActionDest: 150 Annotation: Subtype: Link Rect: 61, 339, 72, 347 ActionDest: 144 Annotation: Subtype: Link Rect: 59, 304, 75, 312 ActionDest: 150 Annotation: Subtype: Link Rect: 61, 264, 72, 272 ActionDest: 144 Annotation: Subtype: Link Rect: 59, 224, 75, 232 ActionDest: 150 Annotation: Subtype: Link Rect: 59, 192, 75, 200 ActionDest: 150 Annotation: Subtype: Link Rect: 59, 159, 75, 168 ActionDest: 150 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 59, 401, 75, 409 ActionDest: 150 Annotation: Subtype: Link Rect: 59, 339, 75, 347 ActionDest: 150 Annotation: Subtype: Link Rect: 59, 299, 75, 307 ActionDest: 150 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 508, 713, 514, 725 ActionDest: 112 Annotation: Subtype: Link Rect: 283, 678, 300, 687 ActionDest: 150 Annotation: Subtype: Link Rect: 300, 678, 317, 687 ActionDest: 150 Annotation: Subtype: Link Rect: 544, 665, 551, 674 ActionDest: 137 Annotation: Subtype: Link Rect: 295, 627, 312, 636 ActionDest: 150 Annotation: Subtype: Link Rect: 378, 627, 395, 636 ActionDest: 150 Annotation: Subtype: Link Rect: 380, 602, 397, 611 ActionDest: 150 Annotation: Subtype: Link Rect: 349, 552, 366, 561 ActionDest: 150 Annotation: Subtype: Link Rect: 367, 552, 384, 561 ActionDest: 150 Annotation: Subtype: Link Rect: 470, 552, 487, 561 ActionDest: 150 Annotation: Subtype: Link Rect: 269, 540, 286, 549 ActionDest: 150 Annotation: Subtype: Link Rect: 256, 489, 263, 498 ActionDest: 137 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 56, 360, 71, 369 ActionDest: 150 Annotation: Subtype: Link Rect: 56, 306, 71, 315 ActionDest: 150 Annotation: Subtype: Link Rect: 56, 221, 71, 230 ActionDest: 150 Annotation: Subtype: Link Rect: 56, 133, 71, 141 ActionDest: 150 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 52, 373, 68, 381 ActionDest: 150 Annotation: Subtype: Link Rect: 56, 275, 71, 283 ActionDest: 150 Annotation: Subtype: Link Rect: 766, 226, 780, 234 ActionDest: 150 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 439, 728, 446, 737 ActionDest: 137 Annotation: Subtype: Link Rect: 294, 703, 311, 712 ActionDest: 150 Annotation: Subtype: Link Rect: 402, 690, 419, 699 ActionDest: 150 Annotation: Subtype: Link Rect: 491, 653, 503, 662 ActionDest: 141 Annotation: Subtype: Link Rect: 503, 653, 515, 662 ActionDest: 141 Annotation: Subtype: Link Rect: 516, 652, 528, 662 ActionDest: 147 Annotation: Subtype: Link Rect: 204, 627, 221, 636 ActionDest: 150 Annotation: Subtype: Link Rect: 289, 615, 301, 624 ActionDest: 147 Annotation: Subtype: Link Rect: 385, 590, 401, 599 ActionDest: 150 Annotation: Subtype: Link Rect: 357, 565, 364, 574 ActionDest: 137 Annotation: Subtype: Link Rect: 189, 539, 206, 549 ActionDest: 153 Annotation: Subtype: Link Rect: 206, 539, 223, 549 ActionDest: 153 Annotation: Subtype: Link Rect: 514, 527, 521, 536 ActionDest: 137 Annotation: Subtype: Link Rect: 521, 527, 538, 536 ActionDest: 153 Annotation: Subtype: Link Rect: 540, 527, 557, 536 ActionDest: 153 Annotation: Subtype: Link Rect: 210, 502, 222, 511 ActionDest: 141 Annotation: Subtype: Link Rect: 441, 414, 458, 423 ActionDest: 153 Annotation: Subtype: Link Rect: 460, 401, 477, 410 ActionDest: 153 Annotation: Subtype: Link Rect: 522, 389, 539, 398 ActionDest: 150 Annotation: Subtype: Link Rect: 540, 389, 557, 398 ActionDest: 153 Annotation: Subtype: Link Rect: 333, 376, 350, 385 ActionDest: 150 Annotation: Subtype: Link Rect: 389, 376, 406, 385 ActionDest: 153 Annotation: Subtype: Link Rect: 531, 339, 538, 347 ActionDest: 137 Annotation: Subtype: Link Rect: 539, 339, 556, 347 ActionDest: 153 Annotation: Subtype: Link Rect: 192, 301, 209, 310 ActionDest: 153 Annotation: Subtype: Link Rect: 210, 301, 226, 310 ActionDest: 153 Annotation: Subtype: Link Rect: 391, 250, 408, 260 ActionDest: 153 Annotation: Subtype: Link Rect: 515, 225, 532, 234 ActionDest: 153 Annotation: Subtype: Link Rect: 314, 200, 331, 209 ActionDest: 153 Annotation: Subtype: Link Rect: 399, 173, 406, 185 ActionDest: 121 Annotation: Subtype: Link Rect: 239, 163, 256, 172 ActionDest: 150 Annotation: Subtype: Link Rect: 257, 163, 274, 172 ActionDest: 153 Annotation: Subtype: Link Rect: 404, 163, 416, 172 ActionDest: 141 Annotation: Subtype: Link Rect: 206, 112, 223, 122 ActionDest: 150 Annotation: Subtype: Link Rect: 259, 75, 276, 84 ActionDest: 153 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 347, 675, 364, 684 ActionDest: 153 Annotation: Subtype: Link Rect: 196, 561, 213, 570 ActionDest: 153 Annotation: Subtype: Link Rect: 213, 561, 230, 570 ActionDest: 153 Annotation: Subtype: Link Rect: 525, 549, 542, 558 ActionDest: 153 Annotation: Subtype: Link Rect: 217, 511, 234, 520 ActionDest: 153 Annotation: Subtype: Link Rect: 539, 511, 556, 520 ActionDest: 153 Annotation: Subtype: Link Rect: 497, 473, 514, 483 ActionDest: 153 Annotation: Subtype: Link Rect: 514, 473, 531, 483 ActionDest: 153 Annotation: Subtype: Link Rect: 532, 473, 549, 483 ActionDest: 153 Annotation: Subtype: Link Rect: 194, 436, 201, 445 ActionDest: 124 Annotation: Subtype: Link Rect: 370, 411, 387, 420 ActionDest: 153 Annotation: Subtype: Link Rect: 243, 398, 260, 407 ActionDest: 150 Annotation: Subtype: Link Rect: 195, 348, 212, 357 ActionDest: 153 Annotation: Subtype: Link Rect: 213, 348, 230, 357 ActionDest: 153 Annotation: Subtype: Link Rect: 371, 348, 388, 357 ActionDest: 153 Annotation: Subtype: Link Rect: 478, 323, 495, 332 ActionDest: 153 Annotation: Subtype: Link Rect: 272, 260, 289, 269 ActionDest: 153 Annotation: Subtype: Link Rect: 396, 222, 413, 231 ActionDest: 153 Annotation: Subtype: Link Rect: 413, 222, 430, 231 ActionDest: 153 Annotation: Subtype: Link Rect: 431, 222, 448, 231 ActionDest: 153 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 172, 395, 188, 403 ActionDest: 150 Annotation: Subtype: Link Rect: 172, 363, 188, 371 ActionDest: 153 Annotation: Subtype: Link Rect: 174, 331, 185, 339 ActionDest: 144 Annotation: Subtype: Link Rect: 172, 287, 188, 296 ActionDest: 153 Annotation: Subtype: Link Rect: 172, 239, 188, 247 ActionDest: 150 Annotation: Subtype: Link Rect: 172, 212, 188, 221 ActionDest: 153 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 71, 349, 86, 357 ActionDest: 153 Annotation: Subtype: Link Rect: 71, 242, 86, 251 ActionDest: 153 Annotation: Subtype: Link Rect: 71, 183, 86, 191 ActionDest: 150 Annotation: Subtype: Link Rect: 71, 129, 86, 137 ActionDest: 153 Annotation: Subtype: Link Rect: 71, 80, 86, 89 ActionDest: 153 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 398, 715, 415, 724 ActionDest: 153 Annotation: Subtype: Link Rect: 416, 715, 433, 724 ActionDest: 153 Annotation: Subtype: Link Rect: 398, 678, 409, 687 ActionDest: 141 Annotation: Subtype: Link Rect: 410, 678, 427, 687 ActionDest: 153 Annotation: Subtype: Link Rect: 427, 678, 444, 687 ActionDest: 156 Annotation: Subtype: Link Rect: 362, 652, 379, 662 ActionDest: 156 Annotation: Subtype: Link Rect: 383, 652, 399, 662 ActionDest: 156 Annotation: Subtype: Link Rect: 241, 627, 258, 636 ActionDest: 156 Annotation: Subtype: Link Rect: 261, 627, 278, 636 ActionDest: 156 Annotation: Subtype: Link Rect: 473, 602, 485, 611 ActionDest: 141 Annotation: Subtype: Link Rect: 485, 602, 497, 611 ActionDest: 141 Annotation: Subtype: Link Rect: 498, 602, 510, 611 ActionDest: 141 Annotation: Subtype: Link Rect: 510, 602, 522, 611 ActionDest: 147 Annotation: Subtype: Link Rect: 422, 565, 439, 574 ActionDest: 156 Annotation: Subtype: Link Rect: 528, 489, 540, 498 ActionDest: 141 Annotation: Subtype: Link Rect: 330, 464, 347, 473 ActionDest: 153 Annotation: Subtype: Link Rect: 347, 464, 364, 473 ActionDest: 156 Annotation: Subtype: Link Rect: 191, 451, 208, 460 ActionDest: 156 Annotation: Subtype: Link Rect: 334, 401, 346, 410 ActionDest: 141 Annotation: Subtype: Link Rect: 346, 401, 363, 410 ActionDest: 156 Annotation: Subtype: Link Rect: 420, 376, 437, 385 ActionDest: 150 Annotation: Subtype: Link Rect: 438, 376, 455, 385 ActionDest: 156 Annotation: Subtype: Link Rect: 375, 326, 387, 335 ActionDest: 141 Annotation: Subtype: Link Rect: 191, 301, 203, 310 ActionDest: 144 Annotation: Subtype: Link Rect: 292, 238, 309, 247 ActionDest: 156 Annotation: Subtype: Link Rect: 526, 225, 543, 234 ActionDest: 153 Annotation: Subtype: Link Rect: 508, 213, 525, 222 ActionDest: 156 Annotation: Subtype: Link Rect: 207, 188, 224, 197 ActionDest: 156 Annotation: Subtype: Link Rect: 220, 87, 237, 96 ActionDest: 156 Annotation: Subtype: Link Rect: 448, 87, 465, 96 ActionDest: 156 Annotation: Subtype: Link Rect: 256, 74, 273, 84 ActionDest: 156 Annotation: Subtype: Link Rect: 528, 74, 545, 84 ActionDest: 156 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 502, 725, 519, 734 ActionDest: 156 Annotation: Subtype: Link Rect: 519, 725, 536, 734 ActionDest: 156 Annotation: Subtype: Link Rect: 539, 725, 556, 734 ActionDest: 156 Annotation: Subtype: Link Rect: 495, 700, 512, 709 ActionDest: 156 Annotation: Subtype: Link Rect: 280, 637, 297, 646 ActionDest: 156 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 122, 415, 160, 425 Annotation: Subtype: Link Rect: 150, 392, 188, 402 Annotation: Subtype: Link Rect: 150, 369, 188, 379 Annotation: Subtype: Link Rect: 194, 369, 230, 379 Annotation: Subtype: Link Rect: 59, 346, 96, 356 Annotation: Subtype: Link Rect: 415, 323, 453, 333 Annotation: Subtype: Link Rect: 131, 300, 168, 310 Annotation: Subtype: Link Rect: 104, 277, 141, 287 Annotation: Subtype: Link Rect: 511, 264, 548, 275 Annotation: Subtype: Link Rect: 174, 241, 211, 252 Annotation: Subtype: Link Rect: 353, 207, 391, 218 Annotation: Subtype: Link Rect: 59, 185, 96, 195 Annotation: Subtype: Link Rect: 104, 150, 141, 160 Annotation: Subtype: Link Rect: 147, 150, 183, 160 Annotation: Subtype: Link Rect: 485, 138, 522, 149 Annotation: Subtype: Link Rect: 311, 126, 348, 137 Annotation: Subtype: Link Rect: 59, 104, 96, 114 Annotation: Subtype: Link Rect: 419, 92, 456, 103 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 236, 724, 274, 735 Annotation: Subtype: Link Rect: 95, 701, 133, 712 Annotation: Subtype: Link Rect: 263, 678, 301, 689 Annotation: Subtype: Link Rect: 307, 678, 343, 689 Annotation: Subtype: Link Rect: 159, 655, 197, 665 Annotation: Subtype: Link Rect: 127, 632, 164, 642 Annotation: Subtype: Link Rect: 170, 632, 206, 642 Annotation: Subtype: Link Rect: 404, 620, 441, 631 Annotation: Subtype: Link Rect: 193, 597, 230, 608 Annotation: Subtype: Link Rect: 237, 597, 273, 608 Annotation: Subtype: Link Rect: 351, 574, 389, 585 Annotation: Subtype: Link Rect: 59, 552, 96, 562 Annotation: Subtype: Link Rect: 86, 517, 124, 527 Annotation: Subtype: Link Rect: 322, 447, 359, 458 Annotation: Subtype: Link Rect: 145, 425, 183, 435 Annotation: Subtype: Link Rect: 272, 401, 310, 412 Annotation: Subtype: Link Rect: 316, 401, 352, 412 Annotation: Subtype: Link Rect: 118, 345, 155, 355 Annotation: Subtype: Link Rect: 432, 321, 469, 332 Annotation: Subtype: Link Rect: 229, 299, 267, 309 Annotation: Subtype: Link Rect: 204, 276, 241, 286 Annotation: Subtype: Link Rect: 142, 253, 180, 263 Annotation: Subtype: Link Rect: 59, 218, 96, 228 Annotation: Subtype: Link Rect: 236, 194, 273, 205 Annotation: Subtype: Link Rect: 415, 171, 452, 182 Annotation: Subtype: Link Rect: 504, 160, 542, 171 Annotation: Subtype: Link Rect: 213, 137, 251, 148 Annotation: Subtype: Link Rect: 387, 114, 425, 125 Annotation: Subtype: Link Rect: 160, 80, 198, 90 Annotation: Subtype: Link Rect: 204, 80, 240, 90 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 131, 724, 168, 735 Annotation: Subtype: Link Rect: 456, 689, 494, 700 Annotation: Subtype: Link Rect: 222, 667, 260, 677 Annotation: Subtype: Link Rect: 266, 667, 302, 677 Annotation: Subtype: Link Rect: 290, 643, 328, 654 Annotation: Subtype: Link Rect: 173, 621, 210, 631 Annotation: Subtype: Link Rect: 187, 597, 225, 608 Annotation: Subtype: Link Rect: 231, 597, 267, 608 Annotation: Subtype: Link Rect: 122, 563, 159, 573 Annotation: Subtype: Link Rect: 103, 529, 141, 539 Annotation: Subtype: Link Rect: 59, 506, 96, 516 Annotation: Subtype: Link Rect: 59, 471, 96, 481 Annotation: Subtype: Link Rect: 127, 448, 164, 458 Annotation: Subtype: Link Rect: 156, 425, 193, 435 Annotation: Subtype: Link Rect: 140, 391, 177, 401 Annotation: Subtype: Link Rect: 59, 368, 96, 378 Annotation: Subtype: Link Rect: 147, 345, 184, 355 Annotation: Subtype: Link Rect: 213, 322, 249, 332 Annotation: Subtype: Link Rect: 299, 298, 336, 309 Annotation: Subtype: Link Rect: 343, 298, 379, 309 Annotation: Subtype: Link Rect: 59, 276, 96, 286 Annotation: Subtype: Link Rect: 59, 253, 96, 263 Annotation: Subtype: Link Rect: 102, 253, 138, 263 Annotation: Subtype: Link Rect: 113, 230, 150, 240 Annotation: Subtype: Link Rect: 497, 206, 534, 217 Annotation: Subtype: Link Rect: 253, 183, 291, 194 Annotation: Subtype: Link Rect: 118, 161, 155, 171 Annotation: Subtype: Link Rect: 519, 114, 557, 125 Annotation: Subtype: Link Rect: 59, 103, 95, 113 Annotation: Subtype: Link Rect: 520, 91, 557, 102 Annotation: Subtype: Link Rect: 59, 80, 95, 90 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 374, 724, 412, 735 Annotation: Subtype: Link Rect: 275, 701, 313, 712 Annotation: Subtype: Link Rect: 319, 701, 355, 712 Annotation: Subtype: Link Rect: 323, 678, 361, 689 Annotation: Subtype: Link Rect: 332, 666, 560, 677 Annotation: Subtype: Link Rect: 56, 654, 275, 665 Annotation: Subtype: Link Rect: 452, 631, 489, 642 Annotation: Subtype: Link Rect: 504, 608, 541, 619 Annotation: Subtype: Link Rect: 498, 597, 535, 608 Annotation: Subtype: Link Rect: 243, 574, 280, 585 Annotation: Subtype: Link Rect: 104, 552, 141, 562 Annotation: Subtype: Link Rect: 265, 516, 303, 527 Annotation: Subtype: Link Rect: 254, 493, 291, 504 Annotation: Subtype: Link Rect: 297, 493, 333, 504 Annotation: Subtype: Link Rect: 272, 436, 309, 447 Annotation: Subtype: Link Rect: 178, 413, 216, 424 Annotation: Subtype: Link Rect: 222, 413, 258, 424 Annotation: Subtype: Link Rect: 59, 379, 96, 389 Annotation: Subtype: Link Rect: 108, 356, 145, 366 Annotation: Subtype: Link Rect: 170, 333, 207, 343 Annotation: Subtype: Link Rect: 113, 310, 150, 320 Annotation: Subtype: Link Rect: 275, 286, 312, 297 Annotation: Subtype: Link Rect: 156, 264, 193, 274 Annotation: Subtype: Link Rect: 200, 264, 236, 274 Annotation: Subtype: Link Rect: 59, 230, 96, 240 Annotation: Subtype: Link Rect: 102, 230, 138, 240 Annotation: Subtype: Link Rect: 317, 206, 355, 217 Annotation: Subtype: Link Rect: 361, 206, 397, 217 Annotation: Subtype: Link Rect: 173, 172, 210, 182 Annotation: Subtype: Link Rect: 59, 138, 96, 148 Annotation: Subtype: Link Rect: 102, 138, 138, 148 Annotation: Subtype: Link Rect: 283, 114, 320, 125 Annotation: Subtype: Link Rect: 326, 114, 362, 125 Annotation: Subtype: Link Rect: 447, 103, 485, 113 Annotation: Subtype: Link Rect: 396, 79, 434, 90 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 192, 724, 229, 735 Annotation: Subtype: Link Rect: 236, 724, 272, 735 Annotation: Subtype: Link Rect: 342, 701, 380, 712 Annotation: Subtype: Link Rect: 159, 678, 197, 689 Annotation: Subtype: Link Rect: 140, 655, 177, 665 Annotation: Subtype: Link Rect: 511, 631, 549, 642 Annotation: Subtype: Link Rect: 307, 608, 344, 619 Annotation: Subtype: Link Rect: 209, 586, 246, 596 Annotation: Subtype: Link Rect: 217, 562, 254, 573 Annotation: Subtype: Link Rect: 187, 528, 225, 539 Annotation: Subtype: Link Rect: 237, 482, 274, 493 Annotation: Subtype: Link Rect: 296, 459, 334, 470 Annotation: Subtype: Link Rect: 230, 436, 267, 447 Annotation: Subtype: Link Rect: 429, 413, 467, 424 Annotation: Subtype: Link Rect: 187, 378, 225, 389 Annotation: Subtype: Link Rect: 140, 356, 177, 366 Annotation: Subtype: Link Rect: 369, 332, 407, 343 Annotation: Subtype: Link Rect: 376, 309, 413, 320 Annotation: Subtype: Link Rect: 273, 286, 311, 297 Annotation: Subtype: Link Rect: 277, 263, 314, 274 Annotation: Subtype: Link Rect: 342, 240, 379, 251 Annotation: Subtype: Link Rect: 491, 217, 529, 228 Annotation: Subtype: Link Rect: 353, 194, 390, 205 Annotation: Subtype: Link Rect: 95, 161, 133, 171 Annotation: Subtype: Link Rect: 468, 148, 505, 159 Annotation: Subtype: Link Rect: 369, 102, 407, 113 Annotation: Subtype: Link Rect: 487, 79, 524, 90 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 279, 724, 316, 735 Annotation: Subtype: Link Rect: 363, 701, 401, 712 Annotation: Subtype: Link Rect: 227, 678, 264, 689 Annotation: Subtype: Link Rect: 178, 655, 215, 665 Annotation: Subtype: Link Rect: 59, 621, 96, 631 Annotation: Subtype: Link Rect: 59, 598, 96, 608 Annotation: Subtype: Link Rect: 450, 585, 488, 596 Annotation: Subtype: Link Rect: 273, 562, 311, 573 Annotation: Subtype: Link Rect: 104, 540, 142, 550 Annotation: Subtype: Link Rect: 118, 506, 155, 516 Annotation: Subtype: Link Rect: 441, 470, 478, 481 Annotation: Subtype: Link Rect: 449, 459, 487, 470 Annotation: Subtype: Link Rect: 287, 424, 325, 435 Annotation: Subtype: Link Rect: 486, 401, 523, 412 Annotation: Subtype: Link Rect: 135, 368, 173, 378 Annotation: Subtype: Link Rect: 59, 333, 96, 343 Annotation: Subtype: Link Rect: 102, 333, 138, 343 Annotation: Subtype: Link Rect: 295, 309, 333, 320 Annotation: Subtype: Link Rect: 349, 286, 387, 297 Annotation: Subtype: Link Rect: 189, 263, 227, 274 Annotation: Subtype: Link Rect: 250, 240, 288, 251 Annotation: Subtype: Link Rect: 502, 217, 539, 228 Annotation: Subtype: Link Rect: 519, 194, 557, 205 Annotation: Subtype: Link Rect: 236, 172, 274, 182 Annotation: Subtype: Link Rect: 187, 137, 225, 148 Annotation: Subtype: Link Rect: 178, 114, 216, 125 Annotation: Subtype: Link Rect: 445, 102, 483, 113 Annotation: Subtype: Link Rect: 489, 102, 525, 113 Annotation: Subtype: Link Rect: 104, 80, 141, 90 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 363, 724, 401, 735 Annotation: Subtype: Link Rect: 407, 724, 443, 735 Annotation: Subtype: Link Rect: 59, 701, 96, 712 Annotation: Subtype: Link Rect: 102, 701, 138, 712 Annotation: Subtype: Link Rect: 237, 678, 275, 689 Annotation: Subtype: Link Rect: 456, 654, 493, 665 Annotation: Subtype: Link Rect: 464, 631, 501, 642 Annotation: Subtype: Link Rect: 59, 609, 96, 619 Annotation: Subtype: Link Rect: 479, 585, 517, 596 Annotation: Subtype: Link Rect: 362, 562, 400, 573 Annotation: Subtype: Link Rect: 406, 562, 442, 573 Annotation: Subtype: Link Rect: 104, 540, 142, 550 Annotation: Subtype: Link Rect: 104, 517, 141, 527 Annotation: Subtype: Link Rect: 272, 494, 309, 504 Annotation: Subtype: Link Rect: 236, 470, 273, 481 Annotation: Subtype: Link Rect: 279, 470, 316, 481 Annotation: Subtype: Link Rect: 59, 437, 96, 447 Annotation: Subtype: Link Rect: 102, 437, 138, 447 Annotation: Subtype: Link Rect: 187, 413, 225, 424 Annotation: Subtype: Link Rect: 231, 413, 267, 424 Annotation: Subtype: Link Rect: 427, 390, 464, 401 Annotation: Subtype: Link Rect: 471, 390, 507, 401 Annotation: Subtype: Link Rect: 59, 356, 96, 366 Annotation: Subtype: Link Rect: 192, 332, 229, 343 Annotation: Subtype: Link Rect: 283, 309, 320, 320 Annotation: Subtype: Link Rect: 59, 276, 96, 286 Annotation: Subtype: Link Rect: 520, 252, 557, 263 Annotation: Subtype: Link Rect: 59, 241, 95, 251 Annotation: Subtype: Link Rect: 519, 217, 557, 228 Annotation: Subtype: Link Rect: 59, 207, 95, 217 Annotation: Subtype: Link Rect: 95, 172, 133, 182 Annotation: Subtype: Link Rect: 353, 148, 391, 159 Annotation: Subtype: Link Rect: 280, 125, 318, 136 Annotation: Subtype: Link Rect: 261, 91, 299, 102 Annotation: Subtype: Link Rect: 305, 91, 341, 102 Checksum: 74e306c9 Type: CRC32 Checksum: 54267ee45132f460333a8134b328af42 Type: MD5 Checksum: 74fc4350f16be29308e3f0c59744c1e5c0db89cd Type: SHA-1