9b65c834cfc840272970a45037192c8b pmc_35071266.pdf 996750e26609a08c431d3d2c4110ce0c80e4d2b7 pmc_35071266.pdf 9856ce5ebe847d7e174c030b4473e202474619fdd1b0475ee6120026260d1786 pmc_35071266.pdf Title: A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL): Study Protocol and Patient Recruitment Subject: Background: In an earlier monocentric study, we have developed a novel non-invasive test system for the prediction of renal allograft rejection, based on the detection of a specific urine metabolite constellation. Keywords: kidney transplant rejection, urinary metabolites, biomarker, NMR-spectroscopy, non-invasive test Author: Miriam C. Banas Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Jan 3 08:04:08 2022 CET ModDate: Mon Jan 3 11:05:51 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1342305 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BYTBZJ+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 35 0 HXBJIY+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 40 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 53 0 QPXMYB+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 55 0 QSPWDR+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 60 0 KCSHBU+MTSY Type 1C Custom yes yes yes 62 0 XZCQYH+MinionPro-Regular Type 1C Custom yes yes no 70 0 ETFRIA+MinionPro-It Type 1C Custom yes yes no 78 0 YKOOCS+MinionPro-Bold Type 1C Custom yes yes no 81 0 CVSDCX+MTSYB Type 1C Custom yes yes no 103 0 IAAFVL+RMTMI Type 1C WinAnsi yes yes no 105 0 IOLGNI+MTGU Type 1C Custom yes yes no 108 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-19 02:41:07 CEST RepresentationInformation: pmc_35071266.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-31 03:33:17 CET Size: 1342305 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 299 FreeObjects: 18 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARA匀伀䰀㨀 匀琀甀搀礀 倀爀漀琀漀挀漀氀 愀渀搀 倀愀琀椀攀渀琀 刀攀挀爀甀椀琀洀攀渀琩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㈷‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㌯䅣瑩潮⽇潔漯偲敶′㘠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Kidney Biopsies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: NMR-Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Statistical Analysis Strategy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Sample Size Estimation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Primary Endpoint Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Secondary Endpoint Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Distribution of Banff Categories Within Case (Rejection), Control, and Additional Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Type of Renal Allograft Rejections Dependent From Time After Transplantation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Detection of Donor-Specific Antibodies (DSA) Dependent on Sample Classification and Banff Categories Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Distribution of Chronic Kidney Disease (CKD) Stages Among Status, Time After Renal Transplantation, and Recipient Age Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL): Study Protocol and Patient Recruitment Author: Miriam C. Banas Subject: Background: In an earlier monocentric study, we have developed a novel non-invasive test system for the prediction of renal allograft rejection, based on the detection of a specific urine metabolite constellation. 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Miriam C. 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