e400ff79e2c6e378b32e219e415d8d01 jouinobio_a2022m10v235p111932.pdf 0e67d297b25ce2289726f6e19173e7eda02a07a5 jouinobio_a2022m10v235p111932.pdf 5f293b2422672380e7e4310993a4dd92a9237a18771adc40d064e00cf09a24c8 jouinobio_a2022m10v235p111932.pdf Title: Solution chemical properties and anticancer potential of 8-hydroxyquinoline hydrazones and their oxidovanadium(IV) complexes Subject: Journal of Inorganic Biochemistry, 235 (2022) 111932. doi:10.1016/j.jinorgbio.2022.111932 Keywords: Oxidovanadium(IV) complexes,8-hydroxyquinoline derivatives,Schiff bases,Solution stability,Speciation,Anticancer Author: Nádia Ribeiro Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Oct 10 18:41:01 2022 CEST ModDate: Tue Oct 11 12:01:07 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 5513979 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID 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complexes Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Experimental part Destination: mk:H1_2 Children: Item: Title: 2.1 Materials and methods Destination: mk:H2_1 Item: Title: 2.2 Synthesis of the 8-hydroxyquinoline hydrazones (L1 L6) Destination: mk:H2_2 Item: Title: 2.3 Synthesis of the oxidovanadium(IV) complexes Destination: mk:H2_3 Item: Title: 2.4 UV Vis spectrophotometric measurements, solubility and lipophilicity assays Destination: mk:H2_4 Item: Title: 2.5 EPR spectroscopy measurements Destination: mk:H2_5 Item: Title: 2.6 DFT calculations Destination: mk:H2_6 Item: Title: 2.7 Agarose gel electrophoresis for complex/DNA interactions Destination: mk:H2_7 Item: Title: 2.8 Cell culture and cytotoxicity experiments Destination: mk:H2_8 Children: Item: Title: 2.8.1 Culture conditions Destination: mk:H3_9 Item: Title: 2.8.2 Sulforhodamine B (SRB) assay Destination: mk:H3_10 Item: Title: 2.9 Flow cytometry analyses Destination: mk:H2_11 Children: Item: Title: 2.9.1 Annexin V staining Destination: mk:H3_12 Item: Title: 2.9.2 Caspase 3/7 staining Destination: mk:H3_13 Item: Title: 2.9.3 ɣH2AX staining Destination: mk:H3_14 Item: Title: 2.9.4 ROS activation Destination: mk:H3_15 Item: Title: 3 Results and discussion Destination: mk:H1_3 Children: Item: Title: 3.1 Synthesis and characterization of the 8-hydroxyquinoline hydrazones Destination: mk:H2_16 Item: Title: 3.2 Proton dissociation processes, lipophilicity and solubility of the ligand precursors Destination: mk:H2_17 Item: Title: 3.3 Synthesis and characterization of the oxidovanadium(IV) complexes Destination: mk:H2_18 Item: Title: 3.4 Stability of the oxidovanadium(IV) complexes in solution Destination: mk:H2_19 Item: Title: 3.5 Coordination modes of the ligands Destination: mk:H2_20 Item: Title: 3.6 EPR spectroscopy and DFT calculations Destination: mk:H2_21 Item: Title: 3.7 Interaction with biomolecules Destination: mk:H2_22 Item: Title: 3.8 Cytotoxicity Destination: mk:H2_23 Item: Title: 3.9 Mechanisms of cell death Destination: mk:H2_24 Item: Title: 3.10 DNA damage in cells Destination: mk:H2_25 Item: Title: 4 Conclusions Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of Competing Interest Destination: mk:HH1_3 Item: Title: Data availability Destination: datalink4 Item: Title: Acknowledgements Destination: mk:HH1_5 Item: Title: Appendix A Supplementary data Destination: mk:H1_6 Item: Title: References Destination: mk:HH2_1 Info: Title: Solution chemical properties and anticancer potential of 8-hydroxyquinoline hydrazones and their oxidovanadium(IV) complexes Author: Nádia Ribeiro Subject: Journal of Inorganic Biochemistry, 235 (2022) 111932. doi:10.1016/j.jinorgbio.2022.111932 Keywords: Oxidovanadium(IV) complexes,8-hydroxyquinoline derivatives,Schiff bases,Solution stability,Speciation,Anticancer Creator: Elsevier Producer: Acrobat Distiller 8.1.0 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Journal of Inorganic Biochemistry, 235 (2022) 111932. doi:10.1016/j.jinorgbio.2022.111932 Oxidovanadium(IV) complexes 8-hydroxyquinoline derivatives Schiff bases Solution stability Speciation Anticancer Solution chemical properties and anticancer potential of 8-hydroxyquinoline hydrazones and their oxidovanadium(IV) complexes Nádia Ribeiro Ipek Bulut Vivien Pósa Baris Sergi Giuseppe Sciortino João Costa Pessoa Luisa B. Maia Valeria Ugone Eugenio Garribba Éva A. Enyedy Ceyda Acilan Isabel Correia VoR 11th October 2022 Acrobat Distiller 8.1.0 (Windows) Oxidovanadium(IV) complexes,8-hydroxyquinoline derivatives,Schiff bases,Solution stability,Speciation,Anticancer 11th October 2022 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.jinorgbio.2022.111932 noindex journal © 2022 The Authors. 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