da9e9279ab5463abab0390da1cfd9eb0  Novel_cannabinoid..._2022.pdf
66bd73479dc4df3a52fb84b97622cb30bd459cd6  Novel_cannabinoid..._2022.pdf
de72d5d48ec118e099a1b667e052226b34889f332f4ab42134721aa5c3718dca  Novel_cannabinoid..._2022.pdf

Title:          Novel cannabinoid release system: Encapsulation of a cannabidiol precursor into γ-cyclodextrin metal-organic frameworks
Subject:        Journal of Drug Delivery Science and Technology, 79 (2023) 104085. doi:10.1016/j.jddst.2022.104085
Keywords:       γ-Cyclodextrin-metal-organic frameworks (γ-CD-MOFs),Cannabidiol (CBD),Cannabinoids,Drug delivery systems (DDS),Olivetol (OLV)
Author:         Jorge Rodríguez-Martínez
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   17th December 2022
ModDate:        Sat Dec 17 13:11:41 2022 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      3139672 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
METFMR+CharisSIL                     CID TrueType      Identity-H       yes yes yes    647  0
LIHPHR+STIX-Regular                  Type 1C           Custom           yes yes yes    650  0
TQYHIS+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    653  0
KCDNSV+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    656  0
WTQBYS+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    658  0
HTHNSB+Univers                       Type 1C           Builtin          yes yes yes    660  0
SRCINO+CharisSIL                     CID TrueType      Identity-H       yes yes yes    665  0
QHKTMR+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes     75  0
RTSPKB+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes     81  0
QWGUJN+STIX-Italic                   Type 1C           Custom           yes yes yes     83  0
JFWGXU+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     88  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-01-12 02:30:23 CET
 RepresentationInformation: Novel_cannabinoid..._2022.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-12-26 01:39:44 CET
  Size: 3139672
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   Offset: 3130472
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Novel cannabinoid release system: Encapsulation of a cannabidiol precursor into γ-cyclodextrin metal-organic frameworks
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: 2 Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
        Children: 
         Item: 
          Title: 2.1 Reagents
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
         Item: 
          Title: 2.2 Preparation of the samples
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
         Item: 
          Title: 2.3 Drug release and quantification
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
         Item: 
          Title: 2.4 Scanning electron microscope and energy-dispersive X-ray spectroscopy
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: 2.5 X-ray powder diffraction analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: 2.6 Attenuated total reflection-fourier transform Infrared Spectroscopy analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: 3 Results and discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
        Children: 
         Item: 
          Title: 3.1 Structural properties of γ-CD-MOFs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
         Item: 
          Title: 3.2 Reaction synthesis yield and olivetol content in γ-CD-MOFs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
         Item: 
          Title: 3.3 Characterization of γ-CD-MOFs and olivetol interaction: ATR-FTIR analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
       Item: 
        Title: 4 Conclusions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
       Item: 
        Title: Author statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
       Item: 
        Title: Declaration of competing interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
       Item: 
        Title: Data availability
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
       Item: 
        Title: Appendix A Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: KCDNSV+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: METFMR+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: JFWGXU+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TQYHIS+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: WTQBYS+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: WTQBYS+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: QWGUJN+STIX-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 30
      FontDescriptor: 
       FontName: QWGUJN+STIX-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HTHNSB+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: HTHNSB+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: LIHPHR+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 14
      FontDescriptor: 
       FontName: LIHPHR+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QHKTMR+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: QHKTMR+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: METFMR+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: METFMR+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: JFWGXU+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: JFWGXU+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: TQYHIS+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TQYHIS+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: KCDNSV+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: KCDNSV+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 8.0-c001 79.328f76e, 2022/08/01-19:10:29        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jddst.2022.104085</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.jddst.2022.104085</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Drug Delivery Science and Technology, 79 (2023) 104085. doi:10.1016/j.jddst.2022.104085</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>γ-Cyclodextrin-metal-organic frameworks (γ-CD-MOFs)</rdf:li>
               <rdf:li>Cannabidiol (CBD)</rdf:li>
               <rdf:li>Cannabinoids</rdf:li>
               <rdf:li>Drug delivery systems (DDS)</rdf:li>
               <rdf:li>Olivetol (OLV)</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Novel cannabinoid release system: Encapsulation of a cannabidiol precursor into γ-cyclodextrin metal-organic frameworks</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Jorge Rodríguez-Martínez</rdf:li>
               <rdf:li>María-Jesús Sánchez-Martín</rdf:li>
               <rdf:li>Oscar López-Patarroyo</rdf:li>
               <rdf:li>Manuel Valiente</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <pdf:CreationDate--Text>17th December 2022</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>γ-Cyclodextrin-metal-organic frameworks (γ-CD-MOFs),Cannabidiol (CBD),Cannabinoids,Drug delivery systems (DDS),Olivetol (OLV)</pdf:Keywords>
         <pdfx:CreationDate--Text>17th December 2022</pdfx:CreationDate--Text>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:doi>10.1016/j.jddst.2022.104085</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>© 2022 The Authors. Published by Elsevier B.V.</prism:copyright>
         <prism:coverDate>2023-01-01</prism:coverDate>
         <prism:coverDisplayDate>1 January 2023</prism:coverDisplayDate>
         <prism:doi>10.1016/j.jddst.2022.104085</prism:doi>
         <prism:issn>1773-2247</prism:issn>
         <prism:pageRange>104085</prism:pageRange>
         <prism:publicationName>Journal of Drug Delivery Science and Technology</prism:publicationName>
         <prism:startingPage>104085</prism:startingPage>
         <prism:url>https://doi.org/10.1016/j.jddst.2022.104085</prism:url>
         <prism:volume>79</prism:volume>
         <xmp:CreateDate>2022-12-17T08:09:43</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:MetadataDate>2022-12-17T13:11:41+01:00</xmp:MetadataDate>
         <xmp:ModifyDate>2022-12-17T13:11:41+01:00</xmp:ModifyDate>
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:28f8d3fc-5d8e-294d-ad82-94d852c23806</xmpMM:InstanceID>
         <xmpRights:Marked>True</xmpRights:Marked>
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 161, 571, 305, 582
       Flags: Print
       Destination: 603
      Annotation: 
       Subtype: Link
       Rect: 305, 579, 309, 584
       Flags: Print
       Destination: 603
      Annotation: 
       Subtype: Link
       Rect: 305, 576, 311, 587
       Flags: Print
       Destination: 603
      Annotation: 
       Subtype: Link
       Rect: 312, 571, 432, 582
       Flags: Print
       Destination: 603
      Annotation: 
       Subtype: Link
       Rect: 126, 294, 131, 302
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 133, 294, 138, 302
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 127, 273, 131, 281
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 182, 241, 187, 249
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 67, 210, 71, 218
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 186, 168, 190, 176
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 521, 294, 525, 302
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 507, 273, 511, 281
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 514, 273, 518, 281
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 412, 241, 421, 249
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 384, 200, 393, 208
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 337, 158, 346, 166
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 348, 158, 357, 166
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 98, 114, 188, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 278, 667, 393, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 182, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 188, 748, 406, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 425, 59, 557, 70
      Annotation: 
       Subtype: Link
       Rect: 37, 49, 72, 61
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 274, 720, 283, 728
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 92, 678, 101, 686
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 103, 678, 112, 686
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 92, 626, 101, 634
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 82, 563, 91, 571
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 227, 500, 236, 508
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 274, 458, 283, 466
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 66, 427, 75, 435
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 77, 427, 86, 435
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 72, 396, 81, 404
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 65, 364, 74, 372
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 65, 333, 74, 341
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 178, 302, 187, 309
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 238, 260, 247, 268
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 40, 218, 49, 226
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 234, 155, 243, 163
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 230, 124, 239, 132
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 40, 103, 49, 111
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 430, 458, 435, 466
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 458, 437, 467, 445
       Flags: Print
       Destination: 29
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 437, 71, 445
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 247, 396, 275, 404
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 37, 364, 48, 372
       Flags: Print
       Destination: 5
      Annotation: 
       Subtype: Link
       Rect: 341, 458, 362, 466
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 377, 458, 386, 466
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 418, 426, 445, 434
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 346, 395, 380, 403
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 458, 364, 487, 372
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 392, 301, 411, 309
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 371, 217, 376, 225
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 543, 165, 552, 173
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 543, 81, 552, 89
       Flags: Print
       Destination: 33
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 104, 427, 138, 435
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 223, 343, 232, 351
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 269, 322, 288, 330
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 52, 312, 78, 320
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 40, 249, 60, 257
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 108, 218, 117, 226
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 203, 197, 212, 205
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 249, 134, 268, 142
       Flags: Print
       Destination: 9
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 730, 283, 738
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 173, 636, 182, 644
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 232, 615, 236, 623
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 238, 615, 247, 623
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 88, 485, 93, 493
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 185, 433, 194, 441
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 143, 328, 152, 336
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 154, 328, 163, 336
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 231, 307, 259, 315
       Flags: Print
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 149, 286, 158, 294
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 185, 202, 205, 210
       Flags: Print
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 497, 444, 518, 452
       Flags: Print
       Destination: 17
      Annotation: 
       Subtype: Link
       Rect: 356, 370, 364, 378
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 367, 370, 376, 378
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 378, 370, 387, 378
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 410, 238, 431, 246
       Flags: Print
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 480, 228, 489, 236
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 491, 228, 513, 236
       Flags: Print
       Destination: 33
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 129, 163, 137
       Flags: Print
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 178, 129, 200, 137
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 489, 87, 508, 95
       Flags: Print
       Destination: 23
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 720, 122, 728
       Flags: Print
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 150, 584, 159, 592
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 235, 553, 244, 561
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 82, 479, 91, 487
       Flags: Print
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 516, 491, 557, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 481, 426, 489
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 380, 417, 499, 423
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 483, 393, 555, 399
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 385, 386, 391
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 353, 458, 359
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 522, 337, 555, 343
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 329, 411, 336
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 455, 305, 527, 312
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 297, 368, 304
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 372, 265, 507, 272
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 459, 241, 554, 248
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 233, 359, 240
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 358, 218, 484, 224
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 522, 194, 555, 200
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 186, 418, 192
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 377, 154, 502, 160
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 473, 138, 544, 144
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 130, 353, 136
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 427, 98, 503, 104
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 90, 390, 96
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 386, 66, 527, 73
       Flags: Print
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 150, 732, 276, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 724, 83, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 163, 700, 284, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 176, 676, 252, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 668, 111, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 264, 644, 286, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 636, 174, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 102, 604, 238, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 264, 580, 286, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 572, 215, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 252, 557, 285, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 549, 135, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 196, 533, 268, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 525, 91, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 137, 493, 275, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 104, 477, 217, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 445, 200, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 240, 429, 285, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 421, 145, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 214, 389, 286, 396
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 381, 123, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 82, 349, 209, 356
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 77, 317, 203, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 114, 301, 216, 308
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 104, 278, 247, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 401, 700, 527, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 519, 684, 552, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 434, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 460, 652, 531, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 356, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 503, 620, 548, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 612, 383, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 517, 596, 550, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 588, 405, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 557, 423, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 432, 541, 514, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 533, 374, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 382, 501, 525, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 406, 477, 526, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 358, 453, 464, 459
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 429, 545, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 421, 404, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 522, 405, 555, 411
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 397, 419, 403
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 451, 373, 522, 380
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 365, 380, 372
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 380, 341, 494, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 333, 555, 340
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 325, 483, 332
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 473, 301, 549, 308
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 294, 388, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 385, 270, 538, 276
       Flags: Print
  Checksum: 9db155fa
   Type: CRC32
  Checksum: da9e9279ab5463abab0390da1cfd9eb0
   Type: MD5
  Checksum: 66bd73479dc4df3a52fb84b97622cb30bd459cd6
   Type: SHA-1