def663396a59796f2591714fec1dc3bf nutrients_14_05084_v2.pdf 198e4f022c4dbc578b5556b44e890e49d7f39418 nutrients_14_05084_v2.pdf be63ab604d8d4f08c2b4be8e50d8dbebcef6b3a949ddde7e783568f40a46bc69 nutrients_14_05084_v2.pdf Title: Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study Subject: Gambling disorder (GD) is a modestly prevalent and severe condition for which neurobiology is not yet fully understood. Although alterations in signals involved in energy homeostasis have been studied in substance use disorders, they have yet to be examined in detail in GD. The aims of the present study were to compare different endocrine and neuropsychological factors between individuals with GD and healthy controls (HC) and to explore endocrine interactions with neuropsychological and clinical variables. A case–control design was performed in 297 individuals with GD and 41 individuals without (healthy controls; HCs), assessed through a semi-structured clinical interview and a psychometric battery. For the evaluation of endocrine and anthropometric variables, 38 HCs were added to the 41 HCs initially evaluated. Individuals with GD presented higher fasting plasma ghrelin (p < 0.001) and lower LEAP2 and adiponectin concentrations (p < 0.001) than HCs, after adjusting for body mass index (BMI). The GD group reported higher cognitive impairment regarding cognitive flexibility and decision-making strategies, a worse psychological state, higher impulsivity levels, and a more dysfunctional personality profile. Despite failing to find significant associations between endocrine factors and either neuropsychological or clinical aspects in the GD group, some impaired cognitive dimensions (i.e., WAIS Vocabulary test and WCST Perseverative errors) and lower LEAP2 concentrations statistically predicted GD presence. The findings from the present study suggest that distinctive neuropsychological and endocrine dysfunctions may operate in individuals with GD and predict GD presence. Further exploration of endophenotypic vulnerability pathways in GD appear warranted, especially with respect to etiological and therapeutic potentials. Keywords: gambling disorder; addictive behavior; impulsive–compulsive behavior; gut hormones; adipocytokines; neuropsychology Author: Mikel Etxandi, Isabel Baenas, Bernat Mora-Maltas, Roser Granero, Fernando Fernández-Aranda, Sulay Tovar, Neus Solé-Morata, Ignacio Lucas, Sabela Casado, Mónica Gómez-Peña, Laura Moragas, Amparo del Pino-Gutiérrez, Ester Codina, Eduardo Valenciano-Mendoza, Marc N. Potenza, Carlos Diéguez and Susana Jiménez-Murcia Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 1 10:37:04 2022 CET ModDate: Thu Dec 1 10:40:34 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 824268 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZZTQUO+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 DLUKEC+VnURWPalladioL Type 1 Custom yes yes no 15 0 YYGLAJ+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 PIUZHO+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 XUYTWY+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 XYPWHM+CMSY10 Type 1 Builtin yes yes no 74 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 81 0 FAECIJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 88 0 PCOKFJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 102 0 PCOKFK+PalatinoLinotype CID TrueType Identity-H yes yes yes 105 0 PCOKFL+PalatinoLinotype TrueType WinAnsi yes yes no 111 0 PCOKGN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 114 0 PCOMHD+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 117 0 PCOOIM+Symbol Type 1C Custom yes yes yes 128 0 PCOOGJ+ArialNarrow,Bold TrueType WinAnsi yes yes no 133 0 PCOOGK+Arial CID TrueType Identity-H yes yes yes 136 0 PCOOHL+Arial,Bold CID TrueType Identity-H yes yes yes 142 0 PCOKFJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 148 0 PCOKFK+PalatinoLinotype CID TrueType Identity-H yes yes yes 151 0 PCOKFL+PalatinoLinotype TrueType WinAnsi yes yes no 157 0 PCOKGN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 160 0 JPKROM+VnURWPalladioL-Italic Type 1 Custom yes yes no 188 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-24 02:29:14 CEST RepresentationInformation: nutrients_14_05084_v2.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-13 01:34:22 CEST Size: 824268 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 483 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Hormonal Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Neuropsychological Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Clinical Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Other Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Comparison of Endocrine Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Comparison of Neuropsychological and Clinical Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Associations between Endocrine Variables and Neuropsychological and Clinical Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Predictive Model for GD Presence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Info: Title: Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case Control Study Author: Mikel Etxandi, Isabel Baenas, Bernat Mora-Maltas, Roser Granero, Fernando Fernández-Aranda, Sulay Tovar, Neus Solé-Morata, Ignacio Lucas, Sabela Casado, Mónica Gómez-Peña, Laura Moragas, Amparo del Pino-Gutiérrez, Ester Codina, Eduardo Valenciano-Mendoza, Marc N. Potenza, Carlos Diéguez and Susana Jiménez-Murcia Subject: Gambling disorder (GD) is a modestly prevalent and severe condition for which neurobiology is not yet fully understood. Although alterations in signals involved in energy homeostasis have been studied in substance use disorders, they have yet to be examined in detail in GD. The aims of the present study were to compare different endocrine and neuropsychological factors between individuals with GD and healthy controls (HC) and to explore endocrine interactions with neuropsychological and clinical variables. A case control design was performed in 297 individuals with GD and 41 individuals without (healthy controls; HCs), assessed through a semi-structured clinical interview and a psychometric battery. For the evaluation of endocrine and anthropometric variables, 38 HCs were added to the 41 HCs initially evaluated. Individuals with GD presented higher fasting plasma ghrelin (p < 0.001) and lower LEAP2 and adiponectin concentrations (p < 0.001) than HCs, after adjusting for body mass index (BMI). The GD group reported higher cognitive impairment regarding cognitive flexibility and decision-making strategies, a worse psychological state, higher impulsivity levels, and a more dysfunctional personality profile. Despite failing to find significant associations between endocrine factors and either neuropsychological or clinical aspects in the GD group, some impaired cognitive dimensions (i.e., WAIS Vocabulary test and WCST Perseverative errors) and lower LEAP2 concentrations statistically predicted GD presence. The findings from the present study suggest that distinctive neuropsychological and endocrine dysfunctions may operate in individuals with GD and predict GD presence. Further exploration of endophenotypic vulnerability pathways in GD appear warranted, especially with respect to etiological and therapeutic potentials. 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426, 66, 464, 77 Annotation: Subtype: Link Rect: 470, 66, 506, 77 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 236, 722, 273, 733 Annotation: Subtype: Link Rect: 59, 688, 96, 698 Annotation: Subtype: Link Rect: 232, 652, 269, 664 Annotation: Subtype: Link Rect: 109, 619, 146, 629 Annotation: Subtype: Link Rect: 318, 595, 355, 606 Annotation: Subtype: Link Rect: 473, 572, 511, 583 Annotation: Subtype: Link Rect: 313, 537, 350, 548 Annotation: Subtype: Link Rect: 59, 481, 96, 491 Annotation: Subtype: Link Rect: 102, 481, 138, 491 Checksum: 5962ba41 Type: CRC32 Checksum: def663396a59796f2591714fec1dc3bf Type: MD5 Checksum: 198e4f022c4dbc578b5556b44e890e49d7f39418 Type: SHA-1