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false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Language: en-US Outlines: Item: Title: Dupilumab reduced impact of severe exacerbations on lung function in patients with moderate-­to-­severe type 2 asthma Children: Item: Title: Abstract Item: Title: 1|INTRODUCTION Item: Title: 2|METHODS Children: Item: Title: 2.1|Study design Item: Title: 2.2|Patients Item: Title: 2.3|Endpoints Item: Title: 2.4|Statistical analysis Item: Title: 3|RESULTS Children: Item: Title: 3.1|Change in pre-­ and post-­BD FEV1 Item: Title: 3.2|Smoking history Item: Title: 3.3|Change from baseline in post-­BD FEV1 after onset of the first exacerbation Item: Title: 3.4|Change from baseline in ACQ-­5 scores Item: Title: 4|DISCUSSION Item: Title: AUTHOR CONTRIBUTIONS Item: Title: ACKNOWLEDGMENTS Item: Title: CONFLICT OF 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