209e6b11bedcaab83642eff70ded7189 pmc_10804447.pdf b2bafd18d7157af4a2b1d932fe110e29a611f980 pmc_10804447.pdf 81e7fc2ab09504bcfe1e95fdc4566ba0098ffebc1ce6be97f5efd1d84ad0414e pmc_10804447.pdf Title: Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy Keywords: dilated cardiomyopathy, genetics, genotype, predictor, genetic variant Author: Luis Escobar-Lopez, Juan Pablo Ochoa, Ana Royuela, Job A.J. Verdonschot, Matteo Dal Ferro, Maria Angeles Espinosa, Maria Sabater-Molina, Maria Gallego-Delgado, Jose M. Larrañaga-Moreira, Jose M. Garcia-Pinilla, Maria Teresa Basurte-Elorz, José F. Rodríguez-Palomares, Vicente Climent, Francisco J. Bermudez-Jimenez, María Victoria Mogollón-Jiménez, Javier Lopez, Maria Luisa Peña-Peña, Ana Garcia-Alvarez, Bernardo López-Abel, Tomas Ripoll-Vera, Julian Palomino-Doza, Antoni Bayes-Genis, Ramon Brugada, Uxua Idiazabal, Jesus G. Mirelis, Fernando Dominguez, Michiel T.H.M. Henkens, Ingrid P.C. Krapels, Han G. Brunner, Alessia Paldino, Denise Zaffalon, Luisa Mestroni, Gianfranco Sinagra, Stephane R.B. Heymans, Marco Merlo, Pablo Garcia-Pavia Creator: Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) Producer: Antenna House PDF Output Library 7.3.1863 CreationDate: Tue Jan 23 16:44:32 2024 CET ModDate: Tue Jan 23 16:44:32 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 26 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 915976 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica-Bold Type 1 Custom no no yes 11 0 Helvetica Type 1 Custom no no yes 14 0 Times-Roman Type 1 Custom no no yes 68 0 Times-Bold Type 1 Custom no no yes 77 0 Times-BoldItalic Type 1 Standard no no no 592 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-08 02:47:52 CEST RepresentationInformation: pmc_10804447.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-30 02:39:31 CEST Size: 915976 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 662 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: METHODS Children: Item: Title: STUDY POPULATION: DERIVATION AND VALIDATION COHORTS. Item: Title: VARIANT CLASSIFICATION. Item: Title: CANDIDATE PREDICTOR VARIABLES. Item: Title: MODEL DEVELOPMENT AND INTERNAL VALIDATION. Item: Title: EXTERNAL VALIDATION. Item: Title: GENERAL STATISTICAL METHODS. Item: Title: RESULTS Children: Item: Title: CHARACTERISTICS OF THE DERIVATION COHORT. Item: Title: MODEL DEVELOPMENT AND INTERNAL VALIDATION. Item: Title: Model presentation. Item: Title: Internal validation. Item: Title: CHARACTERISTICS OF THE VALIDATION COHORT. Item: Title: External validation. Item: Title: Score performance. Item: Title: DISCUSSION Children: Item: Title: STUDY LIMITATIONS. Item: Title: CONCLUSIONS Item: Title: References Item: Title: FIGURE 1 Item: Title: FIGURE 2 Item: Title: CENTRAL ILLUSTRATION Item: Title: TABLE 1 Item: Title: TABLE 2 Item: Title: TABLE 3 Item: Title: TABLE 4 Item: Title: TABLE 5 Item: Title: TABLE 6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 152 ImageHeight: 152 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1424 ImageHeight: 2100 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1192 ImageHeight: 876 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1792 ImageHeight: 2100 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: Times-BoldItalic Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 143 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 132 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-Bold FirstChar: 32 LastChar: 128 FontDescriptor: FontName: Times-Bold Flags: Nonsymbolic FontBBox: -168, -218, 1000, 935 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica FirstChar: 32 LastChar: 137 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 EncodingDictionary: Differences: true ToUnicode: true XMP: 2024-01-23T10:44:32-05:00 2024-01-23T10:44:32-05:00 application/pdf Antenna House PDF Output Library 7.3.1863 dilated cardiomyopathy, genetics, genotype, predictor, genetic variant Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) 2024-01-23T10:44:32-05:00 Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy Luis Escobar-Lopez, Juan Pablo Ochoa, Ana Royuela, Job A.J. Verdonschot, Matteo Dal Ferro, Maria Angeles Espinosa, Maria Sabater-Molina, Maria Gallego-Delgado, Jose M. Larrañaga-Moreira, Jose M. Garcia-Pinilla, Maria Teresa Basurte-Elorz, José F. Rodríguez-Palomares, Vicente Climent, Francisco J. Bermudez-Jimenez, María Victoria Mogollón-Jiménez, Javier Lopez, Maria Luisa Peña-Peña, Ana Garcia-Alvarez, Bernardo López-Abel, Tomas Ripoll-Vera, Julian Palomino-Doza, Antoni Bayes-Genis, Ramon Brugada, Uxua Idiazabal, Jesus G. Mirelis, Fernando Dominguez, Michiel T.H.M. Henkens, Ingrid P.C. Krapels, Han G. Brunner, Alessia Paldino, Denise Zaffalon, Luisa Mestroni, Gianfranco Sinagra, Stephane R.B. 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