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      Title: Study protocol for a randomised, double-­blinded, placebo-­controlled phase III trial examining the add-­on efficacy, cost–utility and neurobiological effects of low-­dose naltrexone (LDN) in patients with fibromyalgia (INNOVA study)
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        Title: Abstract
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        Title: Introduction
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         Item: 
          Title: Fibromyalgia: definition, prevalence and pharmaceutical indications
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          Title: Pathogenesis of FMS
         Item: 
          Title: Low-dose naltrexone (LDN): a promising treatment for FMS
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        Title: Methods and analysis
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          Title: Trial design
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          Title: Sample size
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          Title: Eligibility criteria
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            Title: General selection criteria
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            Title: Additional selection criteria for the biomarkers and neuroimaging substudy (50% of patients in each study arm)
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          Title: Recruitment strategy, procedure and randomisation
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          Title: Data management, central monitoring and audit
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          Title: Treatments
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            Title: Low-dose naltrexone
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            Title: Placebo
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          Title: Ecological momentary assessment
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          Title: Inflammatory biomarkers
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          Title: Neuroimaging
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          Title: Statistical analysis
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          Title: Patient and public involvement
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        Title: Ethics and dissemination
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          Title: Trial status
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          Title: Confidentially
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  Checksum: f327829a
   Type: CRC32
  Checksum: b32a695d532ab972ecd96fa0328495fb
   Type: MD5
  Checksum: b36af33790d8fcb3f708911956116e9ed1672127
   Type: SHA-1