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Title:          A de novo paradigm for male infertility
Subject:        Nature Communications, doi:10.1038/s41467-021-27132-8
Keywords:       
Author:         M. S. Oud
Creator:        Springer
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      Title: A de novo paradigm for male infertility
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       Item: 
        Title: Results
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         Item: 
          Title: Discovery of de novo mutations in infertile male trios
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          Title: Intolerance analysis of genes with de novo loss-of-function mutations
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          Title: Missense intolerance in de novo mutation genes
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          Title: Protein–nobreakprotein interactions reveal link to mRNA splicing
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          Title: DNMs uncovering recessive disease and analysis of maternally inherited mutations
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          Title: Further analysis in additional cohorts of infertile males
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          Title: Phasing of de novo mutations to identify parent of origin
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       Item: 
        Title: Discussion
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       Item: 
        Title: Methods
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         Item: 
          Title: Cohort of infertile patients and fertile parent trios
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         Item: 
          Title: Immunofluorescence staining of human testis biopsies
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         Item: 
          Title: Cohort of verified fertile Dutch parents
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         Item: 
          Title: Exome sequencing
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         Item: 
          Title: Variant filtration and interpretation
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          Title: CNV analysis
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          Title: Variant validation
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         Item: 
          Title: Functional enrichment
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          Title: Additional cohorts of infertile men
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         Item: 
          Title: Burden testing
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          Title: Phasing analysis to determine parent-of-origin
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        Title: Reporting summary
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        Title: Data availability
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        Title: Code availability
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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        Title: Competing interests
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        Title: Additional information
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   Info: 
    Title: A de novo paradigm for male infertility
    Author: M. S. Oud
    Subject: Nature Communications, doi:10.1038/s41467-021-27132-8
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Dec 21 16:59:33 CET 2021
    ModDate: Tue Jan 04 20:15:27 CET 2022
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