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Custom yes yes no 980 0 SCENHJ+CMSY7 Type 1C Custom yes yes no 979 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-24 02:33:53 CET RepresentationInformation: pmc_35060899.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-31 03:34:36 CET Size: 1850854 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1138 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-­19 patients in an observational translational study Children: Item: Title: Abstract Item: Title: Editor's evaluation Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Study design Item: Title: SARS-CoV-2 detection and quantification Item: Title: Genotyping Item: Title: Blood sampling Item: Title: RNAseq Item: Title: Peripheral blood cell populations Item: Title: Inflammatory mediators Item: Title: Ex-vivo experiments Item: Title: Clinical trial simulations Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Study cohort Item: Title: IFIH1 rs1190760 variants and inflammatory response to SARS-CoV-2 Item: Title: Ex-vivo effects of dexamethasone in IFIH1 variants Item: Title: Impact of IFIH1 variants on outcomes in critically ill COVID-19 patients Item: Title: In-silico clinical trials Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Additional information Children: Item: Title: Funding Item: Title: Author contributions Item: Title: Author ORCIDs Item: Title: Ethics Item: Title: Decision letter and Author response Item: Title: Additional files Children: Item: Title: Supplementary files Children: Item: Title: In-silico clinical trials Item: Title: References Item: Title: Appendix 1 Children: Item: Title: Hazard ratio estimation and in-silico clinical trials Children: Item: Title: Estimation of hazard ratios from the RECOVERY trial Info: Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Jan 21 12:48:46 CET 2022 ModDate: Fri Jan 21 12:48:48 CET 2022 ID: 0x72b970107a21cf4b8617d0ba4e1c2e01, 0x5609d2e42a336046b65f5fbbcdb1af33 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 33 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 33 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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