4bc7523ca920c49e6c9d83f736568b53 pmc_35102215.pdf f55395c96ac6dc6f4d0f9aa6fbce37370a46ef44 pmc_35102215.pdf 622c0e818f90dc43ab14cee0f32451841b5554ef9f312fdbdd6a0b4bdeb538bc pmc_35102215.pdf Title: Metabolomics study of COVID-19 patients in four different clinical stages Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-05667-0 Author: Alberto Valdés Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jan 25 06:58:39 2022 CET ModDate: Tue Jan 25 16:10:06 2022 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3499699 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JOMEYR+Wingdings-Regular Type 1C WinAnsi yes yes yes 430 0 MinionPro-Regular Type 1C Custom yes no yes 43 0 QEDMPX+Corbel-Bold CID TrueType Identity-H yes yes yes 45 0 Corbel2 TrueType WinAnsi yes no yes 46 0 ADHZZD+Corbel CID TrueType Identity-H yes yes yes 47 0 Corbel3 CID TrueType Identity-H yes no yes 463 0 IGZNCN+Code2000 CID TrueType Identity-H yes yes yes 44 0 Corbel4 TrueType WinAnsi yes no yes 57 0 MinionPro-Bold Type 1C Custom yes no yes 70 0 MinionPro-It Type 1C Custom yes no yes 85 0 YTTZSH+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 246 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-07 04:30:06 CEST RepresentationInformation: pmc_35102215.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2022-02-07 03:34:35 CET Size: 3499699 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 503 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Metabolomics study of COVID-19 patients in four different clinical stages Children: Item: Title: Results Children: Item: Title: Metabolite identification. Item: Title: Analysis of samples at hospital admission. Item: Title: Follow up study of mild disease patients at hospital discharge. Item: Title: Discussion Item: Title: Conclusion Item: Title: Methods Children: Item: Title: Patient recruitment and sample obtention. Item: Title: Chemicals and reagents. Item: Title: Metabolite extraction. Item: Title: Reverse phase liquid chromatography-quadrupole-time of flight mass spectrometry (RPHPLC-qTOF MSMS) analysis. Item: Title: Quality control. Item: Title: Data processing. Item: Title: Data post-processing and statistical analysis. Item: Title: Data visualization, enrichment and pathway analysis. Item: Title: References Item: Title: Acknowledgements Info: Title: Metabolomics study of COVID-19 patients in four different clinical stages Author: Alberto Valdés Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-05667-0 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Jan 25 07:28:39 CET 2022 ModDate: Tue Jan 25 16:10:06 CET 2022 ID: 0xcc532496d85e95f4485650683ed02f35, 0xbc5bcbbf1988bd2510ebe9c9974b2b41 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 918 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 1276 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 1049 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: IGZNCN+Code2000 Encoding: Identity-H ToUnicode: true Font: BaseFont: QEDMPX+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: ADHZZD+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JOMEYR+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: JOMEYR+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: YTTZSH+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: YTTZSH+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: IGZNCN+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IGZNCN+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true Font: BaseFont: DQMOEX+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DQMOEX+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: QEDMPX+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QEDMPX+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2022-01-25T11:28:39+05:30 Springer 2022-01-25T16:10:06+01:00 2022-01-25T16:10:06+01:00 application/pdf https://doi.org/10.1038/s41598-022-05667-0 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-022-05667-0 Metabolomics study of COVID-19 patients in four different clinical stages Alberto Valdés Lorena Ortega Moreno Silvia Rojo Rello Antonio Orduña David Bernardo Alejandro Cifuentes 10.1038/s41598-022-05667-0 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-022-05667-0 10.1038/s41598-022-05667-0 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-022-05667-0 noindex springer.com springerlink.com VoR uuid:5e79b307-5d75-40be-b18c-bfe153243c7c uuid:3c4f0060-50e4-4ff4-805c-d408432d5010 default 1 converted uuid:5f04f750-6af6-46ea-962e-5db7a28bf401 converted to PDF/A-2b pdfToolbox 2022-01-25T11:29:26+05:30 converted uuid:4c4a0e79-5ba2-4ccc-a4d5-fceca4de6923 converted to PDF/A-2b pdfToolbox 2022-01-25T11:30:08+05:30 Adobe PDF Library 15.0; 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