1db5bb3e932c1bcef9e4909e16ec6741 pmc_35111166.pdf d4b4d3218ba8b48bcd35e80bf974f5f8a0996471 pmc_35111166.pdf 7aa945ebedfaf0726da583ffd367f6fc9454b54ab4e2a13be1cfbc2768b32cdb pmc_35111166.pdf Title: Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells Subject: Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS) Keywords: ANKRD55, IL6ST, sgp130, multiple sclerosis, autoimmune Author: Jorge Mena Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Jan 12 08:49:04 2022 CET ModDate: Wed Jan 12 11:19:13 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 8388953 bytes Optimized: no PDF version: 1.4 name type 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indirect destination - referenced object 'B27' cannot be found Offset: 8360055 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 8360055 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B46' cannot be found Offset: 8360055 MIMEtype: application/pdf PDFMetadata: Objects: 740 FreeObjects: 2 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Patients and Controls Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Peripheral Blood Mononuclear Cell Subpopulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Isolation of Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Sorting of Classical, Intermediate, and Non-Classical Monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Monocyte-Derived Dendritic Cell Differentiation and Maturation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: DNA Extraction, RNA Isolation, and cDNA Synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Primer Design, qPCR, Drop Digital PCR, and Genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: ANKRD55 and IL6ST Gene Expression Patterns in CD4+ T Cells and Monocyte-Derived Dendritic Cells of Multiple Sclerosis Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: ANKRD55 Is Expressed in Immature Monocyte-Derived Dendritic Cells and Induced by Retinoic Acid Receptor Alpha Agonist AM580 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: ANKRD55 Expression Is Downregulated in IFN-γ/LPS-Matured Monocyte-Derived Dendritic Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Multiple Sclerosis Risk Single-Nucleotide Polymorphisms Modulate the Expression of ANKRD55 and IL6ST in Immature Monocyte-Deri瘀攀搀 䐀攀渀搀爀椀琀椀挀 䌀攀氀氀猩㸾൥湤潢樍㜳㘠〠潢樼㰯偡牥湴‷㈱‰⁒⽎數琠㜳㔠〠刯䑥獴⣾＀猀㌀开㌩⽐牥瘠㜳㜠〠刯呩瑬攨ANKRD55 Expression Is Downregulated in IFN-γ/LPS-Matured Monocyte-Derived Dendritic Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: ANKRD55 and IL6ST Gene Expression Patterns in CD4+ T Cells and Monocyte-Derived Dendritic Cells of Multiple Sclerosis Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells Author: Jorge Mena Subject: Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS) Keywords: ANKRD55, IL6ST, sgp130, multiple sclerosis, autoimmune Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Jan 12 08:49:04 CET 2022 ModDate: Wed Jan 12 11:19:13 CET 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Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells Jorge Mena Iraide Alloza Raquel Tulloch Navarro Ane Aldekoa Javier D&iacute ez Garc&iacute a Ane Villanueva Etxebarria Cecilia Lindskog Alfredo Antigüedad Sabas Boyero Mar&iacute a del Mar Mendibe-Bilbao Amaya &Aacute lvarez de Arcaya José Luis Sánchez Menoyo Luciana Midaglia Noelia Villarrubia Sunny Malhotra Xavier Montalban Luisa Mar&iacute a Villar Manuel Comabella Koen Vandenbroeck Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS) ANKRD55 IL6ST sgp130 multiple sclerosis autoimmune uuid:1477fd99-8e46-45dc-87a3-f877216b4a35 uuid:5deb06bb-fe84-4ad4-ad87-efc5d7f935c9 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 601, 497, 622 Annotation: Subtype: Link Rect: 175, 578, 536, 599 Annotation: Subtype: Link Rect: 175, 555, 519, 576 Annotation: 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