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    Outlines: 
     Item: 
      Title: Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
      Children: 
       Item: 
        Title: Editor's evaluation
       Item: 
        Title: Introduction
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: 5-Fluorouracil + irinotecan treatment induces mucin production
         Item: 
          Title: The mucin regulator KChIP3 is a risk factor for CRC with high MUC5AC expression
         Item: 
          Title: Modulation of KChIP3 levels alters CRC cells’ chemoresistance
         Item: 
          Title: Inhibition of MUC5AC secretion enhances the effect of chemotherapy
         Item: 
          Title: Specific inhibition of NCX enhances 5-FU + iri.-dependent damage in both cells and patient-derived organoids
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        Title: Discussion
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         Item: 
          Title: Cancer cells produce mucins as a protective response to chemotherapy
         Item: 
          Title: KChIP3, a novel risk factor for mucinous CRC
         Item: 
          Title: Combined treatment with NCX inhibitors improves chemotherapy efficacy
         Item: 
          Title: Conclusions
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        Title: Materials and methods
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         Item: 
          Title: Bioinformatics analysis
         Item: 
          Title: Reagents and antibodies
         Item: 
          Title: Cell lines
          Children: 
           Item: 
            Title: HT29-M6
           Item: 
            Title: HT29-18N2
         Item: 
          Title: Patient-derived organoid
         Item: 
          Title: Survival curves
         Item: 
          Title: qRT-PCR analysis
         Item: 
          Title: Secretion assay and Western blot
         Item: 
          Title: Comet assay
         Item: 
          Title: Cell viability assay
         Item: 
          Title: Microscopy and colocalization analysis
         Item: 
          Title: Alcian blue staining
         Item: 
          Title: Statistical analysis
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        Title: Acknowledgements
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        Title: Additional information
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         Item: 
          Title: Competing interests
         Item: 
          Title: Funding
         Item: 
          Title: Author contributions
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          Title: Author ORCIDs
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          Title: Decision letter and Author response
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        Title: Additional files
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         Item: 
          Title: Supplementary files
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   Type: CRC32
  Checksum: d669c1f4532122bbe18f85c2fa0c38b5
   Type: MD5
  Checksum: 6e7c3b5387f0790271cb65bb665cf9136c1f4441
   Type: SHA-1