01f2eb527f128f5c2b7c5989ef3bd209 pmc_35173603.pdf be079bf48a05ec300c082da68cc954c877b53d52 pmc_35173603.pdf 886b8adcfa7709d9fb6227f2ea641eb3d9ec57932cc7a9e2a376393d7cf6fb1e pmc_35173603.pdf Title: Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model Subject: Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Keywords: amyloid, prions, Alzheimer's disease, spreading, protein misfolding, seeding, cattle Author: Ines Moreno-Gonzalez and Claudio Soto Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Jan 25 14:10:17 2022 CET ModDate: Tue Jan 25 14:44:45 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1420616 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YHODQT+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 33 0 PDOXNP+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 38 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 51 0 MWOGZF+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 53 0 WWFCCX+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 59 0 DBEMWX+MTGU Type 1C Custom yes yes no 61 0 GEAWMZ+MinionPro-It Type 1C Custom yes yes no 107 0 HLLSTD+MinionPro-Regular Type 1C Custom yes yes no 69 0 CWSIBA+MinionPro-Bold Type 1C Custom yes yes no 138 0 SAOPWI+MTSY Type 1C Custom yes yes yes 147 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 151 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-10 02:22:53 CEST RepresentationInformation: pmc_35173603.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-27 18:38:59 CET Size: 1420616 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 392 FreeObjects: 15 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Cattle Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Human Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Brain Homogenate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Western Blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Histology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Animal Inoculation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Histological Quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Info: Title: Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model Author: Ines Moreno-Gonzalez and Claudio Soto Subject: Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Keywords: amyloid, prions, Alzheimer's disease, spreading, protein misfolding, seeding, cattle Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Jan 25 14:40:17 CET 2022 ModDate: Tue Jan 25 15:14:45 CET 2022 ID: 0x8c90b3aff7b30547a521f074d0dc0785, 0x777e9daefecac34f9b747e1c4006c05a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 992 ImageHeight: 898 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 1426 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 992 ImageHeight: 1270 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 992 ImageHeight: 668 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1367 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: YHODQT+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: YHODQT+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: SAOPWI+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: SAOPWI+MTSY Flags: Symbolic FontBBox: 0, -83, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MWOGZF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 242 FontDescriptor: FontName: MWOGZF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HLLSTD+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: HLLSTD+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PDOXNP+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 150 FontDescriptor: FontName: PDOXNP+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -30, -214, 826, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CWSIBA+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: CWSIBA+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 823, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WWFCCX+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 122 FontDescriptor: FontName: WWFCCX+HelveticaNeueLTStd-MdIt Flags: Serif, Nonsymbolic FontBBox: -49, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GEAWMZ+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 169 FontDescriptor: FontName: GEAWMZ+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DBEMWX+MTGU FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: DBEMWX+MTGU Flags: Symbolic FontBBox: 0, -206, 607, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2022-01-25T18:40:17+05:30 LaTeX with hyperref package + hypdvips 2022-01-25T19:14:45+05:30 2022-01-25T19:14:45+05:30 application/pdf Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Ines Moreno-Gonzalez and Claudio Soto Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model amyloid prions Alzheimer's disease spreading protein misfolding seeding cattle amyloid, prions, Alzheimer's disease, spreading, protein misfolding, seeding, cattle dvips + MiKTeX GPL Ghostscript 9.0 uuid:e2c049bc-de64-44cd-bc87-a80ed2a936e3 uuid:bc6ce9d7-28ea-422a-b588-ee5d9218b1f1 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 202, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 465, 728, 508, 736 Annotation: Subtype: Link Rect: 508, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 140, 38 Annotation: Subtype: Link Rect: 144, 30, 204, 38 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 454, 160, 463 Annotation: Subtype: Link Rect: 96, 317, 160, 324 Annotation: Subtype: Link Rect: 78, 297, 160, 304 Annotation: Subtype: Link Rect: 74, 75, 160, 84 Annotation: Subtype: Link Rect: 176, 581, 551, 671 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 169, 596, 188, 607 Destination: External Annotation: Subtype: Link Rect: 191, 596, 211, 607 Destination: External Annotation: Subtype: Link Rect: 214, 596, 289, 607 Destination: External Annotation: Subtype: Link Rect: 43, 584, 64, 596 Destination: External Annotation: Subtype: Link Rect: 66, 584, 142, 596 Destination: External Annotation: Subtype: Link Rect: 145, 584, 165, 596 Destination: External Annotation: Subtype: Link Rect: 75, 550, 141, 561 Destination: External Annotation: Subtype: Link Rect: 143, 550, 163, 561 Destination: External Annotation: Subtype: Link Rect: 166, 493, 212, 504 Destination: External Annotation: Subtype: Link Rect: 217, 493, 237, 504 Destination: External Annotation: Subtype: Link Rect: 241, 493, 260, 504 Destination: External Annotation: Subtype: Link Rect: 265, 493, 285, 504 Destination: External Annotation: Subtype: Link Rect: 171, 458, 205, 470 Destination: External Annotation: Subtype: Link Rect: 208, 458, 228, 470 Destination: External Annotation: Subtype: Link Rect: 240, 412, 259, 424 Destination: External Annotation: Subtype: Link Rect: 265, 412, 285, 424 Destination: External Annotation: Subtype: Link Rect: 238, 355, 81, 355 Destination: External Annotation: Subtype: Link Rect: 86, 344, 106, 355 Destination: External Annotation: Subtype: Link Rect: 112, 344, 131, 355 Destination: External Annotation: Subtype: Link Rect: 136, 344, 156, 355 Destination: External Annotation: Subtype: Link Rect: 85, 286, 127, 298 Destination: External Annotation: Subtype: Link Rect: 131, 286, 152, 298 Destination: External Annotation: Subtype: Link Rect: 156, 286, 209, 298 Destination: External Annotation: Subtype: Link Rect: 213, 286, 233, 298 Destination: External Annotation: Subtype: Link Rect: 79, 241, 113, 252 Destination: External Annotation: Subtype: Link Rect: 116, 241, 136, 252 Destination: External Annotation: Subtype: Link Rect: 138, 241, 210, 252 Destination: External Annotation: Subtype: Link Rect: 213, 241, 233, 252 Destination: External Annotation: Subtype: Link Rect: 220, 160, 265, 172 Destination: External Annotation: Subtype: Link Rect: 268, 160, 289, 172 Destination: External Annotation: Subtype: Link Rect: 43, 149, 136, 160 Destination: External Annotation: Subtype: Link Rect: 139, 149, 159, 160 Destination: External Annotation: Subtype: Link Rect: 162, 149, 216, 160 Destination: External Annotation: Subtype: Link Rect: 219, 149, 239, 160 Destination: External Annotation: Subtype: Link Rect: 242, 149, 289, 160 Destination: External Annotation: Subtype: Link Rect: 43, 137, 64, 149 Destination: External Annotation: Subtype: Link Rect: 128, 103, 184, 115 Destination: External Annotation: Subtype: Link Rect: 188, 103, 208, 115 Destination: External Annotation: Subtype: Link Rect: 212, 103, 261, 115 Destination: External Annotation: Subtype: Link Rect: 265, 103, 285, 115 Destination: External Annotation: Subtype: Link Rect: 171, 80, 265, 92 Destination: External Annotation: Subtype: Link Rect: 268, 80, 289, 92 Destination: External Annotation: Subtype: Link Rect: 43, 69, 127, 80 Destination: External Annotation: Subtype: Link Rect: 134, 69, 154, 80 Destination: External Annotation: Subtype: Link Rect: 502, 697, 549, 708 Destination: External Annotation: Subtype: Link Rect: 304, 685, 324, 697 Destination: External Annotation: Subtype: Link Rect: 520, 674, 324, 674 Destination: External Annotation: Subtype: Link Rect: 326, 662, 346, 674 Destination: External Annotation: Subtype: Link Rect: 349, 662, 402, 674 Destination: External Annotation: Subtype: Link Rect: 404, 662, 428, 674 Destination: External Annotation: Subtype: Link Rect: 502, 628, 549, 640 Destination: External Annotation: Subtype: Link Rect: 304, 617, 324, 628 Destination: External Annotation: Subtype: Link Rect: 407, 559, 501, 571 Destination: External Annotation: Subtype: Link Rect: 504, 559, 525, 571 Destination: External Annotation: Subtype: Link Rect: 528, 559, 324, 559 Destination: External Annotation: Subtype: Link Rect: 327, 548, 347, 559 Destination: External Annotation: Subtype: Link Rect: 350, 548, 399, 559 Destination: External Annotation: Subtype: Link Rect: 402, 548, 422, 559 Destination: External Annotation: Subtype: Link Rect: 425, 548, 460, 559 Destination: External Annotation: Subtype: Link Rect: 463, 548, 483, 559 Destination: External Annotation: Subtype: Link Rect: 479, 456, 341, 456 Destination: External Annotation: Subtype: Link Rect: 345, 445, 365, 456 Destination: External Annotation: Subtype: Link Rect: 307, 422, 362, 433 Destination: External Annotation: Subtype: Link Rect: 364, 422, 384, 433 Destination: External Annotation: Subtype: Link Rect: 391, 236, 488, 247 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 321, 708, 383, 720 Destination: External Annotation: Subtype: Link Rect: 385, 708, 405, 720 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 47, 706, 150, 717 Destination: External Annotation: Subtype: Link Rect: 121, 695, 225, 705 Destination: External Annotation: Subtype: Link Rect: 133, 672, 237, 682 Destination: External Annotation: Subtype: Link Rect: 69, 594, 130, 605 Destination: External Annotation: Subtype: Link Rect: 133, 594, 153, 605 Destination: External Annotation: Subtype: Link Rect: 132, 557, 174, 567 Destination: External Annotation: Subtype: Link Rect: 47, 500, 88, 510 Destination: External Annotation: Subtype: Link Rect: 221, 477, 262, 487 Destination: External Annotation: Subtype: Link Rect: 168, 454, 210, 464 Destination: External Annotation: Subtype: Link Rect: 47, 408, 87, 419 Destination: External Annotation: Subtype: Link Rect: 226, 328, 267, 338 Destination: External Annotation: Subtype: Link Rect: 182, 248, 223, 258 Destination: External Annotation: Subtype: Link Rect: 82, 193, 180, 204 Destination: External Annotation: Subtype: Link Rect: 186, 193, 206, 204 Destination: External Annotation: Subtype: Link Rect: 212, 193, 262, 204 Destination: External Annotation: Subtype: Link Rect: 268, 193, 289, 204 Destination: External Annotation: Subtype: Link Rect: 43, 181, 103, 193 Destination: External Annotation: Subtype: Link Rect: 108, 181, 128, 193 Destination: External Annotation: Subtype: Link Rect: 47, 113, 109, 124 Destination: External Annotation: Subtype: Link Rect: 111, 113, 132, 124 Destination: External Annotation: Subtype: Link Rect: 470, 225, 511, 235 Destination: External Annotation: Subtype: Link Rect: 307, 145, 348, 155 Destination: External Annotation: Subtype: Link Rect: 449, 99, 489, 109 Destination: External Annotation: Subtype: Link Rect: 510, 64, 551, 75 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 192, 262, 221, 271 Destination: External Annotation: Subtype: Link Rect: 47, 110, 88, 121 Destination: External Annotation: Subtype: Link Rect: 423, 683, 464, 693 Destination: External Annotation: Subtype: Link Rect: 388, 534, 429, 545 Destination: External Annotation: Subtype: Link Rect: 505, 477, 546, 487 Destination: External Annotation: Subtype: Link Rect: 477, 454, 519, 464 Destination: External Annotation: Subtype: Link Rect: 505, 397, 546, 407 Destination: External Annotation: Subtype: Link Rect: 395, 351, 430, 361 Destination: External Annotation: Subtype: Link Rect: 353, 236, 394, 247 Destination: External Annotation: Subtype: Link Rect: 307, 179, 348, 189 Destination: External Annotation: Subtype: Link Rect: 508, 168, 549, 178 Destination: External Annotation: Subtype: Link Rect: 368, 110, 421, 121 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 169, 205, 210, 216 Destination: External Annotation: Subtype: Link Rect: 407, 433, 442, 445 Destination: External Annotation: Subtype: Link Rect: 447, 433, 467, 445 Destination: External Annotation: Subtype: Link Rect: 472, 433, 491, 445 Destination: External Annotation: Subtype: Link Rect: 496, 433, 516, 445 Destination: External Annotation: Subtype: Link Rect: 521, 433, 348, 433 Destination: External Annotation: Subtype: Link Rect: 351, 422, 372, 433 Destination: External Annotation: Subtype: Link Rect: 421, 307, 527, 319 Destination: External Annotation: Subtype: Link Rect: 529, 307, 549, 319 Destination: External Annotation: Subtype: Link Rect: 304, 296, 345, 307 Destination: External Annotation: Subtype: Link Rect: 349, 296, 369, 307 Destination: External Annotation: Subtype: Link Rect: 372, 296, 447, 307 Destination: External Annotation: Subtype: Link Rect: 451, 296, 471, 307 Destination: External Annotation: Subtype: Link Rect: 336, 239, 393, 250 Destination: External Annotation: Subtype: Link Rect: 396, 239, 416, 250 Destination: External Annotation: Subtype: Link Rect: 418, 204, 475, 216 Destination: External Annotation: Subtype: Link Rect: 478, 204, 499, 216 Destination: External Annotation: Subtype: Link Rect: 502, 204, 549, 216 Destination: External Annotation: Subtype: Link Rect: 304, 193, 324, 204 Destination: External Annotation: Subtype: Link Rect: 326, 193, 367, 204 Destination: External Annotation: Subtype: Link Rect: 370, 193, 390, 204 Destination: External Annotation: Subtype: Link Rect: 333, 158, 368, 170 Destination: External Annotation: Subtype: Link Rect: 369, 158, 390, 170 Destination: External Annotation: Subtype: Link Rect: 391, 158, 410, 170 Destination: External Annotation: Subtype: Link Rect: 412, 158, 432, 170 Destination: External Annotation: Subtype: Link Rect: 434, 158, 486, 170 Destination: External Annotation: Subtype: Link Rect: 488, 158, 512, 170 Destination: External Annotation: Subtype: Link Rect: 512, 158, 519, 170 Destination: External Annotation: Subtype: Link Rect: 521, 158, 346, 158 Destination: External Annotation: Subtype: Link Rect: 349, 147, 369, 158 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 153, 120, 215, 132 Destination: External Annotation: Subtype: Link Rect: 219, 120, 239, 132 Destination: External Annotation: Subtype: Link Rect: 244, 120, 289, 132 Destination: External Annotation: Subtype: Link Rect: 43, 109, 64, 120 Destination: External Annotation: Subtype: Link Rect: 521, 189, 549, 201 Destination: External Annotation: Subtype: Link Rect: 304, 178, 324, 189 Destination: External Annotation: Subtype: Link Rect: 326, 178, 372, 189 Destination: External Annotation: Subtype: Link Rect: 374, 178, 394, 189 Destination: External Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 175, 548, 259, 559 Destination: External Annotation: Subtype: Link Rect: 265, 548, 285, 559 Destination: External Annotation: Subtype: Link Rect: 91, 514, 144, 525 Destination: External Annotation: Subtype: Link Rect: 149, 514, 169, 525 Destination: External Annotation: Subtype: Link Rect: 187, 479, 263, 491 Destination: External Annotation: Subtype: Link Rect: 265, 479, 285, 491 Destination: External Annotation: Subtype: Link Rect: 182, 342, 288, 353 Destination: External Annotation: Subtype: Link Rect: 43, 330, 64, 342 Destination: External Annotation: Subtype: Link Rect: 67, 330, 108, 342 Destination: External Annotation: Subtype: Link Rect: 111, 330, 131, 342 Destination: External Annotation: Subtype: Link Rect: 134, 330, 208, 342 Destination: External Annotation: Subtype: Link Rect: 212, 330, 232, 342 Destination: External Annotation: Subtype: Link Rect: 153, 273, 231, 284 Destination: External Annotation: Subtype: Link Rect: 236, 273, 257, 284 Destination: External Annotation: Subtype: Link Rect: 262, 273, 66, 273 Destination: External Annotation: Subtype: Link Rect: 72, 261, 92, 273 Destination: External Annotation: Subtype: Link Rect: 193, 239, 241, 250 Destination: External Annotation: Subtype: Link Rect: 246, 239, 266, 250 Destination: External Annotation: Subtype: Link Rect: 265, 193, 64, 193 Destination: External Annotation: Subtype: Link Rect: 68, 181, 88, 193 Destination: External Annotation: Subtype: Link Rect: 206, 147, 261, 158 Destination: External Annotation: Subtype: Link Rect: 265, 147, 285, 158 Destination: External Annotation: Subtype: Link Rect: 552, 132, 303, 156 Annotation: Subtype: Link Rect: 327, 92, 412, 100 Annotation: Subtype: Link Rect: 399, 73, 471, 81 Annotation: Subtype: Link Rect: 43, 28, 140, 36 Annotation: Subtype: Link Rect: 144, 28, 204, 36 Annotation: Subtype: Link Rect: 422, 28, 551, 37 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 66, 687, 161, 697 Annotation: Subtype: Link Rect: 187, 661, 233, 668 Annotation: Subtype: Link Rect: 66, 623, 194, 630 Annotation: Subtype: Link Rect: 95, 583, 176, 593 Annotation: Subtype: Link Rect: 200, 566, 266, 573 Annotation: Subtype: Link Rect: 133, 538, 190, 545 Annotation: Subtype: Link Rect: 105, 508, 169, 517 Annotation: Subtype: Link Rect: 66, 470, 159, 479 Annotation: Subtype: Link Rect: 66, 434, 142, 441 Annotation: Subtype: Link Rect: 163, 396, 252, 403 Annotation: Subtype: Link Rect: 292, 357, 52, 376 Annotation: Subtype: Link Rect: 66, 320, 133, 327 Annotation: Subtype: Link Rect: 220, 292, 289, 299 Annotation: Subtype: Link Rect: 66, 262, 166, 271 Annotation: Subtype: Link Rect: 163, 243, 242, 252 Annotation: Subtype: Link Rect: 150, 205, 244, 214 Annotation: Subtype: Link Rect: 215, 167, 281, 176 Annotation: Subtype: Link Rect: 222, 140, 287, 148 Annotation: Subtype: Link Rect: 66, 92, 164, 101 Annotation: Subtype: Link Rect: 363, 698, 485, 706 Annotation: Subtype: Link Rect: 327, 660, 435, 668 Annotation: Subtype: Link Rect: 327, 631, 416, 640 Annotation: Subtype: Link Rect: 327, 594, 403, 602 Annotation: Subtype: Link Rect: 410, 565, 469, 573 Annotation: Subtype: Link Rect: 345, 528, 435, 536 Annotation: Subtype: Link Rect: 459, 508, 551, 517 Annotation: Subtype: Link Rect: 327, 479, 393, 488 Annotation: Subtype: Link Rect: 381, 451, 473, 460 Annotation: Subtype: Link Rect: 327, 424, 419, 431 Annotation: Subtype: Link Rect: 327, 396, 412, 403 Annotation: Subtype: Link Rect: 327, 356, 441, 366 Annotation: Subtype: Link Rect: 327, 337, 436, 347 Annotation: Subtype: Link Rect: 429, 320, 505, 327 Annotation: Subtype: Link Rect: 552, 281, 313, 300 Annotation: Subtype: Link Rect: 327, 244, 412, 252 Annotation: Subtype: Link Rect: 327, 205, 430, 214 Annotation: Subtype: Link Rect: 370, 167, 449, 176 Annotation: Subtype: Link Rect: 439, 150, 492, 157 Annotation: Subtype: Link Rect: 352, 129, 431, 138 Annotation: Subtype: Link Rect: 356, 101, 435, 110 Annotation: Subtype: Link Rect: 439, 72, 518, 81 Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 66, 679, 162, 687 Annotation: Subtype: Link Rect: 66, 641, 131, 649 Annotation: Subtype: Link Rect: 66, 613, 188, 621 Annotation: Subtype: Link Rect: 292, 582, 52, 603 Annotation: Subtype: Link Rect: 66, 546, 146, 554 Annotation: Subtype: Link Rect: 341, 586, 367, 593 Annotation: Subtype: Link Rect: 367, 586, 399, 593 Annotation: Subtype: Link Rect: 399, 586, 435, 594 Annotation: Subtype: Link Rect: 435, 586, 458, 593 Annotation: Subtype: Link Rect: 458, 585, 486, 594 Annotation: Subtype: Link Rect: 43, 29, 140, 37 Annotation: Subtype: Link Rect: 144, 29, 204, 37 Annotation: Subtype: Link Rect: 422, 29, 551, 38 Checksum: e05c6351 Type: CRC32 Checksum: 01f2eb527f128f5c2b7c5989ef3bd209 Type: MD5 Checksum: be079bf48a05ec300c082da68cc954c877b53d52 Type: SHA-1