378135b4b1d266b69b3ac29521d851d7 pmc_35204199.pdf f22b76c3ce6ff9c5d6959b57a949ea6d445832e3 pmc_35204199.pdf 8e81eafecd469cb964f3dfc49b675994aa81cfc15eacf804eae80ce305f5dcf9 pmc_35204199.pdf Title: Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial Subject: Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D. Keywords: antioxidants; Mediterranean diet; flavonoids; phenolic acids; obesity; glucose; HbA1c; glycosylated hemoglobin; metabolic syndrome Author: Anna Tresserra-Rimbau, Sara Castro-Barquero, Nerea Becerra-Tomás, Nancy Babio, Miguel Ángel Martínez-González, Dolores Corella, Montserrat Fitó, Dora Romaguera, Jesús Vioque, Angel M. Alonso-Gomez, Julia Wärnberg, José Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Naomi Cano-Ibáñez, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín Sánchez, Josep Vidal, Clotilde Vázquez, Emili Ros, Francisco Javier Basterra, María Fernández de la Puente, Eva M. Asensio, Olga Castañer, Vanessa Bullón-Vela, Lucas Tojal-Sierra, Enrique Gómez-Gracia, Eugenio Cases-Pérez, Jadwiga Konieczna, Antonio García-Ríos, Tamara Casañas-Quintana, María Rosa Bernal-Lopez, José Manuel Santos-Lozano, Virginia Esteve-Luque, Cristina Bouzas, Zenaida Vázquez-Ruiz, Antoni Palau-Galindo, Rocio Barragan, Mercè López Grau, Cristina Razquín, Leire Goicolea-Güemez, Estefanía Toledo, Manel Vila Vergaz, Rosa M. Lamuela-Raventós and Jordi Salas-Salvadó Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Feb 16 06:47:17 2022 CET ModDate: Wed Feb 16 06:50:15 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 773453 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WHLIZK+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 KWUCKX+VnURWPalladioL Type 1 Custom yes yes no 15 0 UNGTPH+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 EWUWCF+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MOUSLQ+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 KUDXZB+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 FFDGWE+CMSY10 Type 1 Builtin yes yes no 78 0 HIBGOB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 97 0 HIBGOD+PalatinoLinotype TrueType WinAnsi yes yes no 100 0 HIBGPF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 103 0 PDXFNG+PazoMath-Bold Type 1 Builtin yes yes no 113 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 117 0 JXPXXJ+EURM10 Type 1 Builtin yes yes no 124 0 MDIKPC+CMBSY10 Type 1 Builtin yes yes no 128 0 HIBGOB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 167 0 HIBGOC+PalatinoLinotype CID TrueType Identity-H yes yes yes 170 0 HIBGOD+PalatinoLinotype TrueType WinAnsi yes yes no 176 0 HIBGPF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 179 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 200 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-16 02:35:54 CEST RepresentationInformation: pmc_35204199.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-27 18:35:23 CET Size: 773453 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 400 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Dietary Assessment and Polyphenol Intake Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Ascertainment of the Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Assessment of Covariates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Anthocyanidins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Proanthocyanidins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Flavones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Flavonols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Hydroxybenzoic and Hydroxycinnamic Acids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Lignans Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Stilbenes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Effect Modification by Diabetes Status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Strengths and Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Info: Title: Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial Author: Anna Tresserra-Rimbau, Sara Castro-Barquero, Nerea Becerra-Tomás, Nancy Babio, Miguel Ángel Martínez-González, Dolores Corella, Montserrat Fitó, Dora Romaguera, Jesús Vioque, Angel M. Alonso-Gomez, Julia Wärnberg, José Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Naomi Cano-Ibáñez, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín Sánchez, Josep Vidal, Clotilde Vázquez, Emili Ros, Francisco Javier Basterra, María Fernández de la Puente, Eva M. Asensio, Olga Castañer, Vanessa Bullón-Vela, Lucas Tojal-Sierra, Enrique Gómez-Gracia, Eugenio Cases-Pérez, Jadwiga Konieczna, Antonio García-Ríos, Tamara Casañas-Quintana, María Rosa Bernal-Lopez, José Manuel Santos-Lozano, Virginia Esteve-Luque, Cristina Bouzas, Zenaida Vázquez-Ruiz, Antoni Palau-Galindo, Rocio Barragan, Mercè López Grau, Cristina Razquín, Leire Goicolea-Güemez, Estefanía Toledo, Manel Vila Vergaz, Rosa M. Lamuela-Raventós and Jordi Salas-Salvadó Subject: Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D. 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