d1b0d8c43fe4ae00faa0ac7005ef7b17 pmc_35207138.pdf 7845c53aa4df56b49d0721ce060d9f61b67201bc pmc_35207138.pdf dd9adf16d1ed944e946af93c3d7bf658be0a71e388b4cf92168a678d0f9340b2 pmc_35207138.pdf Title: Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology Subject: In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes' characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases. Keywords: membrane elasticity; red blood cells; hemodynamics; hemorheology; microfluidics Author: Claudia Trejo-Soto, Guillermo R. Lázaro, Ignacio Pagonabarraga and Aurora Hernández-Machado Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Feb 13 14:30:42 2022 CET ModDate: Sun Feb 13 14:37:01 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4599360 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WNJHKS+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 QFRCSL+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 IJQAAC+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 27 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 31 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 35 0 RNKVDG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 YALZVG+CMSY10 Type 1 Builtin yes yes no 75 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 84 0 OXVPRU+PazoMath-Italic Type 1 Builtin yes yes no 91 0 ZZFUXD+PazoMath Type 1 Builtin yes yes no 95 0 SOSTRQ+CMR10 Type 1 Builtin yes yes no 99 0 NXPIZV+CMEX10 Type 1 Builtin yes yes no 106 0 SYFPBV+CMMI10 Type 1 Builtin yes yes no 120 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-21 02:33:28 CET RepresentationInformation: pmc_35207138.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-27 18:34:01 CET Size: 4599360 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 684 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Cell Membranes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Cell Membrane Modeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Cell Membrane Dynamics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Membrane Dynamics and Hydrodynamic Coupling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Human Red Blood Cells and Blood Components Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Human Red Blood Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Blood Components Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Hemodynamics and Hemorheology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Hemodynamics and Hemorheology for a Single Cell Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Experimental Hemorheology: Collective Behavior of Red Blood Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Comparison with Numerical Results of the Collective Behavior of RBCs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Hemorheological Pathologies and Emergent Microfluidics Diagnostics Techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Info: Title: Microfluidics Approach to the Mechanical Properties of Red Blood Cell Membrane and Their Effect on Blood Rheology Author: Claudia Trejo-Soto, Guillermo R. Lázaro, Ignacio Pagonabarraga and Aurora Hernández-Machado Subject: In this article, we describe the general features of red blood cell membranes and their effect on blood flow and blood rheology. We first present a basic description of membranes and move forward to red blood cell membranes' characteristics and modeling. We later review the specific properties of red blood cells, presenting recent numerical and experimental microfluidics studies that elucidate the effect of the elastic properties of the red blood cell membrane on blood flow and hemorheology. Finally, we describe specific hemorheological pathologies directly related to the mechanical properties of red blood cells and their effect on microcirculation, reviewing microfluidic applications for the diagnosis and treatment of these diseases. 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