807740f65cfd9d4c0dd7c28be199ffb6 pmc_35208510.pdf b00e1c000abe7356da1ed26bfc3880746bae7e26 pmc_35208510.pdf c194d08c3fb5f80847b99285ef9578b2f3e0624b99bdf9b3055e1dd088836962 pmc_35208510.pdf Title: MDR Tuberculosis Treatment Subject: Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising pharmacological advances in the paradigm of MDR TB treatment: new and repurposed drugs have shown excellent bactericidal and sterilizing activity against Mycobacterium tuberculosis and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the most important drugs currently used to treat MDR TB, the recommended regimens to treat MDR TB, and we also summarize new insights into the treatment of patients with MDR TB. Keywords: tuberculosis; MDR; treatment Author: Juan Espinosa-Pereiro, Adrian Sánchez-Montalvá, Maria Luisa Aznar and Maria Espiau Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 28 01:37:31 2022 CET ModDate: Fri Jan 28 09:17:39 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 34 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 564740 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 IEFSKB+VnURWPalladioL Type 1 Custom yes yes no 15 0 QTIQBL+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 IUINYY+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 OXGLVM+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 36 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 40 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 44 0 HVRRJG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 LJZOLZ+CMSY10 Type 1 Builtin yes yes no 78 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-04-02 02:22:29 CEST RepresentationInformation: pmc_35208510.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-02-27 18:32:58 CET Size: 564740 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 858 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: MDR TB Recommended Regimens and Duration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Main Drugs Used to Treat MDR TB Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Diarylquinolines: Bedaquiline (BDQ) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Mechanism of Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Nitroimidazoles: Delamanid (DLM) and Pretonamid (PTM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Resistances Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Oxazolidinones: Linezolid (LZD) and Tedizolid (TDZ) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Mechanism of Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Other Oxazolidinediones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Fluoroquinolones: Levofloxacin and Moxifloxacin Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Resistances Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Adverse Effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Clofazimine (CFZ) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Aminoglycosides and Capreomycin Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Mechanism of Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Ethionamide and Prothionamide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Resistances Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Cycloserine and Terizidone Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Children: Item: Title: Mechanism of Action Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Posology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Adverse Events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Resistances Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: Interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Children Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: Appendix A Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Info: Title: MDR Tuberculosis Treatment Author: Juan Espinosa-Pereiro, Adrian Sánchez-Montalvá, Maria Luisa Aznar and Maria Espiau Subject: Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues to be one of the most important threats to controlling the TB epidemic. Over the last few years, there have been promising pharmacological advances in the paradigm of MDR TB treatment: new and repurposed drugs have shown excellent bactericidal and sterilizing activity against Mycobacterium tuberculosis and several all-oral short regimens to treat MDR TB have shown promising results. The purpose of this comprehensive review is to summarize the most important drugs currently used to treat MDR TB, the recommended regimens to treat MDR TB, and we also summarize new insights into the treatment of patients with MDR TB. Keywords: tuberculosis; MDR; treatment Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 28 01:37:31 CET 2022 ModDate: Fri Jan 28 09:17:39 CET 2022 ID: 0x3954c587cc9ffb5b6fb4400bac87e889, 0x3954c587cc9ffb5b6fb4400bac87e889 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: QTIQBL+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 134 FontDescriptor: FontName: QTIQBL+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IUINYY+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: IUINYY+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: AIQCCL+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 161 FontDescriptor: FontName: AIQCCL+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OXGLVM+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: OXGLVM+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LJZOLZ+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: LJZOLZ+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: IEFSKB+VnURWPalladioL FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: IEFSKB+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 34, 323, 152, 332 Annotation: Subtype: Link Rect: 34, 313, 93, 320 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 178, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 155, 681, 166, 695 Annotation: Subtype: Link Rect: 508, 681, 519, 695 Annotation: Subtype: Link Rect: 294, 308, 300, 317 ActionDest: 150 Annotation: Subtype: Link Rect: 477, 270, 484, 279 ActionDest: 150 Annotation: Subtype: Link Rect: 406, 145, 413, 154 ActionDest: 150 Annotation: Subtype: Link Rect: 549, 107, 556, 116 ActionDest: 150 Annotation: Subtype: Link Rect: 115, 17, 272, 28 Annotation: Subtype: Link Rect: 404, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 384, 86, 403 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 331, 736, 338, 744 ActionDest: 150 Annotation: Subtype: Link Rect: 341, 736, 348, 744 ActionDest: 150 Annotation: Subtype: Link Rect: 549, 723, 556, 732 ActionDest: 150 Annotation: Subtype: Link Rect: 459, 647, 466, 657 ActionDest: 150 Annotation: Subtype: Link Rect: 469, 647, 481, 657 ActionDest: 153 Annotation: Subtype: Link Rect: 432, 623, 444, 631 ActionDest: 153 Annotation: Subtype: Link Rect: 447, 623, 459, 631 ActionDest: 153 Annotation: Subtype: Link Rect: 544, 585, 556, 594 ActionDest: 153 Annotation: Subtype: Link Rect: 348, 522, 360, 531 ActionDest: 153 Annotation: Subtype: Link Rect: 361, 447, 373, 456 ActionDest: 153 Annotation: Subtype: Link Rect: 347, 293, 354, 305 ActionDest: 82 Annotation: Subtype: Link Rect: 507, 203, 519, 212 ActionDest: 153 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 395, 735, 407, 744 ActionDest: 153 Annotation: Subtype: Link Rect: 364, 723, 376, 732 ActionDest: 153 Annotation: Subtype: Link Rect: 356, 685, 368, 694 ActionDest: 153 Annotation: Subtype: Link Rect: 553, 360, 560, 372 ActionDest: 85 Annotation: Subtype: Link Rect: 309, 286, 321, 295 ActionDest: 153 Annotation: Subtype: Link Rect: 480, 273, 492, 282 ActionDest: 153 Annotation: Subtype: Link Rect: 495, 273, 507, 282 ActionDest: 153 Annotation: Subtype: Link Rect: 279, 194, 291, 204 ActionDest: 153 Annotation: Subtype: Link Rect: 291, 194, 303, 204 ActionDest: 153 Annotation: Subtype: Link Rect: 492, 157, 504, 166 ActionDest: 153 Annotation: Subtype: Link Rect: 504, 157, 516, 166 ActionDest: 153 Annotation: Subtype: Link Rect: 413, 132, 424, 141 ActionDest: 153 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 440, 687, 452, 696 ActionDest: 153 Annotation: Subtype: Link Rect: 246, 661, 258, 671 ActionDest: 153 Annotation: Subtype: Link Rect: 480, 561, 492, 570 ActionDest: 153 Annotation: Subtype: Link Rect: 544, 511, 556, 520 ActionDest: 156 Annotation: Subtype: Link Rect: 317, 473, 329, 482 ActionDest: 156 Annotation: Subtype: Link Rect: 330, 473, 342, 482 ActionDest: 156 Annotation: Subtype: Link Rect: 549, 410, 556, 419 ActionDest: 153 Annotation: Subtype: Link Rect: 192, 372, 204, 381 ActionDest: 156 Annotation: Subtype: Link Rect: 403, 334, 415, 344 ActionDest: 153 Annotation: Subtype: Link Rect: 387, 297, 399, 306 ActionDest: 156 Annotation: Subtype: Link Rect: 485, 246, 496, 255 ActionDest: 156 Annotation: Subtype: Link Rect: 413, 196, 425, 205 ActionDest: 156 Annotation: Subtype: Link Rect: 425, 196, 437, 205 ActionDest: 156 Annotation: Subtype: Link Rect: 337, 146, 349, 155 ActionDest: 156 Annotation: Subtype: Link Rect: 320, 70, 332, 79 ActionDest: 156 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 544, 725, 556, 734 ActionDest: 156 Annotation: Subtype: Link Rect: 544, 700, 556, 709 ActionDest: 156 Annotation: Subtype: Link Rect: 274, 637, 286, 646 ActionDest: 156 Annotation: Subtype: Link Rect: 273, 486, 285, 495 ActionDest: 156 Annotation: Subtype: Link Rect: 226, 461, 238, 470 ActionDest: 156 Annotation: Subtype: Link Rect: 228, 423, 240, 432 ActionDest: 153 Annotation: Subtype: Link Rect: 403, 184, 415, 193 ActionDest: 156 Annotation: Subtype: Link Rect: 448, 159, 459, 168 ActionDest: 156 Annotation: Subtype: Link Rect: 532, 146, 544, 156 ActionDest: 156 Annotation: Subtype: Link Rect: 544, 146, 556, 156 ActionDest: 156 Annotation: Subtype: Link Rect: 520, 84, 532, 93 ActionDest: 156 Annotation: Subtype: Link Rect: 532, 83, 544, 93 ActionDest: 156 Annotation: Subtype: Link Rect: 544, 83, 556, 93 ActionDest: 156 Annotation: Subtype: Link Rect: 531, 71, 543, 80 ActionDest: 156 Annotation: Subtype: Link Rect: 544, 71, 556, 80 ActionDest: 156 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 247, 687, 259, 696 ActionDest: 159 Annotation: Subtype: Link Rect: 367, 624, 379, 633 ActionDest: 159 Annotation: Subtype: Link Rect: 390, 599, 402, 608 ActionDest: 156 Annotation: Subtype: Link Rect: 402, 599, 414, 608 ActionDest: 156 Annotation: Subtype: Link Rect: 206, 574, 218, 583 ActionDest: 153 Annotation: Subtype: Link Rect: 529, 498, 541, 507 ActionDest: 153 Annotation: Subtype: Link Rect: 396, 473, 407, 482 ActionDest: 159 Annotation: Subtype: Link Rect: 273, 385, 285, 394 ActionDest: 159 Annotation: Subtype: Link Rect: 213, 348, 225, 357 ActionDest: 159 Annotation: Subtype: Link Rect: 431, 323, 443, 332 ActionDest: 159 Annotation: Subtype: Link Rect: 283, 297, 295, 307 ActionDest: 153 Annotation: Subtype: Link Rect: 296, 222, 308, 231 ActionDest: 159 Annotation: Subtype: Link Rect: 483, 197, 494, 206 ActionDest: 159 Annotation: Subtype: Link Rect: 434, 147, 446, 156 ActionDest: 153 Annotation: Subtype: Link Rect: 532, 134, 544, 143 ActionDest: 159 Annotation: Subtype: Link Rect: 544, 134, 556, 143 ActionDest: 159 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 453, 725, 465, 734 ActionDest: 159 Annotation: Subtype: Link Rect: 525, 700, 537, 709 ActionDest: 159 Annotation: Subtype: Link Rect: 289, 637, 301, 646 ActionDest: 159 Annotation: Subtype: Link Rect: 483, 624, 495, 633 ActionDest: 159 Annotation: Subtype: Link Rect: 359, 574, 371, 583 ActionDest: 159 Annotation: Subtype: Link Rect: 523, 498, 535, 507 ActionDest: 153 Annotation: Subtype: Link Rect: 544, 373, 556, 382 ActionDest: 156 Annotation: Subtype: Link Rect: 490, 348, 502, 357 ActionDest: 156 Annotation: Subtype: Link Rect: 515, 297, 527, 307 ActionDest: 153 Annotation: Subtype: Link Rect: 424, 260, 436, 269 ActionDest: 153 Annotation: Subtype: Link Rect: 384, 184, 396, 194 ActionDest: 156 Annotation: Subtype: Link Rect: 527, 159, 539, 168 ActionDest: 153 Annotation: Subtype: Link Rect: 492, 109, 504, 118 ActionDest: 159 Annotation: Subtype: Link Rect: 286, 84, 298, 93 ActionDest: 159 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 422, 725, 434, 734 ActionDest: 153 Annotation: Subtype: Link Rect: 544, 637, 556, 646 ActionDest: 159 Annotation: Subtype: Link Rect: 205, 599, 217, 608 ActionDest: 159 Annotation: Subtype: Link Rect: 389, 587, 401, 596 ActionDest: 159 Annotation: Subtype: Link Rect: 538, 536, 550, 545 ActionDest: 159 Annotation: Subtype: Link Rect: 241, 486, 253, 495 ActionDest: 159 Annotation: Subtype: Link Rect: 529, 436, 540, 445 ActionDest: 159 Annotation: Subtype: Link Rect: 455, 410, 467, 419 ActionDest: 162 Annotation: Subtype: Link Rect: 310, 385, 322, 394 ActionDest: 162 Annotation: Subtype: Link Rect: 386, 347, 398, 356 ActionDest: 162 Annotation: Subtype: Link Rect: 300, 322, 312, 331 ActionDest: 162 Annotation: Subtype: Link Rect: 312, 322, 324, 331 ActionDest: 162 Annotation: Subtype: Link Rect: 357, 259, 369, 269 ActionDest: 162 Annotation: Subtype: Link Rect: 245, 234, 257, 243 ActionDest: 153 Annotation: Subtype: Link Rect: 258, 234, 270, 243 ActionDest: 156 Annotation: Subtype: Link Rect: 237, 222, 249, 231 ActionDest: 153 Annotation: Subtype: Link Rect: 466, 184, 478, 193 ActionDest: 162 Annotation: Subtype: Link Rect: 469, 146, 481, 156 ActionDest: 162 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 515, 675, 527, 684 ActionDest: 162 Annotation: Subtype: Link Rect: 202, 612, 214, 621 ActionDest: 153 Annotation: Subtype: Link Rect: 215, 612, 227, 621 ActionDest: 162 Annotation: Subtype: Link Rect: 226, 599, 238, 608 ActionDest: 162 Annotation: Subtype: Link Rect: 428, 586, 440, 596 ActionDest: 162 Annotation: Subtype: Link Rect: 544, 574, 556, 583 ActionDest: 162 Annotation: Subtype: Link Rect: 517, 536, 529, 545 ActionDest: 153 Annotation: Subtype: Link Rect: 195, 474, 207, 483 ActionDest: 153 Annotation: Subtype: Link Rect: 503, 448, 515, 457 ActionDest: 156 Annotation: Subtype: Link Rect: 222, 386, 234, 395 ActionDest: 162 Annotation: Subtype: Link Rect: 544, 360, 556, 370 ActionDest: 153 Annotation: Subtype: Link Rect: 302, 285, 314, 294 ActionDest: 162 Annotation: Subtype: Link Rect: 491, 273, 503, 282 ActionDest: 162 Annotation: Subtype: Link Rect: 504, 273, 516, 282 ActionDest: 162 Annotation: Subtype: Link Rect: 205, 235, 217, 244 ActionDest: 162 Annotation: Subtype: Link Rect: 275, 197, 287, 206 ActionDest: 162 Annotation: Subtype: Link Rect: 199, 122, 211, 131 ActionDest: 162 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 364, 709, 376, 718 ActionDest: 159 Annotation: Subtype: Link Rect: 214, 684, 226, 693 ActionDest: 159 Annotation: Subtype: Link Rect: 467, 672, 479, 681 ActionDest: 162 Annotation: Subtype: Link Rect: 480, 672, 492, 681 ActionDest: 162 Annotation: Subtype: Link Rect: 385, 634, 397, 643 ActionDest: 162 Annotation: Subtype: Link Rect: 339, 621, 351, 630 ActionDest: 162 Annotation: Subtype: Link Rect: 352, 621, 364, 630 ActionDest: 162 Annotation: Subtype: Link Rect: 239, 596, 251, 605 ActionDest: 162 Annotation: Subtype: Link Rect: 251, 596, 263, 605 ActionDest: 162 Annotation: Subtype: Link Rect: 259, 584, 271, 593 ActionDest: 165 Annotation: Subtype: Link Rect: 436, 571, 448, 580 ActionDest: 162 Annotation: Subtype: Link Rect: 441, 483, 453, 492 ActionDest: 162 Annotation: Subtype: Link Rect: 453, 483, 465, 492 ActionDest: 162 Annotation: Subtype: Link Rect: 217, 458, 234, 467 ActionDest: 165 Annotation: Subtype: Link Rect: 234, 458, 251, 467 ActionDest: 165 Annotation: Subtype: Link Rect: 229, 446, 241, 455 ActionDest: 162 Annotation: Subtype: Link Rect: 242, 446, 259, 455 ActionDest: 165 Annotation: Subtype: Link Rect: 259, 446, 276, 455 ActionDest: 165 Annotation: Subtype: Link Rect: 452, 433, 468, 442 ActionDest: 165 Annotation: Subtype: Link Rect: 469, 433, 486, 442 ActionDest: 165 Annotation: Subtype: Link Rect: 544, 421, 556, 430 ActionDest: 162 Annotation: Subtype: Link Rect: 227, 383, 239, 392 ActionDest: 162 Annotation: Subtype: Link Rect: 240, 383, 257, 392 ActionDest: 165 Annotation: Subtype: Link Rect: 257, 383, 274, 392 ActionDest: 165 Annotation: Subtype: Link Rect: 386, 358, 403, 367 ActionDest: 165 Annotation: Subtype: Link Rect: 409, 295, 426, 304 ActionDest: 165 Annotation: Subtype: Link Rect: 429, 295, 446, 304 ActionDest: 165 Annotation: Subtype: Link Rect: 193, 270, 210, 279 ActionDest: 165 Annotation: Subtype: Link Rect: 525, 245, 542, 254 ActionDest: 165 Annotation: Subtype: Link Rect: 496, 220, 508, 229 ActionDest: 162 Annotation: Subtype: Link Rect: 241, 182, 258, 191 ActionDest: 165 Annotation: Subtype: Link Rect: 357, 116, 367, 128 ActionDest: 150 Annotation: Subtype: Link Rect: 374, 119, 391, 128 ActionDest: 165 Annotation: Subtype: Link Rect: 391, 119, 408, 128 ActionDest: 165 Annotation: Subtype: Link Rect: 199, 81, 216, 90 ActionDest: 165 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 539, 725, 556, 734 ActionDest: 165 Annotation: Subtype: Link Rect: 460, 700, 477, 709 ActionDest: 165 Annotation: Subtype: Link Rect: 224, 662, 241, 671 ActionDest: 165 Annotation: Subtype: Link Rect: 527, 662, 544, 671 ActionDest: 165 Annotation: Subtype: Link Rect: 198, 637, 210, 646 ActionDest: 159 Annotation: Subtype: Link Rect: 194, 612, 211, 621 ActionDest: 165 Annotation: Subtype: Link Rect: 211, 612, 228, 621 ActionDest: 165 Annotation: Subtype: Link Rect: 483, 549, 495, 558 ActionDest: 153 Annotation: Subtype: Link Rect: 251, 499, 263, 508 ActionDest: 153 Annotation: Subtype: Link Rect: 419, 448, 431, 457 ActionDest: 153 Annotation: Subtype: Link Rect: 477, 398, 489, 407 ActionDest: 156 Annotation: Subtype: Link Rect: 522, 298, 534, 307 ActionDest: 156 Annotation: Subtype: Link Rect: 361, 184, 378, 194 ActionDest: 165 Annotation: Subtype: Link Rect: 295, 160, 312, 168 ActionDest: 165 Annotation: Subtype: Link Rect: 457, 71, 474, 80 ActionDest: 165 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 340, 725, 356, 734 ActionDest: 165 Annotation: Subtype: Link Rect: 452, 700, 464, 709 ActionDest: 153 Annotation: Subtype: Link Rect: 449, 649, 466, 658 ActionDest: 165 Annotation: Subtype: Link Rect: 228, 586, 245, 595 ActionDest: 165 Annotation: Subtype: Link Rect: 337, 561, 349, 570 ActionDest: 156 Annotation: Subtype: Link Rect: 527, 536, 544, 545 ActionDest: 168 Annotation: Subtype: Link Rect: 265, 448, 282, 457 ActionDest: 168 Annotation: Subtype: Link Rect: 285, 448, 302, 457 ActionDest: 168 Annotation: Subtype: Link Rect: 258, 423, 270, 432 ActionDest: 153 Annotation: Subtype: Link Rect: 222, 372, 239, 381 ActionDest: 168 Annotation: Subtype: Link Rect: 239, 372, 256, 381 ActionDest: 168 Annotation: Subtype: Link Rect: 457, 322, 474, 331 ActionDest: 168 Annotation: Subtype: Link Rect: 321, 297, 333, 306 ActionDest: 153 Annotation: Subtype: Link Rect: 522, 272, 534, 281 ActionDest: 156 Annotation: Subtype: Link Rect: 406, 247, 423, 256 ActionDest: 168 Annotation: Subtype: Link Rect: 341, 221, 353, 231 ActionDest: 153 Annotation: Subtype: Link Rect: 353, 221, 365, 231 ActionDest: 156 Annotation: Subtype: Link Rect: 366, 221, 383, 231 ActionDest: 168 Annotation: Subtype: Link Rect: 484, 108, 501, 117 ActionDest: 168 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 493, 725, 509, 734 ActionDest: 168 Annotation: Subtype: Link Rect: 512, 725, 528, 734 ActionDest: 168 Annotation: Subtype: Link Rect: 242, 587, 259, 596 ActionDest: 168 Annotation: Subtype: Link Rect: 438, 536, 455, 545 ActionDest: 168 Annotation: Subtype: Link Rect: 464, 524, 481, 533 ActionDest: 168 Annotation: Subtype: Link Rect: 477, 499, 494, 508 ActionDest: 168 Annotation: Subtype: Link Rect: 494, 499, 511, 508 ActionDest: 168 Annotation: Subtype: Link Rect: 402, 486, 419, 495 ActionDest: 168 Annotation: Subtype: Link Rect: 422, 486, 439, 495 ActionDest: 168 Annotation: Subtype: Link Rect: 435, 410, 452, 419 ActionDest: 168 Annotation: Subtype: Link Rect: 377, 385, 388, 394 ActionDest: 153 Annotation: Subtype: Link Rect: 413, 164, 425, 173 ActionDest: 153 Annotation: Subtype: Link Rect: 426, 164, 438, 173 ActionDest: 153 Annotation: Subtype: Link Rect: 530, 88, 547, 97 ActionDest: 168 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 191, 697, 208, 706 ActionDest: 168 Annotation: Subtype: Link Rect: 317, 684, 334, 693 ActionDest: 168 Annotation: Subtype: Link Rect: 321, 672, 338, 681 ActionDest: 168 Annotation: Subtype: Link Rect: 424, 621, 436, 630 ActionDest: 153 Annotation: Subtype: Link Rect: 271, 533, 288, 542 ActionDest: 168 Annotation: Subtype: Link Rect: 490, 483, 506, 492 ActionDest: 168 Annotation: Subtype: Link Rect: 366, 445, 382, 454 ActionDest: 172 Annotation: Subtype: Link Rect: 261, 432, 278, 442 ActionDest: 172 Annotation: Subtype: Link Rect: 470, 420, 486, 429 ActionDest: 172 Annotation: Subtype: Link Rect: 432, 369, 439, 379 ActionDest: 150 Annotation: Subtype: Link Rect: 417, 307, 429, 316 ActionDest: 153 Annotation: Subtype: Link Rect: 525, 269, 541, 278 ActionDest: 172 Annotation: Subtype: Link Rect: 327, 244, 344, 253 ActionDest: 172 Annotation: Subtype: Link Rect: 359, 206, 371, 215 ActionDest: 153 Annotation: Subtype: Link Rect: 236, 156, 253, 165 ActionDest: 172 Annotation: Subtype: Link Rect: 256, 156, 273, 165 ActionDest: 172 Annotation: Subtype: Link Rect: 204, 118, 221, 127 ActionDest: 172 Annotation: Subtype: Link Rect: 499, 106, 516, 115 ActionDest: 172 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 535, 697, 552, 706 ActionDest: 172 Annotation: Subtype: Link Rect: 483, 634, 495, 643 ActionDest: 153 Annotation: Subtype: Link Rect: 507, 609, 519, 618 ActionDest: 153 Annotation: Subtype: Link Rect: 234, 546, 246, 555 ActionDest: 156 Annotation: Subtype: Link Rect: 510, 546, 527, 555 ActionDest: 172 Annotation: Subtype: Link Rect: 475, 483, 491, 492 ActionDest: 172 Annotation: Subtype: Link Rect: 492, 483, 508, 492 ActionDest: 172 Annotation: Subtype: Link Rect: 545, 458, 556, 467 ActionDest: 153 Annotation: Subtype: Link Rect: 367, 420, 384, 429 ActionDest: 172 Annotation: Subtype: Link Rect: 319, 320, 331, 329 ActionDest: 153 Annotation: Subtype: Link Rect: 199, 231, 215, 240 ActionDest: 172 Annotation: Subtype: Link Rect: 388, 219, 405, 228 ActionDest: 172 Annotation: Subtype: Link Rect: 251, 194, 268, 203 ActionDest: 172 Annotation: Subtype: Link Rect: 255, 131, 272, 140 ActionDest: 172 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 466, 687, 483, 696 ActionDest: 172 Annotation: Subtype: Link Rect: 483, 687, 499, 696 ActionDest: 172 Annotation: Subtype: Link Rect: 539, 599, 556, 608 ActionDest: 172 Annotation: Subtype: Link Rect: 292, 561, 309, 570 ActionDest: 172 Annotation: Subtype: Link Rect: 309, 561, 326, 570 ActionDest: 172 Annotation: Subtype: Link Rect: 230, 486, 247, 495 ActionDest: 172 Annotation: Subtype: Link Rect: 501, 448, 508, 457 ActionDest: 150 Annotation: Subtype: Link Rect: 488, 335, 505, 344 ActionDest: 172 Annotation: Subtype: Link Rect: 434, 285, 451, 294 ActionDest: 172 Annotation: Subtype: Link Rect: 466, 260, 473, 269 ActionDest: 150 Annotation: Subtype: Link Rect: 474, 260, 481, 269 ActionDest: 150 Annotation: Subtype: Link Rect: 481, 260, 498, 269 ActionDest: 168 Annotation: Subtype: Link Rect: 309, 159, 321, 168 ActionDest: 156 Annotation: Subtype: Link Rect: 417, 134, 429, 143 ActionDest: 153 Annotation: Subtype: Link Rect: 430, 134, 442, 143 ActionDest: 153 Annotation: Subtype: Link Rect: 442, 134, 454, 143 ActionDest: 153 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 440, 725, 457, 734 ActionDest: 172 Annotation: Subtype: Link Rect: 421, 662, 437, 671 ActionDest: 172 Annotation: Subtype: Link Rect: 495, 649, 511, 658 ActionDest: 172 Annotation: Subtype: Link Rect: 237, 586, 253, 596 ActionDest: 172 Annotation: Subtype: Link Rect: 518, 574, 525, 583 ActionDest: 150 Annotation: Subtype: Link Rect: 297, 524, 314, 533 ActionDest: 168 Annotation: Subtype: Link Rect: 434, 411, 451, 420 ActionDest: 172 Annotation: Subtype: Link Rect: 539, 323, 556, 332 ActionDest: 172 Annotation: Subtype: Link Rect: 493, 285, 510, 294 ActionDest: 172 Annotation: Subtype: Link Rect: 191, 234, 203, 243 ActionDest: 153 Annotation: Subtype: Link Rect: 269, 83, 286, 92 ActionDest: 172 Annotation: Subtype: Link Rect: 286, 83, 303, 92 ActionDest: 172 Annotation: Subtype: Link Rect: 469, 71, 486, 80 ActionDest: 172 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 530, 709, 547, 718 ActionDest: 175 Annotation: Subtype: Link Rect: 214, 684, 231, 693 ActionDest: 175 Annotation: Subtype: Link Rect: 281, 659, 298, 668 ActionDest: 175 Annotation: Subtype: Link Rect: 392, 634, 409, 643 ActionDest: 175 Annotation: Subtype: Link Rect: 426, 583, 443, 593 ActionDest: 175 Annotation: Subtype: Link Rect: 443, 583, 460, 593 ActionDest: 175 Annotation: Subtype: Link Rect: 519, 495, 536, 504 ActionDest: 175 Annotation: Subtype: Link Rect: 539, 495, 556, 504 ActionDest: 175 Annotation: Subtype: Link Rect: 359, 470, 371, 479 ActionDest: 156 Annotation: Subtype: Link Rect: 517, 445, 529, 454 ActionDest: 153 Annotation: Subtype: Link Rect: 369, 382, 386, 391 ActionDest: 175 Annotation: Subtype: Link Rect: 376, 369, 393, 379 ActionDest: 175 Annotation: Subtype: Link Rect: 291, 344, 308, 353 ActionDest: 175 Annotation: Subtype: Link Rect: 462, 332, 479, 341 ActionDest: 175 Annotation: Subtype: Link Rect: 480, 332, 497, 341 ActionDest: 175 Annotation: Subtype: Link Rect: 186, 307, 203, 316 ActionDest: 175 Annotation: Subtype: Link Rect: 206, 307, 223, 316 ActionDest: 175 Annotation: Subtype: Link Rect: 446, 307, 462, 316 ActionDest: 175 Annotation: Subtype: Link Rect: 465, 307, 482, 316 ActionDest: 175 Annotation: Subtype: Link Rect: 227, 269, 244, 278 ActionDest: 175 Annotation: Subtype: Link Rect: 231, 244, 248, 253 ActionDest: 175 Annotation: Subtype: Link Rect: 450, 80, 467, 89 ActionDest: 175 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 458, 671, 475, 680 ActionDest: 175 Annotation: Subtype: Link Rect: 315, 634, 332, 643 ActionDest: 175 Annotation: Subtype: Link Rect: 262, 571, 274, 580 ActionDest: 156 Annotation: Subtype: Link Rect: 363, 495, 380, 504 ActionDest: 175 Annotation: Subtype: Link Rect: 352, 483, 369, 492 ActionDest: 175 Annotation: Subtype: Link Rect: 430, 407, 447, 416 ActionDest: 175 Annotation: Subtype: Link Rect: 413, 395, 430, 404 ActionDest: 178 Annotation: Subtype: Link Rect: 237, 331, 254, 341 ActionDest: 175 Annotation: Subtype: Link Rect: 294, 256, 306, 265 ActionDest: 153 Annotation: Subtype: Link Rect: 339, 231, 351, 240 ActionDest: 153 Annotation: Subtype: Link Rect: 540, 206, 556, 215 ActionDest: 168 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 305, 537, 322, 546 ActionDest: 178 Annotation: Subtype: Link Rect: 194, 499, 210, 508 ActionDest: 178 Annotation: Subtype: Link Rect: 478, 474, 495, 483 ActionDest: 178 Annotation: Subtype: Link Rect: 314, 436, 330, 445 ActionDest: 178 Annotation: Subtype: Link Rect: 237, 424, 253, 433 ActionDest: 178 Annotation: Subtype: Link Rect: 513, 411, 529, 420 ActionDest: 178 Annotation: Subtype: Link Rect: 313, 373, 330, 382 ActionDest: 178 Annotation: Subtype: Link Rect: 330, 373, 347, 382 ActionDest: 178 Annotation: Subtype: Link Rect: 415, 336, 432, 345 ActionDest: 178 Annotation: Subtype: Link Rect: 433, 336, 450, 345 ActionDest: 178 Annotation: Subtype: Link Rect: 296, 260, 313, 269 ActionDest: 178 Annotation: Subtype: Link Rect: 287, 198, 304, 207 ActionDest: 178 Annotation: Subtype: Link Rect: 307, 198, 324, 207 ActionDest: 178 Annotation: Subtype: Link Rect: 320, 72, 337, 81 ActionDest: 168 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 276, 725, 283, 734 ActionDest: 150 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 446, 183, 484, 194 Annotation: Subtype: Link Rect: 490, 183, 526, 194 Annotation: Subtype: Link Rect: 479, 160, 515, 171 Annotation: Subtype: Link Rect: 521, 160, 557, 171 Annotation: Subtype: Link Rect: 265, 125, 303, 136 Annotation: Subtype: Link Rect: 517, 102, 555, 113 Annotation: Subtype: Link Rect: 469, 79, 504, 90 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 95, 713, 132, 723 Annotation: Subtype: Link Rect: 507, 689, 543, 700 Annotation: Subtype: Link Rect: 300, 654, 337, 665 Annotation: Subtype: Link Rect: 407, 631, 444, 642 Annotation: Subtype: Link Rect: 131, 563, 168, 573 Annotation: Subtype: Link Rect: 175, 563, 211, 573 Annotation: Subtype: Link Rect: 359, 516, 560, 527 Annotation: Subtype: Link Rect: 149, 437, 186, 447 Annotation: Subtype: Link Rect: 192, 437, 228, 447 Annotation: Subtype: Link Rect: 444, 390, 482, 401 Annotation: Subtype: Link Rect: 311, 378, 560, 389 Annotation: Subtype: Link Rect: 56, 367, 132, 378 Annotation: Subtype: Link Rect: 503, 344, 540, 355 Annotation: Subtype: Link Rect: 260, 310, 297, 320 Annotation: Subtype: Link Rect: 287, 286, 325, 297 Annotation: Subtype: Link Rect: 103, 253, 141, 263 Annotation: Subtype: Link Rect: 340, 217, 377, 228 Annotation: Subtype: Link Rect: 212, 183, 249, 194 Annotation: Subtype: Link Rect: 347, 160, 384, 171 Annotation: Subtype: Link Rect: 390, 160, 426, 171 Annotation: Subtype: Link Rect: 118, 126, 155, 136 Annotation: Subtype: Link Rect: 161, 126, 197, 136 Annotation: Subtype: Link Rect: 210, 91, 247, 102 Annotation: Subtype: Link Rect: 254, 91, 290, 102 Annotation: Subtype: Link Rect: 376, 68, 414, 79 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 289, 724, 327, 735 Annotation: Subtype: Link Rect: 112, 678, 150, 689 Annotation: Subtype: Link Rect: 305, 643, 342, 654 Annotation: Subtype: Link Rect: 271, 608, 308, 619 Annotation: Subtype: Link Rect: 124, 585, 440, 596 Annotation: Subtype: Link Rect: 239, 551, 277, 562 Annotation: Subtype: Link Rect: 489, 516, 526, 527 Annotation: Subtype: Link Rect: 380, 493, 418, 504 Annotation: Subtype: Link Rect: 424, 493, 460, 504 Annotation: Subtype: Link Rect: 356, 482, 560, 493 Annotation: Subtype: Link Rect: 56, 470, 427, 481 Annotation: Subtype: Link Rect: 211, 413, 249, 424 Annotation: Subtype: Link Rect: 255, 413, 291, 424 Annotation: Subtype: Link Rect: 459, 390, 497, 401 Annotation: Subtype: Link Rect: 251, 344, 289, 355 Annotation: Subtype: Link Rect: 103, 322, 141, 332 Annotation: Subtype: Link Rect: 289, 286, 327, 297 Annotation: Subtype: Link Rect: 211, 263, 249, 274 Annotation: Subtype: Link Rect: 210, 229, 247, 240 Annotation: Subtype: Link Rect: 473, 194, 510, 205 Annotation: Subtype: Link Rect: 117, 161, 155, 171 Annotation: Subtype: Link Rect: 161, 161, 197, 171 Annotation: Subtype: Link Rect: 59, 126, 96, 136 Annotation: Subtype: Link Rect: 102, 126, 138, 136 Annotation: Subtype: Link Rect: 59, 92, 96, 102 Annotation: Subtype: Link Rect: 102, 92, 138, 102 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 152, 713, 190, 723 Annotation: Subtype: Link Rect: 196, 713, 232, 723 Annotation: Subtype: Link Rect: 183, 678, 221, 689 Annotation: Subtype: Link Rect: 227, 678, 263, 689 Annotation: Subtype: Link Rect: 103, 644, 141, 654 Annotation: Subtype: Link Rect: 104, 598, 141, 608 Annotation: Subtype: Link Rect: 367, 562, 405, 573 Annotation: Subtype: Link Rect: 433, 539, 470, 550 Annotation: Subtype: Link Rect: 211, 447, 248, 458 Annotation: Subtype: Link Rect: 380, 413, 418, 424 Annotation: Subtype: Link Rect: 424, 413, 460, 424 Annotation: Subtype: Link Rect: 59, 379, 96, 389 Annotation: Subtype: Link Rect: 102, 379, 138, 389 Annotation: Subtype: Link Rect: 439, 344, 476, 355 Annotation: Subtype: Link Rect: 301, 321, 339, 332 Annotation: Subtype: Link Rect: 425, 298, 463, 309 Annotation: Subtype: Link Rect: 428, 263, 466, 274 Annotation: Subtype: Link Rect: 140, 230, 177, 240 Annotation: Subtype: Link Rect: 382, 218, 420, 228 Annotation: Subtype: Link Rect: 95, 195, 133, 205 Annotation: Subtype: Link Rect: 274, 171, 312, 182 Annotation: Subtype: Link Rect: 59, 138, 96, 148 Annotation: Subtype: Link Rect: 102, 138, 138, 148 Annotation: Subtype: Link Rect: 140, 103, 177, 113 Annotation: Subtype: Link Rect: 184, 103, 220, 113 Page: Sequence: 29 Annotations: Annotation: Subtype: Link Rect: 276, 712, 314, 723 Annotation: Subtype: Link Rect: 104, 678, 142, 689 Annotation: Subtype: Link Rect: 210, 655, 247, 665 Annotation: Subtype: Link Rect: 451, 620, 489, 631 Annotation: Subtype: Link Rect: 97, 598, 135, 608 Annotation: Subtype: Link Rect: 307, 562, 344, 573 Annotation: Subtype: Link Rect: 351, 562, 387, 573 Annotation: Subtype: Link Rect: 344, 528, 381, 539 Annotation: Subtype: Link Rect: 387, 528, 423, 539 Annotation: Subtype: Link Rect: 443, 505, 480, 516 Annotation: Subtype: Link Rect: 486, 505, 522, 516 Annotation: Subtype: Link Rect: 166, 471, 203, 481 Annotation: Subtype: Link Rect: 210, 471, 246, 481 Annotation: Subtype: Link Rect: 358, 447, 396, 458 Annotation: Subtype: Link Rect: 402, 447, 438, 458 Annotation: Subtype: Link Rect: 519, 424, 556, 435 Annotation: Subtype: Link Rect: 166, 390, 203, 401 Annotation: Subtype: Link Rect: 389, 367, 427, 378 Annotation: Subtype: Link Rect: 183, 333, 221, 343 Annotation: Subtype: Link Rect: 295, 298, 333, 309 Annotation: Subtype: Link Rect: 258, 263, 296, 274 Annotation: Subtype: Link Rect: 302, 263, 338, 274 Annotation: Subtype: Link Rect: 109, 230, 146, 240 Annotation: Subtype: Link Rect: 152, 230, 188, 240 Annotation: Subtype: Link Rect: 156, 194, 194, 205 Annotation: Subtype: Link Rect: 200, 194, 236, 205 Annotation: Subtype: Link Rect: 520, 171, 557, 182 Annotation: Subtype: Link Rect: 519, 148, 556, 159 Annotation: Subtype: Link Rect: 241, 114, 278, 125 Annotation: Subtype: Link Rect: 109, 92, 146, 102 Annotation: Subtype: Link Rect: 499, 79, 537, 90 Page: Sequence: 30 Annotations: Annotation: Subtype: Link Rect: 233, 724, 270, 735 Annotation: Subtype: Link Rect: 211, 701, 248, 712 Annotation: Subtype: Link Rect: 170, 678, 208, 689 Annotation: Subtype: Link Rect: 158, 644, 196, 654 Annotation: Subtype: Link Rect: 202, 644, 238, 654 Annotation: Subtype: Link Rect: 240, 620, 278, 631 Annotation: Subtype: Link Rect: 284, 620, 320, 631 Annotation: Subtype: Link Rect: 205, 574, 243, 585 Annotation: Subtype: Link Rect: 211, 539, 249, 550 Annotation: Subtype: Link Rect: 282, 517, 319, 527 Annotation: Subtype: Link Rect: 175, 482, 212, 493 Annotation: Subtype: Link Rect: 140, 448, 177, 458 Annotation: Subtype: Link Rect: 477, 401, 515, 412 Annotation: Subtype: Link Rect: 521, 401, 557, 412 Annotation: Subtype: Link Rect: 367, 378, 405, 389 Annotation: Subtype: Link Rect: 411, 367, 449, 378 Annotation: Subtype: Link Rect: 455, 367, 491, 378 Annotation: Subtype: Link Rect: 261, 344, 298, 355 Annotation: Subtype: Link Rect: 521, 321, 557, 332 Annotation: Subtype: Link Rect: 520, 309, 557, 320 Annotation: Subtype: Link Rect: 113, 287, 151, 297 Annotation: Subtype: Link Rect: 471, 263, 508, 274 Annotation: Subtype: Link Rect: 424, 240, 461, 251 Annotation: Subtype: Link Rect: 304, 206, 341, 217 Annotation: Subtype: Link Rect: 270, 171, 307, 182 Annotation: Subtype: Link Rect: 314, 171, 350, 182 Annotation: Subtype: Link Rect: 109, 149, 146, 159 Annotation: Subtype: Link Rect: 152, 149, 188, 159 Annotation: Subtype: Link Rect: 404, 114, 441, 125 Annotation: Subtype: Link Rect: 447, 114, 483, 125 Annotation: Subtype: Link Rect: 152, 92, 190, 102 Annotation: Subtype: Link Rect: 196, 92, 232, 102 Annotation: Subtype: Link Rect: 460, 68, 497, 79 Annotation: Subtype: Link Rect: 503, 68, 538, 79 Page: Sequence: 31 Annotations: Annotation: Subtype: Link Rect: 349, 724, 387, 735 Annotation: Subtype: Link Rect: 245, 689, 282, 700 Annotation: Subtype: Link Rect: 469, 666, 507, 677 Annotation: Subtype: Link Rect: 484, 643, 522, 654 Annotation: Subtype: Link Rect: 122, 609, 159, 619 Annotation: Subtype: Link Rect: 256, 574, 293, 585 Annotation: Subtype: Link Rect: 59, 540, 96, 550 Annotation: Subtype: Link Rect: 102, 540, 138, 550 Annotation: Subtype: Link Rect: 59, 506, 96, 516 Annotation: Subtype: Link Rect: 102, 506, 138, 516 Annotation: Subtype: Link Rect: 345, 482, 383, 493 Annotation: Subtype: Link Rect: 389, 482, 425, 493 Annotation: Subtype: Link Rect: 429, 459, 466, 470 Annotation: Subtype: Link Rect: 473, 459, 509, 470 Annotation: Subtype: Link Rect: 169, 436, 206, 447 Annotation: Subtype: Link Rect: 194, 413, 232, 424 Annotation: Subtype: Link Rect: 180, 367, 218, 378 Annotation: Subtype: Link Rect: 416, 355, 454, 366 Annotation: Subtype: Link Rect: 138, 310, 176, 320 Annotation: Subtype: Link Rect: 118, 276, 155, 286 Annotation: Subtype: Link Rect: 161, 276, 197, 286 Annotation: Subtype: Link Rect: 59, 241, 96, 251 Annotation: Subtype: Link Rect: 102, 241, 138, 251 Annotation: Subtype: Link Rect: 104, 207, 141, 217 Annotation: Subtype: Link Rect: 147, 207, 183, 217 Annotation: Subtype: Link Rect: 481, 194, 516, 205 Annotation: Subtype: Link Rect: 522, 194, 557, 205 Annotation: Subtype: Link Rect: 228, 172, 266, 182 Annotation: Subtype: Link Rect: 272, 172, 308, 182 Annotation: Subtype: Link Rect: 440, 148, 477, 159 Annotation: Subtype: Link Rect: 484, 148, 520, 159 Annotation: Subtype: Link Rect: 140, 126, 177, 136 Annotation: Subtype: Link Rect: 518, 102, 555, 113 Annotation: Subtype: Link Rect: 291, 80, 328, 90 Page: Sequence: 32 Annotations: Annotation: Subtype: Link Rect: 293, 724, 330, 735 Annotation: Subtype: Link Rect: 228, 701, 264, 712 Annotation: Subtype: Link Rect: 149, 644, 186, 654 Annotation: Subtype: Link Rect: 192, 644, 228, 654 Annotation: Subtype: Link Rect: 220, 609, 257, 619 Annotation: Subtype: Link Rect: 263, 609, 299, 619 Annotation: Subtype: Link Rect: 441, 585, 479, 596 Annotation: Subtype: Link Rect: 485, 585, 521, 596 Annotation: Subtype: Link Rect: 451, 562, 489, 573 Annotation: Subtype: Link Rect: 352, 528, 389, 539 Annotation: Subtype: Link Rect: 521, 516, 557, 527 Annotation: Subtype: Link Rect: 397, 493, 435, 504 Annotation: Subtype: Link Rect: 463, 482, 560, 493 Annotation: Subtype: Link Rect: 56, 470, 255, 481 Annotation: Subtype: Link Rect: 486, 401, 524, 412 Annotation: Subtype: Link Rect: 391, 391, 429, 401 Annotation: Subtype: Link Rect: 435, 391, 471, 401 Annotation: Subtype: Link Rect: 295, 367, 332, 378 Annotation: Subtype: Link Rect: 338, 367, 374, 378 Annotation: Subtype: Link Rect: 390, 344, 428, 355 Annotation: Subtype: Link Rect: 434, 344, 470, 355 Annotation: Subtype: Link Rect: 520, 332, 557, 343 Annotation: Subtype: Link Rect: 122, 299, 159, 309 Annotation: Subtype: Link Rect: 166, 299, 202, 309 Annotation: Subtype: Link Rect: 94, 276, 132, 286 Annotation: Subtype: Link Rect: 436, 252, 473, 263 Annotation: Subtype: Link Rect: 316, 229, 354, 240 Annotation: Subtype: Link Rect: 231, 194, 268, 205 Annotation: Subtype: Link Rect: 145, 172, 183, 182 Annotation: Subtype: Link Rect: 373, 160, 410, 171 Annotation: Subtype: Link Rect: 417, 160, 453, 171 Annotation: Subtype: Link Rect: 59, 138, 96, 148 Annotation: Subtype: Link Rect: 102, 138, 138, 148 Annotation: Subtype: Link Rect: 354, 114, 391, 125 Annotation: Subtype: Link Rect: 222, 91, 259, 102 Annotation: Subtype: Link Rect: 265, 91, 301, 102 Annotation: Subtype: Link Rect: 59, 69, 96, 79 Annotation: Subtype: Link Rect: 102, 69, 138, 79 Page: Sequence: 33 Annotations: Annotation: Subtype: Link Rect: 513, 724, 550, 735 Annotation: Subtype: Link Rect: 108, 690, 146, 700 Annotation: Subtype: Link Rect: 104, 655, 141, 665 Annotation: Subtype: Link Rect: 109, 621, 146, 631 Annotation: Subtype: Link Rect: 448, 597, 486, 608 Annotation: Subtype: Link Rect: 161, 574, 199, 585 Annotation: Subtype: Link Rect: 205, 574, 241, 585 Annotation: Subtype: Link Rect: 210, 551, 248, 562 Annotation: Subtype: Link Rect: 213, 528, 249, 539 Annotation: Subtype: Link Rect: 519, 459, 557, 470 Annotation: Subtype: Link Rect: 432, 436, 469, 447 Annotation: Subtype: Link Rect: 522, 424, 557, 435 Annotation: Subtype: Link Rect: 238, 401, 276, 412 Annotation: Subtype: Link Rect: 263, 367, 300, 378 Annotation: Subtype: Link Rect: 131, 345, 168, 355 Annotation: Subtype: Link Rect: 181, 322, 217, 332 Annotation: Subtype: Link Rect: 459, 309, 497, 320 Annotation: Subtype: Link Rect: 503, 309, 539, 320 Annotation: Subtype: Link Rect: 330, 275, 368, 286 Annotation: Subtype: Link Rect: 374, 275, 410, 286 Annotation: Subtype: Link Rect: 356, 252, 393, 263 Annotation: Subtype: Link Rect: 129, 218, 167, 228 Annotation: Subtype: Link Rect: 521, 206, 557, 217 Annotation: Subtype: Link Rect: 138, 149, 176, 159 Annotation: Subtype: Link Rect: 104, 115, 141, 125 Annotation: Subtype: Link Rect: 147, 115, 183, 125 Annotation: Subtype: Link Rect: 366, 91, 403, 102 Annotation: Subtype: Link Rect: 409, 91, 445, 102 Page: Sequence: 34 Annotations: Annotation: Subtype: Link Rect: 109, 713, 146, 723 Annotation: Subtype: Link Rect: 59, 678, 96, 689 Annotation: Subtype: Link Rect: 102, 678, 138, 689 Annotation: Subtype: Link Rect: 200, 644, 237, 654 Annotation: Subtype: Link Rect: 521, 620, 557, 631 Annotation: Subtype: Link Rect: 367, 597, 405, 608 Annotation: Subtype: Link Rect: 510, 585, 548, 596 Annotation: Subtype: Link Rect: 522, 562, 557, 573 Annotation: Subtype: Link Rect: 127, 540, 164, 550 Annotation: Subtype: Link Rect: 59, 506, 96, 516 Annotation: Subtype: Link Rect: 102, 506, 138, 516 Annotation: Subtype: Link Rect: 458, 493, 560, 504 Annotation: Subtype: Link Rect: 56, 482, 400, 493 Annotation: Subtype: Link Rect: 293, 447, 331, 458 Annotation: Subtype: Link Rect: 337, 447, 373, 458 Annotation: Subtype: Link Rect: 346, 413, 384, 424 Annotation: Subtype: Link Rect: 390, 413, 426, 424 Annotation: Subtype: Link Rect: 265, 378, 303, 389 Annotation: Subtype: Link Rect: 460, 355, 497, 366 Annotation: Subtype: Link Rect: 522, 332, 557, 343 Checksum: 02ee389c Type: CRC32 Checksum: 807740f65cfd9d4c0dd7c28be199ffb6 Type: MD5 Checksum: b00e1c000abe7356da1ed26bfc3880746bae7e26 Type: SHA-1