cf551688c26e6f6777f91d39fc118a52 pmc_35218324.pdf f04accb37f866bea354771dfe7d55ab41404736b pmc_35218324.pdf d6304ba9f41efec2d5d1d2441a2cddcc4f730a22d83d87d9ce73cfa6f9d59dc7 pmc_35218324.pdf Title: Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria Creator: Arbortext Advanced Print Publisher 11.2.5182/W-x64 Producer: PDFlib+PDI 9.1.2p4 (C++/Win64) CreationDate: Sat Feb 12 02:39:47 2022 CET ModDate: Sat Feb 12 02:43:35 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1172104 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XMNFGF+Lato-Regular Type 1C Custom yes yes yes 414 0 LSKUUR+STIX-Bold Type 1C Custom yes yes yes 419 0 NMSPHR+Lato-Bold Type 1C Custom yes yes yes 411 0 TOQPEI+Lato-Bold CID TrueType Identity-H yes yes yes 421 0 LPCZXB+Lato-Regular CID TrueType Identity-H yes yes yes 426 0 XCWUMW+STIXGeneral Type 1C Custom yes yes yes 431 0 SYSUPD+Lato-Italic Type 1C Custom yes yes yes 436 0 ESSTIX-Two Type 1 Builtin yes no yes 239 0 TeX_CM_Maths_Symbols Type 1 Builtin yes no yes 257 0 SLAOAU+Lato-BoldItalic Type 1C Custom yes yes yes 253 0 KMYTUG+STIXGeneral-Bold Type 1C Custom yes yes yes 254 0 NLFDQF+ArialMT Type 1 Custom yes yes no 266 0 IBSEMY+Arial-BoldMT Type 1 Custom yes yes no 88 0 Helvetica-Bold Type 1 Custom no no no 261 0 XINEDD+Arial-BoldMT Type 1 Custom yes yes no 103 0 SQCTMX+Arial-BoldMT Type 1 Custom yes yes no 119 0 LDADBX+Arial-BoldMT Type 1 Custom yes yes no 154 0 ZBJATW+Lato-Italic CID TrueType Identity-H yes yes yes 273 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-19 02:33:09 CEST RepresentationInformation: pmc_35218324.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-06 18:36:28 CET Size: 1172104 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 518 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Children: Item: Title: 1 | BACKGROUND Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: 2 | METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: 2.1 | Study design and patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: 2.2 | Assessment of patient‐reported outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: 2.3 | Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: 3 | RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: 3.1 | Baseline characteristics from the Phase 2b core and extension studies were well balanced Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: 3.2 | Many patients with CSU experienced sleep impairment at baseline, some of which was substantial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 3.3 | Ligelizumab achieved numerically greater improvements in Weekly Sleep Interference scores compared with placebo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 3.4 | Weekly Activity Interference scores improved and remained stable throughout treatment with ligelizumab Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 3.5 | Dermatology Life Quality Index improvement was numerically greater for patients treated with ligelizumab compared wit ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 3.6 | Ligelizumab led to numerically greater improvements in Presenteeism and Overall Work Impairment compared with omalizu ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 4 | DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 5 | CONCLUSIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: CONFLICT OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: AUTHOR CONTRIBUTIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Info: Title: Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria Creator: Arbortext Advanced Print Publisher 11.2.5182/W-x64 Producer: PDFlib+PDI 9.1.2p4 (C++/Win64) CreationDate: Sat Feb 12 03:09:47 CET 2022 ModDate: Sat Feb 12 03:13:35 CET 2022 ID: 0x4a8310ea194242cea3ff014444260572, 0x438db6ed55e555418f82d6261b0d81db Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: ZBJATW+Lato-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: TOQPEI+Lato-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: LPCZXB+Lato-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: TeX_CM_Maths_Symbols FirstChar: 1 LastChar: 255 FontDescriptor: FontName: TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true Font: BaseFont: LSKUUR+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LSKUUR+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SYSUPD+Lato-Italic FontSubset: true FirstChar: 1 LastChar: 41 FontDescriptor: FontName: SYSUPD+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NMSPHR+Lato-Bold FontSubset: true FirstChar: 1 LastChar: 66 FontDescriptor: FontName: NMSPHR+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SLAOAU+Lato-BoldItalic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: SLAOAU+Lato-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -110, -250, 1049, 937 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XMNFGF+Lato-Regular FontSubset: true FirstChar: 1 LastChar: 89 FontDescriptor: FontName: XMNFGF+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KMYTUG+STIXGeneral-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KMYTUG+STIXGeneral-Bold Flags: Nonsymbolic, ForceBold FontBBox: -178, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XCWUMW+STIXGeneral FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: XCWUMW+STIXGeneral Flags: Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ESSTIX-Two FirstChar: 33 LastChar: 168 FontDescriptor: FontName: ESSTIX-Two Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true CIDFontType2: Font: BaseFont: ZBJATW+Lato-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZBJATW+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -502, -269, 1291, 1078 FontFile2: true Font: BaseFont: TOQPEI+Lato-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TOQPEI+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -603, -285, 1344, 1100 FontFile2: true Font: BaseFont: LPCZXB+Lato-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LPCZXB+Lato-Regular Flags: Nonsymbolic FontBBox: -547, -269, 1343, 1079 FontFile2: true XMP: 2022-02-12T07:09:47+05:30 Arbortext Advanced Print Publisher 11.2.5182/W-x64 2022-02-12T07:13:35+05:30 2022-02-12T07:13:35+05:30 PDFlib+PDI 9.1.2p4 (C++/Win64) False 10.1002/clt2.12121 10.1002/(ISSN)2045-7022 3 PStill version 1.84.42 VoR 10.1002/clt2.12121 application/pdf Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria uuid:189ba062-826a-476a-8825-86a4fbb330e3 uuid:5c5dd21e-56a7-4b2a-9fe7-78f58bd6c92f Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 62, 729, 124, 736 Flags: No flags set Annotation: Subtype: Link Rect: 155, 598, 161, 610 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 163, 593, 172, 604 Flags: No flags set Annotation: Subtype: Link Rect: 280, 598, 285, 610 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 288, 593, 297, 604 Flags: No flags set Annotation: Subtype: Link Rect: 426, 598, 432, 610 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 434, 593, 443, 604 Flags: No flags set Annotation: Subtype: Link Rect: 128, 580, 134, 592 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 248, 580, 253, 592 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 256, 575, 264, 586 Flags: No flags set Annotation: Subtype: Link Rect: 334, 580, 339, 592 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 342, 575, 350, 586 Flags: No flags set Annotation: Subtype: Link Rect: 461, 580, 466, 592 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 132, 562, 137, 574 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 257, 562, 262, 574 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 409, 562, 415, 574 Flags: No flags set Destination: 381 Annotation: Subtype: Link Rect: 66, 281, 177, 288 Flags: No flags set Annotation: Subtype: Link Rect: 45, 270, 153, 277 Flags: No flags set Annotation: Subtype: Link Rect: 163, 595, 172, 604 Flags: No flags set Annotation: Subtype: Link Rect: 288, 595, 297, 604 Flags: No flags set Annotation: Subtype: Link Rect: 434, 595, 443, 604 Flags: No flags set Annotation: Subtype: Link Rect: 256, 577, 264, 586 Flags: No flags set Annotation: Subtype: Link Rect: 342, 577, 350, 586 Flags: No flags set Annotation: Subtype: Link Rect: 398, 28, 506, 35 Flags: No flags set Annotation: Subtype: Link Rect: 45, 18, 154, 25 Flags: No flags set Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 240, 493, 250, 501 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 166, 454, 169, 462 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 73, 441, 76, 449 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 209, 441, 212, 449 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 89, 415, 92, 423 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 262, 350, 266, 358 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 85, 285, 91, 293 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 193, 247, 208, 255 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 281, 234, 288, 242 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 171, 208, 178, 216 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 178, 169, 185, 177 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 281, 143, 288, 151 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 350, 544, 357, 552 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 534, 532, 541, 540 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 384, 415, 391, 423 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 345, 376, 352, 384 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 506, 234, 513, 242 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 401, 152, 406, 160 Flags: No flags set Destination: 43 Annotation: Subtype: Link Rect: 470, 78, 477, 86 Flags: No flags set Destination: 182 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 169, 427, 176, 435 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 64, 168, 79, 176 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 56, 129, 71, 137 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 176, 77, 191, 85 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 353, 427, 360, 435 Flags: No flags set Destination: 182 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 332, 167, 337, 175 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 341, 171, 348, 179 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 105, 644, 108, 652 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 90, 629, 93, 636 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 139, 458, 141, 466 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 143, 443, 146, 450 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 152, 427, 155, 434 Flags: No flags set Destination: 61 Annotation: Subtype: Link Rect: 71, 400, 74, 408 Flags: No flags set Destination: 61 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 141, 682, 151, 690 Flags: No flags set Destination: 81 Annotation: Subtype: Link Rect: 462, 682, 472, 690 Flags: No flags set Destination: 81 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 432, 101, 442, 109 Flags: No flags set Destination: 81 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 274, 450, 284, 458 Flags: No flags set Destination: 94 Annotation: Subtype: Link Rect: 176, 424, 186, 432 Flags: No flags set Destination: 94 Annotation: Subtype: Link Rect: 120, 256, 130, 264 Flags: No flags set Destination: 111 Annotation: Subtype: Link Rect: 221, 191, 231, 199 Flags: No flags set Destination: 111 Annotation: Subtype: Link Rect: 219, 75, 224, 83 Flags: No flags set Destination: 126 Annotation: Subtype: Link Rect: 274, 75, 284, 83 Flags: No flags set Destination: 146 Annotation: Subtype: Link Rect: 407, 437, 417, 445 Flags: No flags set Destination: 146 Annotation: Subtype: Link Rect: 443, 78, 450, 86 Flags: No flags set Destination: 182 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 398, 78, 408, 86 Flags: No flags set Destination: 182 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 272, 621, 276, 629 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 281, 530, 288, 538 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 204, 336, 211, 344 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 80, 271, 86, 279 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 165, 219, 172, 227 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 519, 712, 526, 720 Flags: No flags set Destination: 182 Annotation: Subtype: Link Rect: 526, 566, 549, 574 Flags: No flags set Annotation: Subtype: Link Rect: 306, 554, 381, 561 Flags: No flags set Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 115, 566, 126, 573 Flags: No flags set Annotation: Subtype: Link Rect: 126, 566, 269, 573 Flags: No flags set Annotation: Subtype: Link Rect: 99, 553, 110, 561 Flags: No flags set Annotation: Subtype: Link Rect: 110, 553, 253, 561 Flags: No flags set Annotation: Subtype: Link Rect: 112, 540, 123, 548 Flags: No flags set Annotation: Subtype: Link Rect: 123, 540, 266, 548 Flags: No flags set Annotation: Subtype: Link Rect: 103, 527, 114, 535 Flags: No flags set Annotation: Subtype: Link Rect: 114, 527, 256, 535 Flags: No flags set Annotation: Subtype: Link Rect: 76, 514, 87, 522 Flags: No flags set Annotation: Subtype: Link Rect: 87, 514, 231, 522 Flags: No flags set Annotation: Subtype: Link Rect: 130, 339, 244, 347 Flags: No flags set Annotation: Subtype: Link Rect: 384, 658, 499, 666 Flags: No flags set Annotation: Subtype: Link Rect: 499, 501, 549, 509 Flags: No flags set Annotation: Subtype: Link Rect: 324, 491, 385, 498 Flags: No flags set Annotation: Subtype: Link Rect: 471, 93, 535, 101 Flags: No flags set Annotation: Subtype: Link Rect: 319, 80, 379, 88 Flags: No flags set Annotation: Subtype: Link Rect: 115, 567, 123, 576 Flags: No flags set Annotation: Subtype: Link Rect: 99, 555, 107, 563 Flags: No flags set Annotation: Subtype: Link Rect: 112, 542, 121, 550 Flags: No flags set Annotation: Subtype: Link Rect: 103, 529, 111, 537 Flags: No flags set Annotation: Subtype: Link Rect: 76, 516, 85, 524 Flags: No flags set Checksum: 290079ca Type: CRC32 Checksum: cf551688c26e6f6777f91d39fc118a52 Type: MD5 Checksum: f04accb37f866bea354771dfe7d55ab41404736b Type: SHA-1