1b3d7f3988588ac77517cd1f6e06cbbf pmc_7613607.pdf ad8843a920dfa13e41d0bb3a14dd877b9b7ad06d pmc_7613607.pdf 0b0b12d7dfa55a5a0ffeff08e6ac5b512abb26bc861e771ebc5b25a980246950 pmc_7613607.pdf Title: ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Subject: Journal of Structural Biology, 214 (2022) 107872. doi:10.1016/j.jsb.2022.107872 Author: J. Jiménez de la Morena Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Sep 3 12:47:17 2022 CEST ModDate: Sat Sep 3 13:00:52 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 14579850 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MOJDYK+Univers Type 1C Builtin yes yes yes 864 0 YQPTOW+CharisSIL CID TrueType Identity-H yes yes yes 868 0 SRBSFD+TeX_CM_Roman Type 1C Builtin yes yes yes 873 0 ZPJDHL+CharisSIL-Bold CID TrueType Identity-H yes yes yes 877 0 QPCEUJ+CharisSIL-Italic CID TrueType Identity-H yes yes yes 882 0 POZUUJ+CharisSIL CID TrueType Identity-H yes yes yes 855 0 RAXZAR+STIX-Regular Type 1C Custom yes yes yes 340 0 SCKHCH+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 345 0 KQXZAN+CharisSIL-Italic CID TrueType Identity-H yes yes yes 332 0 AATEDD+STIX-Italic Type 1C Custom yes yes yes 353 0 RNBMOH+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 359 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-03 02:32:38 CET RepresentationInformation: pmc_7613607.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-10 02:12:51 CET Size: 14579850 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 968 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 2 The cryoET pipeline Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Children: Item: Title: 2.1 Data and metadata import Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 2.2 Tilt series movies alignment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 2.3 CTF estimation and correction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 2.4 Tilt series alignment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 2.5 Tomogram reconstruction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 2.6 Tomogram denoising Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 2.7 Tomogram particle picking Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 2.8 Picking pruning tools Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 2.9 Subtomogram averaging (STA) and per-particle per-tilt refinement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 2.10 Heterogeneity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Children: Item: Title: 2.10.1 Continuous conformational variability analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 2.11 Post-processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Children: Item: Title: 2.11.1 Local resolution estimation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: 2.11.2 Subtomogram subtraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: 2.11.3 Map back Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: 2.12 Visualization tools Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: 3 Workflow examples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Children: Item: Title: 3.1 Workflow 1: From tilt series to particle picking Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: 3.2 Workflow 2: Directional picking Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: 3.3 Workflow 3: Subtomogram averaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: 3.4 Workflow 4: The “SPA leap” Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: 4 A collaborative software project Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Item: Title: 5 Current status and future work Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22eeefeb Item: Title: 6 Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17d0685f Children: Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3891771e Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78ac1102 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2de8284b Item: Title: Appendix A Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@396e2f39 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a74868d Info: Title: ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation Author: J. Jiménez de la Morena Subject: Journal of Structural Biology, 214 (2022) 107872. doi:10.1016/j.jsb.2022.107872 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Sep 03 12:47:17 CEST 2022 ModDate: Sat Sep 03 13:00:52 CEST 2022 ID: 0xf9f3f819b0cc53c691009bd83e2c5cc2, 0xd304935dd4c81e7e699841309fa30c6b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: QPCEUJ+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: YQPTOW+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: RNBMOH+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: ZPJDHL+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MOJDYK+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: MOJDYK+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: AATEDD+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: AATEDD+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RAXZAR+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: RAXZAR+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SRBSFD+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: SRBSFD+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SCKHCH+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: SCKHCH+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: QPCEUJ+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QPCEUJ+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: YQPTOW+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YQPTOW+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: RNBMOH+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RNBMOH+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: ZPJDHL+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZPJDHL+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: application/pdf 10.1016/j.jsb.2022.107872 Elsevier Inc. Journal of Structural Biology, 214 (2022) 107872. doi:10.1016/j.jsb.2022.107872 ScipionTomo: Towards cryo-electron tomography software integration, reproducibility, and validation J. Jiménez de la Morena P. Conesa Y.C. Fonseca F.P. de Isidro-Gómez D. Herreros E. Fernández-Giménez D. Strelak E. Moebel T.O. Buchholz F. Jug A. Martinez-Sanchez M. Harastani S. Jonic J.J. Conesa A. Cuervo P. Losana I. Sánchez M. Iceta L. del Cano M. Gragera R. Melero G. Sharov D. Castaño-Díez A. Koster J.G. Piccirillo J.L. Vilas J. Otón R. Marabini C.O.S. Sorzano J.M. Carazo journal Journal of Structural Biology © 2022 The Authors. Published by Elsevier Inc. 1047-8477 214 3 1 September 2022 2022-09-01 107872 107872 10.1016/j.jsb.2022.107872 https://doi.org/10.1016/j.jsb.2022.107872 2010-04-23 true 10.1016/j.jsb.2022.107872 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.jsb.2022.107872 noindex 2010-04-23 true 3rd September 2022 sciencedirect.com elsevier.com Elsevier 2022-09-03T11:00:52 2022-09-03T10:47:17 2022-09-03T11:00:52 True 3rd September 2022 Acrobat Distiller 8.1.0 (Windows) uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 155, 571, 469, 582 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 144, 563, 209, 574 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 210, 558, 269, 569 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 269, 558, 348, 569 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 348, 563, 355, 574 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 355, 558, 396, 569 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 396, 563, 403, 574 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 404, 558, 471, 569 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 77, 550, 83, 561 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 84, 545, 158, 556 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 158, 545, 273, 556 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 273, 545, 456, 556 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 77, 532, 325, 543 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 325, 532, 410, 543 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 410, 532, 464, 543 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 464, 532, 471, 543 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 102, 519, 205, 530 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 205, 519, 271, 530 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 271, 524, 277, 535 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 278, 519, 363, 530 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 363, 524, 369, 535 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 370, 527, 374, 532 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 370, 519, 438, 530 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 438, 524, 444, 535 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 445, 527, 449, 532 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 445, 519, 449, 530 Flags: Print Destination: 840 Annotation: Subtype: Link Rect: 223, 302, 319, 309 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 233, 292, 299, 300 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 309, 145, 409, 152 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 103, 104, 157, 111 Flags: Print Annotation: Subtype: Link Rect: 216, 104, 277, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 278, 667, 393, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 175, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 219, 748, 375, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 405, 59, 552, 70 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 215, 689, 285, 696 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 272, 636, 288, 644 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 37, 626, 150, 634 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 244, 553, 288, 561 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 37, 542, 90, 550 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 131, 542, 218, 550 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 249, 542, 288, 550 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 532, 55, 540 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 93, 532, 186, 540 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 224, 532, 288, 540 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 521, 78, 529 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 112, 521, 218, 529 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 266, 521, 288, 529 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 511, 98, 519 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 127, 511, 205, 519 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 244, 511, 288, 519 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 500, 55, 508 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 87, 500, 159, 508 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 485, 626, 552, 634 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 467, 563, 488, 571 Flags: Print Destination: 1 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 37, 594, 58, 602 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 172, 385, 261, 393 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 236, 364, 288, 372 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 354, 144, 362 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 378, 636, 443, 644 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 464, 559, 520, 567 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 425, 548, 472, 556 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 440, 517, 461, 525 Flags: Print Destination: 44 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 271, 87, 288, 95 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 37, 77, 128, 85 Flags: Print Destination: 169 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 40, 689, 124, 696 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 178, 500, 257, 508 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 238, 458, 288, 466 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 49, 448, 239, 456 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 274, 427, 288, 435 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 49, 416, 283, 424 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 202, 395, 267, 403 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 155, 165, 226, 173 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 40, 155, 103, 163 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 202, 144, 283, 152 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 309, 573, 418, 581 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 461, 71, 541, 79 Flags: Print Destination: 209 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 168, 647, 196, 655 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 232, 353, 288, 361 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 343, 55, 351 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 123, 343, 205, 351 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 195, 123, 288, 131 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 113, 76, 121 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 253, 102, 288, 110 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 92, 81, 100 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 514, 636, 557, 644 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 306, 626, 324, 633 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 519, 626, 557, 633 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 306, 615, 324, 623 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 527, 521, 547, 529 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 518, 385, 557, 393 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 306, 374, 383, 382 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 492, 312, 511, 320 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 447, 175, 466, 183 Flags: Print Destination: 44 Annotation: Subtype: Link Rect: 318, 102, 340, 110 Flags: Print Destination: 110 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 65, 228, 125, 236 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 529, 123, 548, 131 Flags: Print Destination: 110 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 194, 277, 214, 285 Flags: Print Destination: 120 Annotation: Subtype: Link Rect: 123, 196, 143, 204 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 67, 186, 143, 194 Flags: Print Destination: 169 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 46, 326, 71, 334 Flags: Print Destination: 147 Annotation: Subtype: Link Rect: 273, 269, 288, 277 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 259, 102, 267 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 176, 133, 201, 141 Flags: Print Destination: 158 Annotation: Subtype: Link Rect: 439, 284, 463, 292 Flags: Print Destination: 158 Annotation: Subtype: Link Rect: 468, 65, 492, 73 Flags: Print Destination: 158 Annotation: Subtype: Link Rect: 399, 369, 417, 376 Flags: Print Destination: 110 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 177, 293, 201, 301 Flags: Print Destination: 169 Annotation: Subtype: Link Rect: 112, 210, 187, 218 Flags: Print Destination: 209 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 75, 344, 140, 352 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 142, 281, 288, 289 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 49, 271, 67, 279 Flags: Print Destination: 209 Page: Label: 12 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 516, 320, 557, 328 Flags: Print Annotation: Subtype: Link Rect: 306, 310, 419, 318 Flags: Print Annotation: Subtype: Link Rect: 306, 271, 555, 277 Flags: Print Annotation: Subtype: Link Rect: 318, 263, 548, 269 Flags: Print Annotation: Subtype: Link Rect: 318, 255, 546, 261 Flags: Print Annotation: Subtype: Link Rect: 318, 247, 534, 253 Flags: Print Annotation: Subtype: Link Rect: 318, 239, 555, 245 Flags: Print Annotation: Subtype: Link Rect: 318, 231, 361, 237 Flags: Print Annotation: Subtype: Link Rect: 432, 191, 553, 198 Flags: Print Annotation: Subtype: Link Rect: 306, 183, 555, 190 Flags: Print Annotation: Subtype: Link Rect: 318, 175, 366, 182 Flags: Print Annotation: Subtype: Link Rect: 306, 167, 533, 174 Flags: Print Annotation: Subtype: Link Rect: 318, 159, 546, 166 Flags: Print Annotation: Subtype: Link Rect: 318, 151, 540, 158 Flags: Print Annotation: Subtype: Link Rect: 318, 143, 432, 150 Flags: Print Annotation: Subtype: Link Rect: 306, 135, 539, 142 Flags: Print Annotation: Subtype: Link Rect: 318, 127, 535, 134 Flags: Print Annotation: Subtype: Link Rect: 318, 119, 402, 126 Flags: Print Annotation: Subtype: Link Rect: 306, 111, 548, 118 Flags: Print Annotation: Subtype: Link Rect: 318, 103, 366, 110 Flags: Print Annotation: Subtype: Link Rect: 306, 95, 553, 102 Flags: Print Annotation: Subtype: Link Rect: 318, 88, 482, 94 Flags: Print Annotation: Subtype: Link Rect: 306, 80, 553, 86 Flags: Print Annotation: Subtype: Link Rect: 318, 72, 555, 78 Flags: Print Annotation: Subtype: Link Rect: 318, 64, 523, 70 Flags: Print Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 37, 732, 281, 738 Flags: Print Annotation: Subtype: Link Rect: 49, 724, 286, 730 Flags: Print Annotation: Subtype: Link Rect: 49, 716, 81, 722 Flags: Print Annotation: Subtype: Link Rect: 37, 708, 270, 714 Flags: Print Annotation: Subtype: Link Rect: 49, 700, 273, 706 Flags: Print Annotation: Subtype: Link Rect: 49, 692, 128, 698 Flags: Print Annotation: Subtype: Link Rect: 37, 684, 279, 690 Flags: Print Annotation: Subtype: Link Rect: 49, 676, 286, 682 Flags: Print Annotation: Subtype: Link Rect: 49, 668, 210, 674 Flags: Print Annotation: Subtype: Link Rect: 37, 660, 261, 666 Flags: Print Annotation: Subtype: Link Rect: 49, 652, 286, 658 Flags: Print Annotation: Subtype: Link Rect: 49, 644, 286, 651 Flags: Print Annotation: Subtype: Link Rect: 49, 636, 122, 643 Flags: Print Annotation: Subtype: Link Rect: 37, 628, 274, 635 Flags: Print Annotation: Subtype: Link Rect: 49, 620, 261, 627 Flags: Print Annotation: Subtype: Link Rect: 37, 612, 286, 619 Flags: Print Annotation: Subtype: Link Rect: 49, 604, 286, 611 Flags: Print Annotation: Subtype: Link Rect: 49, 596, 74, 603 Flags: Print Annotation: Subtype: Link Rect: 37, 588, 273, 595 Flags: Print Annotation: Subtype: Link Rect: 49, 580, 286, 587 Flags: Print Annotation: Subtype: Link Rect: 49, 572, 255, 579 Flags: Print Annotation: Subtype: Link Rect: 37, 565, 286, 571 Flags: Print Annotation: Subtype: Link Rect: 49, 557, 286, 563 Flags: Print Annotation: Subtype: Link Rect: 49, 549, 111, 555 Flags: Print Annotation: Subtype: Link Rect: 37, 541, 275, 547 Flags: Print Annotation: Subtype: Link Rect: 49, 533, 238, 539 Flags: Print Annotation: Subtype: Link Rect: 37, 501, 279, 507 Flags: Print Annotation: Subtype: Link Rect: 49, 493, 277, 499 Flags: Print Annotation: Subtype: Link Rect: 49, 485, 197, 491 Flags: Print Annotation: Subtype: Link Rect: 37, 469, 285, 475 Flags: Print Annotation: Subtype: Link Rect: 49, 461, 75, 467 Flags: Print Annotation: Subtype: Link Rect: 37, 453, 275, 459 Flags: Print Annotation: Subtype: Link Rect: 49, 445, 284, 451 Flags: Print Annotation: Subtype: Link Rect: 37, 437, 286, 443 Flags: Print Annotation: Subtype: Link Rect: 49, 429, 277, 435 Flags: Print Annotation: Subtype: Link Rect: 49, 421, 197, 427 Flags: Print Annotation: Subtype: Link Rect: 37, 413, 275, 419 Flags: Print Annotation: Subtype: Link Rect: 49, 405, 172, 411 Flags: Print Annotation: Subtype: Link Rect: 37, 397, 284, 403 Flags: Print Annotation: Subtype: Link Rect: 49, 389, 258, 396 Flags: Print Annotation: Subtype: Link Rect: 37, 381, 283, 388 Flags: Print Annotation: Subtype: Link Rect: 49, 373, 282, 380 Flags: Print Annotation: Subtype: Link Rect: 49, 365, 99, 372 Flags: Print Annotation: Subtype: Link Rect: 211, 349, 286, 356 Flags: Print Annotation: Subtype: Link Rect: 49, 341, 96, 348 Flags: Print Annotation: Subtype: Link Rect: 134, 309, 262, 316 Flags: Print Annotation: Subtype: Link Rect: 306, 732, 539, 738 Flags: Print Annotation: Subtype: Link Rect: 318, 724, 536, 730 Flags: Print Annotation: Subtype: Link Rect: 318, 716, 446, 722 Flags: Print Annotation: Subtype: Link Rect: 306, 708, 545, 714 Flags: Print Annotation: Subtype: Link Rect: 318, 700, 414, 706 Flags: Print Annotation: Subtype: Link Rect: 306, 692, 547, 698 Flags: Print Annotation: Subtype: Link Rect: 318, 684, 553, 690 Flags: Print Annotation: Subtype: Link Rect: 306, 676, 545, 682 Flags: Print Annotation: Subtype: Link Rect: 318, 668, 555, 674 Flags: Print Annotation: Subtype: Link Rect: 318, 660, 361, 666 Flags: Print Annotation: Subtype: Link Rect: 306, 652, 530, 658 Flags: Print Annotation: Subtype: Link Rect: 318, 644, 521, 651 Flags: Print Annotation: Subtype: Link Rect: 306, 620, 552, 627 Flags: Print Annotation: Subtype: Link Rect: 318, 612, 526, 619 Flags: Print Annotation: Subtype: Link Rect: 318, 604, 538, 611 Flags: Print Annotation: Subtype: Link Rect: 318, 572, 444, 579 Flags: Print Annotation: Subtype: Link Rect: 306, 565, 555, 571 Flags: Print Annotation: Subtype: Link Rect: 318, 557, 462, 563 Flags: Print Annotation: Subtype: Link Rect: 306, 549, 555, 555 Flags: Print Annotation: Subtype: Link Rect: 318, 541, 550, 547 Flags: Print Annotation: Subtype: Link Rect: 318, 533, 542, 539 Flags: Print Annotation: Subtype: Link Rect: 318, 525, 428, 531 Flags: Print Annotation: Subtype: Link Rect: 499, 501, 545, 507 Flags: Print Annotation: Subtype: Link Rect: 318, 493, 398, 499 Flags: Print Annotation: Subtype: Link Rect: 344, 461, 473, 467 Flags: Print Annotation: Subtype: Link Rect: 306, 453, 540, 459 Flags: Print Annotation: Subtype: Link Rect: 318, 445, 552, 451 Flags: Print Annotation: Subtype: Link Rect: 318, 437, 542, 443 Flags: Print Annotation: Subtype: Link Rect: 318, 429, 456, 435 Flags: Print Annotation: Subtype: Link Rect: 344, 397, 466, 403 Flags: Print Annotation: Subtype: Link Rect: 306, 389, 555, 396 Flags: Print Annotation: Subtype: Link Rect: 318, 381, 543, 388 Flags: Print Annotation: Subtype: Link Rect: 318, 373, 343, 380 Flags: Print Annotation: Subtype: Link Rect: 306, 349, 554, 356 Flags: Print Annotation: Subtype: Link Rect: 318, 341, 541, 348 Flags: Print Annotation: Subtype: Link Rect: 318, 333, 343, 340 Flags: Print Checksum: 8294b898 Type: CRC32 Checksum: 1b3d7f3988588ac77517cd1f6e06cbbf Type: MD5 Checksum: ad8843a920dfa13e41d0bb3a14dd877b9b7ad06d Type: SHA-1