34a3edacf08888797fc323f8c57a246a pmc_7614743.pdf d0869bcea4eed2ed6ef56bc0c4d1452b8996f61c pmc_7614743.pdf 93da9965119b69d99ebdaa35dbbbc4614ace38e3f43ce0dfd330385341e6a410 pmc_7614743.pdf Title: DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium Author: Jolien Rijlaarsdam, Marta Cosin-Tomas, Laura Schellhas, Sarina Abrishamcar, Anni Malmberg, Alexander Neumann, Janine F. Felix, Jordi Sunyer, Kristine B. Gutzkow, Regina Grazuleviciene, John Wright, Mariza Kampouri, Heather J. Zar, Dan J. Stein, Kati Heinonen, Katri Räikkönen, Jari Lahti, Anke Hüls, Doretta Caramaschi, Silvia Alemany, Charlotte A. M. Cecil Creator: Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) Producer: Antenna House PDF Output Library 7.3.1863 CreationDate: Thu Jul 13 05:06:43 2023 CEST ModDate: Thu Jul 13 05:06:43 2023 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 792304 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica-Bold Type 1 Custom no no yes 11 0 Helvetica Type 1 Custom no no yes 14 0 Times-Roman Type 1 Custom no no yes 45 0 Times-Bold Type 1 Custom no no yes 53 0 Helvetica-BoldOblique Type 1 Standard no no no 65 0 RSRMBU+Code2000 CID TrueType Identity-H yes yes yes 285 0 Times-BoldItalic Type 1 Standard no no no 594 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-11-18 02:43:39 CET RepresentationInformation: pmc_7614743.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-11-09 02:18:53 CET Size: 792304 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 544 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Participants Item: Title: Measures Children: Item: Title: DNA methylation Item: Title: General psychopathology factor Item: Title: Covariates Item: Title: Statistical analyses Children: Item: Title: General psychopathology factor Item: Title: Cohort-specific EWAS Item: Title: Meta-analysis Item: Title: Differentially methylated regions Item: Title: Follow-up analyses Item: Title: Results Children: Item: Title: General psychopathology factor Item: Title: Epigenome-wide meta-analysis Children: Item: Title: Sensitivity analyses Item: Title: Differentially methylated regions Item: Title: Follow-up analyses Item: Title: Discussion Item: Title: References Item: Title: Fig. 1 Item: Title: Fig. 2 Item: Title: Table 1 Item: Title: Table 2 Item: Title: Table 3 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1048 ImageHeight: 2100 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1344 ImageHeight: 2098 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: RSRMBU+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: Helvetica-BoldOblique Font: BaseFont: Times-BoldItalic Font: BaseFont: Times-Bold FirstChar: 32 LastChar: 130 FontDescriptor: FontName: Times-Bold Flags: Nonsymbolic FontBBox: -168, -218, 1000, 935 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 131 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic FontBBox: -170, -228, 1003, 962 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 135 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica FirstChar: 32 LastChar: 133 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: RSRMBU+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RSRMBU+Code2000 Flags: Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true XMP: 2023-07-12T23:06:43-04:00 2023-07-12T23:06:43-04:00 application/pdf Antenna House PDF Output Library 7.3.1863 Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) 2023-07-12T23:06:43-04:00 DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium Jolien Rijlaarsdam, Marta Cosin-Tomas, Laura Schellhas, Sarina Abrishamcar, Anni Malmberg, Alexander Neumann, Janine F. Felix, Jordi Sunyer, Kristine B. Gutzkow, Regina Grazuleviciene, John Wright, Mariza Kampouri, Heather J. Zar, Dan J. Stein, Kati Heinonen, Katri Räikkönen, Jari Lahti, Anke Hüls, Doretta Caramaschi, Silvia Alemany, Charlotte A. M. Cecil Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: CC BY 4.0 Rect: 185, 362, 221, 370 LastModified: D:20230712230643-04'00' Annotation: Subtype: Link Contents: http://www.nature.com/reprints Rect: 264, 117, 364, 125 LastModified: D:20230712230643-04'00' Page: Sequence: 2 Page: Sequence: 3 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Contents: https://www.r-project.org/ Rect: 337, 521, 441, 531 LastModified: D:20230712230643-04'00' Page: Sequence: 7 Annotations: Annotation: Subtype: Link Contents: http://mqtldb.godmc.org.uk/ Rect: 466, 595, 490, 605 LastModified: D:20230712230643-04'00' Annotation: Subtype: Link Contents: mqtldb.godmc.org.uk/ Rect: 150, 581, 238, 591 LastModified: D:20230712230643-04'00' Annotation: Subtype: Link Contents: https://helixomics.isglobal.org/ Rect: 281, 455, 405, 465 LastModified: D:20230712230643-04'00' Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Contents: https://rdrr.io/github/isglobal-brge/EASIER/ Rect: 271, 216, 430, 225 LastModified: D:20230712230643-04'00' Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Page: Sequence: 20 Page: Sequence: 21 Page: Sequence: 22 Checksum: ee043e87 Type: CRC32 Checksum: 34a3edacf08888797fc323f8c57a246a Type: MD5 Checksum: d0869bcea4eed2ed6ef56bc0c4d1452b8996f61c Type: SHA-1