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825782 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 569 FreeObjects: 39 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Improving the Early Detection of Clinically Significant Prostate Cancer in Men in the Challenging Prostate Imaging-Reporting a渀搀 䐀愀琀愀 匀礀猀琀攀洀 ㌀ 䌀愀琀攀最漀爀礩㸾൥湤潢樍㔵㌠〠潢樍㰼⽐慲敮琠㔵㈠〠刯乥硴‵㘱‰⁒⽄敳瑛ㄠ〠刯䙩瑒‰‷㤴‵㜵‷㤴崯呩瑬攨1 Introduction Destination: 1 Children: Item: Title: 1 Introduction Destination: 1 Item: Title: 2 Patients and methods Destination: 1 Children: Item: Title: 2.1 Design, setting, and participants Destination: 1 Item: Title: 2.2 Testing Destination: 1 Item: Title: 2.3 Outcome measurements Destination: 1 Item: Title: 2.4 Statistical analysis Destination: 1 Item: Title: 3 Results Destination: 1 Children: Item: Title: 3.1 Efficacy of Proclarix, PSAD, and the ERSPC MRI predictive model for csPCa detection across the PI-RADS categories Destination: 1 Item: Title: 3.2 Characteristics of the cohort of men with PI-RADS 3 findings Destination: 1 Item: Title: 3.3 Efficacy, net benefit, and clinical utility of Proclarix, PSAD and MRI-ERSPC predictive model for csPCa detection in PI-RA䐀匀 ㌩㸾൥湤潢樍㔶ㄠ〠潢樍㰼⽆楲獴‵㘲‰⁒⽐慲敮琠㔵㈠〠刯乥硴‵㔸‰⁒⽄敳瑛ㄠ〠刯䙩瑒′㘠㜷㤠㔹㘠㜷㥝⽃潵湴‴⽌慳琠㔶㌠〠刯偲敶‵㔳‰⁒⽔楴汥⣾＀㈀ 倀愀琀椀攀渀琀猀 愀渀搀 洀攀琀栀漀搀猩㸾൥湤潢樍㔶㈠〠潢樍㰼⽐慲敮琠㔶ㄠ〠刯乥硴‵㘵‰⁒⽄敳瑛ㄠ〠刯䙩瑒′㘠㜶〠㔹㘠㜶そ⽔楴汥⣾＀㈀⸀㄀ 䐀攀猀椀最渀Ⰰ 猀攀琀琀椀渀最Ⰰ 愀渀搀 瀀愀爀琀椀挀椀瀀愀渀琀猩㸾൥湤潢樍㔶㌠〠潢樍㰼⽐慲敮琠㔶ㄠ〠刯䑥獴嬳ㄠ〠刯䙩瑒‰‷㤴‵㜰‷㤴崯偲敶‵㘴‰⁒⽔楴汥⣾＀㈀⸀㐀 匀琀愀琀椀猀琀椀挀愀氀 愀渀愀氀礀猀椀猩㸾൥湤潢樍㔶㐠〠潢樍㰼⽐慲敮琠㔶ㄠ〠刯乥硴‵㘳‰⁒⽄敳瑛㌱‰⁒⽆楴删〠㜹㐠㔷〠㜹㑝⽐牥瘠㔶㔠〠刯呩瑬攨2.3 Outcome measurements Destination: 1 Item: Title: 4 Discussion Destination: 1 Item: Title: 5 Conclusions Destination: 1 Item: Title: Appendix A Supplementary data Destination: 1 Item: Title: References Destination: 1 Info: Title: Improving the Early Detection of Clinically Significant Prostate Cancer in Men in the Challenging Prostate Imaging-Reporting and Data System 3 Category Author: Juan Morote Subject: European Urology Open Science, 37 (2022) 38-44. doi:10.1016/j.euros.2021.12.009 Keywords: Clinically significant prostate cancer; Multiparametric magnetic resonance imaging; Proclarix; Prostate-specific antigen density; European Randomized Study of Screening for Prostate Cancer predictive model Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Mon Feb 14 13:43:22 CET 2022 ModDate: Wed Feb 23 14:44:37 CET 2022 ID: 0x7cce01122ad22627e01e6448ed3dc69c, 0xbf7d358a3dbd0149b987fe8f417f986e Filters: FilterPipeline: FlateDecode FilterPipeline: CCITTFaxDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 1651 ImageHeight: 466 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 296 ImageHeight: 373 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 65 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: 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Semidey Richard Mast Anna Santamaria Jacques Planas Enrique Trilla European Urology Open Science, 37 (2022) 38-44. doi:10.1016/j.euros.2021.12.009 The Author(s) Clinically significant prostate cancer Multiparametric magnetic resonance imaging Proclarix Prostate-specific antigen density European Randomized Study of Screening for Prostate Cancer predictive model VoR 10.1016/j.euros.2021.12.009 noindex 6.5 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-02-23T18:44:37+05:30 2022-02-14T17:43:22+05:30 2022-02-23T18:44:37+05:30 True Acrobat Distiller 8.0.0 (Windows) Unknown Clinically significant prostate cancer; Multiparametric magnetic resonance imaging; Proclarix; Prostate-specific antigen density; European Randomized Study of Screening for Prostate Cancer predictive model uuid:fa609704-edd3-4338-9883-b63697422fa3 uuid:1e369915-e751-43c0-b118-3fe15f953cbf journal European Urology Open Science © 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association of Urology. 2666-1683 37 March 2022 38-44 38 44 10.1016/j.euros.2021.12.009 https://doi.org/10.1016/j.euros.2021.12.009 2010-04-23 true 10.1016/j.euros.2021.12.009 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 38 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 47, 614, 47, 625 Destination: null Annotation: Subtype: Link Rect: 47, 584, 47, 599 Destination: null Annotation: Subtype: Link Rect: 47, 507, 47, 518 Destination: null Annotation: Subtype: Link Rect: 112, 512, 116, 523 Destination: 424 Annotation: Subtype: Link Rect: 118, 512, 123, 523 Destination: 424 Annotation: Subtype: Link Rect: 125, 512, 129, 523 Destination: 424 Annotation: Subtype: Link Rect: 131, 509, 135, 522 Destination: 424 Annotation: Subtype: Link Rect: 234, 512, 239, 523 Destination: 424 Annotation: Subtype: Link Rect: 326, 512, 331, 523 Destination: 424 Annotation: Subtype: Link Rect: 400, 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