9c00a68d05d70fcfcbb21c2204a56104 pmc_8904370.pdf 0a88e46ce1216d69a729b289a53f575c008414cd pmc_8904370.pdf 724b4664e4dfd8f4409e65c0031d4e1e6196c95730443760a7327e94fd45137e pmc_8904370.pdf Title: Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes Subject: The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Keywords: type 1 diabetes (T1D), partial remission phase, honeymoon, biomarkers, pediatrics, prediction model, immune cell subpopulations, autoimmunity Author: Laia Gomez-Muñoz Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Feb 17 23:35:32 2022 CET ModDate: Fri Feb 18 00:55:25 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 12674758 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KJGOPG+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 1203 0 KJGOPH+AdvOT01861455.I Type 1C WinAnsi yes yes no 1204 0 KJGPAI+AdvOT1deab444.I Type 1C WinAnsi yes yes no 1205 0 KJGPAJ+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 1206 0 KJGPAK+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 1207 0 KJGPAL+AdvPSA323 Type 1C WinAnsi yes yes no 1208 0 KJGPAM+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 1209 0 KJGPAN+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 1210 0 KJGPAO+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 1218 0 KJGPCO+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 1224 0 KJGPCP+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 1225 0 KJGPGO+AdvOT1ef757c0 Type 1C Custom yes yes yes 556 0 KJGPGP+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 563 0 KJGPHA+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 568 0 KJGPIB+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 569 0 KJGPIC+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 583 0 KJGPJD+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 574 0 KJGPJE+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 579 0 KJGPLE+AdvOT34fe1490.B+20 Type 1C WinAnsi yes yes no 594 0 KJGPLF+AdvOT6e5d2ec0+22 Type 1C Custom yes yes yes 595 0 KJGPMF+AdvOT1deab444.I+22 Type 1C Custom yes yes yes 586 0 KJGPOG+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 597 0 KJHKLP+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 605 0 KJHLCO+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 600 0 KJKAIJ+AdvOT1ef757c0+01 Type 1C Custom yes yes no 627 0 KJKAIK+AdvTT58d178b9+03 Type 1C Custom yes yes yes 622 0 KJKAKL+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 629 0 KJKANK+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 630 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-14 02:29:13 CEST RepresentationInformation: pmc_8904370.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-28 07:25:31 CEST Size: 12674758 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B76' cannot be found Offset: 12639743 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B77' cannot be found Offset: 12639743 MIMEtype: application/pdf PDFMetadata: Objects: 1294 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Sample Collection, Longitudinal T1D Follow-Up, and PR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Clinical and Laboratory Testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Serum Cytokine Quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Clinical Features and Metabolic Data of Pediatric Patients With T1D Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Increase in Effector Memory CD4+ and CD8+ T Lymphocytes at the PR Phase Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Decrease in Total and Memory TREG at the PR Phase Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Increase in Regulatory B Lymphocyte Subpopulations After One-Year Follow-Up for Patients That Experienced the PR Phase Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Innate Immune Cells Are Altered at the Initial Stages of T1D and During the PR Phase Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Increase in the Concentration of Cytokines at T1D Onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Increase in the Concentration of Cytokines at T1D Onset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: An Index-Based Model Comprising the Percentage of TREG, DCs, and Monocytes at T1D Onset Could Predict the PR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes Author: Laia Gomez-Muñoz Subject: The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Keywords: type 1 diabetes (T1D), partial remission phase, honeymoon, biomarkers, pediatrics, prediction model, immune cell subpopulations, autoimmunity Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Feb 17 23:35:32 CET 2022 ModDate: Fri Feb 18 00:55:25 CET 2022 ID: 0x82978ebebf3a53ddf3fa4b4c8888b7fd, 0xc69cba5c6dba4c498cb934d7f0d380c6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3071 ImageHeight: 4372 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1297 ImageHeight: 638 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 326 ImageHeight: 1275 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: 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Publisher 10.0.1306/W Unicode 2022-02-18T07:55:25+08:00 application/pdf The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes Laia Gomez-Muñoz David Perna-Barrull Josep M. Caroz-Armayones Marta Murillo Silvia Rodriguez-Fernandez Aina Valls Federico Vazquez Jacobo Perez Raquel Corripio Luis Castaño Joan Bel Marta Vives-Pi type 1 diabetes (T1D) partial remission phase honeymoon biomarkers pediatrics prediction model immune cell subpopulations autoimmunity uuid:0a7293bb-6487-4de7-a211-c43e95c9e8e0 uuid:c9632e24-1fc1-4963-8ecf-ccd0f698ae44 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 589, 470, 610 Annotation: Subtype: Link Rect: 175, 566, 466, 587 Annotation: Subtype: Link Rect: 175, 543, 474, 564 Annotation: Subtype: Link Rect: 175, 520, 336, 541 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 413, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 444, 158, 452 Annotation: Subtype: Link Rect: 110, 295, 158, 302 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 463, 728, 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