6d05c16a901627e05da13eeeb5defb4c pmc_8911114.pdf 7f0756dc647f5ad8895ae5c53db44ad58f5c9b57 pmc_8911114.pdf 40e065b54fbfb3c2adcad16478ac84a8d5ff35f51d5f96e099f7b8538462c359 pmc_8911114.pdf Title: Social Responsiveness and Psychosocial Functioning in Adults with Prader–Willi Syndrome Subject: Although various studies have investigated symptoms of autism spectrum disorder (ASD) in Prader–Willi syndrome (PWS), little is known about the consequences of these symptoms, especially in psychosocial function. We aimed to explore ASD symptoms in adults with PWS with special attention to psychosocial functionality. This cross-sectional study included 26 adults (15 women) with PWS who attended a reference unit for rare diseases. Participants’ primary caregivers completed the Social Responsiveness Scale (SRS), and clinicians assessed multidimensional functioning with the Personal and Social Performance Scale (PSP). Impaired social responsiveness was identified in20 (76.9%) participants, and manifest to marked difficulties in social functioning were identified in13 (50%). Participants with impaired social responsiveness (SRS 60) had significantly worse scores in functionality measured with the PSP (U = 12.5; p = 0.009) and with three of the four PSP main areas. Moreover, scores for the Social Cognition domain of the SRS correlated positively with the Socially useful activities (p < 0.05) and Personal and social relationships (p < 0.01) main areas of the PSP. These results suggest that difficulties in social skills should be assessed in all psychosocial evaluations of patients with PWS. Keywords: Prader–Willi syndrome; autism; autism spectrum disorders; social responsiveness;social function; functionality; function Author: Meritxell Fernández-Lafitte, Jesus Cobo, Ramon Coronas, Isabel Parra, Joan Carles Oliva, Aida Àlvarez, Susanna Esteba-Castillo, Olga Giménez-Palop, Diego J. Palao and Assumpta Caixàs Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Mar 5 12:00:44 2022 CET ModDate: Sat Mar 5 12:04:15 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 311548 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YQMKHR+VnURWPalladioL Type 1 Custom yes yes no 10 0 NGRMHR+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 UIMBMA+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 EUOZDH+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 28 0 CAWYFT+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 40 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 44 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 48 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 60 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 63 0 JLZORU+EURM10 Type 1 Builtin yes yes no 91 0 APQRRX+URWPalladioL-BoldItal Type 1 Custom yes yes no 95 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 120 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-30 02:31:28 CEST RepresentationInformation: pmc_8911114.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-28 07:26:00 CEST Size: 311548 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 288 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Design and Sample Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Sociodemographic and Clinical Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: The Personal and Social Performance Scale Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Social Responsiveness Scale Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Relationship between the Personal and Social Performance Scale and Social Responsiveness Scale Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Strengths and Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: Social Responsiveness and Psychosocial Functioning in Adults with Prader Willi Syndrome Author: Meritxell Fernández-Lafitte, Jesus Cobo, Ramon Coronas, Isabel Parra, Joan Carles Oliva, Aida Àlvarez, Susanna Esteba-Castillo, Olga Giménez-Palop, Diego J. Palao and Assumpta Caixàs Subject: Although various studies have investigated symptoms of autism spectrum disorder (ASD) in Prader Willi syndrome (PWS), little is known about the consequences of these symptoms, especially in psychosocial function. We aimed to explore ASD symptoms in adults with PWS with special attention to psychosocial functionality. This cross-sectional study included 26 adults (15 women) with PWS who attended a reference unit for rare diseases. Participants’ primary caregivers completed the Social Responsiveness Scale (SRS), and clinicians assessed multidimensional functioning with the Personal and Social Performance Scale (PSP). Impaired social responsiveness was identified in20 (76.9%) participants, and manifest to marked difficulties in social functioning were identified in13 (50%). Participants with impaired social responsiveness (SRS 60) had significantly worse scores in functionality measured with the PSP (U = 12.5; p = 0.009) and with three of the four PSP main areas. Moreover, scores for the Social Cognition domain of the SRS correlated positively with the Socially useful activities (p < 0.05) and Personal and social relationships (p < 0.01) main areas of the PSP. These results suggest that difficulties in social skills should be assessed in all psychosocial evaluations of patients with PWS. 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