8991efa7c5aa41cc304911068d9c49b8 pmc_8918662.pdf 306ac5657630c279ca200c9c60420c12b0e9ca6f pmc_8918662.pdf adc21df5127d1392717b5b9597530cc6f2a3ad869b2facb0a7e3a946c2aec0a2 pmc_8918662.pdf Title: Missing Links Between Gene Function and Physiology in Genomics Subject: Knowledge of biological organisms at the molecular level that has been gathered is now organized into databases, often within ontological frameworks. Keywords: gene ontology, microbial annotations, gene function, challenges and issues, mechanisms and physiology Author: Julio Collado-Vides Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Feb 22 09:37:29 2022 CET ModDate: Tue Feb 22 13:10:30 2022 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 872937 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZWHOMW+MinionPro-Regular Type 1 Custom yes yes no 26 0 JRMLAZ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 27 0 GYHEKL+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 28 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 33 0 ZBADOX+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 34 0 VEWWKU+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 35 0 STMPBU+MinionPro-Bold Type 1 Custom yes yes no 93 0 NWWPTU+MinionPro-It Type 1 Custom yes yes no 94 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-07 04:29:01 CEST RepresentationInformation: pmc_8918662.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2022-03-28 07:26:34 CEST Size: 872937 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 5 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Missing Links Between Gene Function and Physiology in Genomics Children: Item: Title: Introduction Children: Item: Title: Functional Categorization Versus Understanding Item: Title: Granularity of Gene Functions Versus Physiological Processes Item: Title: Dealing With Unknowns Item: Title: Orthology-Based Annotations Item: Title: Universal Principles of Microbial Physiology Item: Title: Physiology (High-Level) Drives Mechanism (Low-Level) and Not the Other Way Around Item: Title: Physiology Versus Mechanisms (Molecular Biology) Item: Title: Phenotypic High-Throughput Annotations? Item: Title: Conclusion Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZBADOX+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: ZBADOX+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VEWWKU+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 237 FontDescriptor: FontName: VEWWKU+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZWHOMW+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: ZWHOMW+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JRMLAZ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: JRMLAZ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GYHEKL+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 148 FontDescriptor: FontName: GYHEKL+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: STMPBU+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: STMPBU+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NWWPTU+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: NWWPTU+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true XMP: gene ontology, microbial annotations, gene function, challenges and issues, mechanisms and physiology pdfTeX-1.40.18 1.5 application/pdf fphys-13-815874.tex Missing Links Between Gene Function and Physiology in Genomics Knowledge of biological organisms at the molecular level that has been gathered is now organized into databases, often within ontological frameworks. 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