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Producer: Acrobat Distiller 21.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Thu Mar 10 09:01:07 2022 CET ModDate: Thu Mar 10 09:04:53 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 612.284 x 790.866 pts Page rot: 0 File size: 4106542 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FGCPIB+TimesNewRomanMTStd Type 1C Custom yes yes yes 65 0 FGCPIC+TimesNewRomanMTStd-BoldIt Type 1C Custom yes yes yes 66 0 FGCPID+TimesNewRomanMTStd-Italic Type 1C Custom yes yes yes 67 0 FGCPIE+Helvetica-Bold Type 1C Custom yes yes no 68 0 FGCPLE+CMBSY10 Type 1C Custom yes yes yes 69 0 FGDAEB+SFRM0800 Type 1C Custom yes yes yes 70 0 FGDAGC+Helvetica Type 1C Custom yes yes no 71 0 FGDAJB+MTSYB Type 1C Custom yes yes yes 72 0 FGDAJC+RMTMIB Type 1C Custom yes yes yes 73 0 FGDALD+CMSY10 Type 1C Custom yes yes yes 74 0 FGDALE+SFRM0500 Type 1C Custom yes yes yes 75 0 FGDALF+MTSY Type 1C Custom yes yes yes 76 0 FGDALG+RMTMI Type 1C Custom yes yes yes 77 0 FGDAOG+TimesLTStd-Roman Type 1C Custom yes yes yes 153 0 FGDAPG+TimesNewRomanMTStd-Bold Type 1C Custom yes yes yes 154 0 FGDHLO+SFRM1000 Type 1C Custom yes yes yes 297 0 FGEBPA+TimesNewRomanPS Type 1C Custom yes yes no 439 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-18 02:28:47 CEST RepresentationInformation: pmc_8934637.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-28 07:34:55 CEST Size: 4106542 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 597 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Info: Title: Author: Subject: Keywords: Creator: XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc. 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Cecilia Salvoro Beatriz Cortés Ramon Amela Xavier Farre Jon Lerga-Jaso Marta Puig Jose Francisco Sánchez-Herrero Victor Moreno Manuel Perucho Lauro Sumoy Lluís Armengol Olivier Delaneau Mario Cáceres Rafael de Cid David Torrents Nucleic Acids Research Oxford University Press Pages: Page: Label: 2464 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 153, 630, 163, 644 Annotation: Subtype: Link Rect: 301, 630, 311, 644 Annotation: Subtype: Link Rect: 458, 630, 467, 644 Annotation: Subtype: Link Rect: 375, 598, 385, 612 Annotation: Subtype: Link Rect: 320, 582, 330, 596 Annotation: Subtype: Link Rect: 118, 550, 128, 565 Annotation: Subtype: Link Rect: 257, 550, 266, 565 Page: Label: 2465 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 287, 618, 294, 630 Destination: 364 Annotation: Subtype: Link Rect: 128, 541, 135, 553 Destination: 364 Annotation: Subtype: Link Rect: 108, 530, 115, 542 Destination: 364 Annotation: Subtype: Link Rect: 53, 441, 304, 467 Annotation: Subtype: 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