5ceb0f10fdf2ad7e5efd6608b120667b pmc_8942775.pdf 3ee876f4b66c3eba9a22965ae6c93a3c74867dfa pmc_8942775.pdf 1ef6ebf9ccbc331be9019146440e94e5aa3803070abd03b0fafdc6749722178f pmc_8942775.pdf Title: fphar-2022-832589 1..19 Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Mar 4 19:21:36 2022 CET ModDate: Fri Mar 4 19:21:36 2022 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 4735374 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ODJHMJ+AdvOTb316e848.B Type 1C WinAnsi yes yes no 750 0 ODJHMK+AdvOTaef7d8ec.BI Type 1C WinAnsi yes yes no 751 0 ODJHML+AdvOT810131c9.I Type 1C WinAnsi yes yes no 752 0 ODJHMM+AdvOT810131c9.I+20 Type 1C WinAnsi yes yes no 753 0 ODJHNM+AdvOT3e5a32a2.I Type 1C WinAnsi yes yes no 758 0 ODJHNN+AdvOTd86a71d2 Type 1C WinAnsi yes yes no 759 0 ODJHNO+AdvOTd86a71d2+fb Type 1C Custom yes yes yes 760 0 ODJHNP+AdvOT310e2d14+03 Type 1C Custom yes yes yes 761 0 ODJIEO+AdvOT3e5a32a2.I+20 Type 1C WinAnsi yes yes no 773 0 ODJIEP+AdvOT3e5a32a2.I+fb Type 1C Custom yes yes yes 774 0 ODJION+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 459 0 ODJIOO+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 452 0 ODJIOP+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 454 0 ODJIOM+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 464 0 ODJJAP+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 471 0 ODJJBA+AdvOT310e2d14+22 Type 1C Custom yes yes yes 465 0 ODJJBB+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 478 0 ODJJCC+AdvOTb316e848.B+20 Type 1C WinAnsi yes yes no 474 0 ODJOFD+AdvOTb65e897d.B+03 Type 1C Custom yes yes yes 481 0 ODKGCE+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 487 0 ODKGCF+AdvOT23421851 Type 1C WinAnsi yes yes no 488 0 ODKGDG+AdvOTd86a71d2+20 Type 1C WinAnsi yes yes no 493 0 ODKGDH+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 496 0 ODKGDI+AdvOT310e2d14 Type 1C WinAnsi yes yes no 484 0 ODLAJJ+AdvOT175de09a.I Type 1C WinAnsi yes yes no 501 0 ODLAJK+AdvOT5e4d79fc Type 1C WinAnsi yes yes no 502 0 ODMIPF+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 503 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-07 04:28:51 CEST RepresentationInformation: pmc_8942775.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2022-03-28 07:43:35 CEST Size: 4735374 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 812 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Actio ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Materials and Methods Destination: flink2 Children: Item: Title: Commercial Peptides and Antagonists Destination: slink1 Item: Title: In House-Peptide Synthesis Destination: slink2 Item: Title: Cell Culture and Transfection Destination: slink3 Item: Title: cAMP Assay Measurement Destination: slink4 Item: Title: Animal Welfare and Ethical Statement Destination: slink5 Item: Title: Capsaicin-Induced Dermal Vasodilation - Laser Doppler Imaging Overview Destination: slink6 Item: Title: Capsaicin-Induced Dermal Vasodilation – Antagonist Screening and Dose-Ranging Study Destination: slink7 Item: Title: Capsaicin-Induced Dermal Vasodilation - Dose-Duration Study Destination: slink8 Item: Title: Data Analysis Destination: slink9 Item: Title: Results Destination: flink3 Children: Item: Title: αCGRP7-37 and Cysteine-Substituted αCGRP8-37 Analogues Retain Antagonist Activities at Human CGRP and AMY1 Receptors Destination: slink10 Item: Title: Palmitoylation at the N-Terminus or at Position 24 but not at the C-Terminal Region (Position 35) Retains Antagonist Activi ... Destination: slink11 Item: Title: Lipidated αCGRP8-37 Analogues Display Enhanced Antagonist Activities at the Human CGRP Receptor Endogenously Expressed in S ... Destination: slink12 Children: Item: Title: Lipidated αCGRP8-37 Analogues but not αCGRP8-37 Exhibit Behavior Consistent With Delayed Dissociation at CGRP and AMY1 Rece ... Destination: sslink1 Item: Title: Lipidated αCGRP8-37 Analogues Display Antagonist Activities at AM1, AM2, and CT Receptors Destination: sslink2 Item: Title: Lipidated αCGRP8-37 Analogues Display Comparable Antagonist Activities Between Human and Mouse CGRP and AMY1 Receptors Destination: sslink3 Item: Title: Effects of Antagonists on the Capsaicin-Induced Dermal Vasodilatory Response Destination: sslink4 Item: Title: Establishing the Capsaicin-Induced Dermal Vasodilatory Model Destination: sslink1 Item: Title: Lipidated hαCGRP8-37 Analogues Antagonize CGRP Action in vivo Destination: sslink2 Item: Title: Discussion Destination: slink13 Children: Item: Title: Lipidated hαCGRP8-37 Analogues Retain Antagonist Activity In Vitro Destination: sslink5 Item: Title: Lipidated hαCGRP8-37 Peptide Antagonists May Have Altered Receptor Binding Kinetics Destination: sslink6 Item: Title: Lipidated αCGRP8-37 Peptide Antagonists Attenuate CGRP Action In Vivo Destination: sslink7 Item: Title: Conclusion Destination: slink14 Item: Title: Data Availability Statement Destination: flink4 Item: Title: Ethics Statement Destination: flink5 Item: Title: Author Contributions Destination: flink6 Item: Title: Funding Destination: flink7 Item: Title: Acknowledgments Destination: slink15 Item: Title: Supplementary Material Destination: flink8 Item: Title: References Destination: rlink1 Info: Title: fphar-2022-832589 1..19 Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Mar 04 19:51:36 CET 2022 ModDate: Fri Mar 04 19:51:36 CET 2022 ID: 0x5d605e407946132e2304cab5428ff3c1, 0x940d8806461cd246abb54d11731b9243 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1606 ImageHeight: 1680 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1306 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