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valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 442 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Low-Energy Electron Irradiation of Tick-Borne Encephalitis Virus Provides a Protective Inactivated Vaccine Destination: bmark_-1014913193 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and Methods Destination: s2 Children: Item: Title: Cell and Virus Culture Destination: s2_1 Item: Title: LEEI-Based Inactivation Destination: s2_2 Item: Title: Chemical Inactivation Destination: s2_3 Item: Title: Verification of TBEV Inactivation Destination: s2_4 Item: Title: ELISA Destination: s2_5 Item: Title: Virus Neutralization Assay Destination: s2_6 Item: Title: TBEV Immunization and Challenge Experiment Destination: s2_7 Item: Title: Quantification of Viral RNA and Infectious Virus in Organ Homogenates Destination: s2_8 Item: Title: Statistical Analysis Destination: s2_9 Item: Title: Results Destination: s3 Children: Item: Title: LEEI-Based Inactivation of TBEV Destination: s3_1 Item: Title: Conservation of Antigenicity Upon Inactivation Destination: s3_2 Item: Title: LEEI and Formaldehyde Inactivated TBEV Elicit Binding and Neutralizing Humoral Immune Responses in Mice Destination: s3_3 Item: Title: LEEI- and Formaldehyde Inactivated TBEV Vaccine Protect Mice Against TBEV Challenge Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data Availability Statement Destination: s5 Item: Title: Ethics Statement Destination: s6 Item: Title: Author Contributions Destination: s7 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Title: Low-Energy Electron Irradiation of Tick-Borne Encephalitis Virus Provides a Protective Inactivated Vaccine Author: Julia Finkensieper Subject: Tick-borne encephalitis virus (TBEV) is a zoonotic flavivirus which is endemic in many European 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